Lista de obras - Michelandrea De Cesare - Dominio Público Uruguay

1,4-Substituted Triazoles as Nonsteroidal Anti-Androgens for Prostate Cancer Treatment

artículo científico publicado en 2017

3-Arylidene-N-hydroxyoxindoles: A New Class of Compounds Endowed with Antitumor Activity

artículo científico publicado en 2016

8,11-dihydroxy-6-[(aminoalkyl)amino]-7H-benzo[e]perimidin-7-ones with activity in multidrug-resistant cell lines: synthesis and antitumor evaluation

artículo científico publicado en 1999

A new avenue toward androgen receptor pan-antagonists: C2 sterically hindered substitution of hydroxy-propanamides

artículo científico publicado en 2014

Antitumor activity of a novel homodimeric SMAC mimetic in ovarian carcinoma.

artículo científico publicado en 2013

Antitumor activity of miR-34a in peritoneal mesothelioma relies on c-MET and AXL inhibition: persistent activation of ERK and AKT signaling as a possible cytoprotective mechanism

artículo científico publicado en 2017

Antitumor activity of the combination of synthetic retinoid ST1926 and cisplatin in ovarian carcinoma models

artículo científico publicado en 2007

Ascites Regression and Survival Increase in Mice Bearing Advanced-stage Human Ovarian Carcinomas and Repeatedly Treated Intraperitoneally With CpG-ODN

artículo científico publicado en 2010

Biodistribution of haematoporphyrin analogues in a lung carcinoma model

article

Biological properties of IDN5174, a new synthetic camptothecin with the open lactone ring

artículo científico publicado en 2006

Biphenyl-4-yl-acrylohydroxamic acids: Identification of a novel indolyl-substituted HDAC inhibitor with antitumor activity.

artículo científico publicado en 2016

Cellular bases of the antitumor activity of a 7-substituted camptothecin in hormone-refractory human prostate carcinoma models

artículo científico publicado en 2003

Cellular basis of antiproliferative and antitumor activity of the novel camptothecin derivative, gimatecan, in bladder carcinoma models

artículo científico publicado en 2005

Characterization of an established human, malignant, glioblastoma cell line (GBM) and its response to conventional drugs.

artículo científico publicado en 1994

Configurational requirements of the sugar moiety for the pharmacological activity of anthracycline disaccharides

artículo científico publicado en 1999

CpG-oligodeoxynucleotides exert remarkable antitumor activity against diffuse malignant peritoneal mesothelioma orthotopic xenografts.

artículo científico publicado en 2016

Design, modeling, synthesis and biological activity evaluation of camptothecin-linked platinum anticancer agents

artículo científico publicado en 2013

Design, synthesis and biological evaluation of novel dimeric and tetrameric cRGD-paclitaxel conjugates for integrin-assisted drug delivery

artículo científico publicado en 2015

Design, synthesis, and biological evaluation of novel cRGD-paclitaxel conjugates for integrin-assisted drug delivery.

artículo científico publicado en 2012

Design, synthesis, and evaluation of biphenyl-4-yl-acrylohydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors

artículo científico publicado en 2008

Dimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part II: Structural and biological characterization

artículo científico publicado en 2012

Down-regulation of human telomerase reverse transcriptase through specific activation of RNAi pathway quickly results in cancer cell growth impairment

scientific article published on 01 February 2007

E-ring-modified 7-oxyiminomethyl camptothecins: Synthesis and preliminary in vitro and in vivo biological evaluation

artículo científico publicado en 2008

Effects of MnDPDP and ICRF-187 on Doxorubicin-Induced Cardiotoxicity and Anticancer Activity

artículo científico publicado en 2012

Efficacy and toxicity profile of oral topotecan in a panel of human tumour xenografts

artículo científico publicado en 2000

Efficacy of a Selective Binder of αVβ3 Integrin Linked to the Tyrosine Kinase Inhibitor Sunitinib in Ovarian Carcinoma Preclinical Models

artículo científico publicado en 2019

Efficacy of the novel camptothecin gimatecan against orthotopic and metastatic human tumor xenograft models

artículo científico publicado en 2004

Enhanced antitumour efficacy of gimatecan in combination with Bcl-2 antisense oligonucleotide in human melanoma xenografts.

artículo científico publicado en 2005

Eradication of Ovarian Tumor Xenografts by Locoregional Administration of Targeted Immunotherapy

artículo científico publicado en 2008

FoxO-1 contributes to the efficacy of the combination of the XPO1 inhibitor selinexor and cisplatin in ovarian carcinoma preclinical models.

artículo científico publicado en 2017

Improved apoptotic cell death in drug-resistant non-small-cell lung cancer cells by tumor necrosis factor-related apoptosis-inducing ligand-based treatment.

artículo científico publicado en 2013

Influence of the adamantyl moiety on the activity of biphenylacrylohydroxamic acid-based HDAC inhibitors

artículo científico publicado en 2014

Inhibition of proteasome deubiquitinating activity as a new cancer therapy

artículo científico publicado en 2011

Intracellular accumulation and DNA damage persistence as determinants of human squamous cell carcinoma hypersensitivity to the novel camptothecin ST1968.

artículo científico publicado en 2008

Isoxazolo(aza)naphthoquinones: a new class of cytotoxic Hsp90 inhibitors

artículo científico publicado en 2012

Modulation of cell growth and cisplatin sensitivity by membrane gamma-glutamyltransferase in melanoma cells.

artículo científico publicado en 2006

Natural and semisynthetic azaphilones as a new scaffold for Hsp90 inhibitors

artículo científico publicado en 2010

Novel 1H-pyrrolo[2,3-b]pyridine derivative nortopsentin analogues: synthesis and antitumor activity in peritoneal mesothelioma experimental models.

artículo científico publicado en 2013

Novel 7-oxyiminomethyl derivatives of camptothecin with potent in vitro and in vivo antitumor activity

artículo científico publicado en 2001

Novel 7-substituted camptothecins with potent antitumor activity

artículo científico publicado en 2000

Novel cytotoxic 7-iminomethyl and 7-aminomethyl derivatives of camptothecin.

artículo científico publicado en 2001

Preclinical efficacy of ST1976, a novel camptothecin analog of the 7-oxyiminomethyl series

artículo científico publicado en 2006

Preclinical profile of antitumor activity of a novel hydrophilic camptothecin, ST1968.

artículo científico publicado en 2008

Ribozyme-mediated down-regulation of survivin expression sensitizes human melanoma cells to topotecan in vitro and in vivo

artículo científico publicado en 2004

Ribozyme-mediated inhibition of survivin expression increases spontaneous and drug-induced apoptosis and decreases the tumorigenic potential of human prostate cancer cells

artículo científico publicado en 2004

Role of tyrosyl-DNA phosphodiesterase 1 and inter-players in regulation of tumor cell sensitivity to topoisomerase I inhibition.

artículo científico publicado en 2011

Sensitization of ovarian carcinoma cells to the atypical retinoid ST1926 by the histone deacetylase inhibitor, RC307: enhanced DNA damage response

artículo científico publicado en 2010

Smac mimetics induce inflammation and necrotic tumour cell death by modulating macrophage activity

artículo científico publicado en 2013

Spontaneous lung metastases in a human lung tumor xenograft: a new experimental model

artículo científico publicado en 1996

Sulfonates-PMMA nanoparticles conjugates: a versatile system for multimodal application

artículo científico publicado en 2012

Synergistic antitumor activity of cetuximab and namitecan in human squamous cell carcinoma models relies on cooperative inhibition of EGFR expression and depends on high EGFR gene copy number

artículo científico publicado en 2013

Synergistic antitumor effects of novel HDAC inhibitors and paclitaxel in vitro and in vivo

artículo científico publicado en 2011

Synergistic interaction between the novel histone deacetylase inhibitor ST2782 and the proteasome inhibitor bortezomib in platinum-sensitive and resistant ovarian carcinoma cells

artículo científico publicado en 2012

Synthesis and Superpotent Anticancer Activity of Tubulysins Carrying Non-hydrolysable N-Substituents on Tubuvaline

artículo científico publicado en 2017

Synthesis and biological evaluation of imidazolo[2,1-b]benzothiazole derivatives, as potential p53 inhibitors

artículo científico publicado en 2011

Synthesis and cytotoxic activity of polyamine analogues of camptothecin

artículo científico publicado en 2006

TLR9 agonists oppositely modulate DNA repair genes in tumor versus immune cells and enhance chemotherapy effects.

artículo científico publicado en 2011

Targeting peptidyl-prolyl isomerase pin1 to inhibit tumor cell aggressiveness.

artículo científico publicado en 2016

The curative efficacy of namitecan (ST1968) in preclinical models of pediatric sarcoma is associated with antiangiogenic effects.

artículo científico publicado en 2012

Tissue distribution, antitumour activity and in vivo apoptosis induction by MEN10755 in nude mice

artículo científico publicado en 2001

YM155 sensitizes triple-negative breast cancer to membrane-bound TRAIL through p38 MAPK- and CHOP-mediated DR5 upregulation.

artículo científico publicado en 2014

miR-205 impairs the autophagic flux and enhances cisplatin cytotoxicity in castration-resistant prostate cancer cells

artículo científico publicado en 2013

miR-205 regulates basement membrane deposition in human prostate: implications for cancer development

artículo científico publicado en 2012

Lista de obras de Michelandrea De Cesare

1,4-Substituted Triazoles as Nonsteroidal Anti-Androgens for Prostate Cancer Treatment

3-Arylidene-N-hydroxyoxindoles: A New Class of Compounds Endowed with Antitumor Activity

8,11-dihydroxy-6-[(aminoalkyl)amino]-7H-benzo[e]perimidin-7-ones with activity in multidrug-resistant cell lines: synthesis and antitumor evaluation

A new avenue toward androgen receptor pan-antagonists: C2 sterically hindered substitution of hydroxy-propanamides

Antitumor activity of a novel homodimeric SMAC mimetic in ovarian carcinoma.

Antitumor activity of miR-34a in peritoneal mesothelioma relies on c-MET and AXL inhibition: persistent activation of ERK and AKT signaling as a possible cytoprotective mechanism

Antitumor activity of the combination of synthetic retinoid ST1926 and cisplatin in ovarian carcinoma models

Ascites Regression and Survival Increase in Mice Bearing Advanced-stage Human Ovarian Carcinomas and Repeatedly Treated Intraperitoneally With CpG-ODN

Biodistribution of haematoporphyrin analogues in a lung carcinoma model

Biological properties of IDN5174, a new synthetic camptothecin with the open lactone ring

Biphenyl-4-yl-acrylohydroxamic acids: Identification of a novel indolyl-substituted HDAC inhibitor with antitumor activity.

Cellular bases of the antitumor activity of a 7-substituted camptothecin in hormone-refractory human prostate carcinoma models

Cellular basis of antiproliferative and antitumor activity of the novel camptothecin derivative, gimatecan, in bladder carcinoma models

Characterization of an established human, malignant, glioblastoma cell line (GBM) and its response to conventional drugs.

Configurational requirements of the sugar moiety for the pharmacological activity of anthracycline disaccharides

CpG-oligodeoxynucleotides exert remarkable antitumor activity against diffuse malignant peritoneal mesothelioma orthotopic xenografts.

Design, modeling, synthesis and biological activity evaluation of camptothecin-linked platinum anticancer agents

Design, synthesis and biological evaluation of novel dimeric and tetrameric cRGD-paclitaxel conjugates for integrin-assisted drug delivery

Design, synthesis, and biological evaluation of novel cRGD-paclitaxel conjugates for integrin-assisted drug delivery.

Design, synthesis, and evaluation of biphenyl-4-yl-acrylohydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors

Dimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part II: Structural and biological characterization

Down-regulation of human telomerase reverse transcriptase through specific activation of RNAi pathway quickly results in cancer cell growth impairment

E-ring-modified 7-oxyiminomethyl camptothecins: Synthesis and preliminary in vitro and in vivo biological evaluation

Effects of MnDPDP and ICRF-187 on Doxorubicin-Induced Cardiotoxicity and Anticancer Activity

Efficacy and toxicity profile of oral topotecan in a panel of human tumour xenografts

Efficacy of a Selective Binder of αVβ3 Integrin Linked to the Tyrosine Kinase Inhibitor Sunitinib in Ovarian Carcinoma Preclinical Models

Efficacy of the novel camptothecin gimatecan against orthotopic and metastatic human tumor xenograft models

Enhanced antitumour efficacy of gimatecan in combination with Bcl-2 antisense oligonucleotide in human melanoma xenografts.

Eradication of Ovarian Tumor Xenografts by Locoregional Administration of Targeted Immunotherapy

FoxO-1 contributes to the efficacy of the combination of the XPO1 inhibitor selinexor and cisplatin in ovarian carcinoma preclinical models.

Improved apoptotic cell death in drug-resistant non-small-cell lung cancer cells by tumor necrosis factor-related apoptosis-inducing ligand-based treatment.

Influence of the adamantyl moiety on the activity of biphenylacrylohydroxamic acid-based HDAC inhibitors

Inhibition of proteasome deubiquitinating activity as a new cancer therapy

Intracellular accumulation and DNA damage persistence as determinants of human squamous cell carcinoma hypersensitivity to the novel camptothecin ST1968.

Isoxazolo(aza)naphthoquinones: a new class of cytotoxic Hsp90 inhibitors

Modulation of cell growth and cisplatin sensitivity by membrane gamma-glutamyltransferase in melanoma cells.

Natural and semisynthetic azaphilones as a new scaffold for Hsp90 inhibitors

Novel 1H-pyrrolo[2,3-b]pyridine derivative nortopsentin analogues: synthesis and antitumor activity in peritoneal mesothelioma experimental models.

Novel 7-oxyiminomethyl derivatives of camptothecin with potent in vitro and in vivo antitumor activity

Novel 7-substituted camptothecins with potent antitumor activity

Novel cytotoxic 7-iminomethyl and 7-aminomethyl derivatives of camptothecin.

Preclinical efficacy of ST1976, a novel camptothecin analog of the 7-oxyiminomethyl series

Preclinical profile of antitumor activity of a novel hydrophilic camptothecin, ST1968.

Ribozyme-mediated down-regulation of survivin expression sensitizes human melanoma cells to topotecan in vitro and in vivo

Ribozyme-mediated inhibition of survivin expression increases spontaneous and drug-induced apoptosis and decreases the tumorigenic potential of human prostate cancer cells

Role of tyrosyl-DNA phosphodiesterase 1 and inter-players in regulation of tumor cell sensitivity to topoisomerase I inhibition.

Sensitization of ovarian carcinoma cells to the atypical retinoid ST1926 by the histone deacetylase inhibitor, RC307: enhanced DNA damage response

Smac mimetics induce inflammation and necrotic tumour cell death by modulating macrophage activity

Spontaneous lung metastases in a human lung tumor xenograft: a new experimental model

Sulfonates-PMMA nanoparticles conjugates: a versatile system for multimodal application

Synergistic antitumor activity of cetuximab and namitecan in human squamous cell carcinoma models relies on cooperative inhibition of EGFR expression and depends on high EGFR gene copy number

Synergistic antitumor effects of novel HDAC inhibitors and paclitaxel in vitro and in vivo

Synergistic interaction between the novel histone deacetylase inhibitor ST2782 and the proteasome inhibitor bortezomib in platinum-sensitive and resistant ovarian carcinoma cells

Synthesis and Superpotent Anticancer Activity of Tubulysins Carrying Non-hydrolysable N-Substituents on Tubuvaline

Synthesis and biological evaluation of imidazolo[2,1-b]benzothiazole derivatives, as potential p53 inhibitors

Synthesis and cytotoxic activity of polyamine analogues of camptothecin

TLR9 agonists oppositely modulate DNA repair genes in tumor versus immune cells and enhance chemotherapy effects.

Targeting peptidyl-prolyl isomerase pin1 to inhibit tumor cell aggressiveness.

The curative efficacy of namitecan (ST1968) in preclinical models of pediatric sarcoma is associated with antiangiogenic effects.

Tissue distribution, antitumour activity and in vivo apoptosis induction by MEN10755 in nude mice

YM155 sensitizes triple-negative breast cancer to membrane-bound TRAIL through p38 MAPK- and CHOP-mediated DR5 upregulation.

miR-205 impairs the autophagic flux and enhances cisplatin cytotoxicity in castration-resistant prostate cancer cells

miR-205 regulates basement membrane deposition in human prostate: implications for cancer development