Lista de obras - Stephen Griffin - Dominio Público Uruguay

"Too little, too late?" Will inhibitors of the hepatitis C virus p7 ion channel ever be used in the clinic?

artículo científico publicado en 2014

A Conserved Proline between Domains II and III of Hepatitis C Virus NS5A Influences both RNA Replication and Virus Assembly

artículo científico publicado en 2009

A conserved basic loop in hepatitis C virus p7 protein is required for amantadine-sensitive ion channel activity in mammalian cells but is dispensable for localization to mitochondria

artículo científico publicado en 2004

A link between translation of the hepatitis C virus polyprotein and polymerase function; possible consequences for hyperphosphorylation of NS5A.

artículo científico publicado en 2006

A novel method for the measurement of hepatitis C virus infectious titres using the IncuCyte ZOOM and its application to antiviral screening ⬇️

artículo científico publicado en 2015

Alkyl-imino sugars inhibit the pro-oncogenic ion channel function of human papillomavirus (HPV) E5 ⬇️

scholarly article by Laura F Wetherill published in October 2018

Chimeric GB virus B genomes containing hepatitis C virus p7 are infectious in vivo

artículo científico publicado en 2008

Determinants of Hepatitis C Virus p7 Ion Channel Function and Drug Sensitivity Identified In Vitro

artículo científico publicado en 2009

Direct visualization of the small hydrophobic protein of human respiratory syncytial virus reveals the structural basis for membrane permeability

artículo científico publicado en 2010

Domain III of NS5A contributes to both RNA replication and assembly of hepatitis C virus particles

artículo científico publicado en 2009

Evidence for the formation of a heptameric ion channel complex by the hepatitis C virus p7 protein in vitro

artículo científico publicado en 2006

Expression of hepatitis C virus (HCV) structural proteins in trans facilitates encapsidation and transmission of HCV subgenomic RNA.

artículo científico publicado en 2009

Genetic and functional heterogeneity of the hepatitis C virus p7 ion channel during natural chronic infection

artículo científico publicado en 2011

Genotype-dependent sensitivity of hepatitis C virus to inhibitors of the p7 ion channel

artículo científico publicado en 2008

Genotype-specific differences in structural features of hepatitis C virus (HCV) p7 membrane protein

artículo científico publicado en 2015

HIV: future and futuristic therapies

artículo científico publicado el 1 de noviembre de 2001

Hepatitis C virus-induced autophagy is independent of the unfolded protein response

artículo científico publicado en 2012

High-risk human papillomavirus E5 oncoprotein displays channel-forming activity sensitive to small-molecule inhibitors ⬇️

artículo científico publicado en 2012

Identification of a novel phosphorylation site in hepatitis C virus NS5A ⬇️

artículo científico publicado en 2010

Inhibition of hepatitis C virus p7 membrane channels in a liposome-based assay system

artículo científico publicado en 2007

Internalization of oncolytic reovirus by human dendritic cell carriers protects the virus from neutralization

artículo científico publicado en 2011

Intracellular proton conductance of the hepatitis C virus p7 protein and its contribution to infectious virus production ⬇️

artículo científico publicado en 2010

Intravenous delivery of oncolytic reovirus to brain tumor patients immunologically primes for subsequent checkpoint blockade. ⬇️

artículo científico publicado en 2018

Ion Channel Function and Cross-Species Determinants in Viral Assembly of Nonprimate Hepacivirus p7 ⬇️

artículo científico publicado en 2016

MicroRNA-18a targeting of the STK4/MST1 tumour suppressor is necessary for transformation in HPV positive cervical cancer

scientific article published on 18 June 2020

Modulation of calcium signaling pathway by hepatitis C virus core protein stimulates NLRP3 inflammasome activation

artículo científico publicado en 2019

Mosquito saliva enhances virus infection through sialokinin-dependent vascular leakage

artículo científico publicado en 2022

Mutations in hepatitis C virus p7 reduce both the egress and infectivity of assembled particles via impaired proton channel function

artículo científico publicado en 2013

NS2 is dispensable for efficient assembly of hepatitis C virus-like particles in a bipartite trans-encapsidation system ⬇️

artículo científico publicado en 2014

Nucleotide requirements at positions +1 to +4 for the initiation of hepatitis C virus positive-strand RNA synthesis

artículo científico publicado en 2011

Oncolytic reovirus as a combined antiviral and anti-tumour agent for the treatment of liver cancer ⬇️

artículo científico publicado en 2016

P12A PHASE I TRIAL OF INTRAVENOUS ONCOLYTIC REOLYSIN® IN PATIENTS WITH BRAIN TUMOURS.

artículo científico publicado en 2014

Plugging the holes in hepatitis C virus antiviral therapy

artículo científico publicado en 2009

Progress in clinical oncolytic virus-based therapy for hepatocellular carcinoma ⬇️

artículo científico publicado en 2015

Rationally derived inhibitors of hepatitis C virus (HCV) p7 channel activity reveal prospect for bimodal antiviral therapy

artículo científico publicado en 2020

Release of Infectious Hepatitis C Virus from Huh7 Cells Occurs via a trans-Golgi Network-to-Endosome Pathway Independent of Very-Low-Density Lipoprotein Secretion ⬇️

artículo científico publicado en 2016

Resistance mutations define specific antiviral effects for inhibitors of the hepatitis C virus p7 ion channel

artículo científico publicado en 2011

Signal peptide cleavage and internal targeting signals direct the hepatitis C virus p7 protein to distinct intracellular membranes

artículo científico publicado en 2005

Site-directed M2 proton channel inhibitors enable synergistic combination therapy for rimantadine-resistant pandemic influenza

scientific article published on 11 August 2020

Site-directed M2 proton channel inhibitors enable synergistic combination therapy for rimantadine-resistant pandemic influenza

Small molecule ligand docking to genotype specific bundle structures of hepatitis C virus (HCV) p7 protein

artículo científico publicado en 2016

Structure-guided design affirms inhibitors of hepatitis C virus p7 as a viable class of antivirals targeting virion release

artículo científico publicado en 2014

Suppression of a pro-apoptotic K+ channel as a mechanism for hepatitis C virus persistence

artículo científico publicado en 2009

Tagging of NS5A expressed from a functional hepatitis C virus replicon

artículo científico publicado en 2006

Targeting hepatitis C virus p7 channel activity reveals prospect for bimodal antiviral prophylaxis

The hepatitis C virus non-structural protein NS5A alters the trafficking profile of the epidermal growth factor receptor

artículo científico publicado en 2008

The major human immunodeficiency virus type 2 (HIV-2) packaging signal is present on all HIV-2 RNA species: cotranslational RNA encapsidation and limitation of Gag protein confer specificity

artículo científico publicado en 2001

The p7 protein of hepatitis C virus forms an ion channel that is blocked by the antiviral drug, Amantadine

artículo científico publicado en 2003

The stability of secreted, acid-labile H77/JFH-1 hepatitis C virus (HCV) particles is altered by patient isolate genotype 1a p7 sequences ⬇️

artículo científico publicado en 2013

The subcellular localization of the hepatitis C virus non-structural protein NS2 is regulated by an ion channel-independent function of the p7 protein ⬇️

artículo científico publicado en 2010

Viroporins: structure, function and potential as antiviral targets ⬇️

artículo científico

Vps4 and the ESCRT-III complex are required for the release of infectious hepatitis C virus particles

artículo científico publicado en 2009

Lista de obras de Stephen Griffin

"Too little, too late?" Will inhibitors of the hepatitis C virus p7 ion channel ever be used in the clinic?

A Conserved Proline between Domains II and III of Hepatitis C Virus NS5A Influences both RNA Replication and Virus Assembly

A conserved basic loop in hepatitis C virus p7 protein is required for amantadine-sensitive ion channel activity in mammalian cells but is dispensable for localization to mitochondria

A link between translation of the hepatitis C virus polyprotein and polymerase function; possible consequences for hyperphosphorylation of NS5A.

A novel method for the measurement of hepatitis C virus infectious titres using the IncuCyte ZOOM and its application to antiviral screening ⬇️

Alkyl-imino sugars inhibit the pro-oncogenic ion channel function of human papillomavirus (HPV) E5 ⬇️

Chimeric GB virus B genomes containing hepatitis C virus p7 are infectious in vivo

Determinants of Hepatitis C Virus p7 Ion Channel Function and Drug Sensitivity Identified In Vitro

Direct visualization of the small hydrophobic protein of human respiratory syncytial virus reveals the structural basis for membrane permeability

Domain III of NS5A contributes to both RNA replication and assembly of hepatitis C virus particles

Evidence for the formation of a heptameric ion channel complex by the hepatitis C virus p7 protein in vitro

Expression of hepatitis C virus (HCV) structural proteins in trans facilitates encapsidation and transmission of HCV subgenomic RNA.

Genetic and functional heterogeneity of the hepatitis C virus p7 ion channel during natural chronic infection

Genotype-dependent sensitivity of hepatitis C virus to inhibitors of the p7 ion channel

Genotype-specific differences in structural features of hepatitis C virus (HCV) p7 membrane protein

HIV: future and futuristic therapies

Hepatitis C virus-induced autophagy is independent of the unfolded protein response

High-risk human papillomavirus E5 oncoprotein displays channel-forming activity sensitive to small-molecule inhibitors ⬇️

Identification of a novel phosphorylation site in hepatitis C virus NS5A ⬇️

Inhibition of hepatitis C virus p7 membrane channels in a liposome-based assay system

Internalization of oncolytic reovirus by human dendritic cell carriers protects the virus from neutralization

Intracellular proton conductance of the hepatitis C virus p7 protein and its contribution to infectious virus production ⬇️

Intravenous delivery of oncolytic reovirus to brain tumor patients immunologically primes for subsequent checkpoint blockade. ⬇️

Ion Channel Function and Cross-Species Determinants in Viral Assembly of Nonprimate Hepacivirus p7 ⬇️

MicroRNA-18a targeting of the STK4/MST1 tumour suppressor is necessary for transformation in HPV positive cervical cancer

Modulation of calcium signaling pathway by hepatitis C virus core protein stimulates NLRP3 inflammasome activation

Mosquito saliva enhances virus infection through sialokinin-dependent vascular leakage

Mutations in hepatitis C virus p7 reduce both the egress and infectivity of assembled particles via impaired proton channel function

NS2 is dispensable for efficient assembly of hepatitis C virus-like particles in a bipartite trans-encapsidation system ⬇️

Nucleotide requirements at positions +1 to +4 for the initiation of hepatitis C virus positive-strand RNA synthesis

Oncolytic reovirus as a combined antiviral and anti-tumour agent for the treatment of liver cancer ⬇️

P12A PHASE I TRIAL OF INTRAVENOUS ONCOLYTIC REOLYSIN® IN PATIENTS WITH BRAIN TUMOURS.

Plugging the holes in hepatitis C virus antiviral therapy

Progress in clinical oncolytic virus-based therapy for hepatocellular carcinoma ⬇️

Rationally derived inhibitors of hepatitis C virus (HCV) p7 channel activity reveal prospect for bimodal antiviral therapy

Release of Infectious Hepatitis C Virus from Huh7 Cells Occurs via a trans-Golgi Network-to-Endosome Pathway Independent of Very-Low-Density Lipoprotein Secretion ⬇️

Resistance mutations define specific antiviral effects for inhibitors of the hepatitis C virus p7 ion channel

Signal peptide cleavage and internal targeting signals direct the hepatitis C virus p7 protein to distinct intracellular membranes

Site-directed M2 proton channel inhibitors enable synergistic combination therapy for rimantadine-resistant pandemic influenza

Site-directed M2 proton channel inhibitors enable synergistic combination therapy for rimantadine-resistant pandemic influenza

Small molecule ligand docking to genotype specific bundle structures of hepatitis C virus (HCV) p7 protein

Structure-guided design affirms inhibitors of hepatitis C virus p7 as a viable class of antivirals targeting virion release

Suppression of a pro-apoptotic K+ channel as a mechanism for hepatitis C virus persistence

Tagging of NS5A expressed from a functional hepatitis C virus replicon

Targeting hepatitis C virus p7 channel activity reveals prospect for bimodal antiviral prophylaxis

The hepatitis C virus non-structural protein NS5A alters the trafficking profile of the epidermal growth factor receptor

The major human immunodeficiency virus type 2 (HIV-2) packaging signal is present on all HIV-2 RNA species: cotranslational RNA encapsidation and limitation of Gag protein confer specificity

The p7 protein of hepatitis C virus forms an ion channel that is blocked by the antiviral drug, Amantadine

The stability of secreted, acid-labile H77/JFH-1 hepatitis C virus (HCV) particles is altered by patient isolate genotype 1a p7 sequences ⬇️

The subcellular localization of the hepatitis C virus non-structural protein NS2 is regulated by an ion channel-independent function of the p7 protein ⬇️

Viroporins: structure, function and potential as antiviral targets ⬇️

Vps4 and the ESCRT-III complex are required for the release of infectious hepatitis C virus particles