Lista de obras - Corrado Santocanale - Dominio Público Uruguay

A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity

artículo científico publicado en 2008

A Mec1- and Rad53-dependent checkpoint controls late-firing origins of DNA replication

artículo científico publicado en 1998

A cell culture system that mimics chronic lymphocytic leukemia cells microenvironment for drug screening and characterization.

artículo científico publicado en 2013

A high through-put screen for small molecules modulating MCM2 phosphorylation identifies Ryuvidine as an inducer of the DNA damage response

artículo científico publicado en 2014

Activation of dormant origins of DNA replication in budding yeast

artículo científico publicado en 1999

An essential role for the Cdc6 protein in forming the pre-replicative complexes of budding yeast

artículo científico publicado en 1996

CDC7 kinase promotes MRE11 fork processing, modulating fork speed and chromosomal breakage

artículo científico publicado en 2020

Cdc7 is an active kinase in human cancer cells undergoing replication stress.

artículo científico publicado en 2006

Cdc7 kinase - a new target for drug development.

scientific article published on January 2010

Cdc7 kinase inhibitors: 5-heteroaryl-3-carboxamido-2-aryl pyrroles as potential antitumor agents. 1. Lead finding.

artículo científico publicado en 2010

Cdc7 kinase inhibitors: pyrrolopyridinones as potential antitumor agents. 1. Synthesis and structure-activity relationships

artículo científico publicado en 2008

Cdc7-dependent and -independent phosphorylation of Claspin in the induction of the DNA replication checkpoint

artículo científico publicado en 2013

Cell cycle-dependent formation of Cdc45-Claspin complexes in human cells is compromized by UV-mediated DNA damage

artículo científico publicado en 2013

Cell division cycle 7 kinase inhibitors: 1H-pyrrolo[2,3-b]pyridines, synthesis and structure-activity relationships

artículo científico publicado en 2009

Characterization of a Dual CDC7/CDK9 Inhibitor in Multiple Myeloma Cellular Models

artículo científico publicado en 2013

Coping with and recovering from hydroxyurea-induced replication fork arrest in budding yeast.

artículo científico publicado en 2000

DDK dependent regulation of TOP2A at centromeres revealed by a chemical genetics approach

artículo científico publicado en 2016

DNA Replication Dynamics and Cellular Responses to ATP Competitive CDC7 Kinase Inhibitors

artículo científico publicado en 2017

DNA mediated chromatin pull-down for the study of chromatin replication.

artículo científico publicado en 2011

Dbf4p, an essential S phase-promoting factor, is targeted for degradation by the anaphase-promoting complex

artículo científico publicado en 2000

Evidence for a Cdc6p-independent mitotic resetting event involving DNA polymerase alpha.

artículo científico publicado en 1998

First Cdc7 Kinase Inhibitors: Pyrrolopyridinones as Potent and Orally Active Antitumor Agents. 2. Lead Discovery

First Cdc7 kinase inhibitors: pyrrolopyridinones as potent and orally active antitumor agents. 2. Lead discovery

artículo científico publicado en 2009

Genomic footprinting of budding yeast replication origins during the cell cycle

artículo científico publicado el 1 de enero de 1997

Hypoxic activation of ATR and the suppression of the initiation of DNA replication through cdc6 degradation

artículo científico publicado en 2011

Isosteric replacement of the Z-enone with haloethyl ketone and E-enone in a resorcylic acid lactone series and biological evaluation.

artículo científico publicado en 2010

Mechanisms of action of a dual Cdc7/Cdk9 kinase inhibitor against quiescent and proliferating CLL cells.

artículo científico publicado en 2011

MicroRNA-29a regulates the benzo[a]pyrene dihydrodiol epoxide-induced DNA damage response through Cdc7 kinase in lung cancer cells

artículo científico publicado en 2013

Non-canonical regulation of homologous recombination DNA repair by the USP9X deubiquitylase

scientific article published on 12 February 2020

Overproduction and functional analysis of DNA primase subunits from yeast and mouse

scientific article published on 01 April 1992

Repression of Mcl-1 expression by the CDC7/CDK9 inhibitor PHA-767491 overcomes bone marrow stroma-mediated drug resistance in AML

artículo científico publicado en 2018

Requirement for PLK1 kinase activity in the maintenance of a robust spindle assembly checkpoint

artículo científico publicado en 2015

Synthesis of Migrastatin Analogues as Inhibitors of Tumour Cell Migration: Exploring Structural Change in and on the Macrocyclic Ring

artículo científico publicado en 2015

Synthesis of Migrastatin Analogues as Inhibitors of Tumour Cell Migration: Exploring Structural Change in and on the Macrocyclic Ring

scientific article published on 04 November 2015

The Deubiquitinase USP9X Maintains DNA Replication Fork Stability and DNA Damage Checkpoint Responses by Regulating CLASPIN during S-Phase.

artículo científico publicado en 2016

The cell cycle regulator phosphorylated retinoblastoma protein is associated with tau pathology in several tauopathies

artículo científico publicado en 2011

The yeast DNA polymerase-primase complex: genes and proteins

artículo científico publicado en 1988

Lista de obras de Corrado Santocanale

A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity

A Mec1- and Rad53-dependent checkpoint controls late-firing origins of DNA replication

A cell culture system that mimics chronic lymphocytic leukemia cells microenvironment for drug screening and characterization.

A high through-put screen for small molecules modulating MCM2 phosphorylation identifies Ryuvidine as an inducer of the DNA damage response

Activation of dormant origins of DNA replication in budding yeast

An essential role for the Cdc6 protein in forming the pre-replicative complexes of budding yeast

CDC7 kinase promotes MRE11 fork processing, modulating fork speed and chromosomal breakage

Cdc7 is an active kinase in human cancer cells undergoing replication stress.

Cdc7 kinase - a new target for drug development.

Cdc7 kinase inhibitors: 5-heteroaryl-3-carboxamido-2-aryl pyrroles as potential antitumor agents. 1. Lead finding.

Cdc7 kinase inhibitors: pyrrolopyridinones as potential antitumor agents. 1. Synthesis and structure-activity relationships

Cdc7-dependent and -independent phosphorylation of Claspin in the induction of the DNA replication checkpoint

Cell cycle-dependent formation of Cdc45-Claspin complexes in human cells is compromized by UV-mediated DNA damage

Cell division cycle 7 kinase inhibitors: 1H-pyrrolo[2,3-b]pyridines, synthesis and structure-activity relationships

Characterization of a Dual CDC7/CDK9 Inhibitor in Multiple Myeloma Cellular Models

Coping with and recovering from hydroxyurea-induced replication fork arrest in budding yeast.

DDK dependent regulation of TOP2A at centromeres revealed by a chemical genetics approach

DNA Replication Dynamics and Cellular Responses to ATP Competitive CDC7 Kinase Inhibitors

DNA mediated chromatin pull-down for the study of chromatin replication.

Dbf4p, an essential S phase-promoting factor, is targeted for degradation by the anaphase-promoting complex

Evidence for a Cdc6p-independent mitotic resetting event involving DNA polymerase alpha.

First Cdc7 Kinase Inhibitors: Pyrrolopyridinones as Potent and Orally Active Antitumor Agents. 2. Lead Discovery

First Cdc7 kinase inhibitors: pyrrolopyridinones as potent and orally active antitumor agents. 2. Lead discovery

Genomic footprinting of budding yeast replication origins during the cell cycle

Hypoxic activation of ATR and the suppression of the initiation of DNA replication through cdc6 degradation

Isosteric replacement of the Z-enone with haloethyl ketone and E-enone in a resorcylic acid lactone series and biological evaluation.

Mechanisms of action of a dual Cdc7/Cdk9 kinase inhibitor against quiescent and proliferating CLL cells.

MicroRNA-29a regulates the benzo[a]pyrene dihydrodiol epoxide-induced DNA damage response through Cdc7 kinase in lung cancer cells

Non-canonical regulation of homologous recombination DNA repair by the USP9X deubiquitylase

Overproduction and functional analysis of DNA primase subunits from yeast and mouse

Repression of Mcl-1 expression by the CDC7/CDK9 inhibitor PHA-767491 overcomes bone marrow stroma-mediated drug resistance in AML

Requirement for PLK1 kinase activity in the maintenance of a robust spindle assembly checkpoint

Synthesis of Migrastatin Analogues as Inhibitors of Tumour Cell Migration: Exploring Structural Change in and on the Macrocyclic Ring

Synthesis of Migrastatin Analogues as Inhibitors of Tumour Cell Migration: Exploring Structural Change in and on the Macrocyclic Ring

The Deubiquitinase USP9X Maintains DNA Replication Fork Stability and DNA Damage Checkpoint Responses by Regulating CLASPIN during S-Phase.

The cell cycle regulator phosphorylated retinoblastoma protein is associated with tau pathology in several tauopathies

The yeast DNA polymerase-primase complex: genes and proteins