Lista de obras - Valentina Zuco - Dominio Público Uruguay

3-Arylidene-N-hydroxyoxindoles: A New Class of Compounds Endowed with Antitumor Activity

artículo científico publicado en 2016

A novel atypical retinoid endowed with proapoptotic and antitumor activity

artículo científico publicado en 2003

A role for c-myc in DNA damage-induced apoptosis in a human TP53-mutant small-cell lung cancer cell line

artículo científico publicado en 2001

ATM- and ATR-mediated response to DNA damage induced by a novel camptothecin, ST1968.

artículo científico publicado en 2009

Antitumor activity of miR-34a in peritoneal mesothelioma relies on c-MET and AXL inhibition: persistent activation of ERK and AKT signaling as a possible cytoprotective mechanism

artículo científico publicado en 2017

Antitumor activity of the combination of synthetic retinoid ST1926 and cisplatin in ovarian carcinoma models

artículo científico publicado en 2007

Apoptosis and growth arrest induced by platinum compounds in U2-OS cells reflect a specific DNA damage recognition associated with a different p53-mediated response.

artículo científico publicado en 2002

Biphenyl-4-yl-acrylohydroxamic acids: Identification of a novel indolyl-substituted HDAC inhibitor with antitumor activity

artículo científico publicado en 2016

Camptothecin-7-yl-methanthiole: semisynthesis and biological evaluation

artículo científico publicado en 2012

Cell cycle checkpoint efficiency and cellular response to paclitaxel in prostate cancer cells

artículo científico publicado en 2001

Cellular bases of the antitumor activity of a 7-substituted camptothecin in hormone-refractory human prostate carcinoma models

artículo científico publicado en 2003

Cellular bases of the antitumor activity of the novel taxane IDN 5109 (BAY59-8862) on hormone-refractory prostate cancer

artículo científico publicado en 2002

Corrigendum to “Natural and semisynthetic azaphilones as a new scaffold for Hsp90 inhibitors” [Bioorg. Med. Chem. 18 (2010) 6031–6043]

scholarly article published in Bioorganic & Medicinal Chemistry

Cyclic pifithrin-alpha sensitizes wild type p53 tumor cells to antimicrotubule agent-induced apoptosis

artículo científico publicado en 2008

Design, synthesis, and evaluation of biphenyl-4-yl-acrylohydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors

artículo científico publicado en 2008

Development of resistance to the atypical retinoid, ST1926, in the lung carcinoma cell line H460 is associated with reduced formation of DNA strand breaks and a defective DNA damage response

artículo científico publicado en 2005

Drug Combinations with Proteasome Inhibitors in Antitumor Therapy ⬇️

artículo científico publicado el 1 de enero de 2013

Efficacy of ST1968 (namitecan) on a topotecan-resistant squamous cell carcinoma

artículo científico publicado en 2010

Evaluation of Mediators Associated with the Inflammatory Response in Prostate Cancer Patients Undergoing Radiotherapy.

artículo científico publicado en 2018

Exosome-like Nanovectors for Drug Delivery in Cancer

scientific article published on 01 January 2019

Histone deacetylase and microtubules as targets for the synthesis of releasable conjugate compounds

artículo científico publicado en 2009

Induction of apoptosis and stress response in ovarian carcinoma cell lines treated with ST1926, an atypical retinoid

artículo científico publicado en 2004

Influence of the adamantyl moiety on the activity of biphenylacrylohydroxamic acid-based HDAC inhibitors

artículo científico publicado en 2014

Intracellular accumulation and DNA damage persistence as determinants of human squamous cell carcinoma hypersensitivity to the novel camptothecin ST1968.

artículo científico publicado en 2008

Investigation on the ZBG-functionality of phenyl-4-yl-acrylohydroxamic acid derivatives as histone deacetylase inhibitors

artículo científico publicado en 2015

Isoxazolo(aza)naphthoquinones: a new class of cytotoxic Hsp90 inhibitors

artículo científico publicado en 2012

Metabolic approach to the enhancement of antitumor effect of chemotherapy: a key role of acetyl-L-carnitine

artículo científico publicado en 2010

Modulation of cell sensitivity to antitumor agents by targeting survival pathways.

artículo científico publicado en 2010

Modulation of survival signaling pathways and persistence of the genotoxic stress as a basis for the synergistic interaction between the atypical retinoid ST1926 and the epidermal growth factor receptor inhibitor ZD1839.

artículo científico publicado en 2005

Namitecan: a hydrophilic camptothecin with a promising preclinical profile

artículo científico

Natural and semisynthetic azaphilones as a new scaffold for Hsp90 inhibitors

artículo científico publicado en 2010

New macrocyclic analogs of the natural histone deacetylase inhibitor FK228; design, synthesis and preliminary biological evaluation

artículo científico publicado en 2015

Overcoming ABC transporter-mediated multidrug resistance: The dual role of tyrosine kinase inhibitors as multitargeting agents.

artículo científico publicado en 2017

PLK1 is a critical determinant of tumor cell sensitivity to CPT11 and its inhibition enhances the drug antitumor efficacy in squamous cell carcinoma models sensitive and resistant to camptothecins.

artículo científico publicado en 2015

Patient-derived solitary fibrous tumour xenografts predict high sensitivity to doxorubicin/dacarbazine combination confirmed in the clinic and highlight the potential effectiveness of trabectedin or eribulin against this tumour.

artículo científico publicado en 2017

Preclinical Activity of New [1,2]Oxazolo[5,4-e]isoindole Derivatives in Diffuse Malignant Peritoneal Mesothelioma.

artículo científico publicado en 2016

Preclinical profile of antitumor activity of a novel hydrophilic camptothecin, ST1968.

artículo científico publicado en 2008

Proteomic analysis of cellular response to novel proapoptotic agents related to atypical retinoids in human IGROV-1 ovarian carcinoma cells

artículo científico publicado en 2011

Quinazolinecarboline alkaloid evodiamine as scaffold for targeting topoisomerase I and sirtuins

artículo científico publicado en 2013

Role of c-myc protein in hormone refractory prostate carcinoma: cellular response to paclitaxel

artículo científico publicado en 2004

Selective cytotoxicity of betulinic acid on tumor cell lines, but not on normal cells

artículo científico publicado en 2002

Sensitization of ovarian carcinoma cells to the atypical retinoid ST1926 by the histone deacetylase inhibitor, RC307: enhanced DNA damage response

artículo científico publicado en 2010

Sensitization of tumor cells by targeting histone deacetylases

artículo científico publicado en 2011

Subcellular localization of the camptothecin analogues, topotecan and gimatecan

artículo científico publicado en 2004

Synergistic antitumor activity of cetuximab and namitecan in human squamous cell carcinoma models relies on cooperative inhibition of EGFR expression and depends on high EGFR gene copy number

artículo científico publicado en 2013

Synergistic antitumor effects of novel HDAC inhibitors and paclitaxel in vitro and in vivo

artículo científico publicado en 2011

Synthesis and Evaluation of the Tumor Cell Growth Inhibitory Potential of New Putative HSP90 Inhibitors.

artículo científico publicado en 2018

Synthesis and Superpotent Anticancer Activity of Tubulysins Carrying Non-hydrolysable N-Substituents on Tubuvaline

artículo científico publicado en 2017

Synthesis and biological evaluation of imidazolo[2,1-b]benzothiazole derivatives, as potential p53 inhibitors

artículo científico publicado en 2011

Synthesis and structure-activity relationships of a new series of retinoid-related biphenyl-4-ylacrylic acids endowed with antiproliferative and proapoptotic activity

artículo científico publicado en 2005

Synthesis and structure-activity relationships of new antiproliferative and proapoptotic retinoid-related biphenyl-4-yl-acrylic acids

artículo científico publicado en 2007

Synthesis, modelling, and antimitotic properties of tricyclic systems characterised by a 2-(5-Phenyl-1H-pyrrol-3-yl)-1,3,4-oxadiazole moiety

artículo científico publicado en 2009

Targeting DNA topoisomerase I with non-camptothecin poisons.

artículo científico

Targeting of RET oncogene by naphthalene diimide-mediated gene promoter G-quadruplex stabilization exerts anti-tumor activity in oncogene-addicted human medullary thyroid cancer.

artículo científico publicado en 2016

Targeting the Akt Kinase to Modulate Survival, Invasiveness and Drug Resistance of Cancer Cells ⬇️

artículo científico publicado el 1 de enero de 2013

Targeting the invasive phenotype of cisplatin-resistant non-small cell lung cancer cells by a novel histone deacetylase inhibitor.

artículo científico publicado en 2015

Telomere as a Therapeutic Target in Dedifferentiated Liposarcoma

artículo científico publicado en 2022

The curative efficacy of namitecan (ST1968) in preclinical models of pediatric sarcoma is associated with antiangiogenic effects.

artículo científico publicado en 2012

The enhancement of antiproliferative and proapoptotic activity of HDAC inhibitors by curcumin is mediated by Hsp90 inhibition

artículo científico publicado en 2009

UV-induced DNA incision and proliferating cell nuclear antigen recruitment to repair sites occur independently of p53-replication protein A interaction in p53 wild type and mutant ovarian carcinoma cells

artículo científico publicado en 2001

[1,2]Oxazolo[5,4-e]isoindoles as promising tubulin polymerization inhibitors.

artículo científico publicado en 2016

miR-205 enhances radiation sensitivity of prostate cancer cells by impairing DNA damage repair through PKCε and ZEB1 inhibition

artículo científico publicado en 2019

miR-875-5p counteracts epithelial-to-mesenchymal transition and enhances radiation response in prostate cancer through repression of the EGFR-ZEB1 axis

artículo científico publicado en 2017

Lista de obras de Valentina Zuco

3-Arylidene-N-hydroxyoxindoles: A New Class of Compounds Endowed with Antitumor Activity

A novel atypical retinoid endowed with proapoptotic and antitumor activity

A role for c-myc in DNA damage-induced apoptosis in a human TP53-mutant small-cell lung cancer cell line

ATM- and ATR-mediated response to DNA damage induced by a novel camptothecin, ST1968.

Antitumor activity of miR-34a in peritoneal mesothelioma relies on c-MET and AXL inhibition: persistent activation of ERK and AKT signaling as a possible cytoprotective mechanism

Antitumor activity of the combination of synthetic retinoid ST1926 and cisplatin in ovarian carcinoma models

Apoptosis and growth arrest induced by platinum compounds in U2-OS cells reflect a specific DNA damage recognition associated with a different p53-mediated response.

Biphenyl-4-yl-acrylohydroxamic acids: Identification of a novel indolyl-substituted HDAC inhibitor with antitumor activity

Camptothecin-7-yl-methanthiole: semisynthesis and biological evaluation

Cell cycle checkpoint efficiency and cellular response to paclitaxel in prostate cancer cells

Cellular bases of the antitumor activity of a 7-substituted camptothecin in hormone-refractory human prostate carcinoma models

Cellular bases of the antitumor activity of the novel taxane IDN 5109 (BAY59-8862) on hormone-refractory prostate cancer

Corrigendum to “Natural and semisynthetic azaphilones as a new scaffold for Hsp90 inhibitors” [Bioorg. Med. Chem. 18 (2010) 6031–6043]

Cyclic pifithrin-alpha sensitizes wild type p53 tumor cells to antimicrotubule agent-induced apoptosis

Design, synthesis, and evaluation of biphenyl-4-yl-acrylohydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors

Development of resistance to the atypical retinoid, ST1926, in the lung carcinoma cell line H460 is associated with reduced formation of DNA strand breaks and a defective DNA damage response

Drug Combinations with Proteasome Inhibitors in Antitumor Therapy ⬇️

Efficacy of ST1968 (namitecan) on a topotecan-resistant squamous cell carcinoma

Evaluation of Mediators Associated with the Inflammatory Response in Prostate Cancer Patients Undergoing Radiotherapy.

Exosome-like Nanovectors for Drug Delivery in Cancer

Histone deacetylase and microtubules as targets for the synthesis of releasable conjugate compounds

Induction of apoptosis and stress response in ovarian carcinoma cell lines treated with ST1926, an atypical retinoid

Influence of the adamantyl moiety on the activity of biphenylacrylohydroxamic acid-based HDAC inhibitors

Intracellular accumulation and DNA damage persistence as determinants of human squamous cell carcinoma hypersensitivity to the novel camptothecin ST1968.

Investigation on the ZBG-functionality of phenyl-4-yl-acrylohydroxamic acid derivatives as histone deacetylase inhibitors

Isoxazolo(aza)naphthoquinones: a new class of cytotoxic Hsp90 inhibitors

Metabolic approach to the enhancement of antitumor effect of chemotherapy: a key role of acetyl-L-carnitine

Modulation of cell sensitivity to antitumor agents by targeting survival pathways.

Modulation of survival signaling pathways and persistence of the genotoxic stress as a basis for the synergistic interaction between the atypical retinoid ST1926 and the epidermal growth factor receptor inhibitor ZD1839.

Namitecan: a hydrophilic camptothecin with a promising preclinical profile

Natural and semisynthetic azaphilones as a new scaffold for Hsp90 inhibitors

New macrocyclic analogs of the natural histone deacetylase inhibitor FK228; design, synthesis and preliminary biological evaluation

Overcoming ABC transporter-mediated multidrug resistance: The dual role of tyrosine kinase inhibitors as multitargeting agents.

PLK1 is a critical determinant of tumor cell sensitivity to CPT11 and its inhibition enhances the drug antitumor efficacy in squamous cell carcinoma models sensitive and resistant to camptothecins.

Patient-derived solitary fibrous tumour xenografts predict high sensitivity to doxorubicin/dacarbazine combination confirmed in the clinic and highlight the potential effectiveness of trabectedin or eribulin against this tumour.

Preclinical Activity of New [1,2]Oxazolo[5,4-e]isoindole Derivatives in Diffuse Malignant Peritoneal Mesothelioma.

Preclinical profile of antitumor activity of a novel hydrophilic camptothecin, ST1968.

Proteomic analysis of cellular response to novel proapoptotic agents related to atypical retinoids in human IGROV-1 ovarian carcinoma cells

Quinazolinecarboline alkaloid evodiamine as scaffold for targeting topoisomerase I and sirtuins

Role of c-myc protein in hormone refractory prostate carcinoma: cellular response to paclitaxel

Selective cytotoxicity of betulinic acid on tumor cell lines, but not on normal cells

Sensitization of ovarian carcinoma cells to the atypical retinoid ST1926 by the histone deacetylase inhibitor, RC307: enhanced DNA damage response

Sensitization of tumor cells by targeting histone deacetylases

Subcellular localization of the camptothecin analogues, topotecan and gimatecan

Synergistic antitumor activity of cetuximab and namitecan in human squamous cell carcinoma models relies on cooperative inhibition of EGFR expression and depends on high EGFR gene copy number

Synergistic antitumor effects of novel HDAC inhibitors and paclitaxel in vitro and in vivo

Synthesis and Evaluation of the Tumor Cell Growth Inhibitory Potential of New Putative HSP90 Inhibitors.

Synthesis and Superpotent Anticancer Activity of Tubulysins Carrying Non-hydrolysable N-Substituents on Tubuvaline

Synthesis and biological evaluation of imidazolo[2,1-b]benzothiazole derivatives, as potential p53 inhibitors

Synthesis and structure-activity relationships of a new series of retinoid-related biphenyl-4-ylacrylic acids endowed with antiproliferative and proapoptotic activity

Synthesis and structure-activity relationships of new antiproliferative and proapoptotic retinoid-related biphenyl-4-yl-acrylic acids

Synthesis, modelling, and antimitotic properties of tricyclic systems characterised by a 2-(5-Phenyl-1H-pyrrol-3-yl)-1,3,4-oxadiazole moiety

Targeting DNA topoisomerase I with non-camptothecin poisons.

Targeting of RET oncogene by naphthalene diimide-mediated gene promoter G-quadruplex stabilization exerts anti-tumor activity in oncogene-addicted human medullary thyroid cancer.

Targeting the Akt Kinase to Modulate Survival, Invasiveness and Drug Resistance of Cancer Cells ⬇️

Targeting the invasive phenotype of cisplatin-resistant non-small cell lung cancer cells by a novel histone deacetylase inhibitor.

Telomere as a Therapeutic Target in Dedifferentiated Liposarcoma

The curative efficacy of namitecan (ST1968) in preclinical models of pediatric sarcoma is associated with antiangiogenic effects.

The enhancement of antiproliferative and proapoptotic activity of HDAC inhibitors by curcumin is mediated by Hsp90 inhibition

UV-induced DNA incision and proliferating cell nuclear antigen recruitment to repair sites occur independently of p53-replication protein A interaction in p53 wild type and mutant ovarian carcinoma cells

[1,2]Oxazolo[5,4-e]isoindoles as promising tubulin polymerization inhibitors.

miR-205 enhances radiation sensitivity of prostate cancer cells by impairing DNA damage repair through PKCε and ZEB1 inhibition

miR-875-5p counteracts epithelial-to-mesenchymal transition and enhances radiation response in prostate cancer through repression of the EGFR-ZEB1 axis