Lista de obras - Gary B. Evans - Dominio Público Uruguay

(4aR,6aS,10aR,10bS)-7,7,10a-Trimethyl-1,4,4a,5,6,6a,7,8,9,10,10a,10b-dodecahydro-2H-naphtho-[2,1-c]pyran (Pyamber). ⬇️

artículo científico publicado en 2011

3-Bromo-7-methoxy-2-(tetrahydropyran-2-yl)pyrazolo[4,3-d]pyrimidine

7-(5-Methyl-sulfanyl-β-d-erythrofuran-osyl)-7H-pyrrolo-[2,3-d]pyrimidin-4-amine monohydrate (MT-tubercidin·H(2)O).

artículo científico publicado en 2010

8-Aza-immucillins as transition-state analogue inhibitors of purine nucleoside phosphorylase and nucleoside hydrolases

artículo científico publicado en 2003

A Designed Approach to Enantiodivergent Enamine Catalysis

artículo científico publicado en 2017

A Picomolar Transition State Analogue Inhibitor of MTAN as a Specific Antibiotic for Helicobacter pylori

artículo científico publicado en 2012

A practical synthesis of (3R,4R)-N-tert-butoxycarbonyl-4-hydroxymethylpyrrolidin-3-ol

artículo científico publicado en 2007

A single point mutation converts a glutaryl-7-aminocephalosporanic acid acylase into an N-acyl-homoserine lactone acylase

artículo científico publicado en 2021

Achieving the ultimate physiological goal in transition state analogue inhibitors for purine nucleoside phosphorylase

artículo científico publicado en 2003

Acyclic Ribooxacarbenium Ion Mimics as Transition State Analogues of Human and Malarial Purine Nucleoside Phosphorylases

artículo científico publicado en 2007

Acyclic phosph(on)ate inhibitors of Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase

artículo científico publicado en 2013

Addition of lithiated 9-deazapurine derivatives to a carbohydrate cyclic imine: convergent synthesis of the aza-C-nucleoside immucillins.

artículo científico publicado en 2001

Altered enthalpy-entropy compensation in picomolar transition state analogues of human purine nucleoside phosphorylase

artículo científico publicado en 2009

Association of HPA axis-related genetic variation with stress reactivity and aggressive behaviour in pigs

artículo científico publicado en 2010

Atomic dissection of the hydrogen bond network for transition-state analogue binding to purine nucleoside phosphorylase

artículo científico publicado en 2002

Azetidine based transition state analogue inhibitors of N-ribosyl hydrolases and phosphorylases

artículo científico publicado en 2008

Bifunctional chiral auxiliaries 6: Alkylations of enolates derived from 1,3-diacylimidazolidine- 2-thiones and 1,3-diacylimidazolidin-2-ones

Biofilm Inhibition via Delivery of Novel Methylthioadenosine Nucleosidase Inhibitors from PVA-Tyramine Hydrogels while Supporting Mesenchymal Stromal Cell Viability

artículo científico publicado en 2018

Bis[(1S)-1,4-azanediyl-1-(9-deazaadenin-9-yl)-1,4-dideoxy-5-methylsulfanyl-D-ribitol] tetrakis(hydrochloride) monohydrate: structure, DFT energy and ligand docking results of a potent methylthioadenosine phosphorylase inhibitor found in different mo

artículo científico publicado en 2010

Book Review of Antisense Drug Technology: Principles, Strategies, and Applications. Second Edition Antisense Drug Technology: Principles, Strategies, and Applications. Second Edition. Edited by Stanley T. Crooke. CRC Press and Taylor & Francis Group

artículo científico publicado en 2008

Concomitant bromination and lactolisation of unsaturated diols with sodium bromite in aqueous acetic acid

Conformational states of human purine nucleoside phosphorylase at rest, at work, and with transition state analogues

artículo científico publicado en 2010

Corrigendum to “Synthesis and utility of sulfated chromogenic carbohydrate model substrates for measuring activities of mucin-desulfating enzymes”

scholarly article published in Carbohydrate Research

Design and synthesis of potent "sulfur-free" transition state analogue inhibitors of 5'-methylthioadenosine nucleosidase and 5'-methylthioadenosine phosphorylase

artículo científico publicado en 2010

Differential mRNA expression of genes in the porcine adrenal gland associated with psychosocial stress.

artículo científico publicado en 2011

Distortional binding of transition state analogs to human purine nucleoside phosphorylase probed by magic angle spinning solid-state NMR.

artículo científico publicado en 2013

E-cadherin-deficient cells have synthetic lethal vulnerabilities in plasma membrane organisation, dynamics and function

artículo científico publicado en 2018

Energetic mapping of transition state analogue interactions with human and Plasmodium falciparum purine nucleoside phosphorylases.

artículo científico

Entropy-driven binding of picomolar transition state analogue inhibitors to human 5'-methylthioadenosine phosphorylase.

artículo científico publicado en 2011

Exploring structure-activity relationships of transition state analogues of human purine nucleoside phosphorylase.

artículo científico publicado en 2003

Femtomolar inhibitors bind to 5'-methylthioadenosine nucleosidases with favorable enthalpy and entropy.

artículo científico publicado en 2012

Femtomolar transition state analogue inhibitors of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Escherichia coli

artículo científico

Four generations of transition-state analogues for human purine nucleoside phosphorylase.

artículo científico publicado en 2010

Growth and metastases of human lung cancer are inhibited in mouse xenografts by a transition state analogue of 5'-methylthioadenosine phosphorylase.

artículo científico publicado en 2010

Imino-C-nucleoside synthesis: heteroaryl lithium carbanion additions to a carbohydrate cyclic imine and nitrone

artículo científico publicado en 2004

Iminoribitol Transition State Analogue Inhibitors of Protozoan Nucleoside Hydrolases†

article

Immucillins ImmA and ImmH Are Effective and Non-toxic in the Treatment of Experimental Visceral Leishmaniasis

artículo científico publicado en 2015

Immucillins Impair Leishmania (L.) infantum chagasi and Leishmania (L.) amazonensis Multiplication In Vitro

artículo científico publicado en 2015

Immucillins in Infectious Diseases

artículo científico publicado en 2017

Inhibition and Structure of Toxoplasma gondii Purine Nucleoside Phosphorylase

artículo científico publicado en 2014

Inhibition and Structure of Trichomonas vaginalis Purine Nucleoside Phosphorylase with Picomolar Transition State Analogues †

artículo científico publicado en 2007

Inhibition of ricin A-chain with pyrrolidine mimics of the oxacarbenium ion transition state.

artículo científico publicado en 2004

Inhibitors of ADP-ribosylating bacterial toxins based on oxacarbenium ion character at their transition states

artículo científico publicado en 2004

Intracellular complexities of acquiring a new enzymatic function revealed by mass-randomisation of active site residues

artículo científico publicado en 2020

Ionic states of substrates and transition state analogues at the catalytic sites of N-ribosyltransferases

artículo científico publicado en 2003

Narrow-Spectrum Antibiotic Targeting of the Radical SAM Enzyme MqnE in Menaquinone Biosynthesis

artículo científico publicado en 2020

Neutron structures of the Helicobacter pylori 5'-methylthioadenosine nucleosidase highlight proton sharing and protonation states

artículo científico publicado en 2016

New Antibiotic Candidates against Helicobacter pylori

artículo científico publicado en 2015

Oligonucleotide transition state analogues of saporin L3.

artículo científico publicado en 2016

Over-the-barrier transition state analogues and crystal structure with Mycobacterium tuberculosis purine nucleoside phosphorylase

artículo científico publicado en 2003

Picomolar inhibitors as transition-state probes of 5'-methylthioadenosine nucleosidases

artículo científico publicado en 2007

Picomolar transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase and X-ray structure with MT-immucillin-A

artículo científico publicado en 2004

Plasmodium falciparum parasites are killed by a transition state analogue of purine nucleoside phosphorylase in a primate animal model

artículo científico publicado en 2011

Plasmodium falciparum purine nucleoside phosphorylase: crystal structures, immucillin inhibitors, and dual catalytic function

artículo científico publicado en 2004

Potentiation of methicillin activity against methicillin-resistant Staphylococcus aureus by diterpenes

scholarly article by K Nicolson published in October 1999

Primordial-like enzymes from bacteria with reduced genomes

artículo científico publicado en 2017

Purine-less death in Plasmodium falciparum induced by immucillin-H, a transition state analogue of purine nucleoside phosphorylase

artículo científico publicado en 2001

Quorum Sensing Controls Adaptive Immunity through the Regulation of Multiple CRISPR-Cas Systems

artículo científico publicado en 2016

Salmonella enterica MTAN at 1.36 Å Resolution: A Structure-Based Design of Tailored Transition State Analogs

artículo científico publicado en 2013

Second generation transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase

artículo científico

Selective Inhibitors of Helicobacter pylori Methylthioadenosine Nucleosidase and Human Methylthioadenosine Phosphorylase

artículo científico publicado en 2019

Structural rationale for the affinity of pico- and femtomolar transition state analogues of Escherichia coli 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase

artículo científico

Structure and inhibition of a quorum sensing target from Streptococcus pneumoniae

artículo científico publicado en 2006

Syntheses and bio-activities of the L-enantiomers of two potent transition state analogue inhibitors of purine nucleoside phosphorylases

artículo científico publicado en 2006

Synthesis and utility of sulfated chromogenic carbohydrate model substrates for measuring activities of mucin-desulfating enzymes

artículo científico publicado en 2002

Synthesis of Transition State Analogue Inhibitors for Purine Nucleoside Phosphorylase and N-Riboside Hydrolases

Synthesis of a Transition State Analogue Inhibitor of Purine Nucleoside Phosphorylase via the Mannich Reaction

artículo científico publicado en 2003

Synthesis of bis-Phosphate Iminoaltritol Enantiomers and Structural Characterization with Adenine Phosphoribosyltransferase

artículo científico publicado en 2017

Synthesis of second-generation transition state analogues of human purine nucleoside phosphorylase

artículo científico publicado en 2003

Targeting a novel Plasmodium falciparum purine recycling pathway with specific immucillins

artículo científico publicado en 2005

Targeting the polyamine pathway with transition-state analogue inhibitors of 5'-methylthioadenosine phosphorylase

artículo científico publicado en 2004

The Immucillins: Design, Synthesis and Application of Transition- State Analogues.

artículo científico

The Synthesis ofN-Ribosyl Transferase Inhibitors Based on a Transition State Blueprint

The synthesis and antibacterial activity of totarol derivatives. Part 1: modifications of ring-C and pro-drugs

artículo científico publicado en 1999

The synthesis and antibacterial activity of totarol derivatives. Part 2: Modifications at C-12 and O-13.

artículo científico publicado en 2000

The synthesis and antibacterial activity of totarol derivatives. Part 3: Modification of ring-B.

artículo científico publicado en 2000

The synthesis of possible transition state analogue inhibitors of thymidine phosphorylase

The transition to magic bullets – transition state analogue drug design

scientific article published on 28 August 2018

Thermodynamic analysis of transition-state features in picomolar inhibitors of human 5'-methylthioadenosine phosphorylase

artículo científico publicado en 2013

Third-generation immucillins: syntheses and bioactivities of acyclic immucillin inhibitors of human purine nucleoside phosphorylase

artículo científico publicado en 2009

Tight binding enantiomers of pre-clinical drug candidates

artículo científico publicado en 2015

Transcriptional responses of PBMC in psychosocially stressed animals indicate an alerting of the immune system in female but not in castrated male pigs.

artículo científico publicado en 2014

Transition State Analogue Inhibitors of 5'-Deoxyadenosine/5'-Methylthioadenosine Nucleosidase from Mycobacterium tuberculosis

artículo científico publicado en 2017

Transition State Analogues Enhanced by Fragment-Based Structural Analysis: Bacterial Methylthioadenosine Nucleosidases

artículo científico publicado en 2020

Transition state analogue discrimination by related purine nucleoside phosphorylases

artículo científico publicado en 2006

Transition state analogue inhibitors of N-ribosyltransferases: new drugs by targeting nucleoside processing enzymes

artículo científico publicado en 2007

Transition state analogue inhibitors of human methylthioadenosine phosphorylase and bacterial methylthioadenosine/S-adenosylhomocysteine nucleosidase incorporating acyclic ribooxacarbenium ion mimics

artículo científico publicado en 2012

Transition state analogue inhibitors of purine nucleoside phosphorylase from Plasmodium falciparum

artículo científico publicado en 2001

Transition state analogues in quorum sensing and SAM recycling

artículo científico publicado en 2008

Transition state analogues of Plasmodium falciparum and human orotate phosphoribosyltransferases

artículo científico publicado en 2013

Transition state analogues rescue ribosomes from saporin-L1 ribosome inactivating protein

artículo científico publicado en 2009

Transition-State Analogues of Campylobacter jejuni 5'-Methylthioadenosine Nucleosidase

artículo científico publicado en 2018

Two-step Ligand Binding in a (βα)8 Barrel Enzyme: SUBSTRATE-BOUND STRUCTURES SHED NEW LIGHT ON THE CATALYTIC CYCLE OF HisA

artículo científico publicado en 2015

l -Enantiomers of Transition State Analogue Inhibitors Bound to Human Purine Nucleoside Phosphorylase

artículo científico publicado en 2008

Lista de obras de Gary B. Evans

(4aR,6aS,10aR,10bS)-7,7,10a-Trimethyl-1,4,4a,5,6,6a,7,8,9,10,10a,10b-dodecahydro-2H-naphtho-[2,1-c]pyran (Pyamber). ⬇️

3-Bromo-7-methoxy-2-(tetrahydropyran-2-yl)pyrazolo[4,3-d]pyrimidine

7-(5-Methyl-sulfanyl-β-d-erythrofuran-osyl)-7H-pyrrolo-[2,3-d]pyrimidin-4-amine monohydrate (MT-tubercidin·H(2)O).

8-Aza-immucillins as transition-state analogue inhibitors of purine nucleoside phosphorylase and nucleoside hydrolases

A Designed Approach to Enantiodivergent Enamine Catalysis

A Picomolar Transition State Analogue Inhibitor of MTAN as a Specific Antibiotic for Helicobacter pylori

A practical synthesis of (3R,4R)-N-tert-butoxycarbonyl-4-hydroxymethylpyrrolidin-3-ol

A single point mutation converts a glutaryl-7-aminocephalosporanic acid acylase into an N-acyl-homoserine lactone acylase

Achieving the ultimate physiological goal in transition state analogue inhibitors for purine nucleoside phosphorylase

Acyclic Ribooxacarbenium Ion Mimics as Transition State Analogues of Human and Malarial Purine Nucleoside Phosphorylases

Acyclic phosph(on)ate inhibitors of Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase

Addition of lithiated 9-deazapurine derivatives to a carbohydrate cyclic imine: convergent synthesis of the aza-C-nucleoside immucillins.

Altered enthalpy-entropy compensation in picomolar transition state analogues of human purine nucleoside phosphorylase

Association of HPA axis-related genetic variation with stress reactivity and aggressive behaviour in pigs

Atomic dissection of the hydrogen bond network for transition-state analogue binding to purine nucleoside phosphorylase

Azetidine based transition state analogue inhibitors of N-ribosyl hydrolases and phosphorylases

Bifunctional chiral auxiliaries 6: Alkylations of enolates derived from 1,3-diacylimidazolidine- 2-thiones and 1,3-diacylimidazolidin-2-ones

Biofilm Inhibition via Delivery of Novel Methylthioadenosine Nucleosidase Inhibitors from PVA-Tyramine Hydrogels while Supporting Mesenchymal Stromal Cell Viability

Bis[(1S)-1,4-azanediyl-1-(9-deazaadenin-9-yl)-1,4-dideoxy-5-methylsulfanyl-D-ribitol] tetrakis(hydrochloride) monohydrate: structure, DFT energy and ligand docking results of a potent methylthioadenosine phosphorylase inhibitor found in different mo

Book Review of Antisense Drug Technology: Principles, Strategies, and Applications. Second Edition Antisense Drug Technology: Principles, Strategies, and Applications. Second Edition. Edited by Stanley T. Crooke. CRC Press and Taylor & Francis Group

Concomitant bromination and lactolisation of unsaturated diols with sodium bromite in aqueous acetic acid

Conformational states of human purine nucleoside phosphorylase at rest, at work, and with transition state analogues

Corrigendum to “Synthesis and utility of sulfated chromogenic carbohydrate model substrates for measuring activities of mucin-desulfating enzymes”

Design and synthesis of potent "sulfur-free" transition state analogue inhibitors of 5'-methylthioadenosine nucleosidase and 5'-methylthioadenosine phosphorylase

Differential mRNA expression of genes in the porcine adrenal gland associated with psychosocial stress.

Distortional binding of transition state analogs to human purine nucleoside phosphorylase probed by magic angle spinning solid-state NMR.

E-cadherin-deficient cells have synthetic lethal vulnerabilities in plasma membrane organisation, dynamics and function

Energetic mapping of transition state analogue interactions with human and Plasmodium falciparum purine nucleoside phosphorylases.

Entropy-driven binding of picomolar transition state analogue inhibitors to human 5'-methylthioadenosine phosphorylase.

Exploring structure-activity relationships of transition state analogues of human purine nucleoside phosphorylase.

Femtomolar inhibitors bind to 5'-methylthioadenosine nucleosidases with favorable enthalpy and entropy.

Femtomolar transition state analogue inhibitors of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Escherichia coli

Four generations of transition-state analogues for human purine nucleoside phosphorylase.

Growth and metastases of human lung cancer are inhibited in mouse xenografts by a transition state analogue of 5'-methylthioadenosine phosphorylase.

Imino-C-nucleoside synthesis: heteroaryl lithium carbanion additions to a carbohydrate cyclic imine and nitrone

Iminoribitol Transition State Analogue Inhibitors of Protozoan Nucleoside Hydrolases†

Immucillins ImmA and ImmH Are Effective and Non-toxic in the Treatment of Experimental Visceral Leishmaniasis

Immucillins Impair Leishmania (L.) infantum chagasi and Leishmania (L.) amazonensis Multiplication In Vitro

Immucillins in Infectious Diseases

Inhibition and Structure of Toxoplasma gondii Purine Nucleoside Phosphorylase

Inhibition and Structure of Trichomonas vaginalis Purine Nucleoside Phosphorylase with Picomolar Transition State Analogues †

Inhibition of ricin A-chain with pyrrolidine mimics of the oxacarbenium ion transition state.

Inhibitors of ADP-ribosylating bacterial toxins based on oxacarbenium ion character at their transition states

Intracellular complexities of acquiring a new enzymatic function revealed by mass-randomisation of active site residues

Ionic states of substrates and transition state analogues at the catalytic sites of N-ribosyltransferases

Narrow-Spectrum Antibiotic Targeting of the Radical SAM Enzyme MqnE in Menaquinone Biosynthesis

Neutron structures of the Helicobacter pylori 5'-methylthioadenosine nucleosidase highlight proton sharing and protonation states

New Antibiotic Candidates against Helicobacter pylori

Oligonucleotide transition state analogues of saporin L3.

Over-the-barrier transition state analogues and crystal structure with Mycobacterium tuberculosis purine nucleoside phosphorylase

Picomolar inhibitors as transition-state probes of 5'-methylthioadenosine nucleosidases

Picomolar transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase and X-ray structure with MT-immucillin-A

Plasmodium falciparum parasites are killed by a transition state analogue of purine nucleoside phosphorylase in a primate animal model

Plasmodium falciparum purine nucleoside phosphorylase: crystal structures, immucillin inhibitors, and dual catalytic function

Potentiation of methicillin activity against methicillin-resistant Staphylococcus aureus by diterpenes

Primordial-like enzymes from bacteria with reduced genomes

Purine-less death in Plasmodium falciparum induced by immucillin-H, a transition state analogue of purine nucleoside phosphorylase

Quorum Sensing Controls Adaptive Immunity through the Regulation of Multiple CRISPR-Cas Systems

Salmonella enterica MTAN at 1.36 Å Resolution: A Structure-Based Design of Tailored Transition State Analogs

Second generation transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase

Selective Inhibitors of Helicobacter pylori Methylthioadenosine Nucleosidase and Human Methylthioadenosine Phosphorylase

Structural rationale for the affinity of pico- and femtomolar transition state analogues of Escherichia coli 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase

Structure and inhibition of a quorum sensing target from Streptococcus pneumoniae

Syntheses and bio-activities of the L-enantiomers of two potent transition state analogue inhibitors of purine nucleoside phosphorylases

Synthesis and utility of sulfated chromogenic carbohydrate model substrates for measuring activities of mucin-desulfating enzymes

Synthesis of Transition State Analogue Inhibitors for Purine Nucleoside Phosphorylase and N-Riboside Hydrolases

Synthesis of a Transition State Analogue Inhibitor of Purine Nucleoside Phosphorylase via the Mannich Reaction

Synthesis of bis-Phosphate Iminoaltritol Enantiomers and Structural Characterization with Adenine Phosphoribosyltransferase

Synthesis of second-generation transition state analogues of human purine nucleoside phosphorylase

Targeting a novel Plasmodium falciparum purine recycling pathway with specific immucillins

Targeting the polyamine pathway with transition-state analogue inhibitors of 5'-methylthioadenosine phosphorylase

The Immucillins: Design, Synthesis and Application of Transition- State Analogues.

The Synthesis ofN-Ribosyl Transferase Inhibitors Based on a Transition State Blueprint

The synthesis and antibacterial activity of totarol derivatives. Part 1: modifications of ring-C and pro-drugs

The synthesis and antibacterial activity of totarol derivatives. Part 2: Modifications at C-12 and O-13.

The synthesis and antibacterial activity of totarol derivatives. Part 3: Modification of ring-B.

The synthesis of possible transition state analogue inhibitors of thymidine phosphorylase

The transition to magic bullets – transition state analogue drug design

Thermodynamic analysis of transition-state features in picomolar inhibitors of human 5'-methylthioadenosine phosphorylase