Lista de obras - Osamu Nagano - Dominio Público Uruguay

ADAM-17 associated with CD44 cleavage and metastasis in oral squamous cell carcinoma.

artículo científico publicado en 2007

Alternative splicing of CD44 mRNA by ESRP1 enhances lung colonization of metastatic cancer cell.

artículo científico publicado en 2012

CD44 Splice Variant v8-10 as a Marker of Serous Ovarian Cancer Prognosis.

artículo científico publicado en 2016

CD44 variant 9 expression in primary early gastric cancer as a predictive marker for recurrence.

artículo científico publicado en 2013

CD44 variant regulates redox status in cancer cells by stabilizing the xCT subunit of system xc(-) and thereby promotes tumor growth

artículo científico publicado en 2011

CD44 variant-dependent regulation of redox balance in EGFR mutation-positive non-small cell lung cancer: A target for treatment.

artículo científico publicado en 2017

CD44+ slow-cycling tumor cell expansion is triggered by cooperative actions of Wnt and prostaglandin E2 in gastric tumorigenesis

artículo científico publicado en 2009

CD44s regulates the TGF-β-mediated mesenchymal phenotype and is associated with poor prognosis in patients with hepatocellular carcinoma

artículo científico publicado en 2012

CD44s signals the acquisition of the mesenchymal phenotype required for anchorage-independent cell survival in hepatocellular carcinoma.

artículo científico publicado en 2013

Development of a functional thyroid model based on an organoid culture system.

artículo científico publicado en 2018

Development of an ErbB4 monoclonal antibody that blocks neuregulin-1-induced ErbB4 activation in cancer cells.

artículo científico publicado en 2016

Distinct metaplastic and inflammatory phenotypes in autoimmune and adenocarcinoma-associated chronic atrophic gastritis

scientific article published on 23 June 2016

Dose-escalation study for the targeting of CD44v+ cancer stem cells by sulfasalazine in patients with advanced gastric cancer (EPOC1205).

artículo científico publicado en 2016

EGFR and ErbB2 are functionally coupled to CD44 and regulate shedding, internalization and motogenic effect of CD44.

artículo científico publicado en 2008

Epigenomic Profiling Discovers Trans-lineage SOX2 Partnerships Driving Tumor Heterogeneity in Lung Squamous Cell Carcinoma

scientific article published on 24 September 2019

Eradication of CD44-variant positive population in head and neck tumors through controlled intracellular navigation of cisplatin-loaded nanomedicines.

artículo científico publicado en 2016

Establishment of a choriocarcinoma model from immortalized normal extravillous trophoblast cells transduced with HRASV12

artículo científico publicado en 2011

Functional role of CD44v-xCT system in the development of spasmolytic polypeptide-expressing metaplasia.

artículo científico publicado en 2013

Gene expression profile of a newly established choriocarcinoma cell line, iC3-1, compared to existing choriocarcinoma cell lines and normal placenta.

artículo científico publicado en 2012

Glucose transporter 1-mediated vascular translocation of nanomedicines enhances accumulation and efficacy in solid tumors

artículo científico publicado en 2019

Glutaminolysis-related genes determine sensitivity to xCT-targeted therapy in head and neck squamous cell carcinoma

scientific article published on 13 September 2019

Gold-nanofève surface-enhanced Raman spectroscopy visualizes hypotaurine as a robust anti-oxidant consumed in cancer survival.

artículo científico publicado en 2018

In vivo assessment of cancerous tumors using boron doped diamond microelectrode

artículo científico publicado en 2012

Inflammatory mediator ultra-low-molecular-weight hyaluronan triggers necrosis of B-precursor leukemia cells with high surface CD44 expression.

artículo científico publicado en 2017

Ink4a/Arf-Dependent Loss of Parietal Cells Induced by Oxidative Stress Promotes CD44-Dependent Gastric Tumorigenesis.

artículo científico publicado en 2015

Involvement of NF-kappaB-mediated maturation of ADAM-17 in the invasion of oral squamous cell carcinoma

artículo científico publicado en 2007

MEK inhibition suppresses metastatic progression of KRAS-mutated gastric cancer

artículo científico publicado en 2022

Macrophage-derived reactive oxygen species suppress miR-328 targeting CD44 in cancer cells and promote redox adaptation

artículo científico publicado en 2013

Maintenance of HCT116 colon cancer cell line conforms to a stochastic model but not a cancer stem cell model.

artículo científico publicado en 2009

Mechanism and biological significance of CD44 cleavage

artículo científico publicado en 2004

Modulation of glucose metabolism by CD44 contributes to antioxidant status and drug resistance in cancer cells.

artículo científico publicado en 2012

Molecular mechanisms regulating dissociation of cell-cell junction of epithelial cells by oxidative stress.

artículo científico publicado en 2009

Phase 1 study of sulfasalazine and cisplatin for patients with CD44v-positive gastric cancer refractory to cisplatin (EPOC1407).

artículo científico publicado en 2017

Phase I study of salazosulfapyridine in combination with cisplatin and pemetrexed for advanced non-small-cell lung cancer.

artículo científico publicado en 2017

Potential of sulfasalazine as a therapeutic sensitizer for CD44 splice variant 9-positive urogenital cancer

artículo científico publicado en 2016

Presenilin-dependent gamma-secretase activity mediates the intramembranous cleavage of CD44.

artículo científico publicado en 2003

Rb depletion results in deregulation of E-cadherin and induction of cellular phenotypic changes that are characteristic of the epithelial-to-mesenchymal transition

artículo científico publicado en 2008

Reactive oxygen species-induced autophagic degradation of Helicobacter pylori CagA is specifically suppressed in cancer stem-like cells

artículo científico publicado en 2012

Sulfasalazine, a therapeutic agent for ulcerative colitis, inhibits the growth of CD44v9(+) cancer stem cells in ulcerative colitis-related cancer.

artículo científico publicado en 2016

The EGF Receptor Promotes the Malignant Potential of Glioma by Regulating Amino Acid Transport System xc(-)

artículo científico publicado en 2016

The anaphase-promoting complex/cyclosome activator Cdh1 modulates Rho GTPase by targeting p190 RhoGAP for degradation.

artículo científico publicado en 2010

The impact of EpCAM expression on response to chemotherapy and clinical outcomes in patients with epithelial ovarian cancer

artículo científico publicado en 2017

Transient depletion of p53 followed by transduction of c-Myc and K-Ras converts ovarian stem-like cells into tumor-initiating cells

artículo científico publicado en 2011

Tumor necrosis factor-alpha regulates transforming growth factor-beta-dependent epithelial-mesenchymal transition by promoting hyaluronan-CD44-moesin interaction.

artículo científico publicado en 2009

Vasodilator oxyfedrine inhibits aldehyde metabolism and thereby sensitizes cancer cells to xCT-targeted therapy

artículo científico publicado en 2019

cRGD peptide installation on cisplatin-loaded nanomedicines enhances efficacy against locally advanced head and neck squamous cell carcinoma bearing cancer stem-like cells.

artículo científico publicado en 2017

xCT inhibition depletes CD44v-expressing tumor cells that are resistant to EGFR-targeted therapy in head and neck squamous cell carcinoma.

artículo científico publicado en 2013

Lista de obras de Osamu Nagano

ADAM-17 associated with CD44 cleavage and metastasis in oral squamous cell carcinoma.

Alternative splicing of CD44 mRNA by ESRP1 enhances lung colonization of metastatic cancer cell.

CD44 Splice Variant v8-10 as a Marker of Serous Ovarian Cancer Prognosis.

CD44 variant 9 expression in primary early gastric cancer as a predictive marker for recurrence.

CD44 variant regulates redox status in cancer cells by stabilizing the xCT subunit of system xc(-) and thereby promotes tumor growth

CD44 variant-dependent regulation of redox balance in EGFR mutation-positive non-small cell lung cancer: A target for treatment.

CD44+ slow-cycling tumor cell expansion is triggered by cooperative actions of Wnt and prostaglandin E2 in gastric tumorigenesis

CD44s regulates the TGF-β-mediated mesenchymal phenotype and is associated with poor prognosis in patients with hepatocellular carcinoma

CD44s signals the acquisition of the mesenchymal phenotype required for anchorage-independent cell survival in hepatocellular carcinoma.

Development of a functional thyroid model based on an organoid culture system.

Development of an ErbB4 monoclonal antibody that blocks neuregulin-1-induced ErbB4 activation in cancer cells.

Distinct metaplastic and inflammatory phenotypes in autoimmune and adenocarcinoma-associated chronic atrophic gastritis

Dose-escalation study for the targeting of CD44v+ cancer stem cells by sulfasalazine in patients with advanced gastric cancer (EPOC1205).

EGFR and ErbB2 are functionally coupled to CD44 and regulate shedding, internalization and motogenic effect of CD44.

Epigenomic Profiling Discovers Trans-lineage SOX2 Partnerships Driving Tumor Heterogeneity in Lung Squamous Cell Carcinoma

Eradication of CD44-variant positive population in head and neck tumors through controlled intracellular navigation of cisplatin-loaded nanomedicines.

Establishment of a choriocarcinoma model from immortalized normal extravillous trophoblast cells transduced with HRASV12

Functional role of CD44v-xCT system in the development of spasmolytic polypeptide-expressing metaplasia.

Gene expression profile of a newly established choriocarcinoma cell line, iC3-1, compared to existing choriocarcinoma cell lines and normal placenta.

Glucose transporter 1-mediated vascular translocation of nanomedicines enhances accumulation and efficacy in solid tumors

Glutaminolysis-related genes determine sensitivity to xCT-targeted therapy in head and neck squamous cell carcinoma

Gold-nanofève surface-enhanced Raman spectroscopy visualizes hypotaurine as a robust anti-oxidant consumed in cancer survival.

In vivo assessment of cancerous tumors using boron doped diamond microelectrode

Inflammatory mediator ultra-low-molecular-weight hyaluronan triggers necrosis of B-precursor leukemia cells with high surface CD44 expression.

Ink4a/Arf-Dependent Loss of Parietal Cells Induced by Oxidative Stress Promotes CD44-Dependent Gastric Tumorigenesis.

Involvement of NF-kappaB-mediated maturation of ADAM-17 in the invasion of oral squamous cell carcinoma

MEK inhibition suppresses metastatic progression of KRAS-mutated gastric cancer

Macrophage-derived reactive oxygen species suppress miR-328 targeting CD44 in cancer cells and promote redox adaptation

Maintenance of HCT116 colon cancer cell line conforms to a stochastic model but not a cancer stem cell model.

Mechanism and biological significance of CD44 cleavage

Modulation of glucose metabolism by CD44 contributes to antioxidant status and drug resistance in cancer cells.

Molecular mechanisms regulating dissociation of cell-cell junction of epithelial cells by oxidative stress.

Phase 1 study of sulfasalazine and cisplatin for patients with CD44v-positive gastric cancer refractory to cisplatin (EPOC1407).

Phase I study of salazosulfapyridine in combination with cisplatin and pemetrexed for advanced non-small-cell lung cancer.

Potential of sulfasalazine as a therapeutic sensitizer for CD44 splice variant 9-positive urogenital cancer

Presenilin-dependent gamma-secretase activity mediates the intramembranous cleavage of CD44.

Rb depletion results in deregulation of E-cadherin and induction of cellular phenotypic changes that are characteristic of the epithelial-to-mesenchymal transition

Reactive oxygen species-induced autophagic degradation of Helicobacter pylori CagA is specifically suppressed in cancer stem-like cells

Sulfasalazine, a therapeutic agent for ulcerative colitis, inhibits the growth of CD44v9(+) cancer stem cells in ulcerative colitis-related cancer.

The EGF Receptor Promotes the Malignant Potential of Glioma by Regulating Amino Acid Transport System xc(-)

The anaphase-promoting complex/cyclosome activator Cdh1 modulates Rho GTPase by targeting p190 RhoGAP for degradation.

The impact of EpCAM expression on response to chemotherapy and clinical outcomes in patients with epithelial ovarian cancer

Transient depletion of p53 followed by transduction of c-Myc and K-Ras converts ovarian stem-like cells into tumor-initiating cells

Tumor necrosis factor-alpha regulates transforming growth factor-beta-dependent epithelial-mesenchymal transition by promoting hyaluronan-CD44-moesin interaction.

Vasodilator oxyfedrine inhibits aldehyde metabolism and thereby sensitizes cancer cells to xCT-targeted therapy

cRGD peptide installation on cisplatin-loaded nanomedicines enhances efficacy against locally advanced head and neck squamous cell carcinoma bearing cancer stem-like cells.

xCT inhibition depletes CD44v-expressing tumor cells that are resistant to EGFR-targeted therapy in head and neck squamous cell carcinoma.