Lista de obras - Kirsi Rilla - Dominio Público Uruguay

4-Methylumbelliferone inhibits hyaluronan synthesis by depletion of cellular UDP-glucuronic acid and downregulation of hyaluronan synthase 2 and 3.

artículo científico publicado en 2009

Activated hyaluronan metabolism in the tumor matrix — Causes and consequences

artículo científico publicado en 2018

Aneuploidy facilitates oncogenic transformation via specific genetic alterations, including Twist2 upregulation

artículo científico publicado en 2013

Autophagy activation clears ELAVL1/HuR-mediated accumulation of SQSTM1/p62 during proteasomal inhibition in human retinal pigment epithelial cells

artículo científico publicado en 2013

Cell protrusions induced by hyaluronan synthase 3 (HAS3) resemble mesothelial microvilli and share cytoskeletal features of filopodia

artículo científico publicado en 2015

Changed lamellipodial extension, adhesion plaques and migration in epidermal keratinocytes containing constitutively expressed sense and antisense hyaluronan synthase 2 (Has2) genes

scientific journal article

Chloropicrin-induced toxic responses in human lung epithelial cells

artículo científico publicado en 2014

Chondrocytic cells express the taurine transporter on their plasma membrane and regulate its expression under anisotonic conditions

artículo científico publicado en 2014

Chronic UVR causes increased immunostaining of CD44 and accumulation of hyaluronan in mouse epidermis

artículo científico publicado en 2011

Correlative Light and Electron Microscopy Reveals the HAS3-Induced Dorsal Plasma Membrane Ruffles

artículo científico publicado en 2015

Correlative light and electron microscopy is a powerful tool to study interactions of extracellular vesicles with recipient cells

scientific article published on 11 February 2019

Crosstalk between Hsp70 molecular chaperone, lysosomes and proteasomes in autophagy-mediated proteolysis in human retinal pigment epithelial cells

artículo científico publicado en 2008

DHCR24 exerts neuroprotection upon inflammation-induced neuronal death.

artículo científico publicado en 2017

Donor simvastatin treatment prevents ischemia-reperfusion and acute kidney injury by preserving microvascular barrier function

artículo científico publicado en 2013

EGF REGULATES HAS2 EXPRESSION, CONTROLS EPIDERMAL THICKNESS AND STIMULATES KERATINOCYTE MIGRATION

EMT induced by EGF and wounding activates hyaluronan synthesis machinery and EV shedding in rat primary mesothelial cells

artículo científico publicado en 2016

Effects of mutations in the post-translational modification sites on the trafficking of hyaluronan synthase 2 (HAS2)

artículo científico publicado en 2018

Elevated expression of hyaluronan synthase 2 associates with decreased survival in diffusely infiltrating astrocytomas

artículo científico publicado en 2018

Epidermal growth factor activates hyaluronan synthase 2 in epidermal keratinocytes and increases pericellular and intracellular hyaluronan

artículo científico publicado en 2001

Expression of hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in serous ovarian carcinomas: inverse correlation between HYAL1 and hyaluronan content

artículo científico publicado en 2009

Extensive CD44-dependent hyaluronan coats on human bone marrow-derived mesenchymal stem cells produced by hyaluronan synthases HAS1, HAS2 and HAS3

artículo científico publicado en 2014

Extracellular vesicles are integral and functional components of the extracellular matrix

artículo científico publicado en 2017

First in vivo detection and characterization of hyaluronan-coated extracellular vesicles in human synovial fluid

artículo científico publicado en 2016

HAS3-induced accumulation of hyaluronan in 3D MDCK cultures results in mitotic spindle misorientation and disturbed organization of epithelium.

artículo científico publicado en 2011

HYALURONAN STIMULATES KERATINOCYTE MIGRATION AND ACTIVATES THE TRANSCRIPTION FACTOR AP-1 IN KERATINOCYTES THROUGH THE JNK PATHWAY

HYALURONAN SYNTHASE 2 (HAS2) REGULATES MIGRATION OF EPIDERMAL KERATINOCYTES

High extent of O-GlcNAcylation in breast cancer cells correlates with the levels of HAS enzymes, accumulation of hyaluronan, and poor outcome

artículo científico publicado en 2016

High levels of TopBP1 induce ATR-dependent shut-down of rRNA transcription and nucleolar segregation.

artículo científico publicado en 2015

High numbers of macrophages, especially M2-like (CD163-positive), correlate with hyaluronan accumulation and poor outcome in breast cancer

artículo científico publicado en 2015

Human mesenchymal stem cells secrete hyaluronan-coated extracellular vesicles.

artículo científico publicado en 2017

Hyaluronan enters keratinocytes by a novel endocytic route for catabolism

artículo científico publicado en 2001

Hyaluronan histochemistry-a potential new tool to assess the progress of liver disease from simple steatosis to hepatocellular carcinoma

artículo científico publicado en 2019

Hyaluronan in cytosol--microinjection-based probing of its existence and suggested functions

artículo científico publicado en 2012

Hyaluronan production enhances shedding of plasma membrane-derived microvesicles

artículo científico publicado en 2013

Hyaluronan synthase 1 (HAS1) produces a cytokine-and glucose-inducible, CD44-dependent cell surface coat

artículo científico publicado en 2013

Hyaluronan synthase 1 (HAS1) requires higher cellular UDP-GlcNAc concentration than HAS2 and HAS3.

artículo científico publicado en 2013

Hyaluronan synthase 1: a mysterious enzyme with unexpected functions

artículo científico publicado en 2015

Hyaluronan synthase 3 (HAS3) overexpression downregulates MV3 melanoma cell proliferation, migration and adhesion

artículo científico publicado en 2015

Hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in the accumulation of hyaluronan in endometrioid endometrial carcinoma

artículo científico publicado en 2010

Hyaluronan synthases (HAS1-3) in stromal and malignant cells correlate with breast cancer grade and predict patient survival

artículo científico publicado en 2013

Hyaluronan synthesis induces microvillus-like cell surface protrusions

artículo científico publicado en 2006

Hyaluronan-coated extracellular vesicles--a novel link between hyaluronan and cancer

artículo científico

Hyaluronan-positive plasma membrane protrusions exist on mesothelial cells in vivo

artículo científico publicado en 2016

Induction of hyaluronan cables and monocyte adherence in epidermal keratinocytes

artículo científico publicado en 2008

Interleukin-1β-induced Reduction of CD44 Ser-325 Phosphorylation in Human Epidermal Keratinocytes Promotes CD44 Homomeric Complexes, Binding to Ezrin, and Extended, Monocyte-adhesive Hyaluronan Coats

artículo científico publicado en 2015

Mannose reduces hyaluronan and leukocytes in wound granulation tissue and inhibits migration and hyaluronan-dependent monocyte binding

artículo científico publicado en 2013

Melanoma cell-derived factors stimulate hyaluronan synthesis in dermal fibroblasts by upregulating HAS2 through PDGFR-PI3K-AKT and p38 signaling

artículo científico publicado en 2012

Mesotheliomas show higher hyaluronan positivity around tumor cells than metastatic pulmonary adenocarcinomas

scientific article published on 25 February 2016

Metastatic state of parent cells influences the uptake and functionality of prostate cancer cell-derived extracellular vesicles.

artículo científico publicado en 2017

Methyl-beta-cyclodextrin suppresses hyaluronan synthesis by down-regulation of hyaluronan synthase 2 through inhibition of Akt.

artículo científico publicado en 2010

Molecular targets of chloropicrin in human airway epithelial cells

artículo científico publicado en 2017

Pericellular hyaluronan coat visualized in live cells with a fluorescent probe is scaffolded by plasma membrane protrusions

artículo científico publicado en 2008

Plasma membrane residence of hyaluronan synthase is coupled to its enzymatic activity

artículo científico publicado en 2005

Precipitation-based extracellular vesicle isolation from rat plasma co-precipitate vesicle-free microRNAs

scientific article published on 18 December 2018

Presynaptic Vesicle Protein SEPTIN5 Regulates the Degradation of APP C-Terminal Fragments and the Levels of Aβ

artículo científico publicado en 2020

Rab10-mediated endocytosis of the hyaluronan synthase HAS3 regulates hyaluronan synthesis and cell adhesion to collagen

artículo científico

Re-evaluation of the role of P-glycoprotein in in vitro drug permeability studies with the bovine brain microvessel endothelial cells

artículo científico publicado en 2013

Role of CD44 in the organization of keratinocyte pericellular hyaluronan

artículo científico publicado en 2011

The Density and Length of Filopodia Associate with the Activity of Hyaluronan Synthesis in Tumor Cells

artículo científico publicado en 2020

The hyaluronan synthesis inhibitor 4-methylumbelliferone prevents keratinocyte activation and epidermal hyperproliferation induced by epidermal growth factor

artículo científico publicado en 2004

Tissue distribution and subcellular localization of hyaluronan synthase isoenzymes

scientific journal article

Transcriptional and post-translational regulation of hyaluronan synthesis.

artículo científico publicado en 2011

UDP-sugar substrates of HAS3 regulate its O-GlcNAcylation, intracellular traffic, extracellular shedding and correlate with melanoma progression

artículo científico publicado en 2016

p62/sequestosome 1 as a regulator of proteasome inhibitor-induced autophagy in human retinal pigment epithelial cells

artículo científico publicado en 2010

Lista de obras de Kirsi Rilla

4-Methylumbelliferone inhibits hyaluronan synthesis by depletion of cellular UDP-glucuronic acid and downregulation of hyaluronan synthase 2 and 3.

Activated hyaluronan metabolism in the tumor matrix — Causes and consequences

Aneuploidy facilitates oncogenic transformation via specific genetic alterations, including Twist2 upregulation

Autophagy activation clears ELAVL1/HuR-mediated accumulation of SQSTM1/p62 during proteasomal inhibition in human retinal pigment epithelial cells

Cell protrusions induced by hyaluronan synthase 3 (HAS3) resemble mesothelial microvilli and share cytoskeletal features of filopodia

Changed lamellipodial extension, adhesion plaques and migration in epidermal keratinocytes containing constitutively expressed sense and antisense hyaluronan synthase 2 (Has2) genes

Chloropicrin-induced toxic responses in human lung epithelial cells

Chondrocytic cells express the taurine transporter on their plasma membrane and regulate its expression under anisotonic conditions

Chronic UVR causes increased immunostaining of CD44 and accumulation of hyaluronan in mouse epidermis

Correlative Light and Electron Microscopy Reveals the HAS3-Induced Dorsal Plasma Membrane Ruffles

Correlative light and electron microscopy is a powerful tool to study interactions of extracellular vesicles with recipient cells

Crosstalk between Hsp70 molecular chaperone, lysosomes and proteasomes in autophagy-mediated proteolysis in human retinal pigment epithelial cells

DHCR24 exerts neuroprotection upon inflammation-induced neuronal death.

Donor simvastatin treatment prevents ischemia-reperfusion and acute kidney injury by preserving microvascular barrier function

EGF REGULATES HAS2 EXPRESSION, CONTROLS EPIDERMAL THICKNESS AND STIMULATES KERATINOCYTE MIGRATION

EMT induced by EGF and wounding activates hyaluronan synthesis machinery and EV shedding in rat primary mesothelial cells

Effects of mutations in the post-translational modification sites on the trafficking of hyaluronan synthase 2 (HAS2)

Elevated expression of hyaluronan synthase 2 associates with decreased survival in diffusely infiltrating astrocytomas

Epidermal growth factor activates hyaluronan synthase 2 in epidermal keratinocytes and increases pericellular and intracellular hyaluronan

Expression of hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in serous ovarian carcinomas: inverse correlation between HYAL1 and hyaluronan content

Extensive CD44-dependent hyaluronan coats on human bone marrow-derived mesenchymal stem cells produced by hyaluronan synthases HAS1, HAS2 and HAS3

Extracellular vesicles are integral and functional components of the extracellular matrix

First in vivo detection and characterization of hyaluronan-coated extracellular vesicles in human synovial fluid

HAS3-induced accumulation of hyaluronan in 3D MDCK cultures results in mitotic spindle misorientation and disturbed organization of epithelium.

HYALURONAN STIMULATES KERATINOCYTE MIGRATION AND ACTIVATES THE TRANSCRIPTION FACTOR AP-1 IN KERATINOCYTES THROUGH THE JNK PATHWAY

HYALURONAN SYNTHASE 2 (HAS2) REGULATES MIGRATION OF EPIDERMAL KERATINOCYTES

High extent of O-GlcNAcylation in breast cancer cells correlates with the levels of HAS enzymes, accumulation of hyaluronan, and poor outcome

High levels of TopBP1 induce ATR-dependent shut-down of rRNA transcription and nucleolar segregation.

High numbers of macrophages, especially M2-like (CD163-positive), correlate with hyaluronan accumulation and poor outcome in breast cancer

Human mesenchymal stem cells secrete hyaluronan-coated extracellular vesicles.

Hyaluronan enters keratinocytes by a novel endocytic route for catabolism

Hyaluronan histochemistry-a potential new tool to assess the progress of liver disease from simple steatosis to hepatocellular carcinoma

Hyaluronan in cytosol--microinjection-based probing of its existence and suggested functions

Hyaluronan production enhances shedding of plasma membrane-derived microvesicles

Hyaluronan synthase 1 (HAS1) produces a cytokine-and glucose-inducible, CD44-dependent cell surface coat

Hyaluronan synthase 1 (HAS1) requires higher cellular UDP-GlcNAc concentration than HAS2 and HAS3.

Hyaluronan synthase 1: a mysterious enzyme with unexpected functions

Hyaluronan synthase 3 (HAS3) overexpression downregulates MV3 melanoma cell proliferation, migration and adhesion

Hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in the accumulation of hyaluronan in endometrioid endometrial carcinoma

Hyaluronan synthases (HAS1-3) in stromal and malignant cells correlate with breast cancer grade and predict patient survival

Hyaluronan synthesis induces microvillus-like cell surface protrusions

Hyaluronan-coated extracellular vesicles--a novel link between hyaluronan and cancer

Hyaluronan-positive plasma membrane protrusions exist on mesothelial cells in vivo

Induction of hyaluronan cables and monocyte adherence in epidermal keratinocytes

Interleukin-1β-induced Reduction of CD44 Ser-325 Phosphorylation in Human Epidermal Keratinocytes Promotes CD44 Homomeric Complexes, Binding to Ezrin, and Extended, Monocyte-adhesive Hyaluronan Coats

Mannose reduces hyaluronan and leukocytes in wound granulation tissue and inhibits migration and hyaluronan-dependent monocyte binding

Melanoma cell-derived factors stimulate hyaluronan synthesis in dermal fibroblasts by upregulating HAS2 through PDGFR-PI3K-AKT and p38 signaling

Mesotheliomas show higher hyaluronan positivity around tumor cells than metastatic pulmonary adenocarcinomas

Metastatic state of parent cells influences the uptake and functionality of prostate cancer cell-derived extracellular vesicles.

Methyl-beta-cyclodextrin suppresses hyaluronan synthesis by down-regulation of hyaluronan synthase 2 through inhibition of Akt.

Molecular targets of chloropicrin in human airway epithelial cells

Pericellular hyaluronan coat visualized in live cells with a fluorescent probe is scaffolded by plasma membrane protrusions

Plasma membrane residence of hyaluronan synthase is coupled to its enzymatic activity

Precipitation-based extracellular vesicle isolation from rat plasma co-precipitate vesicle-free microRNAs

Presynaptic Vesicle Protein SEPTIN5 Regulates the Degradation of APP C-Terminal Fragments and the Levels of Aβ

Rab10-mediated endocytosis of the hyaluronan synthase HAS3 regulates hyaluronan synthesis and cell adhesion to collagen

Re-evaluation of the role of P-glycoprotein in in vitro drug permeability studies with the bovine brain microvessel endothelial cells

Role of CD44 in the organization of keratinocyte pericellular hyaluronan

The Density and Length of Filopodia Associate with the Activity of Hyaluronan Synthesis in Tumor Cells

The hyaluronan synthesis inhibitor 4-methylumbelliferone prevents keratinocyte activation and epidermal hyperproliferation induced by epidermal growth factor

Tissue distribution and subcellular localization of hyaluronan synthase isoenzymes

Transcriptional and post-translational regulation of hyaluronan synthesis.

UDP-sugar substrates of HAS3 regulate its O-GlcNAcylation, intracellular traffic, extracellular shedding and correlate with melanoma progression

p62/sequestosome 1 as a regulator of proteasome inhibitor-induced autophagy in human retinal pigment epithelial cells