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Lista de obras de Andreas Strasser

A critical epithelial survival axis regulated by MCL-1 maintains thymic function in mice

artículo científico publicado en 2017

A decade of molecular cell biology: achievements and challenges

artículo científico publicado en 2011

A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes

artículo científico publicado en 1998

A novel cellular model (SPGM 1) of switching between the pre-B cell and myelomonocytic lineages

artículo científico publicado en 1993

A portrait of the Bcl-2 protein family: life, death, and the whole picture

artículo científico publicado en 1999

A type III effector antagonizes death receptor signalling during bacterial gut infection

artículo científico publicado en 2013

ABT-737 is a useful component of combinatory chemotherapies for chronic myeloid leukaemias with diverse drug-resistance mechanisms

artículo científico publicado en 2007

AMP kinase-mediated activation of the BH3-only protein Bim couples energy depletion to stress-induced apoptosis

artículo científico publicado en 2010

Abnormalities of the immune system induced by dysregulated bcl-2 expression in transgenic mice

Activated T cell death in vivo mediated by proapoptotic bcl-2 family member bim.

artículo científico publicado en 2002

Activation of Fas by FasL induces apoptosis by a mechanism that cannot be blocked by Bcl-2 or Bcl-x(L)

artículo científico publicado en 1999

Activation of the mitogen-activated protein kinase pathway induces transcription of the PAC-1 phosphatase gene

artículo científico publicado en 1996

Alternative splicing of Bim and Erk-mediated Bim(EL) phosphorylation are dispensable for hematopoietic homeostasis in vivo.

artículo científico publicado en 2012

An evolutionary perspective on apoptosis.

artículo científico publicado en 1994

An inducible lentiviral guide RNA platform enables the identification of tumor-essential genes and tumor-promoting mutations in vivo

artículo científico publicado en 2015

Antagonism between MCL-1 and PUMA governs stem/progenitor cell survival during hematopoietic recovery from stress.

artículo científico publicado en 2015

Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia

artículo científico publicado en 2012

Anti-apoptotic proteins BCL-2, MCL-1 and A1 summate collectively to maintain survival of immune cell populations both in vitro and in vivo.

artículo científico publicado en 2017

Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3⁺ regulatory T cells

artículo científico publicado en 2013

Antigen Challenge Inhibits Thymic Emigration

artículo científico publicado en 2006

Apaf-1 and caspase-9 are required for cytokine withdrawal-induced apoptosis of mast cells but dispensable for their functional and clonogenic death

artículo científico publicado en 2005

Apaf-1 and caspase-9 do not act as tumor suppressors in myc-induced lymphomagenesis or mouse embryo fibroblast transformation.

artículo científico publicado en 2004

Apoptosis and autoimmune disease

artículo científico publicado en 1999

Apoptosis and cell division

artículo científico publicado en 2000

Apoptosis induced by proteasome inhibition in cancer cells: predominant role of the p53/PUMA pathway

artículo científico publicado en 2006

Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome

artículo científico publicado en 2002

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

artículo científico publicado en 2007

Apoptosis regulators Fas and Bim cooperate in shutdown of chronic immune responses and prevention of autoimmunity

artículo científico publicado en 2008

Apoptosis regulators Fas and Bim synergistically control T-lymphocyte homeostatic proliferation

artículo científico publicado en 2010

Apoptosis-based dual molecular targeting by INNO-406, a second-generation Bcr-Abl inhibitor, and ABT-737, an inhibitor of antiapoptotic Bcl-2 proteins, against Bcr-Abl-positive leukemia

artículo científico publicado en 2007

Apoptosis-promoted tumorigenesis: gamma-irradiation-induced thymic lymphomagenesis requires Puma-driven leukocyte death.

artículo científico publicado en 2010

Are We Really on the Right TRAIL?

artículo científico publicado en 2005

Autoimmune kidney disease and lymphadenopathy in NODlpr mice are not modified by deficiency in tumor necrosis factor receptor 1 or beta2-microglobulin

artículo científico publicado en 2003

Autoreactive T cells induce necrosis and not BCL-2-regulated or death receptor-mediated apoptosis or RIPK3-dependent necroptosis of transplanted islets in a mouse model of type 1 diabetes.

artículo científico publicado en 2014

B Cell Growth Is Controlled by Phosphatidylinosotol 3-Kinase-Dependent Induction of Rel/NF-κB Regulated c-myc Transcription

artículo científico publicado en 2002

B lymphocytes differentially use the Rel and nuclear factor kappaB1 (NF-kappaB1) transcription factors to regulate cell cycle progression and apoptosis in quiescent and mitogen-activated cells

artículo científico publicado en 1998

BCL-2 family member BOK is widely expressed but its loss has only minimal impact in mice.

artículo científico publicado en 2012

BCL-2 is dispensable for thrombopoiesis and platelet survival

artículo científico publicado en 2015

BCL-2: Long and winding path from discovery to therapeutic target

artículo científico

BCL-W is dispensable for the sustained survival of select Burkitt lymphoma and diffuse large B-cell lymphoma cell lines

scientific article published on 01 January 2020

BCL-XL and MCL-1 are the key BCL-2 family proteins in melanoma cell survival

artículo científico publicado en 2019

BCL-XL exerts a protective role against anemia caused by radiation-induced kidney damage

scientific article published on 25 November 2020

BCL2-modifying factor promotes germ cell loss during murine oogenesis

artículo científico publicado en 2016

BCR-ABL activates pathways mediating cytokine independence and protection against apoptosis in murine hematopoietic cells in a dose-dependent manner

artículo científico publicado en 1998

BCR-signaling-induced cell death demonstrates dependency on multiple BH3-only proteins in a murine model of B-cell lymphoma.

artículo científico publicado en 2015

BET inhibition represses miR17-92 to drive BIM-initiated apoptosis of normal and transformed hematopoietic cells.

artículo científico publicado en 2016

BH3-Mimetic Drugs: Blazing the Trail for New Cancer Medicines

artículo científico publicado en 2018

BH3-Only proteins-essential initiators of apoptotic cell death

artículo científico publicado en 2000

BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes

artículo científico publicado en 2002

BH3-only proapoptotic Bcl-2 family members Noxa and Puma mediate neural precursor cell death.

artículo científico publicado en 2006

BH3-only protein Bid is dispensable for seizure-induced neuronal death and the associated nuclear accumulation of apoptosis-inducing factor

artículo científico publicado en 2010

BH3-only protein Puma contributes to death of antigen-specific T cells during shutdown of an immune response to acute viral infection

artículo científico publicado en 2008

BH3-only proteins - evolutionarily conserved proapoptotic Bcl-2 family members essential for initiating programmed cell death.

artículo científico publicado en 2002

BH3-only proteins Puma and Bim are rate-limiting for gamma-radiation- and glucocorticoid-induced apoptosis of lymphoid cells in vivo.

artículo científico publicado en 2005

BH3-only proteins in apoptosis at a glance

artículo científico publicado en 2012

BIM Deficiency Protects NOD Mice From Diabetes by Diverting Thymocytes to Regulatory T Cells

artículo científico publicado en 2015

BIM regulates apoptosis during mammary ductal morphogenesis, and its absence reveals alternative cell death mechanisms

scientific journal article

Bax and Bak: back-bone of T cell death

artículo científico publicado en 2002

Bcl-2 Antagonists Kill Plasmacytoid Dendritic Cells From Lupus-Prone Mice and Dampen Interferon-α Production

artículo científico publicado en 2015

Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis

scientific journal article

Bcl-2 and thermotolerance cooperate in cell survival.

artículo científico publicado en 1995

Bcl-2 can rescue T lymphocyte development in interleukin-7 receptor-deficient mice but not in mutant rag-1-/- mice

scientific journal article

Bcl-2 does not inhibit cell death induced by the physiological Fas ligand: implications for the existence of type I and type II cells

artículo científico publicado en 2000

Bcl-2 expression promotes B- but not T-lymphoid development in scid mice

scientific journal article

Bcl-2 family member Bcl-G is not a proapoptotic protein.

artículo científico publicado en 2012

Bcl-2 overexpression ameliorates immune complex-mediated arthritis by altering FcγRIIb expression and monocyte homeostasis

artículo científico publicado en 2013

Bcl-2 transgene expression fails to prevent fatal hepatocyte apoptosis induced by endogenous TNFalpha in mice lacking RelA.

artículo científico publicado en 2006

Bcl-2, Bcl-XL and adenovirus protein E1B19kD are functionally equivalent in their ability to inhibit cell death.

artículo científico publicado en 1997

Bcl-2-regulated apoptosis and cytochrome c release can occur independently of both caspase-2 and caspase-9

artículo científico publicado en 2004

Bfk: a novel weakly proapoptotic member of the Bcl-2 protein family with a BH3 and a BH2 region.

artículo científico publicado en 2003

Bid and Bim collaborate during induction of T cell death in persistent infection

artículo científico publicado en 2011

Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic.

artículo científico publicado en 2006

Bim expression in endothelial cells and pericytes is essential for regression of the fetal ocular vasculature

artículo científico publicado en 2017

Bim must be able to engage all pro-survival Bcl-2 family members for efficient tumor suppression

artículo científico publicado en 2011

Bim: a novel member of the Bcl-2 family that promotes apoptosis

artículo científico publicado en 1998

Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis

artículo científico publicado en 2001

CAML regulates Bim-dependent thymocyte death

artículo científico publicado en 2010

CARD11 is dispensable for homeostatic responses and suppressive activity of peripherally induced FOXP3 + regulatory T cells

artículo científico publicado en 2019

CD4+8- and CD4-8+ mature thymocytes require different post-selection processing for final development

article

CD45 links the B cell receptor with cell survival and is required for the persistence of germinal centers

artículo científico publicado en 2005

CD95 (Fas/APO-1) and p53 signal apoptosis independently in diverse cell types

artículo científico publicado en 2000

Can the analysis of BH3-only protein knockout mice clarify the issue of 'direct versus indirect' activation of Bax and Bak?

artículo científico publicado en 2011

Caspase-2 is not required for thymocyte or neuronal apoptosis even though cleavage of caspase-2 is dependent on both Apaf-1 and caspase-9

artículo científico publicado en 2002

Caspase-8 inactivation in T cells increases necroptosis and suppresses autoimmunity in Bim-/- mice

artículo científico publicado en 2011

Caspases signal not only apoptosis but also antigen-induced activation in cells of the immune system

artículo científico publicado en 2003

Cell cycle progression dictates the requirement for BCL2 in natural killer cell survival

artículo científico publicado en 2017

Cell death

artículo científico publicado en 2009

Cell death and thymic tolerance

artículo científico publicado en 2017

Cell death control in lymphocytes.

artículo científico publicado en 2000

Cell death provoked by loss of interleukin-3 signaling is independent of Bad, Bim, and PI3 kinase, but depends in part on Puma

scientific journal article

Cellular stages and molecular steps of murine B-cell development

artículo científico publicado en 1989

Characterisation of a novel A1-specific monoclonal antibody.

artículo científico publicado en 2014

Characterisation of mice lacking all functional isoforms of the pro-survival BCL-2 family member A1 reveals minor defects in the haematopoietic compartment.

artículo científico publicado en 2017

Characterisation of mice lacking the inflammatory caspases-1/11/12 reveals no contribution of caspase-12 to cell death and sepsis

scientific article published on 28 August 2018

Characterization of a novel human BFL-1-specific monoclonal antibody

scientific article published on 12 November 2019

Cisplatin-induced primordial follicle oocyte killing and loss of fertility are not prevented by imatinib

artículo científico publicado en 2012

Combined loss of PUMA and p21 accelerates c-MYC-driven lymphoma development considerably less than loss of one allele of p53.

artículo científico publicado en 2015

Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis

scientific journal article

Concomitant loss of proapoptotic BH3-only Bcl-2 antagonists Bik and Bim arrests spermatogenesis

scientific journal article

Consequences of Zmat3 loss in c-MYC- and mutant KRAS-driven tumorigenesis

artículo científico publicado en 2020

Consequences of the combined loss of BOK and BAK or BOK and BAX.

artículo científico publicado en 2013

Constitutive expression of Bcl-xL or Bcl-2 prevents peptide antigen-induced T cell deletion but does not influence T cell homeostasis after a viral infection

artículo científico publicado en 1998

Continued differentiation during B lymphopoiesis requires signals in addition to cell survival

article

Contrasting patterns of Bim induction and neuroprotection in Bim-deficient mice between hippocampus and neocortex after status epilepticus.

artículo científico publicado en 2009

Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy.

artículo científico publicado en 2014

Control of apoptosis in hematopoietic cells by the Bcl-2 family of proteins

artículo científico publicado en 1999

Control of apoptosis in the immune system: Bcl-2, BH3-only proteins and more

artículo científico publicado en 2001

Coordinated repression of BIM and PUMA by Epstein-Barr virus latent genes maintains the survival of Burkitt lymphoma cells

artículo científico publicado en 2017

Critical B-lymphoid cell intrinsic role of endogenous MCL-1 in c-MYC-induced lymphomagenesis.

artículo científico publicado en 2016

CrmA expression in T lymphocytes of transgenic mice inhibits CD95 (Fas/APO-1)-transduced apoptosis, but does not cause lymphadenopathy or autoimmune disease.

artículo científico publicado en 1996

Cyclic-AMP-dependent protein kinase A regulates apoptosis by stabilizing the BH3-only protein Bim

scientific journal article

DH element reading frame selection is influenced by an Ig heavy chain transgene, but not by bcl-2.

artículo científico publicado en 1995

DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2

scientific article published on 01 October 1994

DNA damage-induced primordial follicle oocyte apoptosis and loss of fertility require TAp63-mediated induction of Puma and Noxa

artículo científico publicado en 2012

DNA repair processes are critical mediators of p53-dependent tumor suppression

artículo científico publicado en 2018

DNA-binding of the Tet-transactivator curtails antigen-induced lymphocyte activation in mice

artículo científico publicado en 2017

Death in the snow: report on Keystone Conference on 'Apoptosis and Programmed Cell Death' at Breckenridge, CO, April 6-11th 1999

artículo científico publicado en 2000

Death of a T cell

artículo científico publicado en 1995

Death receptor-induced apoptosis signalling - essential guardian against autoimmune disease.

artículo científico publicado en 2012

Death squads enlisted by the tumour suppressor p53.

artículo científico publicado en 2005

Deciphering the rules of programmed cell death to improve therapy of cancer and other diseases

artículo científico publicado en 2011

Deep profiling of apoptotic pathways with mass cytometry identifies a synergistic drug combination for killing myeloma cells

artículo científico publicado en 2020

Defects in the Bcl-2-regulated apoptotic pathway lead to preferential increase of CD25 low Foxp3+ anergic CD4+ T cells

artículo científico publicado en 2011

Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim

scientific journal article

Deletion of the BH3-only protein puma protects motoneurons from ER stress-induced apoptosis and delays motoneuron loss in ALS mice

artículo científico publicado en 2007

Deregulated cell death and lymphocyte homeostasis cause premature lethality in mice lacking the BH3-only proteins Bim and Bmf.

artículo científico publicado en 2014

Deregulation of cell survival in lymphomagenesis

artículo científico publicado en 1997

Destruction of tumor vasculature and abated tumor growth upon VEGF blockade is driven by proapoptotic protein Bim in endothelial cells.

artículo científico publicado en 2011

Detection of Bcl-2 family member Bcl-G in mouse tissues using new monoclonal antibodies.

artículo científico publicado en 2012

Differential regulation of macrophage differentiation in response to leukemia inhibitory factor/oncostatin-M/interleukin-6: the effect of enforced expression of the SCL transcription factor

artículo científico publicado en 1995

Discovery and molecular characterization of a Bcl-2-regulated cell death pathway in schistosomes

artículo científico publicado en 2011

Discussion of some 'knowns' and some 'unknowns' about the tumour suppressor p53.

artículo científico publicado en 2019

Does "death receptor" signaling play a role in tumorigenesis and cancer therapy?

artículo científico publicado en 1998

Dr. Josef Steiner Cancer Research Prize Lecture: the role of physiological cell death in neoplastic transformation and in anti-cancer therapy

artículo científico publicado en 1999

Dynein light chain regulates adaptive and innate B cell development by distinctive genetic mechanisms

artículo científico publicado en 2017

E mu-bcl-2 transgene facilitates spontaneous transformation of early pre-B and immunoglobulin-secreting cells but not T cells.

artículo científico publicado en 1993

E6AP ubiquitin ligase regulates PML-induced senescence in Myc-driven lymphomagenesis

artículo científico publicado en 2012

EBV BCL-2 homologue BHRF1 drives chemoresistance and lymphomagenesis by inhibiting multiple cellular pro-apoptotic proteins

artículo científico publicado en 2019

EGF-mediated induction of Mcl-1 at the switch to lactation is essential for alveolar cell survival

artículo científico publicado en 2015

ER stress does not cause upregulation and activation of caspase-2 to initiate apoptosis.

artículo científico publicado en 2013

ER stress triggers apoptosis by activating BH3-only protein Bim

artículo científico publicado en 2007

Effect of a bcl-2 transgene on production and localization of precursor B cells in mouse bone marrow

artículo científico publicado el 1 de septiembre de 1998

Effects of a dominant interfering mutant of FADD on signal transduction in activated T cells

artículo científico publicado en 2001

Efficient T cell receptor–mediated apoptosis in nonobese diabetic mouse thymocytes

artículo científico publicado en 2003

Egalitarian binds dynein light chain to establish oocyte polarity and maintain oocyte fate.

artículo científico publicado en 2004

Elevated Mcl-1 inhibits thymocyte apoptosis and alters thymic selection ⬇️

artículo científico publicado el 29 de junio de 2012

Embryogenesis and Adult Life in the Absence of Intrinsic Apoptosis Effectors BAX, BAK, and BOK

scientific article published on 01 May 2018

Emerging connectivity of programmed cell death pathways and its physiological implications

artículo científico publicado en 2020

Endogenous Bcl-xL is essential for Myc-driven lymphomagenesis in mice

artículo científico publicado en 2011

Endogenous bcl-2 is not required for the development of Emu-myc-induced B-cell lymphoma

artículo científico publicado en 2007

Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease

artículo científico publicado en 1991

Enforced Bcl-2 expression inhibits antigen-mediated clonal elimination of peripheral B cells in an antigen dose-dependent manner and promotes receptor editing in autoreactive, immature B cells

artículo científico publicado en 1997

Enhanced cell survival and tumorigenesis.

artículo científico publicado en 1994

Enhanced stability of Mcl1, a prosurvival Bcl2 relative, blunts stress-induced apoptosis, causes male sterility, and promotes tumorigenesis.

artículo científico publicado en 2013

Erratum: BCL-2 family member BOK is widely expressed but its loss has only minimal impact in mice

scholarly article published in Cell Death & Differentiation

Erratum: Corrigendum: Mcl-1 is essential for the survival of plasma cells

scholarly article published in Nature Immunology

Erratum: corrigenda: BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes

scientific article published in Nature

Essential role for the BH3-only protein Bim but redundant roles for Bax, Bcl-2, and Bcl-w in the control of granulocyte survival

scientific article published on 14 November 2002

Establishment of multipotential and antigen presenting cell lines derived from myeloid leukemias in GM-CSF transgenic mice

artículo científico publicado en 1997

Estrogen influences the differentiation, proliferation, and survival of early B-lineage precursors

scientific article published on 01 March 2000

Evidence against upstream regulation of the unfolded protein response (UPR) by pro-apoptotic BIM and PUMA.

artículo científico publicado en 2014

Expression of a bcl-2 transgene reduces proliferation and slows turnover of developing B lymphocytes in vivo

FADD and caspase-8 are required for cytokine-induced proliferation of hemopoietic progenitor cells.

artículo científico publicado en 2005

FADD and the NF-kappaB family member Bcl-3 regulate complementary pathways to control T-cell survival and proliferation

scholarly article by Svetla Rangelova et al published December 2008 in Immunology

FADD/MORT1 regulates the pre-TCR checkpoint and can function as a tumour suppressor

artículo científico publicado en 2000

FADD/MORT1, a signal transducer that can promote cell death or cell growth.

artículo científico publicado en 1999

FAS Inactivation Releases Unconventional Germinal Center B Cells that Escape Antigen Control and Drive IgE and Autoantibody Production

artículo científico publicado en 2015

Fas death receptor signalling: roles of Bid and XIAP.

artículo científico publicado en 2011

Fas ligand, Bcl-2, granulocyte colony-stimulating factor, and p38 mitogen-activated protein kinase: Regulators of distinct cell death and survival pathways in granulocytes.

artículo científico publicado en 2000

Fas ligand-induced c-Jun kinase activation in lymphoid cells requires extensive receptor aggregation but is independent of DAXX, and Fas-mediated cell death does not involve DAXX, RIP, or RAIDD.

artículo científico publicado en 2000

Fas ligand-mediated immune surveillance by T cells is essential for the control of spontaneous B cell lymphomas

artículo científico publicado en 2014

Fas ligand—cought between scylla and charybdis

artículo científico publicado en 1998

Fas-mediated neutrophil apoptosis is accelerated by Bid, Bak, and Bax and inhibited by Bcl-2 and Mcl-1

artículo científico publicado en 2011

Fatal hepatitis mediated by tumor necrosis factor TNFalpha requires caspase-8 and involves the BH3-only proteins Bid and Bim.

artículo científico publicado en 2009

FcepsilonRI aggregation promotes survival of connective tissue-like mast cells but not mucosal-like mast cells.

artículo científico publicado en 2007

Fold up or perish: unfolded protein response and chemotherapy

artículo científico publicado en 2007

Foxo-mediated Bim transcription is dispensable for the apoptosis of hematopoietic cells that is mediated by this BH3-only protein

artículo científico publicado en 2013

Functional antagonism between pro-apoptotic BIM and anti-apoptotic BCL-XL in MYC-induced lymphomagenesis

artículo científico publicado en 2014

Functional characterization of the Bcl-2 gene family in the zebrafish.

artículo científico publicado en 2006

GATA-1 but not SCL induces megakaryocytic differentiation in an early myeloid line

artículo científico publicado en 1992

Gefitinib-induced killing of NSCLC cell lines expressing mutant EGFR requires BIM and can be enhanced by BH3 mimetics

artículo científico publicado en 2007

Generalized resistance to thymic deletion in the NOD mouse; a polygenic trait characterized by defective induction of Bim.

artículo científico publicado en 2004

Glucose induces pancreatic islet cell apoptosis that requires the BH3-only proteins Bim and Puma and multi-BH domain protein Bax.

artículo científico publicado en 2009

Haematopoietic cell apoptosis

artículo científico publicado en 2007

Hepatocyte growth factor renders BRAF mutant human melanoma cell lines resistant to PLX4032 by downregulating the pro-apoptotic BH3-only proteins PUMA and BIM.

artículo científico publicado en 2016

How do thymic epithelial cells die?

artículo científico publicado en 2018

How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression?

artículo científico publicado en 2017

How important are post-translational modifications in p53 for selectivity in target-gene transcription and tumour suppression?

artículo científico publicado en 2007

How to best preserve oocytes in female cancer patients exposed to DNA damage inducing therapeutics

artículo científico publicado en 2013

Hrk/DP5 contributes to the apoptosis of select neuronal populations but is dispensable for haematopoietic cell apoptosis.

scientific article published on 29 May 2007

Humanized Mcl-1 mice enable accurate pre-clinical evaluation of MCL-1 inhibitors destined for clinical use

Humanized Mcl-1 mice enable accurate preclinical evaluation of MCL-1 inhibitors destined for clinical use

artículo científico publicado en 2018

IMMUNOLOGY: Lymphocyte Survival--Ignorance Is BLys

artículo científico publicado en 2000

IRF4 Activity Is Required in Established Plasma Cells to Regulate Gene Transcription and Mitochondrial Homeostasis

scientific article published on 01 November 2019

Identity of PB76 differentiation antigen and lymphocyte alkaline phosphatase

scientific article published on 01 April 1990

Immature surface Ig+ B cells can continue to rearrange kappa and lambda L chain gene loci

artículo científico publicado en 1993

Impact of conditional deletion of the pro-apoptotic BCL-2 family member BIM in mice

artículo científico publicado en 2014

Impact of loss of NF-κB1, NF-κB2 or c-REL on SLE-like autoimmune disease and lymphadenopathy in Fas(lpr/lpr) mutant mice

artículo científico publicado en 2015

Impact of the combined loss of BOK, BAX and BAK on the hematopoietic system is slightly more severe than compound loss of BAX and BAK ⬇️

artículo científico publicado en 2015

Impaired lactation in mice expressing dominant-negative FADD in mammary epithelium

artículo científico publicado en 2009

In several cell types tumour suppressor p53 induces apoptosis largely via Puma but Noxa can contribute

artículo científico publicado en 2008

In vitro and in vivo assays for osteoclast apoptosis

artículo científico publicado en 2005

Individual and overlapping roles of BH3-only proteins Bim and Bad in apoptosis of lymphocytes and platelets and in suppression of thymic lymphoma development

artículo científico publicado en 2010

Induction of BIM, a proapoptotic BH3-only BCL-2 family member, is critical for neuronal apoptosis

artículo científico publicado en 2001

Induction of cell death by tumour necrosis factor (TNF) receptor 2, CD40 and CD30: a role for TNF-R1 activation by endogenous membrane-anchored TNF.

artículo científico publicado en 1999

Inhibition of apoptosis by BCL2 prevents leukemic transformation of a murine myelodysplastic syndrome

artículo científico publicado en 2012

Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth

artículo científico publicado en 2018

Innate immunodeficiency following genetic ablation of Mcl1 in natural killer cells.

artículo científico publicado en 2014

Insights from Bcl-2 and Myc: malignancy involves abrogation of apoptosis as well as sustained proliferation

artículo científico publicado en 1999

Insights from transgenic mice regarding the role of bcl-2 in normal and neoplastic lymphoid cells

artículo científico publicado en 1994

Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1.

artículo científico publicado en 2007

Intracellular localization of the BCL-2 family member BOK and functional implications

scientific journal article

Intrahepatic murine CD8 T-cell activation associates with a distinct phenotype leading to Bim-dependent death

artículo científico publicado en 2008

Ionizing radiation and chemotherapeutic drugs induce apoptosis in lymphocytes in the absence of Fas or FADD/MORT1 signaling. Implications for cancer therapy

artículo científico publicado en 2000

Is Apaf-1 expression frequently abrogated in melanoma?

article

Is BID required for NOD signalling?

scientific article published on 01 August 2012

Is BOK required for apoptosis induced by endoplasmic reticulum stress?

artículo científico publicado en 2016

Is SIRT2 required for necroptosis?

artículo científico publicado en 2014

Is tumor growth sustained by rare cancer stem cells or dominant clones?

artículo científico publicado en 2008

Islet beta-cells deficient in Bcl-xL develop but are abnormally sensitive to apoptotic stimuli

artículo científico publicado en 2009

It's not over until the FAT lady sings

artículo científico publicado en 2014

Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins

artículo científico publicado en 2002

LUBAC is essential for embryogenesis by preventing cell death and enabling haematopoiesis

artículo científico publicado en 2018

LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L

scientific article published in Nature Communications

Lessons from bcl-2 transgenic mice for immunology, cancer biology and cell death research.

artículo científico publicado en 1996

Life and death during lymphocyte development and function: evidence for two distinct killing mechanisms

artículo científico publicado en 1995

Lineage switch of a mouse pre-B cell line (SPGM-1) to macrophage-like cells after incubation with phorbol ester and calcium ionophore

artículo científico publicado en 1995

Linear ubiquitin chain assembly complex coordinates late thymic T-cell differentiation and regulatory T-cell homeostasis

artículo científico publicado en 2016

Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands

artículo científico publicado en 2004

Loss of BH3-only protein Bim inhibits apoptosis of hemopoietic cells in the fetal liver and male germ cells but not neuronal cells in bcl-x-deficient mice

artículo científico publicado en 2008

Loss of BIM augments resistance of ATM-deficient thymocytes to DNA damage-induced apoptosis but does not accelerate lymphoma development

artículo científico publicado en 2017

Loss of Bim increases T cell production and function in interleukin 7 receptor-deficient mice

artículo científico publicado en 2004

Loss of Mcl-1 protein and inhibition of electron transport chain together induce anoxic cell death

artículo científico publicado en 2006

Loss of NF-κB1 Causes Gastric Cancer with Aberrant Inflammation and Expression of Immune Checkpoint Regulators in a STAT-1-Dependent Manner.

artículo científico publicado en 2018

Loss of PKD1 and loss of Bcl-2 elicit polycystic kidney disease through distinct mechanisms

scientific journal article

Loss of PUMA (BBC3) does not prevent thrombocytopenia caused by the loss of BCL-XL (BCL2L1).

artículo científico publicado en 2016

Loss of PUMA protects the ovarian reserve during DNA-damaging chemotherapy and preserves fertility.

artículo científico publicado en 2018

Loss of Prkar1a leads to Bcl-2 family protein induction and cachexia in mice.

artículo científico publicado en 2014

Loss of TRP53 reduces but does not overcome dependency of lymphoma cells on MCL-1

artículo científico publicado en 2022

Loss of a Single Mcl-1 Allele Inhibits MYC-Driven Lymphomagenesis by Sensitizing Pro-B Cells to Apoptosis

artículo científico publicado en 2016

Loss of c-REL but not NF-κB2 prevents autoimmune disease driven by FasL mutation

artículo científico publicado en 2014

Loss of p53 Causes Stochastic Aberrant X-Chromosome Inactivation and Female-Specific Neural Tube Defects

scientific article published on 01 April 2019

Loss of pro-apoptotic BH3-only Bcl-2 family member Bim does not protect mutant Lurcher mice from neurodegeneration

artículo científico publicado en 2003

Loss of pro-apoptotic Bim promotes accumulation of pulmonary T lymphocytes and enhances allergen-induced goblet cell metaplasia

artículo científico publicado en 2006

Loss of the BH3-only protein Bid does not rescue RelA-deficient embryos from TNF-R1-mediated fatal hepatocyte destruction

artículo científico publicado en 2006

Loss of the BH3-only protein Bmf impairs B cell homeostasis and accelerates gamma irradiation-induced thymic lymphoma development

artículo científico publicado en 2008

Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim inhibits BCR stimulation-induced apoptosis and deletion of autoreactive B cells

artículo científico publicado en 2003

Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim sustains B lymphopoiesis in the absence of IL-7.

artículo científico publicado en 2009

Loss of the proapoptotic BH3-only protein BCL-2 modifying factor prolongs the fertile life span in female mice

artículo científico publicado en 2014

Lymphomas and plasmacytomas in transgenic mice involving bcl2, myc and v-abl.

artículo científico publicado en 1997

MCL-1 Is a Key Antiapoptotic Protein in Human and Rodent Pancreatic β-Cells.

artículo científico publicado en 2017

MCL-1 but not BCL-XL is critical for the development and sustained expansion of thymic lymphoma in p53-deficient mice

artículo científico publicado en 2014

MCL-1 gains occur with high frequency in lung adenocarcinoma and can be targeted therapeutically

scientific article published on 10 September 2020

MCL-1 is required throughout B-cell development and its loss sensitizes specific B-cell subsets to inhibition of BCL-2 or BCL-XL.

artículo científico publicado en 2016

MEK/ERK-mediated phosphorylation of Bim is required to ensure survival of T and B lymphocytes during mitogenic stimulation.

artículo científico publicado en 2009

MOZ regulates B-cell progenitors and, consequently, Moz haploinsufficiency dramatically retards MYC-induced lymphoma development

artículo científico publicado en 2015

Maintaining dendritic cell viability in culture.

artículo científico publicado en 2014

Maximal killing of lymphoma cells by DNA damage-inducing therapy requires not only the p53 targets Puma and Noxa, but also Bim

artículo científico publicado en 2010

Mcl-1 is essential for germinal center formation and B cell memory

artículo científico publicado en 2010

Mcl-1 is essential for the survival of plasma cells

artículo científico publicado en 2013

Mechanisms of beta cell death in diabetes: a minor role for CD95.

artículo científico publicado en 1998

Membrane-bound Fas ligand only is essential for Fas-induced apoptosis

artículo científico publicado en 2009

Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression

artículo científico publicado en 1995

Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming

artículo científico publicado en 2014

Modifications and intracellular trafficking of FADD/MORT1 and caspase-8 after stimulation of T lymphocytes.

artículo científico publicado en 2004

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

artículo científico publicado en 2018

Multiple triggers of cell death in sepsis: death receptor and mitochondrial-mediated apoptosis

scientific article published on 16 February 2007

Mutant TRP53 exerts a target gene-selective dominant-negative effect to drive tumor development

scientific article published on 26 October 2018

Mutations in the p53 and SCID genes cooperate in tumorigenesis

artículo científico publicado en 1996

Mutually exclusive regulation of T cell survival by IL-7R and antigen receptor-induced signals

artículo científico publicado en 2013

Mutually exclusive subsets of BH3-only proteins are activated by the p53 and c-Jun N-terminal kinase/c-Jun signaling pathways during cortical neuron apoptosis induced by arsenite

artículo científico publicado en 2005

Myeloid progenitor cells lacking p53 exhibit delayed up-regulation of Puma and prolonged survival after cytokine deprivation.

artículo científico publicado en 2009

NF-kappaB1 and c-Rel cooperate to promote the survival of TLR4-activated B cells by neutralizing Bim via distinct mechanisms

artículo científico publicado en 2008

NFAT but not NF-kappaB is critical for transcriptional induction of the prosurvival gene A1 after IgE receptor activation in mast cells

artículo científico publicado en 2008

NFκB1 is essential to prevent the development of multiorgan autoimmunity by limiting IL-6 production in follicular B cells

artículo científico publicado en 2016

NKT cell stimulation with glycolipid antigen in vivo: costimulation-dependent expansion, Bim-dependent contraction, and hyporesponsiveness to further antigenic challenge

artículo científico publicado en 2005

Negative selection of semimature CD4(+)8(-)HSA+ thymocytes requires the BH3-only protein Bim but is independent of death receptor signaling

artículo científico publicado en 2004

Neither loss of Bik alone, nor combined loss of Bik and Noxa, accelerate murine lymphoma development or render lymphoma cells resistant to DNA damaging drugs

artículo científico publicado en 2012

Normal thymocyte negative selection in TRAIL-deficient mice

artículo científico publicado en 2003

Novel murine homeo box gene on chromosome 1 expressed in specific hematopoietic lineages and during embryogenesis

artículo científico publicado en 1991

Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2.

artículo científico publicado en 1990

One synchronous wave of B cell development in mouse fetal liver changes at day 16 of gestation from dependence to independence of a stromal cell environment

artículo científico publicado en 1989

Overexpression of Bcl-2 does not rescue impaired B lymphopoiesis in IL-7 receptor-deficient mice but can enhance survival of mature B cells

artículo científico publicado en 1998

Overexpression of the bcl-2 oncogene in the mouse pre-B cell line SPGM-1 protects from apoptosis, but does not affect blocked B-lineage differentiation and lineage switch towards macrophage like cells

artículo científico publicado en 1997

PB76: a novel surface glycoprotein preferentially expressed on mouse pre-B cells and plasma cells detected by the monoclonal antibody G-5-2.

artículo científico publicado en 1988

PHF6 regulates hematopoietic stem and progenitor cells and its loss synergizes with expression of TLX3 to cause leukemia

artículo científico publicado en 2019

PTPN2 regulates T cell lineage commitment and αβ versus γδ specification.

artículo científico publicado en 2017

PUMA promotes apoptosis of hematopoietic progenitors driving leukemic progression in a mouse model of myelodysplasia

artículo científico publicado en 2016

PUMA regulates germ cell loss and primordial follicle endowment in mice

artículo científico publicado en 2014

Peripheral deletion of autoreactive CD8 T cells by cross presentation of self-antigen occurs by a Bcl-2-inhibitable pathway mediated by Bim

artículo científico publicado en 2002

Perturbed development of T and B cells in mice expressing an Hlx homeobox transgene.

artículo científico publicado en 1995

Pharmacological blockade of Bcl-2, Bcl-x(L) and Bcl-w by the BH3 mimetic ABT-737 has only minor impact on tumour development in p53-deficient mice.

artículo científico publicado en 2011

Plasmacytomagenesis in Eμ-v-abl transgenic mice is accelerated when apoptosis is restrained

artículo científico publicado en 2014

Platelet production proceeds independently of the intrinsic and extrinsic apoptosis pathways

artículo científico publicado en 2014

Polycystic kidney disease prevented by transgenic RNA interference

scientific journal article

Positive and negative selection of T cells in T-cell receptor transgenic mice expressing a bcl-2 transgene

artículo científico publicado en 1994

Pro-apoptotic BH3-only Bcl-2 family members in vertebrate model organisms suitable for genetic experimentation

artículo científico publicado en 2002

Pro-apoptotic BIM is an essential initiator of physiological endothelial cell death independent of regulation by FOXO3.

artículo científico publicado en 2014

Pro-apoptotic Bax is the major and Bak an auxiliary effector in cytokine deprivation-induced mast cell apoptosis

artículo científico publicado en 2010

Pro-apoptotic Bim suppresses breast tumor cell metastasis and is a target gene of SNAI2

article

Pro-apoptotic apoptosis protease-activating factor 1 (Apaf-1) has a cytoplasmic localization distinct from Bcl-2 or Bcl-x(L).

artículo científico publicado en 2000

Proapoptotic BH3-only Bcl-2 family member Bik/Blk/Nbk is expressed in hemopoietic and endothelial cells but is redundant for their programmed death

artículo científico publicado en 2004

Proapoptotic BH3-only protein Bid is essential for death receptor-induced apoptosis of pancreatic beta-cells.

artículo científico publicado en 2008

Proapoptotic BH3-only protein Bim is essential for developmentally programmed death of germinal center-derived memory B cells and antibody-forming cells

artículo científico publicado en 2007

Proapoptotic BIM Impacts B Lymphoid Homeostasis by Limiting the Survival of Mature B Cells in a Cell-Autonomous Manner

artículo científico publicado en 2018

Proapoptotic Bak and Bax guard against fatal systemic and organ-specific autoimmune disease

artículo científico publicado en 2013

Proapoptotic Bcl-2 family member Bim is involved in the control of mast cell survival and is induced together with Bcl-XL upon IgE-receptor activation.

artículo científico publicado en 2005

Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

artículo científico publicado en 1999

Progenitor tumours from Emu-bcl-2-myc transgenic mice have lymphomyeloid differentiation potential and reveal developmental differences in cell survival

artículo científico publicado en 1996

Prophylactic treatment with the BH3 mimetic ABT-737 impedes Myc-driven lymphomagenesis in mice

artículo científico publicado en 2012

Prosurvival Bcl-2 family members reveal a distinct apoptotic identity between conventional and plasmacytoid dendritic cells

artículo científico publicado en 2015

Puma and to a lesser extent Noxa are suppressors of Myc-induced lymphomagenesis

artículo científico publicado en 2009

Puma cooperates with Bim, the rate-limiting BH3-only protein in cell death during lymphocyte development, in apoptosis induction

artículo científico publicado en 2006

Puma indirectly activates Bax to cause apoptosis in the absence of Bid or Bim.

artículo científico publicado en 2008

Puma is a dominant regulator of oxidative stress induced Bax activation and neuronal apoptosis.

artículo científico publicado en 2007

RAG-induced DNA lesions activate proapoptotic BIM to suppress lymphomagenesis in p53-deficient mice.

artículo científico publicado en 2016

RIPK1 inhibits ZBP1-driven necroptosis during development

artículo científico publicado en 2016

Rapid B cell apoptosis induced by antigen receptor ligation does not require Fas (CD95/APO-1), the adaptor protein FADD/MORT1 or CrmA-sensitive caspases but is defective in both MRL-+/+ and MRL-lpr/lpr mice

artículo científico publicado en 2000

Rapid hybridoma screening method for the identification of monoclonal antibodies to low-abundance cytoplasmic proteins

artículo científico publicado en 1998

Rapid selection against truncation mutants in yeast reverse two-hybrid screens.

artículo científico publicado en 2001

Re-activation of mitochondrial apoptosis inhibits T-cell lymphoma survival and treatment resistance

artículo científico publicado en 2016

Regulation of memory B-cell survival by the BH3-only protein Puma

artículo científico publicado en 2011

Regulation of osteoclast apoptosis by ubiquitylation of proapoptotic BH3-only Bcl-2 family member Bim.

artículo científico publicado en 2003

Rel-deficient T cells exhibit defects in production of interleukin 3 and granulocyte-macrophage colony-stimulating factor

artículo científico publicado en 1996

Response to Comment on "Tumor Growth Need Not Be Driven by Rare Cancer Stem Cells"

artículo científico publicado en 2007

Response: Does Bid Play a Role in the DNA Damage Response?

article

Role of "cancer stem cells" and cell survival in tumor development and maintenance.

artículo científico publicado en 2008

Role of BH3-only protein Bim in autoimmune and degenerative diseases.

artículo científico publicado en 2003

Role of STAT5 in controlling cell survival and immunoglobulin gene recombination during pro-B cell development

artículo científico publicado en 2009

Role of p63 and the Notch pathway in cochlea development and sensorineural deafness

artículo científico publicado en 2013

Role of proapoptotic BH3-only proteins in Listeria monocytogenes infection

artículo científico publicado en 2016

Selective involvement of BH3-only Bcl-2 family members Bim and Bad in neonatal hypoxia-ischemia

artículo científico publicado en 2006

Selective up-regulation of macrophage function in granulocyte-macrophage colony-stimulating factor transgenic mice

artículo científico publicado en 1991

Sensitization of BCL-2-expressing breast tumors to chemotherapy by the BH3 mimetic ABT-737

artículo científico publicado en 2011

Shutdown of an acute T cell immune response to viral infection is mediated by the proapoptotic Bcl-2 homology 3-only protein Bim ⬇️

artículo científico publicado el 17 de noviembre de 2003

Soluble FAS ligand is not required for pancreatic islet inflammation or beta-cell destruction in non-obese diabetic mice

scientific article published on 23 September 2019

Stimulating p53 down-under: a report from the 1st Australian p53 Workshop

artículo científico publicado en 2013

Subtle Changes in the Levels of BCL-2 Proteins Cause Severe Craniofacial Abnormalities

artículo científico publicado en 2018

Subversion of the Bcl-2 life/death switch in cancer development and therapy.

artículo científico publicado en 2005

Switch from type II to I Fas/CD95 death signaling on in vitro culturing of primary hepatocytes

artículo científico publicado en 2008

T cell survival and function requires the c-Abl tyrosine kinase

artículo científico publicado en 2008

T-lymphocyte death during shutdown of an immune response

artículo científico publicado en 2004

TNF cytokine family: more BAFF-ling complexities

artículo científico publicado en 2001

TNF-induced chronic inflammation does not affect tumorigenesis driven by p53 loss

artículo científico publicado en 2017

Targeting BCL-2–expressing basal-like breast cancer with BH3-mimetics.

artículo científico publicado en 2012

Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53

artículo científico publicado en 2014

The 2019 Lasker Award: T cells and B cells, whose life and death are essential for function of the immune system

scientific article published on 17 October 2019

The BCL-2 pro-survival protein A1 is dispensable for T cell homeostasis on viral infection.

artículo científico publicado en 2017

The BCL-2 protein family, BH3-mimetics and cancer therapy

artículo científico publicado en 2015

The BCL-2 protein family: opposing activities that mediate cell death

artículo científico publicado en 2008

The BH3-Only Protein Bid Is Dispensable for DNA Damage- and Replicative Stress-Induced Apoptosis or Cell-Cycle Arrest

scientific article published on 01 April 2007

The BH3-only protein Puma plays an essential role in cytokine deprivation induced apoptosis of mast cells

artículo científico publicado en 2007

The BH3-only proteins BIM and PUMA are not critical for the reticulocyte apoptosis caused by loss of the pro-survival protein BCL-XL.

artículo científico publicado en 2017

The BH3-only proteins Bim and Puma cooperate to impose deletional tolerance of organ-specific antigens

artículo científico publicado en 2012

The Bcl-2 family and cell death regulation

artículo científico publicado en 1998

The Bcl-2 protein family

scientific article published on 01 January 1999

The CD2-scl transgene alters the phenotype and frequency of T-lymphomas in N-ras transgenic or p53 deficient mice.

artículo científico publicado en 1997

The FLIP Side of Life ⬇️

artículo científico publicado el 15 de enero de 2013

The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models

artículo científico publicado en 2016

The NF-kappaB regulator Bcl-3 and the BH3-only proteins Bim and Puma control the death of activated T cells

artículo científico publicado en 2006

The NF-κB1 transcription factor prevents the intrathymic development of CD8 T cells with memory properties

artículo científico publicado en 2011

The Pseudokinase MLKL and the Kinase RIPK3 Have Distinct Roles in Autoimmune Disease Caused by Loss of Death-Receptor-Induced Apoptosis

artículo científico publicado en 2016

The RUNX3 tumor suppressor upregulates Bim in gastric epithelial cells undergoing transforming growth factor beta-induced apoptosis

artículo científico publicado en 2006

The TACI receptor regulates T-cell-independent marginal zone B cell responses through innate activation-induced cell death

artículo científico publicado en 2013

The Transcription Factor ASCIZ and Its Target DYNLL1 Are Essential for the Development and Expansion of MYC-Driven B Cell Lymphoma

artículo científico publicado en 2016

The Ubiquitin Ligase XIAP Recruits LUBAC for NOD2 Signaling in Inflammation and Innate Immunity

article

The Zinc-finger protein ASCIZ regulates B cell development via DYNLL1 and Bim.

artículo científico publicado en 2012

The anti-apoptosis function of Bcl-2 can be genetically separated from its inhibitory effect on cell cycle entry

artículo científico publicado en 1997

The anti-apoptotic activities of Rel and RelA required during B-cell maturation involve the regulation of Bcl-2 expression

artículo científico publicado en 2000

The cell death inhibitor Bcl-2 and its homologues influence control of cell cycle entry

artículo científico publicado en 1996

The combination of reduced MCL-1 and standard chemotherapeutics is tolerable in mice

artículo científico publicado en 2017

The combined absence of NF-kappa B1 and c-Rel reveals that overlapping roles for these transcription factors in the B cell lineage are restricted to the activation and function of mature cells

artículo científico publicado en 2002

The control of apoptosis in lymphocyte selection

artículo científico publicado en 2003

The essential role of evasion from cell death in cancer

artículo científico publicado en 2011

The great escape: Is immune evasion required for tumor progression?

artículo científico publicado en 1999

The histone deacetylase inhibitors LAQ824 and LBH589 do not require death receptor signaling or a functional apoptosome to mediate tumor cell death or therapeutic efficacy

artículo científico publicado en 2009

The many roles of FAS receptor signaling in the immune system

artículo científico publicado en 2009

The molecular biology of apoptosis

scientific article published on March 1996

The molecular control of DNA damage-induced cell death

artículo científico publicado en 2000

The molecular signature of CD8+ T cells undergoing deletional tolerance

artículo científico publicado en 2009

The ovarian reserve is depleted during puberty in a hormonally driven process dependent on the pro-apoptotic protein BMF

artículo científico publicado en 2017

The physiological relevance of death receptor-mediated apoptosis

artículo científico publicado en 2014

The primordial follicle reserve is not renewed after chemical or γ-irradiation mediated depletion

artículo científico publicado en 2012

The pro-apoptotic BH3-only protein Bid is dispensable for development of insulitis and diabetes in the non-obese diabetic mouse

artículo científico publicado en 2011

The proapoptotic BH3-only protein bim is expressed in hematopoietic, epithelial, neuronal, and germ cells

artículo científico publicado en 2000

The proapoptotic BH3-only proteins Bim and Puma are downstream of endoplasmic reticulum and mitochondrial oxidative stress in pancreatic islets in response to glucotoxicity

artículo científico publicado en 2014

The proapoptotic BH3-only, Bcl-2 family member, Puma is critical for acute ethanol-induced neuronal apoptosis

artículo científico publicado en 2009

The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex

artículo científico publicado en 1999

The protein product of the oncogene bcl-2 is a component of the nuclear envelope, the endoplasmic reticulum, and the outer mitochondrial membrane.

artículo científico publicado en 1994

The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism

artículo científico publicado en 2013

The role of BH3-only protein Bim extends beyond inhibiting Bcl-2-like prosurvival proteins

artículo científico publicado en 2009

The role of BH3-only proteins in the immune system

artículo científico publicado en 2005

The role of Bcl-2 and its pro-survival relatives in tumourigenesis and cancer therapy

scientific article published on 18 March 2011

The role of Rel/NF-kappaB transcription factors in B lymphocyte survival

artículo científico publicado en 2003

The role of bcl-2 in lymphoid differentiation and neoplastic transformation

artículo científico publicado en 1992

The role of bim, a proapoptotic BH3-only member of the Bcl-2 family in cell-death control

artículo científico publicado en 2000

The role of the Bcl-2 protein family in cancer

artículo científico publicado en 2003

The role of the apoptotic machinery in tumor suppression

artículo científico publicado en 2012

The role of the bcl-2/ced-9 gene family in cancer and general implications of defects in cell death control for tumourigenesis and resistance to chemotherapy

artículo científico publicado en 1997

The role of the pro-apoptotic Bcl-2 family member bim in physiological cell death

artículo científico publicado en 2000

The transcriptional regulator Rel is essential for antigen receptor-mediated stimulation of mature T cells but dispensable for positive and negative selection of thymocytes and T cell apoptosis

scholarly article by Andreas Strasser et al published March 1999 in European Journal of Immunology

The transcriptional regulator Rel is essential for antigen receptor-mediated stimulation of mature T cells but dispensable for positive and negative selection of thymocytes and T cell apoptosis

artículo científico publicado en 1999

The transgenic window on lymphoid malignancy

artículo científico publicado en 1989

Therapeutic Response to Non-genotoxic Activation of p53 by Nutlin3a Is Driven by PUMA-Mediated Apoptosis in Lymphoma Cells.

artículo científico publicado en 2016

Thirty years of BCL-2: translating cell death discoveries into novel cancer therapies

artículo científico publicado en 2016

Tissue expression and subcellular localization of the pro-survival molecule Bcl-w

artículo científico publicado en 2001

To live and let die

artículo científico publicado en 2001

Transforming growth factor beta-dependent sequential activation of Smad, Bim, and caspase-9 mediates physiological apoptosis in gastric epithelial cells

artículo científico publicado en 2005

Transgenic expression of CD95 ligand on islet beta cells induces a granulocytic infiltration but does not confer immune privilege upon islet allografts.

artículo científico publicado en 1997

Transgenic expression of dominant-negative Fas-associated death domain protein in beta cells protects against Fas ligand-induced apoptosis and reduces spontaneous diabetes in nonobese diabetic mice.

artículo científico publicado en 2005

Transgenic models of lymphoid neoplasia and development of a pan-hematopoietic vector

scientific journal article

Transgenic overexpression of human Bcl-2 in islet β cells inhibits apoptosis but does not prevent autoimmune destruction

artículo científico publicado en 2000

Translation inhibitors induce cell death by multiple mechanisms and Mcl-1 reduction is only a minor contributor

artículo científico publicado en 2012

Treatment of B-RAF mutant human tumor cells with a MEK inhibitor requires Bim and is enhanced by a BH3 mimetic

artículo científico publicado en 2008

Tumor growth need not be driven by rare cancer stem cells

artículo científico publicado en 2007

Tumor-Suppressor Functions of the TP53 Pathway

artículo científico publicado en 2016

Two molecular pathways initiate mitochondria-dependent dopaminergic neurodegeneration in experimental Parkinson's disease

artículo científico publicado en 2007

Type I interferon drives dendritic cell apoptosis via multiple BH3-only proteins following activation by PolyIC in vivo

artículo científico publicado en 2011

Ultraviolet radiation triggers apoptosis of fibroblasts and skin keratinocytes mainly via the BH3-only protein Noxa.

artículo científico publicado en 2007

Unleashing the power of inhibitors of oncogenic kinases through BH3 mimetics

artículo científico publicado en 2009

Viewing BCL2 and cell death control from an evolutionary perspective

artículo científico publicado en 2017

What do we know about the mechanisms of elimination of autoreactive T and B cells and what challenges remain

artículo científico publicado en 2007

XIAP discriminates between type I and type II FAS-induced apoptosis

artículo científico publicado en 2009

XIAP restricts TNF- and RIP3-dependent cell death and inflammasome activation

artículo científico publicado en 2014

bcl-2 transgene expression inhibits apoptosis in the germinal center and reveals differences in the selection of memory B cells and bone marrow antibody-forming cells

artículo científico publicado en 2000

bcl-2 transgene expression promotes survival and reduces proliferation of CD3-CD4-CD8- T cell progenitors

scientific article published on 01 September 1997

bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship

artículo científico publicado en 1991

cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1- and RIPK3-dependent manner

scientific article published on 04 February 2014

miR17~92 is essential for the survival of hematopoietic stem and progenitor cells by restraining pro-apoptotic BIM

miR17~92 restrains pro-apoptotic BIM to ensure survival of haematopoietic stem and progenitor cells

artículo científico publicado en 2019

p53 efficiently suppresses tumor development in the complete absence of its cell-cycle inhibitory and proapoptotic effectors p21, Puma, and Noxa.

artículo científico publicado en 2013

p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa

artículo científico publicado en 2003

p53-upregulated-modulator-of-apoptosis (PUMA) deficiency affects food intake but does not impact on body weight or glucose homeostasis in diet-induced obesity

artículo científico publicado en 2016

scl, a gene frequently activated in human T cell leukaemia, does not induce lymphomas in transgenic mice.

artículo científico publicado en 1995

“Decisions, decisions ...”: β-catenin–mediated activation of TCF-1 and Lef-1 influences the fate of developing T cells

artículo científico publicado en 2001

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