Lista de obras - Marco J Herold - Dominio Público Uruguay

A non-canonical function of Ezh2 preserves immune homeostasis.

artículo científico publicado en 2017

A point mutation in the signal peptide impairs the development of innate lymphoid cell subsets

artículo científico publicado en 2018

A1/Bfl-1 in leukocyte development and cell death

artículo científico publicado en 2012

Acid sphingomyelinase is required for protection of effector memory T cells against glucocorticoid-induced cell death

artículo científico publicado en 2011

Activation of the MAP kinase pathway induces apoptosis in the Merkel cell carcinoma cell line UISO.

artículo científico publicado en 2007

An inducible lentiviral guide RNA platform enables the identification of tumor-essential genes and tumor-promoting mutations in vivo

artículo científico publicado en 2015

An update on using CRISPR/Cas9 in the one-cell stage mouse embryo for generating complex mutant alleles

artículo científico publicado en 2017

Anti-apoptotic A1 is not essential for lymphoma development in Eµ-Myc mice but helps sustain transplanted Eµ-Myc tumour cells

artículo científico publicado en 2018

Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia

artículo científico publicado en 2012

Anti-apoptotic proteins BCL-2, MCL-1 and A1 summate collectively to maintain survival of immune cell populations both in vitro and in vivo.

artículo científico publicado en 2017

Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3⁺ regulatory T cells

artículo científico publicado en 2013

Apoptotic caspases suppress mtDNA-induced STING-mediated type I IFN production

artículo científico publicado en 2014

BCL-XL and MCL-1 are the key BCL-2 family proteins in melanoma cell survival

artículo científico publicado en 2019

BCL-XL exerts a protective role against anemia caused by radiation-induced kidney damage

scientific article published on 25 November 2020

BET inhibition represses miR17-92 to drive BIM-initiated apoptosis of normal and transformed hematopoietic cells.

artículo científico publicado en 2016

CD8⁺ T cell help is required for efficient induction of EAE in Lewis rats

artículo científico publicado en 2013

CRISPR/Cas9-The ultimate weapon to battle infectious diseases?

artículo científico publicado en 2016

CRISPR/Cas9: A tool for immunological research

artículo científico publicado en 2018

Characterisation of a novel A1-specific monoclonal antibody.

artículo científico publicado en 2014

Characterisation of mice lacking all functional isoforms of the pro-survival BCL-2 family member A1 reveals minor defects in the haematopoietic compartment.

artículo científico publicado en 2017

Characterisation of mice lacking the inflammatory caspases-1/11/12 reveals no contribution of caspase-12 to cell death and sepsis

scientific article published on 28 August 2018

Characterization of a novel human BFL-1-specific monoclonal antibody

scientific article published on 12 November 2019

Clearance of measles virus from persistently infected cells by short hairpin RNA.

artículo científico publicado en 2009

Combination of IAP antagonist and IFNγ activates novel caspase-10- and RIPK1-dependent cell death pathways.

artículo científico publicado en 2017

Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer

artículo científico publicado en 2016

Conditional knockdown of BCL2A1 reveals rate-limiting roles in BCR-dependent B-cell survival.

artículo científico publicado en 2015

Consequences of Zmat3 loss in c-MYC- and mutant KRAS-driven tumorigenesis

artículo científico publicado en 2020

Coordinated repression of BIM and PUMA by Epstein-Barr virus latent genes maintains the survival of Burkitt lymphoma cells

artículo científico publicado en 2017

Critical cancer vulnerabilities identified by unbiased CRISPR/Cas9 screens inform on efficient cancer Immunotherapy

artículo científico publicado en 2020

DNA repair processes are critical mediators of p53-dependent tumor suppression

artículo científico publicado en 2018

DNA-binding of the Tet-transactivator curtails antigen-induced lymphocyte activation in mice

artículo científico publicado en 2017

DR5 and caspase-8 are dispensable in ER stress-induced apoptosis

artículo científico publicado en 2017

Dual targeting of CDK4/6 and BCL2 pathways augments tumor response in estrogen receptor positive breast cancer

artículo científico publicado en 2020

EBV BCL-2 homologue BHRF1 drives chemoresistance and lymphomagenesis by inhibiting multiple cellular pro-apoptotic proteins

artículo científico publicado en 2019

Epigenetic modulators of B cell fate identified through coupled phenotype-transcriptome analysis

artículo científico publicado en 2022

Erratum: Corrigendum: The transcription factor T-bet is essential for the development of NKp46+ innate lymphocytes via the Notch pathway

article

Evidence against upstream regulation of the unfolded protein response (UPR) by pro-apoptotic BIM and PUMA.

artículo científico publicado en 2014

Foxo-mediated Bim transcription is dispensable for the apoptosis of hematopoietic cells that is mediated by this BH3-only protein

artículo científico publicado en 2013

Foxp1 Is Indispensable for Ductal Morphogenesis and Controls the Exit of Mammary Stem Cells from Quiescence

scientific article published on 25 October 2018

GM-CSF Quantity Has a Selective Effect on Granulocytic vs. Monocytic Myeloid Development and Function

artículo científico publicado en 2018

Glucocorticoid-induced apoptosis in animal models of multiple sclerosis.

artículo científico

Glucocorticoids exert opposing effects on macrophage function dependent on their concentration

artículo científico publicado en 2007

HBO1 (KAT7) Does Not Have an Essential Role in Cell Proliferation, DNA Replication, or Histone 4 Acetylation in Human Cells

scientific article published on 30 January 2020

Hepatocyte growth factor renders BRAF mutant human melanoma cell lines resistant to PLX4032 by downregulating the pro-apoptotic BH3-only proteins PUMA and BIM.

artículo científico publicado en 2016

Hierarchy for targeting prosurvival BCL2 family proteins in multiple myeloma: pivotal role of MCL1.

artículo científico publicado en 2016

How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression?

artículo científico publicado en 2017

Hoxb8 regulates expression of microRNAs to control cell death and differentiation.

artículo científico publicado en 2013

Humanized Mcl-1 mice enable accurate preclinical evaluation of MCL-1 inhibitors destined for clinical use

artículo científico publicado en 2018

Impact of conditional deletion of the pro-apoptotic BCL-2 family member BIM in mice

artículo científico publicado en 2014

It's not over until the FAT lady sings

artículo científico publicado en 2014

Loss of NF-κB1 Causes Gastric Cancer with Aberrant Inflammation and Expression of Immune Checkpoint Regulators in a STAT-1-Dependent Manner.

artículo científico publicado en 2018

Loss of TRP53 reduces but does not overcome dependency of lymphoma cells on MCL-1

artículo científico publicado en 2022

Loss of p53 Causes Stochastic Aberrant X-Chromosome Inactivation and Female-Specific Neural Tube Defects

scientific article published on 01 April 2019

MARCH1-mediated ubiquitination of MHC II impacts the MHC I antigen presentation pathway

scientific article published on 12 July 2018

MDM4 is a rational target for treating breast cancers with mutant p53.

artículo científico publicado en 2017

Male sterility in Mcl-1-flox mice is not due to enhanced Mcl1 protein stability.

artículo científico publicado en 2016

Maximal killing of lymphoma cells by DNA damage-inducing therapy requires not only the p53 targets Puma and Noxa, but also Bim

artículo científico publicado en 2010

Mining the Plasma Cell Transcriptome for Novel Cell Surface Proteins

artículo científico publicado en 2018

Modeling breast cancer using CRISPR/Cas9-mediated engineering of human breast organoids

artículo científico publicado en 2019

Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease

scientific article published on 11 December 2019

Mutually exclusive regulation of T cell survival by IL-7R and antigen receptor-induced signals

artículo científico publicado en 2013

Myeloid-derived suppressor activity is mediated by monocytic lineages maintained by continuous inhibition of extrinsic and intrinsic death pathways.

artículo científico publicado en 2014

NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5.

artículo científico publicado en 2015

PEGylation of interferon α2 improves lymphatic exposure after subcutaneous and intravenous administration and improves antitumour efficacy against lymphatic breast cancer metastases.

artículo científico publicado en 2013

PRMT1-mediated H4R3me2a recruits SMARCA4 to promote colorectal cancer progression by enhancing EGFR signaling

artículo científico publicado en 2021

Potent efficacy of MCL-1 inhibitor-based therapies in preclinical models of mantle cell lymphoma

artículo científico publicado en 2019

Pro-apoptotic BIM is an essential initiator of physiological endothelial cell death independent of regulation by FOXO3.

artículo científico publicado en 2014

Proliferation arrest in B-Raf mutant melanoma cell lines upon MAPK pathway activation

artículo científico publicado en 2008

Prosurvival Bcl-2 family members reveal a distinct apoptotic identity between conventional and plasmacytoid dendritic cells

artículo científico publicado en 2015

RAG-induced DNA lesions activate proapoptotic BIM to suppress lymphomagenesis in p53-deficient mice.

artículo científico publicado en 2016

ROCK1 but not LIMK1 or PAK2 is a key regulator of apoptotic membrane blebbing and cell disassembly

scientific article published on 01 May 2019

Reduced expression of the mevalonate pathway enzyme farnesyl pyrophosphate synthase unveils recognition of tumor cells by Vgamma9Vdelta2 T cells

artículo científico publicado en 2009

Restoration of tumor suppression in prostate cancer by targeting the E3 ligase E6AP.

artículo científico publicado en 2016

Single-Cell Transcriptomics Identifies the Adaptation of Scart1+ Vγ6+ T Cells to Skin Residency as Activated Effector Cells

scientific article published on 01 June 2019

Stable silencing of the glucocorticoid receptor in myelin-specific T effector cells by retroviral delivery of shRNA: insight into neuroinflammatory disease

artículo científico publicado en 2009

Synergistic action of the MCL-1 inhibitor S63845 with current therapies in preclinical models of triple-negative and HER2-amplified breast cancer

artículo científico publicado en 2017

Synergistic targeting of breast cancer stem-like cells by human γδ T cells and CD8+ T cells.

artículo científico publicado en 2017

TREML4 receptor regulates inflammation and innate immune cell death during polymicrobial sepsis

artículo científico publicado en 2020

TRIM17 and TRIM28 antagonistically regulate the ubiquitination and anti-apoptotic activity of BCL2A1

artículo científico publicado en 2018

Targeting Mdmx to treat breast cancers with wild-type p53.

artículo científico publicado en 2015

Targeting antiapoptotic A1/Bfl-1 by in vivo RNAi reveals multiple roles in leukocyte development in mice ⬇️

artículo científico publicado el 11 de mayo de 2012

Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53

artículo científico publicado en 2014

The BCL-2 pro-survival protein A1 is dispensable for T cell homeostasis on viral infection.

artículo científico publicado en 2017

The BH3-only proteins Bim and Puma cooperate to impose deletional tolerance of organ-specific antigens

artículo científico publicado en 2012

The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models

artículo científico publicado en 2016

The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation

artículo científico publicado en 2020

The combination of reduced MCL-1 and standard chemotherapeutics is tolerable in mice

artículo científico publicado en 2017

The new editor-targeted genome engineering in the absence of homology-directed repair

artículo científico publicado en 2016

The pro-survival Bcl-2 family member A1 delays spontaneous and FAS ligand-induced apoptosis of activated neutrophils

scientific article published on 18 June 2020

The transcription factor IRF4 represses proapoptotic BMF and BIM to licence multiple myeloma survival

scientific article published on 04 November 2020

The transcription factor T-bet is essential for the development of NKp46+ innate lymphocytes via the Notch pathway

artículo científico publicado en 2013

The ubiquitylation of IL-1β limits its cleavage by caspase-1 and targets it for proteasomal degradation

artículo científico publicado en 2021

Therapeutic Response to Non-genotoxic Activation of p53 by Nutlin3a Is Driven by PUMA-Mediated Apoptosis in Lymphoma Cells.

artículo científico publicado en 2016

Transcription Factor PU.1 Promotes Conventional Dendritic Cell Identity and Function via Induction of Transcriptional Regulator DC-SCRIPT

scientific article published on 02 January 2019

Ubiquitin-like protein 3 (UBL3) is required for MARCH ubiquitination of major histocompatibility complex class II and CD86

artículo científico publicado en 2022

Using CRISPR/Cas9 Technology for Manipulating Cell Death Regulators

artículo científico publicado en 2016

VDAC2 enables BAX to mediate apoptosis and limit tumor development

scientific article published in Nature Communications

miR17~92 is essential for the survival of hematopoietic stem and progenitor cells by restraining pro-apoptotic BIM

miR17~92 restrains pro-apoptotic BIM to ensure survival of haematopoietic stem and progenitor cells

artículo científico publicado en 2019

Lista de obras de Marco J Herold

A non-canonical function of Ezh2 preserves immune homeostasis.

A point mutation in the signal peptide impairs the development of innate lymphoid cell subsets

A1/Bfl-1 in leukocyte development and cell death

Acid sphingomyelinase is required for protection of effector memory T cells against glucocorticoid-induced cell death

Activation of the MAP kinase pathway induces apoptosis in the Merkel cell carcinoma cell line UISO.

An inducible lentiviral guide RNA platform enables the identification of tumor-essential genes and tumor-promoting mutations in vivo

An update on using CRISPR/Cas9 in the one-cell stage mouse embryo for generating complex mutant alleles

Anti-apoptotic A1 is not essential for lymphoma development in Eµ-Myc mice but helps sustain transplanted Eµ-Myc tumour cells

Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia

Anti-apoptotic proteins BCL-2, MCL-1 and A1 summate collectively to maintain survival of immune cell populations both in vitro and in vivo.

Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3⁺ regulatory T cells

Apoptotic caspases suppress mtDNA-induced STING-mediated type I IFN production

BCL-XL and MCL-1 are the key BCL-2 family proteins in melanoma cell survival

BCL-XL exerts a protective role against anemia caused by radiation-induced kidney damage

BET inhibition represses miR17-92 to drive BIM-initiated apoptosis of normal and transformed hematopoietic cells.

CD8⁺ T cell help is required for efficient induction of EAE in Lewis rats

CRISPR/Cas9-The ultimate weapon to battle infectious diseases?

CRISPR/Cas9: A tool for immunological research

Characterisation of a novel A1-specific monoclonal antibody.

Characterisation of mice lacking all functional isoforms of the pro-survival BCL-2 family member A1 reveals minor defects in the haematopoietic compartment.

Characterisation of mice lacking the inflammatory caspases-1/11/12 reveals no contribution of caspase-12 to cell death and sepsis

Characterization of a novel human BFL-1-specific monoclonal antibody

Clearance of measles virus from persistently infected cells by short hairpin RNA.

Combination of IAP antagonist and IFNγ activates novel caspase-10- and RIPK1-dependent cell death pathways.

Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer

Conditional knockdown of BCL2A1 reveals rate-limiting roles in BCR-dependent B-cell survival.

Consequences of Zmat3 loss in c-MYC- and mutant KRAS-driven tumorigenesis

Coordinated repression of BIM and PUMA by Epstein-Barr virus latent genes maintains the survival of Burkitt lymphoma cells

Critical cancer vulnerabilities identified by unbiased CRISPR/Cas9 screens inform on efficient cancer Immunotherapy

DNA repair processes are critical mediators of p53-dependent tumor suppression

DNA-binding of the Tet-transactivator curtails antigen-induced lymphocyte activation in mice

DR5 and caspase-8 are dispensable in ER stress-induced apoptosis

Dual targeting of CDK4/6 and BCL2 pathways augments tumor response in estrogen receptor positive breast cancer

EBV BCL-2 homologue BHRF1 drives chemoresistance and lymphomagenesis by inhibiting multiple cellular pro-apoptotic proteins

Epigenetic modulators of B cell fate identified through coupled phenotype-transcriptome analysis

Erratum: Corrigendum: The transcription factor T-bet is essential for the development of NKp46+ innate lymphocytes via the Notch pathway

Evidence against upstream regulation of the unfolded protein response (UPR) by pro-apoptotic BIM and PUMA.

Foxo-mediated Bim transcription is dispensable for the apoptosis of hematopoietic cells that is mediated by this BH3-only protein

Foxp1 Is Indispensable for Ductal Morphogenesis and Controls the Exit of Mammary Stem Cells from Quiescence

GM-CSF Quantity Has a Selective Effect on Granulocytic vs. Monocytic Myeloid Development and Function

Glucocorticoid-induced apoptosis in animal models of multiple sclerosis.

Glucocorticoids exert opposing effects on macrophage function dependent on their concentration

HBO1 (KAT7) Does Not Have an Essential Role in Cell Proliferation, DNA Replication, or Histone 4 Acetylation in Human Cells

Hepatocyte growth factor renders BRAF mutant human melanoma cell lines resistant to PLX4032 by downregulating the pro-apoptotic BH3-only proteins PUMA and BIM.

Hierarchy for targeting prosurvival BCL2 family proteins in multiple myeloma: pivotal role of MCL1.

How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression?

Hoxb8 regulates expression of microRNAs to control cell death and differentiation.

Humanized Mcl-1 mice enable accurate preclinical evaluation of MCL-1 inhibitors destined for clinical use

Impact of conditional deletion of the pro-apoptotic BCL-2 family member BIM in mice

It's not over until the FAT lady sings

Loss of NF-κB1 Causes Gastric Cancer with Aberrant Inflammation and Expression of Immune Checkpoint Regulators in a STAT-1-Dependent Manner.

Loss of TRP53 reduces but does not overcome dependency of lymphoma cells on MCL-1

Loss of p53 Causes Stochastic Aberrant X-Chromosome Inactivation and Female-Specific Neural Tube Defects

MARCH1-mediated ubiquitination of MHC II impacts the MHC I antigen presentation pathway

MDM4 is a rational target for treating breast cancers with mutant p53.

Male sterility in Mcl-1-flox mice is not due to enhanced Mcl1 protein stability.

Maximal killing of lymphoma cells by DNA damage-inducing therapy requires not only the p53 targets Puma and Noxa, but also Bim

Mining the Plasma Cell Transcriptome for Novel Cell Surface Proteins

Modeling breast cancer using CRISPR/Cas9-mediated engineering of human breast organoids

Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease

Mutually exclusive regulation of T cell survival by IL-7R and antigen receptor-induced signals

Myeloid-derived suppressor activity is mediated by monocytic lineages maintained by continuous inhibition of extrinsic and intrinsic death pathways.

NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5.

PEGylation of interferon α2 improves lymphatic exposure after subcutaneous and intravenous administration and improves antitumour efficacy against lymphatic breast cancer metastases.

PRMT1-mediated H4R3me2a recruits SMARCA4 to promote colorectal cancer progression by enhancing EGFR signaling

Potent efficacy of MCL-1 inhibitor-based therapies in preclinical models of mantle cell lymphoma

Pro-apoptotic BIM is an essential initiator of physiological endothelial cell death independent of regulation by FOXO3.

Proliferation arrest in B-Raf mutant melanoma cell lines upon MAPK pathway activation

Prosurvival Bcl-2 family members reveal a distinct apoptotic identity between conventional and plasmacytoid dendritic cells

RAG-induced DNA lesions activate proapoptotic BIM to suppress lymphomagenesis in p53-deficient mice.

ROCK1 but not LIMK1 or PAK2 is a key regulator of apoptotic membrane blebbing and cell disassembly

Reduced expression of the mevalonate pathway enzyme farnesyl pyrophosphate synthase unveils recognition of tumor cells by Vgamma9Vdelta2 T cells

Restoration of tumor suppression in prostate cancer by targeting the E3 ligase E6AP.

Single-Cell Transcriptomics Identifies the Adaptation of Scart1+ Vγ6+ T Cells to Skin Residency as Activated Effector Cells

Stable silencing of the glucocorticoid receptor in myelin-specific T effector cells by retroviral delivery of shRNA: insight into neuroinflammatory disease

Synergistic action of the MCL-1 inhibitor S63845 with current therapies in preclinical models of triple-negative and HER2-amplified breast cancer

Synergistic targeting of breast cancer stem-like cells by human γδ T cells and CD8+ T cells.

TREML4 receptor regulates inflammation and innate immune cell death during polymicrobial sepsis

TRIM17 and TRIM28 antagonistically regulate the ubiquitination and anti-apoptotic activity of BCL2A1