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Lista de obras de James R. Brown

Airway host-microbiome interactions in chronic obstructive pulmonary disease.

artículo científico publicado en 2019

Bacterial resistance to leucyl-tRNA synthetase inhibitor GSK2251052 develops during treatment of complicated urinary tract infections.

artículo científico publicado en 2014

Comparative genomics of Klebsiella pneumoniae strains with different antibiotic resistance profiles

artículo científico publicado en 2011

Computational biology approaches for selecting host–pathogen drug targets ⬇️

artículo científico publicado el 28 de enero de 2011

Computational biology in anti-tuberculosis drug discovery.

scientific article published on June 2009

Expanding the drug discovery space with predicted metabolite-target interactions

artículo científico publicado en 2021

Gut microbiome differences between metformin- and liraglutide-treated T2DM subjects

artículo científico publicado en 2017

HIV-1 transmission patterns in antiretroviral therapy-naïve, HIV-infected North Americans based on phylogenetic analysis by population level and ultra-deep DNA sequencing

artículo científico publicado en 2014

Host response to respiratory bacterial pathogens as identified by integrated analysis of human gene expression data

artículo científico publicado en 2013

Human microbial metabolites as a source of new drugs.

artículo científico publicado en 2016

Longitudinal profiling of the lung microbiome in the AERIS study demonstrates repeatability of bacterial and eosinophilic COPD exacerbations

artículo científico publicado en 2018

Meta-analysis of human gene expression in response to Mycobacterium tuberculosis infection reveals potential therapeutic targets.

artículo científico publicado en 2018

Microbiome Metabolite Mimics Accelerate Drug Discovery

scientific article published on 03 April 2020

Microbiome changes in healthy volunteers treated with GSK1322322, a novel antibiotic targeting bacterial peptide deformylase

artículo científico publicado en 2014

Minipig and beagle animal model genomes aid species selection in pharmaceutical discovery and development

artículo científico publicado en 2013

Modulating the human gut microbiome as an emerging therapeutic paradigm

artículo científico

Multi-omic meta-analysis identifies functional signatures of airway microbiome in chronic obstructive pulmonary disease

artículo científico publicado en 2020

New compound sets identified from high throughput phenotypic screening against three kinetoplastid parasites: an open resource.

artículo científico publicado en 2015

Novel Role for Protein Inhibitor of Activated STAT 4 (PIAS4) in the Restriction of Herpes Simplex Virus 1 by the Cellular Intrinsic Antiviral Immune Response

artículo científico publicado en 2016

Novel gut-based pharmacology of metformin in patients with type 2 diabetes mellitus.

artículo científico publicado en 2014

Obesity and disease severity magnify disturbed microbiome-immune interactions in asthma patients

scientific article published on 13 December 2019

PICRUSt2 for prediction of metagenome functions

artículo científico publicado en 2020

Phylogenomics of phosphoinositide lipid kinases: perspectives on the evolution of second messenger signaling and drug discovery ⬇️

artículo científico publicado el 5 de enero de 2011

Release of 50 new, drug-like compounds and their computational target predictions for open source anti-tubercular drug discovery

artículo científico publicado en 2015

SUMO Ligase Protein Inhibitor of Activated STAT1 (PIAS1) Is a Constituent Promyelocytic Leukemia Nuclear Body Protein That Contributes to the Intrinsic Antiviral Immune Response to Herpes Simplex Virus 1.

artículo científico publicado en 2016

Selective Spectrum Antibiotic Modulation of the Gut Microbiome in Obesity and Diabetes Rodent Models

artículo científico publicado en 2015

Shared Molecular Signatures Across Neurodegenerative Diseases and Herpes Virus Infections Highlights Potential Mechanisms for Maladaptive Innate Immune Responses.

artículo científico publicado en 2019

Sputum microbiome temporal variability and dysbiosis in chronic obstructive pulmonary disease exacerbations: an analysis of the COPDMAP study.

artículo científico publicado en 2017

T Cell- and Monocyte-Specific RNA-Sequencing Analysis in Septic and Nonseptic Critically Ill Patients and in Patients with Cancer

scientific article published on 04 September 2019

Target prediction for an open access set of compounds active against Mycobacterium tuberculosis

artículo científico publicado en 2013

The Microbiome Factor in Drug Discovery and Development

artículo científico publicado en 2019

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