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Lista de obras de Bernhard K. Keppler

(Aminoethanol)dichloroplatinum(II) complexes: influence of the hydroxyethyl moiety on 5'-GMP and DNA binding, intramolecular stability, the partition coefficient and anticancer activity

artículo científico publicado en 2002

1,1,3,3-Tetramethyl-1,3-disila-2-oxa[3]ferrocenophane: improved synthesis and new crystal structure

18F fluoroethylations: different strategies for the rapid translation of 11C-methylated radiotracers.

artículo científico publicado en 2007

3-Hydroxyflavones vs. 3-hydroxyquinolinones: structure-activity relationships and stability studies on Ru(II)(arene) anticancer complexes with biologically active ligands

artículo científico publicado en 2013

5-Hydr-oxy-2-methyl-4H-pyran-4-one

artículo científico publicado en 2009

A Dogma in Doubt: Hydrolysis of Equatorial Ligands of PtIV Complexes under Physiological Conditions

artículo científico publicado en 2019

A SAR study of novel antiproliferative ruthenium and osmium complexes with quinoxalinone ligands in human cancer cell lines

artículo científico publicado en 2012

A bioinformatics approach to the identification, classification, and analysis of hydroxyproline-rich glycoproteins

artículo científico publicado en 2010

A comparative study of adduct formation between the anticancer ruthenium(III) compound HInd trans-[RuCl4(Ind)2] and serum proteins.

artículo científico publicado en 2004

A glucose derivative as natural alternative to the cyclohexane-1,2-diamine ligand in the anticancer drug oxaliplatin?

artículo científico publicado en 2007

A high-throughput assay for a human telomerase protein-human telomerase RNA interaction

artículo científico publicado en 2006

A novel class of bis- and tris-chelate diam(m)inebis(dicarboxylato)platinum(IV) complexes as potential anticancer prodrugs.

artículo científico publicado en 2014

A novel cytotoxic cerium complex: aquatrichloridobis(1,10-phenanthroline)cerium(III) (KP776). Synthesis, characterization, behavior in H2O, binding towards biomolecules, and antiproliferative activity

artículo científico publicado en 2009

A one step/one pot synthesis of N,N-bis(phosphonomethyl)amino acids and their effects on adipogenic and osteogenic differentiation of human mesenchymal stem cells

artículo científico publicado en 2009

A quantitative structure-activity approach for lipophilicity estimation of antitumor complexes of different metals using microemulsion electrokinetic chromatography

artículo científico publicado en 2011

A strategically designed small molecule attacks alpha-ketoglutarate dehydrogenase in tumor cells through a redox process

artículo científico publicado en 2014

A systematic capillary electrophoresis study on the effect of the buffer composition on the reactivity of the anticancer drug cisplatin to the DNA model 2′-deoxyguanosine 5′-monophosphate (dGMP) ⬇️

artículo científico publicado el 26 de abril de 2013

Activity of two platinum-linked phosphonic acids against autochthonous rat colorectal cancer as well as in two human colon-cancer cell lines

artículo científico publicado en 1992

Albumin-based nanoparticles as magnetic resonance contrast agents: I. Concept, first syntheses and characterisation

artículo científico publicado en 2010

Am(m)ines make the difference: organoruthenium am(m)ine complexes and their chemistry in anticancer drug development

scientific article published on 22 January 2013

Amidines derived from Pt(IV)-mediated nitrile-amino alcohol coupling and their Zn(II)-catalyzed conversion into oxazolines.

artículo científico publicado en 2003

An Organoruthenium Anticancer Agent Shows Unexpected Target Selectivity For Plectin.

artículo científico publicado en 2017

An electrochemical study of antineoplastic gallium, iron and ruthenium complexes with redox noninnocent alpha-N-heterocyclic chalcogensemicarbazones

artículo científico publicado en 2008

Analysis of anticancer platinum(II)-complexes by microemulsion electrokinetic chromatography: separation of diastereomers and estimation of octanol-water partition coefficients

artículo científico publicado en 2005

Analysis of platinum adducts with DNA nucleotides and nucleosides by capillary electrophoresis coupled to ESI-MS: indications of guanosine 5'-monophosphate O6-N7 chelation

artículo científico publicado en 2004

Analysis of quaternary ammonium and phosphonium ionic liquids by reversed-phase high-performance liquid chromatography with charged aerosol detection and unified calibration

artículo científico publicado en 2008

Analytical instrumentation in toxicology

scientific article published on 01 September 1980

Another step toward DNA selective targeting: Ni(II) and Cu(II) complexes of a Schiff base ligand able to bind gene promoter G-quadruplexes

artículo científico publicado en 2016

Antagonistic effects of selenium and lipid peroxides on growth control in early hepatocellular carcinoma.

artículo científico publicado en 2012

Anticancer Activity of Metal Complexes: Involvement of Redox Processes ⬇️

artículo científico publicado el 11 de mayo de 2011

Anticancer activity of methyl-substituted oxaliplatin analogs

artículo científico publicado en 2012

Anticancer activity of the lanthanum compound [tris(1,10-phenanthroline)lanthanum(III)]trithiocyanate (KP772; FFC24).

artículo científico publicado en 2005

Anticancer metal drugs and immunogenic cell death.

artículo científico publicado en 2016

Anticancer-agent-linked phosphonates with antiosteolytic and antineoplastic properties: a promising perspective in the treatment of bone-related malignancies?

artículo científico publicado en 1990

Antineoplastic activity of three ruthenium derivatives against chemically induced colorectal carcinoma in rats

artículo científico publicado en 1992

Antitumor activity of 1.3-diketonato zirconium (IV) and hafnium (IV) complexes

artículo científico publicado en 1985

Antitumor activity of cis-dihalogenobis(1-phenyl-1,3-butanedionato) titanium(IV) compounds against Walker 256 carcinosarcoma. A new class of antineoplastic agents

artículo científico publicado en 1982

Antitumor activity of cis-dihalogenobis(1-phenyl-1,3-butanedionato)titanium (IV) compounds. A new class of antineoplastic agents

scientific article published on 01 January 1983

Antitumor activity of imidazolium-bisimidazole-tetrachlororuthenate (III). A representative of a new class of inorganic antitumor agents

artículo científico publicado en 1986

Antitumor activity of phenyl substituted dihalogenobis (1-phenyl-1,3-butanedionato)titanium (IV) compounds

artículo científico publicado en 1985

Antitumor activity of some ruthenium derivatives in human colon cancer cell lines in vitro

artículo científico publicado en 1992

Antitumor pentamethylcyclopentadienyl rhodium complexes of maltol and allomaltol: synthesis, solution speciation and bioactivity

artículo científico publicado en 2014

Antitumour Organometallics. III. In Vivo Activity of Diphenylantimony(III) and Diorganotin(IV) Dithiophosphorus Derivatives Against P388 Leukemia.

artículo científico publicado en 1994

Antitumour metal compounds: more than theme and variations

artículo científico publicado en 2007

Application of capillary electrophoresis-inductively coupled plasma mass spectrometry to comparative studying of the reactivity of antitumor ruthenium(III) complexes differing in the nature of counter-ion toward human serum proteins.

artículo científico publicado en 2008

Application of capillary electrophoresis-mass spectrometry for the investigation of the binding behavior of oxaliplatin to 5'-GMP in the presence of the sulfur-containing amino acid L-methionine

artículo científico publicado en 2002

Application of ionic liquids for the removal of heavy metals from wastewater and activated sludge

artículo científico publicado en 2012

Application of micellar and microemulsion electrokinetic chromatography for characterization of gallium(III) complexes of pharmaceutical significance

artículo científico publicado en 2007

Aqueous chemistry and antiproliferative activity of a pyrone-based phosphoramidate Ru(arene) anticancer agent.

artículo científico publicado en 2014

Assessment of the preclinical activity of budotitane in three different transplantable tumor systems, its lack of mutagenicity, and first results of clinical phase I studies

artículo científico publicado en 1989

Bacterial ghosts as adjuvant to oxaliplatin chemotherapy in colorectal carcinomatosis

artículo científico publicado en 2018

Behavior of platinum(iv) complexes in models of tumor hypoxia: cytotoxicity, compound distribution and accumulation

artículo científico publicado en 2016

Binding of Antitumor Ruthenium(III) Complexes to Plasma Proteins

artículo científico publicado en 2000

Bioanalysis young investigator: Michael Groessl

artículo científico publicado en 2012

Biodistribution of anti-diabetic Zn(II) complexes in human serum andin vitroprotein-binding studies by means of CZEâ ICP-MS

artículo científico publicado en 2009

Biodistribution of the novel anticancer drug sodium trans-[tetrachloridobis(1H-indazole)ruthenate(III)] KP-1339/IT139 in nude BALB/c mice and implications on its mode of action

artículo científico publicado en 2016

Bioimaging of isosteric osmium and ruthenium anticancer agents by LA-ICP-MS.

artículo científico publicado en 2018

Bioinformatic Identification and Analysis of Hydroxyproline-Rich Glycoproteins in Populus trichocarpa

artículo científico publicado en 2016

Biological activity of ruthenium and osmium arene complexes with modified paullones in human cancer cells.

artículo científico publicado en 2012

Biological evaluation of novel thiomaltol-based organometallic complexes as topoisomerase IIα inhibitors

artículo científico publicado en 2020

Biological properties of novel ruthenium- and osmium-nitrosyl complexes with azole heterocycles

artículo científico publicado en 2016

Biomolecule binding vs. anticancer activity: Reactions of Ru(arene)[(thio)pyr-(id)one] compounds with amino acids and proteins

artículo científico publicado en 2011

Biophysical analysis of natural, double-helical DNA modified by anticancer heterocyclic complexes of ruthenium(III) in cell-free media

artículo científico publicado en 2001

Bis- and Tetrakis(carboxylato)platinum(IV) complexes with mixed axial ligands - synthesis, characterization, and cytotoxicity

artículo científico publicado en 2015

Bulky N(,N)-(di)alkylethane-1,2-diamineplatinum(II) compounds as precursors for generating unsymmetrically substituted platinum(IV) complexes.

artículo científico publicado en 2013

CE in anticancer metallodrug research--an update

artículo científico publicado en 2007

CZE-ICP-MS as a tool for studying the hydrolysis of ruthenium anticancer drug candidates and their reactivity towards the DNA model compound dGMP.

artículo científico publicado en 2007

Calpain-mediated integrin deregulation as a novel mode of action for the anticancer gallium compound KP46.

artículo científico publicado en 2014

Can neutral analytes be concentrated by transient isotachophoresis in micellar electrokinetic chromatography and how much?

artículo científico publicado en 2014

Capillary electrophoresis hyphenated to inductively coupled plasma-mass spectrometry: a novel approach for the analysis of anticancer metallodrugs in human serum and plasma

artículo científico publicado en 2008

Capillary electrophoresis in anti-cancer metallodrug research: advances and future challenges

artículo científico publicado en 2003

Capillary electrophoresis of metal-based drugs.

artículo científico publicado en 2007

Capillary electrophoresis of platinum-group elements. Analytical, speciation and biochemical studies.

artículo científico publicado en 2002

Capillary electrophoretic assay for the stability of tris(8-quinolinolato)gallium(III) in tablet formulations

artículo científico publicado en 2008

Capillary electrophoretic study of carboplatin and analogues with nucleoside monophosphates, di- and trinucleotides

artículo científico publicado en 2001

Capillary electrophoretic study of cisplatin interaction with nucleoside monophosphates, di- and trinucleotides

artículo científico publicado en 1999

Capillary zone electrophoresis and capillary zone electrophoresis–electrospray ionization mass spectrometry studies on the behavior of anticancer cis- and trans-[dihalidobis(2-propanone oxime)platinum(II)] complexes in aqueous solutions

scientific article published on 28 July 2012

Carbohydrate-metal complexes and their potential as anticancer agents

scientific article published on January 2008

Carboxylation of Dihydroxoplatinum(IV) Complexes via a New Synthetic Pathway

artículo científico publicado en 1996

Cellular accumulation and DNA interaction studies of cytotoxic trans-platinum anticancer compounds

artículo científico publicado en 2012

Central European Society for Anticancer Drug Research

artículo científico publicado en 2000

Characterization of interactions between human serum albumin and tumor-inhibiting amino alcohol platinum(II) complexes using capillary electrophoresis.

artículo científico publicado en 2007

Characterization of the binding sites of the anticancer ruthenium(III) complexes KP1019 and KP1339 on human serum albumin via competition studies

artículo científico publicado en 2012

Chemoresistance in rat ovarian tumours

artículo científico publicado en 1991

Chromatin-modifying enzymes as therapeutic targets--Part 1

artículo científico publicado en 2008

Chromatin-modifying enzymes as therapeutic targets--Part 2

artículo científico publicado en 2008

Cisplatin damage: are DNA repair proteins saviors or traitors to the cell?

artículo científico publicado en 2005

Cisplatin-linked phosphonates in the treatment of the transplantable osteosarcoma in vitro and in vivo

artículo científico publicado en 1990

Combination of cadmium and high cholesterol levels as a risk factor for heart fibrosis.

artículo científico publicado en 2015

Comparative antitumor activity of ruthenium derivatives with 5'-deoxy-5-fluorouridine in chemically induced colorectal tumors in SD rats

artículo científico publicado en 1987

Comparative binding of antitumor indazolium [trans-tetrachlorobis(1H-indazole)ruthenate(III)] to serum transport proteins assayed by capillary zone electrophoresis

artículo científico publicado en 2005

Comparative in vitro and in vivo pharmacological investigation of platinum(IV) complexes as novel anticancer drug candidates for oral application.

artículo científico publicado en 2014

Comparative solution equilibrium studies of anticancer gallium(III) complexes of 8-hydroxyquinoline and hydroxy(thio)pyrone ligands.

artículo científico publicado en 2012

Comparative solution equilibrium studies on pentamethylcyclopentadienyl rhodium complexes of 2,2'-bipyridine and ethylenediamine and their interaction with human serum albumin.

artículo científico publicado en 2015

Compared effects of ruthenium red and cis [Ru(NH3)4Cl2]Cl on the isolated ischaemic-reperfused rat heart

artículo científico publicado en 1995

Comparison of the Antiproliferative Activity of Two Antitumour Ruthenium(III) Complexes With Their Apotransferrin and Transferrin-Bound Forms in a Human Colon Cancer Cell Line.

artículo científico publicado en 1996

Comparison of the binding behavior of oxaliplatin, cisplatin and analogues to 5'-GMP in the presence of sulfur-containing molecules by means of capillary electrophoresis and electrospray mass spectrometry

artículo científico publicado en 2001

Complexes of N-hydroxyethyl-N-benzimidazolylmethylethylenediaminediacetic acid with group 12 metals and vanadium-Synthesis, structure and bioactivity of the vanadium complex

artículo científico publicado en 2015

Computational Electrochemistry of Ruthenium Anticancer Agents. Unprecedented Benchmarking of Implicit Solvation Methods

scientific article published on 01 March 2008

Conjugation of organoruthenium(II) 3-(1H-benzimidazol-2-yl)pyrazolo[3,4-b]pyridines and indolo[3,2-d]benzazepines to recombinant human serum albumin: a strategy to enhance cytotoxicity in cancer cells

artículo científico publicado en 2011

Copper(II) complexes with derivatives of pyrazole as potential antioxidant enzyme mimics.

artículo científico publicado en 2012

Cytotoxicity and preliminary mode of action studies of novel 2-aryl-4-thiopyrone-based organometallics.

artículo científico publicado en 2015

DNA Interactions of pH-Sensitive, Antitumor Bis(aminoalcohol)dichloroplatinum(II) Complexes†,‡

scientific article published on 01 December 2006

DNA interactions of dinuclear RuII arene antitumor complexes in cell-free media

artículo científico publicado en 2008

DNA or protein? Capillary zone electrophoresis-mass spectrometry rapidly elucidates metallodrug binding selectivity

artículo científico publicado en 2017

Design, synthesis, physical and chemical characterisation, and biological interactions of lectin-targeted latex nanoparticles bearing Gd-DTPA chelates: an exploration of magnetic resonance molecular imaging (MRMI).

artículo científico publicado en 2005

Determination of binding constants and stoichiometries for platinum anticancer drugs and serum transport proteins by capillary electrophoresis using the Hummel-Dreyer method.

artículo científico publicado en 2005

Determination of cisplatin and its hydrolytic metabolite in human serum by capillary electrophoresis techniques

artículo científico publicado en 2005

Development of an experimental protocol for uptake studies of metal compounds in adherent tumor cells

artículo científico publicado en 2009

Diamminetetrakis(carboxylato)platinum(IV) complexes--synthesis, characterization, and cytotoxicity

artículo científico publicado en 2012

Differences in protein binding and excretion of Triapine and its Fe(III) complex

artículo científico publicado en 2015

Early results from a phase I study on orally administered tris(8-quinolinolato)gallium(III) (FFC11, KP46) in patients with solid tumors--a CESAR study (Central European Society for Anticancer Drug Research--EWIV).

artículo científico publicado en 2005

Effect of cis-, trans-diamminedichloroplatinum(II) and DBP on human serum albumin

artículo científico publicado en 1999

Effect of metal ion complexation and chalcogen donor identity on the antiproliferative activity of 2-acetylpyridine N,N-dimethyl(chalcogen)semicarbazones.

artículo científico publicado en 2007

Effect of reactivity on cellular accumulation and cytotoxicity of oxaliplatin analogues.

artículo científico publicado en 2012

Efficacy of beta-diketonato complexes of titanium, zirconium, and hafnium against chemically induced autochthonous colonic tumors in rats

artículo científico publicado en 1987

Efficacy of new ruthenium complexes against chemically induced autochthonous colorectal carcinoma in rats

scientific article published on 01 May 1989

Efficiently Detecting Metallodrug-Protein Adducts: Ion Trap versus Time-of-Flight Mass Analyzers

artículo científico publicado en 2014

Electron microscopic visualization of telomerase from Euplotes aediculatus bound to a model telomere DNA.

artículo científico

Electronic State of Sodium trans-[Tetrachloridobis(1H-indazole)ruthenate(III)] (NKP-1339) in Tumor, Liver and Kidney Tissue of a SW480-bearing Mouse.

artículo científico publicado en 2017

Elucidation of the interactions of an anticancer ruthenium complex in clinical trials with biomolecules utilizing capillary electrophoresis hyphenated to inductively coupled plasma-mass spectrometry. Short communication

artículo científico publicado en 2008

Emerging roles of the 26S proteasome in nuclear hormone receptor-regulated transcription.

artículo científico publicado en 2010

En route to osmium analogues of KP1019: synthesis, structure, spectroscopic properties and antiproliferative activity of trans-[Os(IV)Cl4(Hazole)2]

artículo científico publicado en 2011

Enhancing lipophilicity as a strategy to overcome resistance against platinum complexes?

artículo científico publicado en 2011

Extraction of natural radionuclides from aqueous solutions by novel maltolate-based task-specific ionic liquids

artículo científico publicado en 2014

Extravasation of Pt-based chemotherapeutics - bioimaging of their distribution in resectates using laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS).

artículo científico publicado en 2015

First example of the solid-state thermal cyclometalation of ligated benzophenone imine giving novel luminescent platinum(II) species.

artículo científico publicado en 2007

Fluorescence properties and cellular distribution of the investigational anticancer drug triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone) and its zinc(II) complex

artículo científico publicado en 2009

Fragmentation methods on the balance: unambiguous top–down mass spectrometric characterization of oxaliplatin–ubiquitin binding sites

artículo científico publicado en 2011

From bench to bedside--preclinical and early clinical development of the anticancer agent indazolium trans-[tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019 or FFC14A).

artículo científico publicado en 2006

From hydrolytically labile to hydrolytically stable Ru(II)-arene anticancer complexes with carbohydrate-derived co-ligands.

artículo científico publicado en 2010

Front Cover: Oxoplatin‐Based Pt(IV) Lipoate Complexes and Their Biological Activity (Chem. Biodiversity 10/2022)

artículo científico publicado en 2022

G-quadruplex vs. duplex-DNA binding of nickel(II) and zinc(II) Schiff base complexes.

artículo científico publicado en 2016

Gallium and other main group metal compounds as antitumor agents.

artículo científico publicado en 2004

Gallium compound GaQ(3) -induced Ca(2+) signalling triggers p53-dependent and -independent apoptosis in cancer cells

artículo científico publicado en 2012

Gallium in cancer treatment

scientific article published on 01 January 2004

Gallium in cancer treatment.

artículo científico publicado en 2002

Gallium(III) and iron(III) complexes of alpha-N-heterocyclic thiosemicarbazones: synthesis, characterization, cytotoxicity, and interaction with ribonucleotide reductase.

artículo científico publicado en 2007

Gold(III) compounds as anticancer agents: relevance of gold-protein interactions for their mechanism of action

artículo científico publicado en 2007

Guanidine platinum(II) complexes: synthesis, in vitro antitumor activity, and DNA interactions.

artículo científico publicado en 2013

HPIC-UV-ICP-SFMS study of the interaction of cisplatin with guanosine monophosphate

artículo científico publicado en 2001

Half-sandwich ruthenium(II) biotin conjugates as biological vectors to cancer cells

artículo científico publicado en 2015

Heavy metals in the mallard Anas platyrhynchos from eastern Austria.

artículo científico publicado en 2016

Heterocyclic complexes of ruthenium(III) induce apoptosis in colorectal carcinoma cells.

artículo científico publicado en 2004

High resolution mass spectrometry for studying the interactions of cisplatin with oligonucleotides

artículo científico publicado en 2008

Highly cytotoxic copper(II) complexes with modified paullone ligands

artículo científico publicado en 2010

Hydrolysis and cytotoxic properties of osmium(II)/(III)-DMSO-azole complexes. Short communication

artículo científico publicado en 2008

Hydrolysis of the tumor-inhibiting ruthenium(III) complexes HIm trans-[RuCl4(im)2] and HInd trans-[RuCl4(ind)2] investigated by means of HPCE and HPLC-MS.

artículo científico publicado en 2001

Hydrolysis study of the bifunctional antitumour compound RAPTA-C, [Ru(η6-p-cymene)Cl2(pta)]

artículo científico publicado en 2008

IRX14 and IRX14-LIKE, two glycosyl transferases involved in glucuronoxylan biosynthesis and drought tolerance in Arabidopsis

artículo científico publicado en 2010

Identification of the structural determinants for anticancer activity of a ruthenium arene peptide conjugate

artículo científico publicado en 2013

Impact of Stepwise NH2-Methylation of Triapine on the Physicochemical Properties, Anticancer Activity, and Resistance Circumvention

artículo científico publicado en 2016

Impact of metal coordination on cytotoxicity of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (triapine) and novel insights into terminal dimethylation.

artículo científico publicado en 2009

Impact of terminal dimethylation on the resistance profile of α-N-heterocyclic thiosemicarbazones

artículo científico publicado en 2012

Improved reaction conditions for the synthesis of new NKP-1339 derivatives and preliminary investigations on their anticancer potential

artículo científico publicado en 2014

In vitro anticancer activity and biologically relevant metabolization of organometallic ruthenium complexes with carbohydrate-based ligands

artículo científico publicado en 2008

Inductively coupled plasma mass spectrometry for metallodrug development: albumin binding and serum distribution of cytotoxic cis- and trans-isomeric platinum(II) complexes

artículo científico publicado en 2014

Influence of ascorbic acid on the activity of the investigational anticancer drug KP1019.

artículo científico publicado en 2011

Influence of extracellular pH on the cytotoxicity, cellular accumulation, and DNA interaction of novel pH-sensitive 2-aminoalcoholatoplatinum(II) complexes

artículo científico publicado en 2013

Influence of reducing agents on the cytotoxic activity of platinum(IV) complexes: induction of G2/M arrest, apoptosis and oxidative stress in A2780 and cisplatin resistant A2780cis cell lines.

artículo científico publicado en 2015

Influence of the Arene Ligand and the Leaving Group on the Anticancer Activity of (Thio)maltol Ruthenium(II)–(η6-Arene) Complexes

Influence of the Number of Axial Bexarotene Ligands on the Cytotoxicity of Pt(IV) Analogs of Oxaliplatin.

artículo científico publicado en 2017

Influence of the π-coordinated arene on the anticancer activity of ruthenium(II) carbohydrate organometallic complexes

artículo científico publicado en 2013

Inhibition of Escherichia coli DNA polymerase I catalysed DNA polymerization by trans-imidazolium-bisimidazoletetrachlororuthenate(III)

scientific article published on 01 October 1991

Inhibition of telomerase activity by preventing proper assemblage.

artículo científico

Inhibitory Effects of the Ruthenium Complex KP1019 in Models of Mammary Cancer Cell Migration and Invasion.

artículo científico publicado en 2009

Inhibitory effects of gallium chloride and tris (8-quinolinolato) gallium III on A549 human malignant cell line

artículo científico publicado en 2000

Interaction of Triapine and related thiosemicarbazones with iron(III)/(II) and gallium(III): a comparative solution equilibrium study.

artículo científico publicado en 2011

Interaction of the anticancer gallium(III) complexes of 8-hydroxyquinoline and maltol with human serum proteins

artículo científico publicado en 2014

Interactions of a novel ruthenium-based anticancer drug (KP1019 or FFC14a) with serum proteins--significance for the patient

artículo científico publicado en 2005

Interactions of antitumor metallodrugs with serum proteins: advances in characterization using modern analytical methodology.

artículo científico publicado en 2006

Interactions of the carrier ligands of antidiabetic metal complexes with human serum albumin: A combined spectroscopic and separation approach with molecular modeling studies

scientific article published on 21 June 2011

Intracellular protein binding patterns of the anticancer ruthenium drugs KP1019 and KP1339.

artículo científico publicado en 2010

Intrinsic and Acquired Forms of Resistance against the Anticancer Ruthenium Compound KP1019 [Indazolium trans-[tetrachlorobis(1H-indazole)ruthenate (III)] (FFC14A)

scientific article published on 26 August 2004

Introducing N-, P-, and S-donor leaving groups: an investigation of the chemical and biological properties of ruthenium, rhodium and iridium thiopyridone piano stool complexes

artículo científico publicado en 2020

Introducing the 4-Phenyl-1,2,3-Triazole Moiety as a Versatile Scaffold for the Development of Cytotoxic Ruthenium(II) and Osmium(II) Arene Cyclometalates

artículo científico publicado en 2016

Investigation of amino acid containing [FeFe] hydrogenase models concerning pendant base effects

artículo científico publicado en 2009

Investigations into the interaction between tumor-inhibiting ruthenium(III) complexes and nucleotides by capillary electrophoresis.

artículo científico publicado en 2001

Ionic liquids for extraction of metals and metal containing compounds from communal and industrial waste water.

artículo científico publicado en 2011

Is the reactivity of M(II)-arene complexes of 3-hydroxy-2(1H)-pyridones to biomolecules the anticancer activity determining parameter?

artículo científico publicado en 2010

Isomeric [RuCl2(dmso)2(indazole)2] complexes: ruthenium(II)-mediated coupling reaction of acetonitrile with 1H-indazole

artículo científico publicado en 2005

KP1019 (FFC14A) from bench to bedside: preclinical and early clinical development--an overview.

artículo científico publicado en 2005

KP1019, a new redox-active anticancer agent--preclinical development and results of a clinical phase I study in tumor patients

artículo científico publicado en 2008

Kinetics of binding properties of 5'-GMP with cisplatin under simulated physiological conditions by capillary electrophoresis

scientific article published on 01 August 2000

L- and D-proline thiosemicarbazone conjugates: coordination behavior in solution and the effect of copper(II) coordination on their antiproliferative activity.

artículo científico publicado en 2012

LA-ICP-MS imaging in multicellular tumor spheroids - a novel tool in the preclinical development of metal-based anticancer drugs.

artículo científico publicado en 2016

LC– and CZE–ICP-MS approaches for the in vivo analysis of the anticancer drug candidate sodium trans-[tetrachloridobis(1H-indazole)ruthenate(iii)] (KP1339) in mouse plasma

artículo científico publicado en 2011

Lectin conjugates as biospecific contrast agents for MRI. Coupling of Lycopersicon esculentum agglutinin to linear water-soluble DTPA-loaded oligomers.

artículo científico publicado en 2011

Lectin-Gd-loaded chitosan hydrogel nanoparticles: a new biospecific contrast agent for MRI

artículo científico publicado en 2011

Loss of CUL4A expression is underlying cisplatin hypersensitivity in colorectal carcinoma cells with acquired trabectedin resistance

artículo científico publicado en 2017

Loss of phosphodiesterase 4D mediates acquired triapine resistance via Epac-Rap1-Integrin signaling.

artículo científico publicado en 2016

Macromolecular Pt(IV) Prodrugs from Poly(organo)phosphazenes.

artículo científico publicado en 2016

Maleimide-functionalised organoruthenium anticancer agents and their binding to thiol-containing biomolecules

artículo científico publicado en 2011

Maleimide-functionalised platinum(IV) complexes as a synthetic platform for targeted drug delivery.

artículo científico publicado en 2013

Maltol-derived ruthenium-cymene complexes with tumor inhibiting properties: the impact of ligand-metal bond stability on anticancer activity in vitro

artículo científico publicado en 2009

Mass Spectrometry Uncovers Molecular Reactivities of Coordination and Organometallic Gold(III) Drug Candidates in Competitive Experiments That Correlate with Their Biological Effects

artículo científico publicado en 2016

Mechanisms underlying reductant-induced reactive oxygen species formation by anticancer copper(II) compounds

artículo científico publicado en 2011

Metabolite sensitivity in the methaqualone radioimmunoassay.

artículo científico publicado en 1977

Metal Ions and Metal Complexes in Alzheimer's Disease.

artículo científico publicado en 2016

Metal NHC Complexes with Naphthalimide Ligands as DNA-Interacting Antiproliferative Agents.

artículo científico publicado en 2016

Metal-Arene Complexes with Indolo[3,2-c]-quinolines: Effects of Ruthenium vs Osmium and Modifications of the Lactam Unit on Intermolecular Interactions, Anticancer Activity, Cell Cycle, and Cellular Accumulation

artículo científico publicado en 2013

Metal-based paullones as putative CDK inhibitors for antitumor chemotherapy

artículo científico publicado en 2007

Microfluidic preparation of [18F]FE@SUPPY and [18F]FE@SUPPY:2 — comparison with conventional radiosyntheses

artículo científico publicado en 2010

Modulation of activity of known cytotoxic ruthenium(III) compound (KP418) with hampered transmembrane transport in electrochemotherapy in vitro and in vivo

artículo científico publicado en 2014

Molecular mode of action of NKP-1339 - a clinically investigated ruthenium-based drug - involves ER- and ROS-related effects in colon carcinoma cell lines

artículo científico publicado en 2016

Mono-carboxylated diaminedichloridoplatinum(IV) complexes--selective synthesis, characterization, and cytotoxicity

artículo científico publicado en 2011

Multi-scale imaging of anticancer platinum(iv) compounds in murine tumor and kidney

scientific article published on 03 February 2016

Multidrug-resistant cancer cells are preferential targets of the new antineoplastic lanthanum compound KP772 (FFC24).

artículo científico publicado en 2007

NCA nucleophilic radiofluorination on substituted benzaldehydes for the preparation of [18F]fluorinated aromatic amino acids

artículo científico publicado en 2005

NKP-1339, a first-in-class anticancer drug showing mild side effects and activity in patients suffering from advanced refractory cancer

artículo científico publicado en 2012

Nanoformulation improves activity of the (pre)clinical anticancer ruthenium complex KP1019.

artículo científico publicado en 2014

Nanoscalic silver possesses broad-spectrum antimicrobial activities and exhibits fewer toxicological side effects than silver sulfadiazine

scholarly article by Oliver Brandt et al published May 2012 in Nanomedicine: Nanotechnology, Biology and Medicine

Natural organic matter and iron export from the Tanner Moor, Austria

artículo científico publicado en 2013

New method for the speciation of ruthenium-based chemotherapeutics in human serum by conjoint liquid chromatography on affinity and anion-exchange monolithic disks

artículo científico publicado en 2014

New platinum-oxicam complexes as anti-cancer drugs. Synthesis, characterization, release studies from smart hydrogels, evaluation of reactivity with selected proteins and cytotoxic activity in vitro

artículo científico publicado en 2010

New tumor-inhibiting metal complexes

artículo científico publicado en 1990

New tumor-inhibiting metal complexes. Chemistry and antitumor properties

artículo científico publicado en 1994

Novel bis(carboxylato)dichlorido(ethane-1,2-diamine)platinum(IV) complexes with exceptionally high cytotoxicity

artículo científico publicado en 2008

Novel cis- and trans-configured bis(oxime)platinum(II) complexes: synthesis, characterization, and cytotoxic activity

artículo científico publicado en 2010

Novel di- and tetracarboxylatoplatinum(IV) complexes. Synthesis, characterization, cytotoxic activity, and DNA platination.

artículo científico publicado en 2007

Novel endothall-containing platinum(IV) complexes: synthesis, characterization, and cytotoxic activity

artículo científico publicado en 2008

Novel oximato-bridged platinum(II) di- and trimer(s): synthetic, structural, and in vitro anticancer activity studies

artículo científico publicado en 2012

Novel p53-dependent anticancer strategy by targeting iron signaling and BNIP3L-induced mitophagy.

artículo científico publicado en 2015

Novel phthiocol-based organometallics with tridentate coordination motif and their unexpected cytotoxic behaviour

artículo científico publicado en 2020

Novel tetracarboxylatoplatinum(IV) complexes as carboplatin prodrugs.

artículo científico publicado en 2012

Novel thiosalicylate-based ionic liquids for heavy metal extractions.

artículo científico publicado en 2016

Organometallic 3-(1H-benzimidazol-2-yl)-1H-pyrazolo[3,4-b]pyridines as potential anticancer agents

artículo científico publicado en 2011

Organometallic Ruthenium and Osmium Compounds of Pyridin-2- and -4-ones as Potential Anticancer Agents

scientific article published on 01 September 2012

Organometallic anticancer complexes of lapachol: metal centre-dependent formation of reactive oxygen species and correlation with cytotoxicity

artículo científico publicado en 2013

Organometallic indolo[3,2-c]quinolines versus indolo[3,2-d]benzazepines: synthesis, structural and spectroscopic characterization, and biological efficacy

artículo científico publicado en 2010

Osmium NAMI-A analogues: synthesis, structural and spectroscopic characterization, and antiproliferative properties.

artículo científico publicado en 2007

Osmium(II)--versus ruthenium(II)--arene carbohydrate-based anticancer compounds: similarities and differences.

artículo científico publicado en 2010

Osmium(IV) complexes with 1H- and 2H-indazoles: tautomer identity versus spectroscopic properties and antiproliferative activity

artículo científico publicado en 2012

PARP2 Is the Predominant Poly(ADP-Ribose) Polymerase in Arabidopsis DNA Damage and Immune Responses.

artículo científico publicado en 2015

Paradoxical effect of dichlorobis(1-phenylbutane-1,3-dionato)molybdenum (IV), (Mo(bzac)2Cl2 on the growth of autochthonous chemically induced colorectal tumors in SD rats

artículo científico publicado en 1987

Pharmacokinetics of a novel anticancer ruthenium complex (KP1019, FFC14A) in a phase I dose-escalation study

artículo científico publicado en 2009

Pharmacological properties of cerium compounds.

artículo científico publicado en 2005

Phosphite-Derivatized Ruthenium-Carbohydrate Complexes in the Catalytic Hydration of Nitriles. Short Communication

artículo científico publicado en 2008

Photoreduction of Terrigenous Fe-Humic Substances Leads to Bioavailable Iron in Oceans

artículo científico publicado en 2016

Photoreduction of Terrigenous Fe-Humic Substances Leads to Bioavailable Iron in Oceans

artículo científico publicado en 2016

Physicochemical Studies and Anticancer Potency of Ruthenium η-p-Cymene Complexes Containing Antibacterial Quinolones

artículo científico publicado en 2011

Platinum group metallodrug-protein binding studies by capillary electrophoresis - inductively coupled plasma-mass spectrometry: a further insight into the reactivity of a novel antitumor ruthenium(III) complex toward human serum proteins

artículo científico publicado en 2006

Platinum metallodrug-protein binding studies by capillary electrophoresis-inductively coupled plasma-mass spectrometry: characterization of interactions between Pt(II) complexes and human serum albumin.

artículo científico publicado en 2004

Poly(lactic acid) nanoparticles of the lead anticancer ruthenium compound KP1019 and its surfactant-mediated activation

artículo científico publicado en 2013

Post-digestion stabilization of osmium enables quantification by ICP-MS in cell culture and tissue

artículo científico publicado en 2017

Preclinical activity of trans-indazolium[tetrachlorobisindazoleruthenate(III)] (NSC 666158; IndCR; KP 1019) against tumour colony-forming units and haematopoietic progenitor cells

scientific article published on 01 December 1997

Preclinical characterization of anticancer gallium(III) complexes: solubility, stability, lipophilicity and binding to serum proteins

scientific article published on 25 July 2006

Preclinical evaluation of dichlorobis(1-phenylbutane-1,3-dionato)titanium (IV) and budotitane. Two representatives of the new class of antitumor-active bis-beta-diketonato metal complexes

artículo científico publicado en 1986

Preclinical evaluation of diethoxy-(1-phenyl-1,3-butanedionato) titanium (IV) in human tumour xenografts

artículo científico publicado en 1984

Preclinical toxicology and tissue gallium distribution of a novel antitumour gallium compound: tris (8-quinolinolato) gallium (III).

artículo científico publicado en 1996

Preparation and characterization of immobilized [A336][MTBA] in PVA-alginate gel beads as novel solid-phase extractants for an efficient recovery of Hg (II) from aqueous solutions.

artículo científico publicado en 2011

Preparation and first evaluation of [(18)F]FE@SUPPY: a new PET tracer for the adenosine A(3) receptor.

artículo científico publicado en 2008

Probing the stability of serum protein–ruthenium(III) drug adducts in the presence of extracellular reductants using CE

artículo científico publicado en 2007

Protein-binding Properties of two Antitumour Ru(III) Complexes to Human Apotransferrin and Apolactoferrin

artículo científico publicado en 1994

Quantitative bioimaging by LA-ICP-MS: a methodological study on the distribution of Pt and Ru in viscera originating from cisplatin- and KP1339-treated mice.

artículo científico publicado en 2014

Rational development of oxaliplatin analogues --synthesis and preliminary structure-activity relationships

artículo científico publicado en 2005

Reaction monitoring of platinum(II) complex--5'-guanosine monophosphate adduct formation by ion exchange liquid chromatography/electrospray ionization mass spectrometry

artículo científico publicado en 2001

Recent developments in the field of tumor-inhibiting metal complexes.

artículo científico publicado en 2003

Redox behavior of tumor-inhibiting ruthenium(iii) complexes and effects of physiological reductants on their binding to GMP

scientific article published on 11 January 2006

Redox-active antineoplastic ruthenium complexes with indazole: correlation of in vitro potency and reduction potential

artículo científico publicado en 2005

Relevance of peat-draining rivers for the riverine input of dissolved iron into the ocean

artículo científico publicado en 2010

Resistance against novel anticancer metal compounds: differences and similarities

artículo científico publicado en 2008

Response Profiling Using Shotgun Proteomics Enables Global Metallodrug Mechanisms of Action To Be Established.

artículo científico publicado en 2016

Reversion of Structure-Activity Relationships of Antitumor Platinum Complexes by Acetoxime but Not Hydroxylamine Ligands

scientific article published on 18 October 2006

Rhodium(I) N-Heterocyclic Carbene Bioorganometallics as in Vitro Antiproliferative Agents with Distinct Effects on Cellular Signaling

artículo científico publicado en 2015

Ribonucleotide reductase as one important target of [Tris(1,10-phenanthroline)lanthanum(III)] trithiocyanate (KP772).

artículo científico publicado en 2009

River-derived humic substances as iron chelators in seawater

artículo científico publicado en 2015

Ruthenium versus platinum: interactions of anticancer metallodrugs with duplex oligonucleotides characterised by electrospray ionisation mass spectrometry

artículo científico publicado en 2010

Ruthenium(II)-arene complexes with functionalized pyridines: synthesis, characterization and cytotoxic activity.

artículo científico publicado en 2009

Ruthenium- and osmium-arene-based paullones bearing a TEMPO free-radical unit as potential anticancer drugs.

artículo científico publicado en 2012

RutheniumII(η6-arene) complexes of thiourea derivatives: synthesis, characterization and urease inhibition

artículo científico publicado en 2014

Ruthenium− and Osmium−Arene Complexes of 2-Substituted Indolo[3,2-c]quinolines: Synthesis, Structure, Spectroscopic Properties, and Antiproliferative Activity ⬇️

artículo científico publicado el 27 de diciembre de 2010

Searching for the magic bullet: anticancer platinum drugs which can be accumulated or activated in the tumor tissue

artículo científico publicado en 2007

Self-assembled Pt2L2 boxes strongly bind G-quadruplex DNA and influence gene expression in cancer cells

artículo científico publicado en 2016

Sensitivity of rodent osteosarcoma clones to platinum-containing phosphonic acid complexes in vitro

artículo científico publicado en 1990

Solid-phase synthesis of oxaliplatin-TAT peptide bioconjugates.

artículo científico publicado en 2012

Solution equilibria and antitumor activities of pentamethylcyclopentadienyl rhodium complexes of picolinic acid and deferiprone

scholarly article by Éva A. Enyedy et al published April 2015 in Journal of Coordination Chemistry

Solution equilibria of anticancer ruthenium(II)-(η(6)-p-cymene)-hydroxy(thio)pyr(id)one complexes: impact of sulfur vs. oxygen donor systems on the speciation and bioactivity

artículo científico publicado en 2013

Solvolysis of the Tumor-Inhibiting Ru(III)-Complex trans-Tetrachlorobis(Indazole)Ruthenate(III).

artículo científico publicado en 2000

Speciation of metal-based nanomaterials in human serum characterized by capillary electrophoresis coupled to ICP-MS: a case study of gold nanoparticles.

artículo científico publicado en 2015

Sphagnum-dominated bog systems are highly effective yet variable sources of bio-available iron to marine waters

artículo científico publicado en 2016

Strategies for the covalent conjugation of a bifunctional chelating agent to albumin: synthesis and characterization of potential MRI contrast agents

scientific article published on 05 November 2010

Structure-activity relationships for NAMI-A-type complexes (HL)[trans-RuCl4L(S-dmso)ruthenate(III)] (L = imidazole, indazole, 1,2,4-triazole, 4-amino-1,2,4-triazole, and 1-methyl-1,2,4-triazole): aquation, redox properties, protein binding, and anti

artículo científico publicado en 2007

Structure-activity relationships for ruthenium and osmium anticancer agents - towards clinical development

artículo científico publicado en 2017

Structure-activity relationships of highly cytotoxic copper(II) complexes with modified indolo[3,2-c]quinoline ligands.

artículo científico publicado en 2010

Structure-activity relationships of targeted RuII(η6-p-cymene) anticancer complexes with flavonol-derived ligands

artículo científico publicado en 2012

Studies of KP46 and KP1019 and the Hydrolysis Product of KP1019 in Lipiodol Emulsions: Preparation and Initial Characterizations as Potential Theragnostic Agents

artículo científico publicado en 2016

Studies on the interactions between human serum albumin and imidazolium [trans-tetrachlorobis(imidazol)ruthenate(III)].

artículo científico publicado en 1999

Studies on the interactions between human serum albumin and trans-indazolium (bisindazole) tetrachlororuthenate(III).

artículo científico publicado en 2000

Studies on the reactivity of organometallic Ru-, Rh- and Os-pta complexes with DNA model compounds

artículo científico publicado en 2007

Subcellular Duplex DNA and G-Quadruplex Interaction Profiling of a Hexagonal PtII Metallacycle

artículo científico publicado en 2019

Synergistic antitumor interactions between newly synthesized ruthenium complexes and cytokines in human colon carcinoma cell lines

artículo científico publicado en 1992

Synthesis and Characterization of New Ethylenediamine Platinum(IV) Complexes Containing Lipophilic Carboxylate Ligands

artículo científico publicado en 1995

Synthesis and antitumor activity of triazolium-bis(triazole)-tetrachlororuthenate (III) and bistriazolium-triazolepentachlororuthenate (III). Two representatives of a new class of inorganic antitumor agents

artículo científico publicado en 1987

Synthesis and biological studies of some gold(I) complexes containing functionalised alkynes

artículo científico publicado en 2009

Synthesis and characterization of novel bis(carboxylato)dichloridobis(ethylamine)platinum(IV) complexes with higher cytotoxicity than cisplatin

artículo científico publicado en 2011

Synthesis and in vitro antitumor potency of (cyclohexane-1,2-diamine)platinum(II) complexes with aminotris(methylenephosphonic acid) as bone-seeking ligand

artículo científico publicado en 2005

Synthesis and reactivity of the aquation product of the antitumor complex trans-[Ru(III)Cl4(indazole)2]-.

artículo científico publicado en 2008

Synthesis and structure-activity relationships of mono- and dialkyl-substituted oxaliplatin derivatives

artículo científico publicado en 2005

Synthesis and structures of novel 1-methylcytosinato-bridged (ethylenediamine)platinum(II) and platinum(III) dinuclear complexes

artículo científico publicado en 2010

Synthesis of (N,N'-Bis(2-Hydroxyethyl)Ethane-1,2-Diamine)Malonatoplatinum(II) and X-Ray Crystal Structure of the Cis-R,S-Isomer

artículo científico publicado en 2000

Synthesis of ferrocenylglucose phosphonite and bisphosphinite: Pd(II) and Pt(II) complexes, Pd-catalyzed allylic alkylation

Synthesis, Characterization and Molecular Structures of some Bismuth(III) Complexes with Thiosemicarbazones and Dithiocarbazonic Acid Methylester Derivatives with Activity against Helicobacter Pylori

artículo científico publicado en 1995

Synthesis, Characterization and Solution Chemistry of trans-Indazoliumtetrachlorobis(Indazole)Ruthenate(III), a New Anticancer Ruthenium Complex. IR, UV, NMR, HPLC Investigations and Antitumor Activity. Crystal Structures of trans-1-Methyl-Indazoliu

artículo científico publicado en 1996

Synthesis, Modification, and Biological Evaluation of a Library of Novel Water-Soluble Thiopyridone-Based Organometallic Complexes and Their Unexpected (Biological) Behavior

scientific article published on 20 January 2020

Synthesis, X-ray diffraction structure, spectroscopic properties and antiproliferative activity of a novel ruthenium complex with constitutional similarity to cisplatin.

artículo científico publicado en 2009

Synthesis, X-ray diffraction structures, spectroscopic properties, and in vitro antitumor activity of isomeric (1H-1,2,4-triazole)Ru(III) complexes.

artículo científico publicado en 2003

Synthesis, characterization, and cytotoxic activity of novel potentially pH-sensitive nonclassical platinum(II) complexes featuring 1,3-dihydroxyacetone oxime ligands.

artículo científico publicado en 2011

Synthesis, characterization, and in vitro antitumor activity of osteotropic diam(m)ineplatinum(II) complexes bearing a N,N-bis(phosphonomethyl)glycine ligand

artículo científico publicado en 2003

Synthesis, crystal structure and cytotoxicity of new oxaliplatin analogues indicating that improvement of anticancer activity is still possible.

artículo científico publicado en 2004

Synthesis, structure, spectroscopic and in vitro antitumour studies of a novel gallium(III) complex with 2-acetylpyridine (4)N-dimethylthiosemicarbazone.

artículo científico publicado en 2002

Synthesis, structure, spectroscopic properties, and antiproliferative activity in vitro of novel osmium(III) complexes with azole heterocycles.

artículo científico publicado en 2008

Synthesis, structures and in vitro cytotoxicity of some cationic cis-platinum(II) complexes containing chelating thiocarbamates

scientific article published on 31 August 2010

Synthesis, structures and in vitro cytotoxicity of some platinum(II) complexes containing thiocarbamate esters

artículo científico publicado en 2008

Synthetic iron complexes as models for natural iron-humic compounds: Synthesis, characterization and algal growth experiments

artículo científico publicado en 2016

Target profiling of an antimetastatic RAPTA agent by chemical proteomics: relevance to the mode of action

artículo científico publicado en 2015

Targeting a Targeted Drug: An Approach Toward Hypoxia-Activatable Tyrosine Kinase Inhibitor Prodrugs.

artículo científico publicado en 2016

Targeting the DNA-topoisomerase complex in a double-strike approach with a topoisomerase inhibiting moiety and covalent DNA binder.

artículo científico publicado en 2012

Task-specific thioglycolate ionic liquids for heavy metal extraction: Synthesis, extraction efficacies and recycling properties.

artículo científico publicado en 2016

Tetracarboxylatoplatinum(IV) complexes featuring monodentate leaving groups - A rational approach toward exploiting the platinum(IV) prodrug strategy

artículo científico publicado en 2015

The First Anticancer Tris(pyrazolyl)borate Molybdenum(IV) Complexes: Tested in Vitro and in Vivo-A Comparison of O,O-, S,O-, and N,N-Chelate Effects

artículo científico publicado en 2019

The biochemical role of the heat shock protein 90 chaperone complex in establishing human telomerase activity.

artículo científico publicado en 2006

The effect of cytoprotective agents in platinum anticancer therapy.

artículo científico publicado en 2004

The effect of formaldehyde solution in the gas chromatographic determination of morphine

artículo científico publicado en 1980

The first example of MEEKC-ICP-MS coupling and its application for the analysis of anticancer platinum complexes

artículo científico publicado en 2010

The first metal-based paullone derivative with high antiproliferative activity in vitro.

artículo científico publicado en 2006

The first ruthenium-based paullones: syntheses, X-ray diffraction structures, and spectroscopic and antiproliferative properties in vitro

artículo científico publicado en 2007

The gallium complex KP46 exerts strong activity against primary explanted melanoma cells and induces apoptosis in melanoma cell lines

artículo científico publicado en 2009

The heterocyclic ruthenium(III) complex KP1019 (FFC14A) causes DNA damage and oxidative stress in colorectal tumor cells.

artículo científico publicado en 2005

The hydration of chloroacetonitriles catalyzed by mono- and dinuclear Ru(II)- and Os(II)-arene complexes.

artículo científico publicado en 2008

The influence of electroporation on cytotoxicity of anticancer ruthenium(III) complex KP1339 in vitro and in vivo.

artículo científico publicado en 2010

The role of the equatorial ligands for the redox behavior, mode of cellular accumulation and cytotoxicity of platinum(IV) prodrugs.

artículo científico publicado en 2016

The ruthenium compound KP1339 potentiates the anticancer activity of sorafenib in vitro and in vivo

artículo científico publicado en 2013

Theoretical investigations and density functional theory based quantitative structure-activity relationships model for novel cytotoxic platinum(IV) complexes

artículo científico publicado en 2012

Therapeutic efficacy of two different cytostatic-linked phosphonates in combination with razoxane in the transplantable osteosarcoma of the rat

artículo científico publicado en 1990

Thiomaltol-Based Organometallic Complexes with 1-Methylimidazole as Leaving Group: Synthesis, Stability, and Biological Behavior.

artículo científico publicado en 2016

Three-dimensional and co-culture models for preclinical evaluation of metal-based anticancer drugs.

artículo científico publicado en 2015

Time-dependent interactions of platinum(II) complexes with 5'-GMP under simulated physiological conditions studies by capillary electrophoresis.

artículo científico publicado en 2000

Total mercury in sediments, macrophytes, and fish from a shallow steppe lake in eastern Austria

artículo científico publicado en 2014

Toward high-throughput monitoring of metallodrug-protein interaction using capillary electrophoresis in chemically modified capillaries

artículo científico publicado en 2008

Towards targeting anticancer drugs: ruthenium(ii)-arene complexes with biologically active naphthoquinone-derived ligand systems.

artículo científico publicado en 2016

Transferring the concept of multinuclearity to ruthenium complexes for improvement of anticancer activity

artículo científico publicado en 2009

Triapine and a more potent dimethyl derivative induce endoplasmic reticulum stress in cancer cells.

artículo científico publicado en 2013

Triapine-mediated ABCB1 induction via PKC induces widespread therapy unresponsiveness but is not underlying acquired triapine resistance.

artículo científico publicado en 2015

Tumor microenvironment in focus: LA-ICP-MS bioimaging of a preclinical tumor model upon treatment with platinum(IV)-based anticancer agents.

artículo científico publicado en 2015

Tumor-inhibiting platinum(II) complexes with aminoalcohol ligands: comparison of the mode of action by capillary electrophoresis and electrospray ionization-mass spectrometry

artículo científico publicado en 2003

Tumorhemmende Metallverbindungen: Entwicklung, Bedeutung und Perspektiven

artículo científico publicado en 2006

Tumour-inhibiting platinum complexes--state of the art and future perspectives.

artículo científico publicado en 2003

Tumour-inhibiting platinum(II) complexes with aminoalcohol ligands: biologically important transformations studied by micellar electrokinetic chromatography, nuclear magnetic resonance spectroscopy and mass spectrometry

artículo científico publicado en 2005

Tuning of lipophilicity and cytotoxic potency by structural variation of anticancer platinum(IV) complexes

artículo científico publicado en 2010

Tuning of redox potentials for the design of ruthenium anticancer drugs -- an electrochemical study of [trans-RuCl(4)L(DMSO)](-) and [trans-RuCl(4)L(2)](-) complexes, where L = imidazole, 1,2,4-triazole, indazole.

artículo científico publicado en 2004

Tuning of redox properties for the design of ruthenium anticancer drugs: part 2. Syntheses, crystal structures, and electrochemistry of potentially antitumor [Ru III/II Cl6-n(Azole)n]z(n = 3, 4, 6) complexes.

artículo científico publicado en 2005

Tuning the hydrophobicity of ruthenium(II)-arene (RAPTA) drugs to modify uptake, biomolecular interactions and efficacy

artículo científico publicado en 2007

Two new "onium" fluorosilicates, the products of interaction of fluorosilicic acid with 12-membered macrocycles: structures and spectroscopic properties

artículo científico publicado en 2007

Unprecedented twofold intramolecular hydroamination in diam(m)ine-dicarboxylatodichloridoplatinum(IV) complexes - ethane-1,2-diamine vs. ammine ligands.

artículo científico publicado en 2008

Unsymmetric mono- and dinuclear platinum(IV) complexes featuring an ethylene glycol moiety: synthesis, characterization, and biological activity

artículo científico publicado en 2012

Update of the preclinical situation of anticancer platinum complexes: novel design strategies and innovative analytical approaches

artículo científico publicado en 2005

Vanadium(IV/V) complexes of Triapine and related thiosemicarbazones: Synthesis, solution equilibrium and bioactivity

artículo científico publicado en 2015

Water-soluble cationic derivatives of indirubin, the active anticancer component from Indigo naturalis

artículo científico publicado en 2012

X-ray Structure Analysis of Indazolium trans-[Tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019) Bound to Human Serum Albumin Reveals Two Ruthenium Binding Sites and Provides Insights into the Drug Binding Mechanism.

artículo científico publicado en 2016

X-ray absorption near edge structure spectroscopy to resolve the in vivo chemistry of the redox-active indazolium trans-[Tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019).

artículo científico publicado en 2013

X-ray absorption spectroscopy of an investigational anticancer gallium(III) drug: interaction with serum proteins, elemental distribution pattern, and coordination of the compound in tissue

artículo científico publicado en 2012

[Os(IV)Cl(5)(Hazole)](-) complexes: synthesis, structure, spectroscopic properties, and antiproliferative activity

artículo científico publicado en 2009

ortho-Quinone tanshinones directly inhibit telomerase through an oxidative mechanism mediated by hydrogen peroxide

artículo científico publicado en 2011

p53 increases intra-cellular calcium release by transcriptional regulation of calcium channel TRPC6 in GaQ3-treated cancer cells

artículo científico publicado en 2013

{(1R,2R,4R)-4-methyl-1,2-cyclohexanediamine}oxalatoplatinum(II): a novel enantiomerically pure oxaliplatin derivative showing improved anticancer activity in vivo

artículo científico publicado en 2010

α-N-Heterocyclic thiosemicarbazones induce ER stress-mediated CHOP activation.

artículo científico publicado en 2010

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