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Lista de obras de Maria João Saraiva

17beta-estradiol induces transthyretin expression in murine choroid plexus via an oestrogen receptor dependent pathway.

artículo científico publicado en 2009

4 ′‐iodo‐4′‐Deoxydoxorubicin and tetracyclines disrupt transthyretin amyloid fibrils in vitro producing noncytotoxic species: screening for TTR fibril disrupters ⬇️

artículo científico publicado el 1 de mayo de 2003

5Alpha-dihydrotestosterone up-regulates transthyretin levels in mice and rat choroid plexus via an androgen receptor independent pathway.

artículo científico publicado en 2008

A Danish kindred with familial amyloid cardiomyopathy revisited: Identification of a mutant transthyretinmethionine111 variant in serum from patients and carriers ⬇️

artículo científico publicado el 1 de julio de 1992

A novel bis-furan scaffold for transthyretin stabilization and amyloid inhibition

scholarly article by Carlos J.V. Simões et al published October 2016 in European Journal of Medicinal Chemistry

A novel compound heterozygote (FAP ATTR Arg104His/ATTR Val30Met) with high serum transthyretin (TTR) and retinol binding protein (RBP) levels.

artículo científico publicado en 1999

A novel nanoparticle delivery system forin vivotargeting of the sciatic nerve: impact on regeneration

A primer of amyloid nomenclature

artículo científico publicado en 2007

Accelerated Abeta deposition in APPswe/PS1deltaE9 mice with hemizygous deletions of TTR (transthyretin).

artículo científico publicado en 2007

Activation of ERK1/2 MAP kinases in familial amyloidotic polyneuropathy

artículo científico publicado en 2006

Activation of the heat shock response in familial amyloidotic polyneuropathy.

artículo científico publicado en 2008

Amyloid fibril protein nomenclature: 2012 recommendations from the Nomenclature Committee of the International Society of Amyloidosis

artículo científico publicado en 2012

Amyloid fibril proteins and amyloidosis: chemical identification and clinical classification International Society of Amyloidosis 2016 Nomenclature Guidelines

artículo científico publicado en 2016

Amyloid: toward terminology clarification. Report from the Nomenclature Committee of the International Society of Amyloidosis.

artículo científico publicado en 2005

Amyloidogenic properties of transthyretin-like protein (TLP) from Escherichia coli

artículo científico publicado en 2008

Anti-apoptotic treatment reduces transthyretin deposition in a transgenic mouse model of Familial Amyloidotic Polyneuropathy

artículo científico publicado en 2008

Antibody recognition of amyloidogenic transthyretin variants in serum of patients with familial amyloidotic polyneuropathy

artículo científico publicado en 2001

ApoA-I cleaved by transthyretin has reduced ability to promote cholesterol efflux and increased amyloidogenicity.

artículo científico publicado en 2007

Aprotinin binding to amyloid fibrils.

artículo científico publicado en 2000

BDNF gene delivery mediated by neuron-targeted nanoparticles is neuroprotective in peripheral nerve injury.

artículo científico publicado en 2016

Binding of epigallocatechin-3-gallate to transthyretin modulates its amyloidogenicity

artículo científico publicado en 2009

Biomarkers in the assessment of therapies for familial amyloidotic polyneuropathy.

artículo científico publicado en 2007

C1q ablation exacerbates amyloid deposition: A study in a transgenic mouse model of ATTRV30M amyloid neuropathy.

artículo científico publicado en 2017

CSF transthyretin neuroprotection in a mouse model of brain ischemia

artículo científico publicado en 2010

Carvedilol treatment reduces transthyretin deposition in a familial amyloidotic polyneuropathy mouse model.

artículo científico publicado en 2010

Cavity filling mutations at the thyroxine-binding site dramatically increase transthyretin stability and prevent its aggregation

artículo científico publicado en 2017

Clearance of extracellular misfolded proteins in systemic amyloidosis: experience with transthyretin

artículo científico

Clusterin overexpression and its possible protective role in transthyretin deposition in familial amyloidotic polyneuropathy

artículo científico publicado en 2011

Comparative Studies of Two Transthyretin Variants with Protective Effects on Familial Amyloidotic Polyneuropathy: TTR R104H and TTR T119M

artículo científico publicado en 2000

Comparative calorimetric study of non-amyloidogenic and amyloidogenic variants of the homotetrameric protein transthyretin

scientific article published on 01 December 2000

Comparative in vitro and ex vivo activities of selected inhibitors of transthyretin aggregation: relevance in drug design

artículo científico publicado en 2007

Controlling amyloid-beta peptide(1-42) oligomerization and toxicity by fluorinated nanoparticles

artículo científico publicado en 2010

Curcumin: A multi-target disease-modifying agent for late-stage transthyretin amyloidosis

artículo científico publicado en 2016

Delivery of an anti-transthyretin Nanobody to the brain through intranasal administration reveals transthyretin expression and secretion by motor neurons.

artículo científico publicado en 2018

Deposition and passage of transthyretin through the blood-nerve barrier in recipients of familial amyloid polyneuropathy livers

artículo científico publicado en 2004

Design and biological activity of beta-sheet breaker peptide conjugates.

artículo científico publicado en 2009

Designing transthyretin mutants affecting tetrameric structure: implications in amyloidogenicity

artículo científico publicado en 2000

Dietary curcumin counteracts extracellular transthyretin deposition: Insights on the mechanism of amyloid inhibition

artículo científico publicado en 2012

Differential expression of Cathepsin E in transthyretin amyloidosis: from neuropathology to the immune system

artículo científico publicado en 2017

Distinct annular oligomers captured along the assembly and disassembly pathways of transthyretin amyloid protofibrils

artículo científico publicado en 2012

Doxycycline disrupts transthyretin amyloid: evidence from studies in a FAP transgenic mice model.

artículo científico publicado en 2006

Doxycycline plus tauroursodeoxycholic acid for transthyretin amyloidosis: a phase II study

artículo científico publicado en 2012

Doxycycline-tauroursodeoxycholic acid treatment: effects in the heart of a transthyretin V30M transgenic mouse model.

artículo científico publicado en 2017

Efficiency of siRNA for removal of transthyretin V30M in a TTR leptomeningeal animal model

artículo científico publicado en 2017

Efficiency of silencing RNA for removal of transthyretin V30M in a TTR leptomeningeal animal model

artículo científico publicado en 2016

Endoplasmic Reticulum Stress Associated with Extracellular Aggregates

scientific article published in Journal of Biological Chemistry

Enlarged ventricles, astrogliosis and neurodegeneration in heat shock factor 1 null mouse brain

artículo científico publicado en 2004

Epigallocatechin-3-gallate as a potential therapeutic drug for TTR-related amyloidosis: "in vivo" evidence from FAP mice models

artículo científico publicado en 2012

Evidence for synergistic action of transthyretin and IGF-I over the IGF-I receptor

article

Evidence for the Role of Megalin in Renal Uptake of Transthyretin

artículo científico publicado en 2000

Familial amyloid polyneuropathy associated with TTRSer50Arg mutation in two Iberian families presenting a novel single base change in the mutant gene

article

Familial amyloid polyneuropathy in a Spanish family with a transthyretin deletion (ΔVal 122) presenting with carpal tunnel syndrome

article

Familial amyloidotic polyneuropathy: transthyretin (prealbumin) variants in kindreds of Italian origin

article

Fibroblasts endocytose and degrade transthyretin aggregates in transthyretin-related amyloidosis

artículo científico publicado en 2013

Force spectroscopy reveals the presence of structurally modified dimers in transthyretin amyloid annular oligomers.

artículo científico publicado en 2016

Gd-nanoparticles functionalization with specific peptides for ß-amyloid plaques targeting

artículo científico publicado en 2016

Gelsolin-related familial amyloidosis, Finnish type, in a Portuguese family: clinical and neurophysiological studies

article

Gender-dependent transthyretin modulation of brain amyloid-β levels: evidence from a mouse model of Alzheimer's disease

artículo científico publicado en 2011

Gene therapy approach to FAP: in vivo influence of T119M in TTR deposition in a transgenic V30M mouse model

artículo científico publicado en 2014

Genetic anticipation in Portuguese kindreds with familial amyloidotic polyneuropathy is unlikely to be caused by triplet repeat expansions

artículo científico publicado en 1999

Genetic microheterogeneity of human transthyretin detected by IEF

article

Glial cells in familial amyloidotic polyneuropathy

artículo científico publicado en 2014

Haplotype analysis of familial amyloidotic polyneuropathy

artículo científico publicado en 1989

Haplotypes and DNA sequence variation within and surrounding the transthyretin gene: genotype-phenotype correlations in familial amyloid polyneuropathy (V30M) in Portugal and Sweden.

artículo científico publicado en 2004

Heparan sulfate/heparin promotes transthyretin fibrillization through selective binding to a basic motif in the protein

artículo científico publicado en 2011

Hepatic production of transthyretin L12P leads to intracellular lysosomal aggregates in a new somatic transgenic mouse model

artículo científico publicado en 2013

Hsf-1 affects podocyte markers NPHS1, NPHS2 and WT1 in a transgenic mouse model of TTRVal30Met-related amyloidosis

artículo científico publicado en 2013

Human TTRV30M localization within podocytes in a transgenic mouse model of transthyretin related amyloidosis: does the environment play a role?

artículo científico publicado en 2012

Human metallothioneins 2 and 3 differentially affect amyloid-beta binding by transthyretin

artículo científico publicado en 2010

Human transthyretin in complex with iododiflunisal: structural features associated with a potent amyloid inhibitor

artículo científico publicado en 2005

Human transthyretin intronic open reading frames are not independently expressed in vivo or part of functional transcripts.

artículo científico publicado en 2003

Immunization in familial amyloidotic polyneuropathy: counteracting deposition by immunization with a Y78F TTR mutant.

artículo científico publicado en 2006

Impairment of autophagy by TTR V30M aggregates: in vivo reversal by TUDCA and curcumin

artículo científico publicado en 2016

Impairment of the ubiquitin–proteasome system associated with extracellular transthyretin aggregates in familial amyloidotic polyneuropathy

artículo científico publicado en 2007

In vitro inhibition of transthyretin aggregate-induced cytotoxicity by full and peptide derived forms of the soluble receptor for advanced glycation end products (RAGE)

artículo científico publicado en 2006

Interleukin-1 signaling pathway as a therapeutic target in transthyretin amyloidosis

artículo científico publicado en 2014

Iodination of salicylic acid improves its binding to transthyretin

artículo científico publicado en 2008

Iodine Atoms: A New Molecular Feature for the Design of Potent Transthyretin Fibrillogenesis Inhibitors

artículo científico publicado en 2009

Isatin derivatives, a novel class of transthyretin fibrillogenesis inhibitors

artículo científico publicado en 2009

Kinetic assay for high-throughput screening of in vitro transthyretin amyloid fibrillogenesis inhibitors.

artículo científico publicado en 2005

MMP-14 overexpression correlates with the neurodegenerative process in familial amyloidotic polyneuropathy.

artículo científico publicado en 2017

Molecular Tweezers Targeting Transthyretin Amyloidosis

artículo científico publicado en 2014

Multimodal imaging Gd-nanoparticles functionalized with Pittsburgh compound B or a nanobody for amyloid plaques targeting

artículo científico publicado en 2017

Mutant fibrinogen A-α-chain associated with hereditary renal amyloidosis and peripheral neuropathy

artículo científico publicado en 2004

Natural polyphenols as modulators of TTR amyloidogenesis:in vitroandin vivoevidences towards therapy

article published in 2012

Natural polyphenols inhibit different steps of the process of transthyretin (TTR) amyloid fibril formation

artículo científico publicado en 2011

Neurodegeneration in familial amyloid polyneuropathy: from pathology to molecular signaling

artículo científico publicado en 2003

Neuronal megalin mediates synaptic plasticity-a novel mechanism underlying intellectual disabilities in megalin gene pathologies

artículo científico publicado en 2020

New transthyretin mutation V28M in a Portuguese kindred with amyloid polyneuropathy.

artículo científico publicado en 2000

Nomenclature 2014: Amyloid fibril proteins and clinical classification of the amyloidosis

artículo científico publicado en 2014

Ocular changes in familial amyloidotic polyneuropathy with dense vitreous opacities

scientific article published on 01 January 1991

Overexpression of Protocadherin-10 in Transthyretin-Related Familial Amyloidotic Polyneuropathy.

artículo científico publicado en 2016

Plasma neurofilament light chain: an early biomarker for hereditary ATTR amyloid polyneuropathy

scientific article published on 06 January 2020

Polymer-doxycycline conjugates as fibril disrupters: an approach towards the treatment of a rare amyloidotic disease.

artículo científico publicado en 2014

Preclinical evaluation of RNAi as a treatment for transthyretin-mediated amyloidosis

artículo científico publicado en 2016

Preimplantation genetic diagnosis for familial amyloidotic polyneuropathy (FAP).

artículo científico publicado en 2001

Prenatal diagnosis of familial amyloidotic polyneuropathy: evidence for an early expression of the associated transthyretin methionine 30

article

Production of recombinant human transthyretin with biological activities toward the understanding of the molecular basis of familial amyloidotic polyneuropathy (FAP).

artículo científico publicado en 1991

Progesterone enhances transthyretin expression in the rat choroid plexus in vitro and in vivo via progesterone receptor

artículo científico publicado en 2010

Protective Role of Anakinra Against Transthyretin-Mediated Axonal Loss and Cell Death in a Mouse Model of Familial Amyloidotic Polyneuropathy

artículo científico publicado en 2015

Randomization of amyloid-β-peptide(1-42) conformation by sulfonated and sulfated nanoparticles reduces aggregation and cytotoxicity

artículo científico publicado en 2010

Screening and biochemical characterization of transthyretin variants in the Portuguese population

article

Search for intermediate structures in transthyretin fibrillogenesis: soluble tetrameric Tyr78Phe TTR expresses a specific epitope present only in amyloid fibrils

scientific article published on 01 December 2000

Selective binding to transthyretin and tetramer stabilization in serum from patients with familial amyloidotic polyneuropathy by an iodinated diflunisal derivative

artículo científico publicado en 2004

Solution structure of the soluble receptor for advanced glycation end products (sRAGE).

artículo científico publicado en 2011

Sporadic Cases of Hereditary Systemic Amyloidosis

artículo científico publicado en 2002

Stability of the transthyretin molecule as a key factor in the interaction with a-beta peptide--relevance in Alzheimer's disease

artículo científico publicado en 2012

Structural basis for the protective role of sulfite against transthyretin amyloid formation

artículo científico publicado en 2007

Structural insights into a zinc-dependent pathway leading to Leu55Pro transthyretin amyloid fibrils

artículo científico publicado en 2011

Structural studies on FAP fibrils: removal of contaminants is essential for the interpretation of X-ray data

Structure and assembly-disassembly properties of wild-type transthyretin amyloid protofibrils observed with atomic force microscopy

artículo científico publicado en 2011

Structure of the Val122Ile variant transthyretin - a cardiomyopathic mutant

artículo científico publicado en 1996

Successful Heart and Liver Transplantation in a Swiss Patient With Glu89Lys Transthyretin Amyloidosis

article

Sulfite and base for the treatment of familial amyloidotic polyneuropathy: two additive approaches to stabilize the conformation of human amyloidogenic transthyretin

artículo científico publicado en 2003

Susceptibility and modifier genes in Portuguese transthyretin V30M amyloid polyneuropathy: complexity in a single-gene disease

article

Synergy of combined doxycycline/TUDCA treatment in lowering Transthyretin deposition and associated biomarkers: studies in FAP mouse models

artículo científico publicado en 2010

TTR Leu 64 in an FAP kindred identified by PCR-RFLP analysis

Targeting a rare amyloidotic disease through rationally designed polymer conjugates.

artículo científico publicado en 2014

The Tetrameric Protein Transthyretin Dissociates to a Non-native Monomer in Solution

scientific article published in Journal of Biological Chemistry

The amyloidogenic potential of transthyretin variants correlates with their tendency to aggregate in solution

artículo científico publicado en 1997

The binding of 2,4-dinitrophenol to wild-type and amyloidogenic transthyretin

artículo científico publicado en 2006

The binding of xanthone derivatives to transthyretin.

artículo científico publicado en 2005

The crystal structure of transthyretin in complex with diethylstilbestrol: a promising template for the design of amyloid inhibitors.

artículo científico publicado en 2004

The heat shock response in FAP: the role of the extracellular chaperone clusterin

artículo científico publicado en 2012

The heat shock response modulates transthyretin deposition in the peripheral and autonomic nervous systems

artículo científico publicado en 2010

The importance of pre-clinical studies in animal models of TTR amyloidosis for the discovery of novel patient disease biomarkers.

artículo científico publicado en 2017

The inflammatory response to sciatic nerve injury in a familial amyloidotic polyneuropathy mouse model

artículo científico publicado en 2014

The molecular interaction of 4'-iodo-4'-deoxydoxorubicin with Leu-55Pro transthyretin 'amyloid-like' oligomer leading to disaggregation

artículo científico publicado en 2000

Thyroid hormone distribution in the mouse brain: the role of transthyretin

artículo científico publicado en 2002

Tissue remodeling after interference RNA mediated knockdown of transthyretin in a familial amyloidotic polyneuropathy mouse model.

artículo científico publicado en 2016

Transthyretin Aggregation and Toxicity

article

Transthyretin Induces Insulin-like Growth Factor I Nuclear Translocation Regulating Its Levels in the Hippocampus

artículo científico publicado en 2014

Transthyretin Leu 68 in a form of cardiac amyloidosis

artículo científico publicado en 1991

Transthyretin Ser 6 gene frequency in individuals without amyloidosis.

artículo científico publicado en 1995

Transthyretin amyloidosis: a tale of weak interactions.

artículo científico publicado en 2001

Transthyretin and Alzheimer's disease: where in the brain?

artículo científico publicado en 2006

Transthyretin binding to A-Beta peptide--impact on A-Beta fibrillogenesis and toxicity.

artículo científico publicado en 2008

Transthyretin decrease in plasma of MCI and AD patients: investigation of mechanisms for disease modulation.

artículo científico publicado en 2012

Transthyretin enhances nerve regeneration

artículo científico publicado en 2007

Transthyretin fibrillogenesis entails the assembly of monomers: a molecular model for in vitro assembled transthyretin amyloid-like fibrils

artículo científico publicado en 2002

Transthyretin gene in Alzheimer's disease patients.

artículo científico publicado en 1996

Transthyretin interacts with metallothionein 2.

artículo científico publicado en 2008

Transthyretin internalization by sensory neurons is megalin mediated and necessary for its neuritogenic activity.

artículo científico publicado en 2009

Transthyretin is a metallopeptidase with an inducible active site

artículo científico publicado en 2012

Transthyretin is involved in depression-like behaviour and exploratory activity

artículo científico publicado en 2004

Transthyretin is not expressed by dorsal root ganglia cells

artículo científico publicado en 2008

Transthyretin is not necessary for thyroid hormone metabolism in conditions of increased hormone demand

artículo científico publicado en 2005

Transthyretin is up-regulated by sex hormones in mice liver.

artículo científico publicado en 2008

Transthyretin knockouts are a new mouse model for increased neuropeptide Y.

artículo científico publicado en 2005

Transthyretin mutations in health and disease.

artículo científico publicado en 1995

Transthyretin participates in beta-amyloid transport from the brain to the liver--involvement of the low-density lipoprotein receptor-related protein 1?

artículo científico publicado en 2016

Transthyretin protects against A-beta peptide toxicity by proteolytic cleavage of the peptide: a mechanism sensitive to the Kunitz protease inhibitor

artículo científico publicado en 2008

Transthyretin provides trophic support via megalin by promoting neurite outgrowth and neuroprotection in cerebral ischemia

scientific article published on 12 August 2016

Transthyretin regulates hippocampal 14-3-3ζ protein levels.

artículo científico publicado en 2013

Transthyretin regulates thyroid hormone levels in the choroid plexus, but not in the brain parenchyma: study in a transthyretin-null mouse model

artículo científico publicado en 2000

Transthyretin stability as a key factor in amyloidogenesis: X-ray analysis at atomic resolution

artículo científico publicado en 2001

Transthyretin stabilization by iododiflunisal promotes amyloid-β peptide clearance, decreases its deposition, and ameliorates cognitive deficits in an Alzheimer's disease mouse model

artículo científico publicado en 2014

Transthyretin, a new cryptic protease

artículo científico publicado en 2004

Transthyretin: a multifaceted protein.

artículo científico publicado en 2014

Transthyretin: no association between serum levels or gene variants and schizophrenia

artículo científico publicado en 2006

Ultrastructure of Familial Amyloid Polyneuropathy Amyloid Fibrils: Examination with High-Resolution Electron Microscopy

article

Unusual Self-Association Properties of Transthyretin Y114C Related to Familial Amyloidotic Polyneuropathy: Effects on Detection and Quantification

artículo científico publicado en 1999

Up-regulation of the extracellular matrix remodeling genes, biglycan, neutrophil gelatinase-associated lipocalin, and matrix metalloproteinase-9 in familial amyloid polyneuropathy.

artículo científico publicado en 2004

X-ray absorption spectroscopy reveals a substantial increase of sulfur oxidation in transthyretin (TTR) upon fibrillization

artículo científico publicado en 2003

X-ray crystallographic studies of two transthyretin variants: further insights into amyloidogenesis

αB-crystallin (HspB5) in familial amyloidotic polyneuropathy.

artículo científico publicado en 2010

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