Lista de obras - Rob Hooft van Huijsduijnen

12/15-lipoxygenase-derived lipid peroxides control receptor tyrosine kinase signaling through oxidation of protein tyrosine phosphatases

artículo científico publicado en 2010

A Phase II pilot trial to evaluate safety and efficacy of ferroquine against early Plasmodium falciparum in an induced blood-stage malaria infection study

scientific article published on 13 September 2016

A discovery and development roadmap for new endectocidal transmission-blocking agents in malaria

article

An NF kappa B-like factor is essential but not sufficient for cytokine induction of endothelial leukocyte adhesion molecule 1 (ELAM-1) gene transcription

artículo científico publicado en 1991

Anticancer properties of distinct antimalarial drug classes

artículo científico publicado en 2013

Applying the SPOT peptide synthesis procedure to the study of protein tyrosine phosphatase substrate specificity: probing for the heavenly match in vitro

artículo científico publicado en 2005

Both Intrinsic Substrate Preference and Network Context Contribute to Substrate Selection of Classical Tyrosine Phosphatases

artículo científico publicado en 2017

Characterization of protein tyrosine phosphatase H1 knockout mice in animal models of local and systemic inflammation

artículo científico publicado en 2010

Characterization of three highly purified influenza virus strains by electron microscopy

artículo científico publicado en 1984

Chemical inducers and transcriptional markers of oligodendrocyte differentiation

artículo científico publicado en 2010

Commonly used cat reporter vectors contain a cAMP-inducible, cryptic enhancer that co-operates with NF-kappa B-sites

artículo científico publicado en 1994

Convergent functional genomics of oligodendrocyte differentiation identifies multiple autoinhibitory signaling circuits

scientific journal article

DNA-methylation of the E-selectin promoter represses NF-kappa B transactivation

artículo científico publicado en 1993

Decompartmentalizing target validation-thinking outside the pipeline boxes

artículo científico publicado en 2006

Designing the next generation of medicines for malaria control and eradication

artículo científico publicado en 2013

Distamycin prolongs E-selectin expression by interacting with a specific NF-kappaB-HMG-I(Y) binding site in the promoter

artículo científico publicado en 1997

Efficacy of OZ439 (artefenomel) against early Plasmodium falciparum blood-stage malaria infection in healthy volunteers

artículo científico publicado en 2016

Erratum to: New developments in anti-malarial target candidate and product profiles

artículo científico publicado en 2017

Evolutionary variation of the CCAAT-binding transcription factor NF-Y

artículo científico publicado en 1992

Expression of protein-tyrosine phosphatases in Acute Myeloid Leukemia cells: FLT3 ITD sustains high levels of DUSP6 expression

artículo científico publicado en 2012

Ferroquine: welcome to the next generation of antimalarials

artículo científico publicado en 2015

Growth hormone signalling: sprouting links between pathways, human genetics and therapeutic options

artículo científico publicado en 2006

Highly controlled gene expression using combinations of a tissue-specific promoter, recombinant adenovirus and a tetracycline-regulatable transcription factor

artículo científico publicado en 1998

Hit and lead criteria in drug discovery for infectious diseases of the developing world

artículo científico

Identification of VHY/Dusp15 as a Regulator of Oligodendrocyte Differentiation through a Systematic Genomics Approach ⬇️

artículo científico publicado el 11 de julio de 2012

Identification of protein tyrosine phosphatases with specificity for the ligand-activated growth hormone receptor

artículo científico publicado en 2003

Improvement of peripheral endothelial dysfunction by protein tyrosine phosphatase inhibitors in heart failure.

artículo científico publicado en 2006

Inducible inhibition of eukaryotic gene expression

artículo científico publicado en 1994

Inhibition of protein tyrosine phosphatases enhances cerebral collateral growth in rats

artículo científico publicado en 2014

Injectable anti-malarials revisited: discovery and development of new agents to protect against malaria

article

Intracellular substrates of brain-enriched receptor protein tyrosine phosphatase rho (RPTPρ/PTPRT)

artículo científico publicado en 2006

Involvement of phosphoinositide 3-kinase gamma, Rac, and PAK signaling in chemokine-induced macrophage migration

artículo científico publicado en 2004

Linking Murine and Human Plasmodium falciparum Challenge Models in a Translational Path for Antimalarial Drug Development

artículo científico publicado en 2016

Malaria

scholarly article by Margaret A. Phillips et al published 3 August 2017 in Nature Reviews Disease Primers

Malaria medicines: a glass half full?

artículo científico

Mapping and identification of protein-protein interactions by two-dimensional far-Western immunoblotting

artículo científico publicado en 2000

Mapping of synergistic components of weakly interacting protein-protein motifs using arrays of paired peptides

artículo científico publicado en 2003

Multidrug-resistant gonorrhea: A research and development roadmap to discover new medicines.

artículo científico publicado en 2017

New developments in anti-malarial target candidate and product profiles

artículo científico publicado en 2017

One subunit of the transcription factor NF-Y maps close to the major histocompatibility complex in murine and human chromosomes ⬇️

artículo científico publicado el 1 de noviembre de 1991

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond

artículo científico publicado en 2016

Open data in drug discovery and development: lessons from malaria

artículo científico publicado en 2016

PTPH1 is a predominant protein-tyrosine phosphatase capable of interacting with and dephosphorylating the T cell receptor zeta subunit

artículo científico publicado en 2003

Probing protein-tyrosine phosphatase substrate specificity using a phosphotyrosine-containing phage library

artículo científico publicado en 2003

Profile of William C. Campbell, Satoshi Ōmura, and Youyou Tu, 2015 Nobel Laureates in Physiology or Medicine

artículo científico publicado en 2015

Properties of a CCAAT box-binding protein

artículo científico publicado en 1987

Prospects for inhibitors of protein tyrosine phosphatase 1B as antidiabetic drugs

artículo científico publicado en 2004

Protein tyrosine phosphatases as drug targets: PTP1B and beyond

artículo científico publicado en 2002

Protein tyrosine phosphatases in glioma biology

artículo científico publicado en 2009

Protein tyrosine phosphatases: dual-specificity phosphatases in health and disease

artículo científico publicado en 2008

Protein-tyrosine phosphatase H1 controls growth hormone receptor signaling and systemic growth

artículo científico publicado en 2007

Reassessing therapeutic antibodies for neglected and tropical diseases

scientific article published on 30 January 2020

Reduction of heart failure by pharmacological inhibition or gene deletion of protein tyrosine phosphatase 1B.

artículo científico publicado en 2012

Sap-1/PTPRH activity is regulated by reversible dimerization

artículo científico publicado en 2005

Selecting protein tyrosine phosphatases as drug targets

artículo científico publicado en 2002

Structural Basis for Selective Inhibition of Mycobacterium tuberculosis Protein Tyrosine Phosphatase PtpB

artículo científico publicado en 2007

The SPOT technique as a tool for studying protein tyrosine phosphatase substrate specificities

artículo científico publicado en 2002

The antimalarial pipeline

The protein tyrosine phosphatase PTPN4/PTP-MEG1, an enzyme capable of dephosphorylating the TCR ITAMs and regulating NF-kappaB, is dispensable for T cell development and/or T cell effector functions

scientific journal article

Tumor suppressor density-enhanced phosphatase-1 (DEP-1) inhibits the RAS pathway by direct dephosphorylation of ERK1/2 kinases

artículo científico publicado en 2009

Two distinct NF-kappa B complexes differing in their larger subunit bind the E-selectin promoter kappa B element ⬇️

artículo científico publicado en 1993

Lista de obras de Rob Hooft van Huijsduijnen

12/15-lipoxygenase-derived lipid peroxides control receptor tyrosine kinase signaling through oxidation of protein tyrosine phosphatases

A Phase II pilot trial to evaluate safety and efficacy of ferroquine against early Plasmodium falciparum in an induced blood-stage malaria infection study

A discovery and development roadmap for new endectocidal transmission-blocking agents in malaria

An NF kappa B-like factor is essential but not sufficient for cytokine induction of endothelial leukocyte adhesion molecule 1 (ELAM-1) gene transcription

Anticancer properties of distinct antimalarial drug classes

Applying the SPOT peptide synthesis procedure to the study of protein tyrosine phosphatase substrate specificity: probing for the heavenly match in vitro

Both Intrinsic Substrate Preference and Network Context Contribute to Substrate Selection of Classical Tyrosine Phosphatases

Characterization of protein tyrosine phosphatase H1 knockout mice in animal models of local and systemic inflammation

Characterization of three highly purified influenza virus strains by electron microscopy

Chemical inducers and transcriptional markers of oligodendrocyte differentiation

Commonly used cat reporter vectors contain a cAMP-inducible, cryptic enhancer that co-operates with NF-kappa B-sites

Convergent functional genomics of oligodendrocyte differentiation identifies multiple autoinhibitory signaling circuits

DNA-methylation of the E-selectin promoter represses NF-kappa B transactivation

Decompartmentalizing target validation-thinking outside the pipeline boxes

Designing the next generation of medicines for malaria control and eradication

Distamycin prolongs E-selectin expression by interacting with a specific NF-kappaB-HMG-I(Y) binding site in the promoter

Efficacy of OZ439 (artefenomel) against early Plasmodium falciparum blood-stage malaria infection in healthy volunteers

Erratum to: New developments in anti-malarial target candidate and product profiles

Evolutionary variation of the CCAAT-binding transcription factor NF-Y

Expression of protein-tyrosine phosphatases in Acute Myeloid Leukemia cells: FLT3 ITD sustains high levels of DUSP6 expression

Ferroquine: welcome to the next generation of antimalarials

Growth hormone signalling: sprouting links between pathways, human genetics and therapeutic options

Highly controlled gene expression using combinations of a tissue-specific promoter, recombinant adenovirus and a tetracycline-regulatable transcription factor

Hit and lead criteria in drug discovery for infectious diseases of the developing world

Identification of VHY/Dusp15 as a Regulator of Oligodendrocyte Differentiation through a Systematic Genomics Approach ⬇️

Identification of protein tyrosine phosphatases with specificity for the ligand-activated growth hormone receptor

Improvement of peripheral endothelial dysfunction by protein tyrosine phosphatase inhibitors in heart failure.

Inducible inhibition of eukaryotic gene expression

Inhibition of protein tyrosine phosphatases enhances cerebral collateral growth in rats

Injectable anti-malarials revisited: discovery and development of new agents to protect against malaria

Intracellular substrates of brain-enriched receptor protein tyrosine phosphatase rho (RPTPρ/PTPRT)

Involvement of phosphoinositide 3-kinase gamma, Rac, and PAK signaling in chemokine-induced macrophage migration

Linking Murine and Human Plasmodium falciparum Challenge Models in a Translational Path for Antimalarial Drug Development

Malaria

Malaria medicines: a glass half full?

Mapping and identification of protein-protein interactions by two-dimensional far-Western immunoblotting

Mapping of synergistic components of weakly interacting protein-protein motifs using arrays of paired peptides

Multidrug-resistant gonorrhea: A research and development roadmap to discover new medicines.

New developments in anti-malarial target candidate and product profiles

One subunit of the transcription factor NF-Y maps close to the major histocompatibility complex in murine and human chromosomes ⬇️

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond

Open data in drug discovery and development: lessons from malaria

PTPH1 is a predominant protein-tyrosine phosphatase capable of interacting with and dephosphorylating the T cell receptor zeta subunit

Probing protein-tyrosine phosphatase substrate specificity using a phosphotyrosine-containing phage library

Profile of William C. Campbell, Satoshi Ōmura, and Youyou Tu, 2015 Nobel Laureates in Physiology or Medicine

Properties of a CCAAT box-binding protein

Prospects for inhibitors of protein tyrosine phosphatase 1B as antidiabetic drugs

Protein tyrosine phosphatases as drug targets: PTP1B and beyond

Protein tyrosine phosphatases in glioma biology

Protein tyrosine phosphatases: dual-specificity phosphatases in health and disease

Protein-tyrosine phosphatase H1 controls growth hormone receptor signaling and systemic growth

Reassessing therapeutic antibodies for neglected and tropical diseases

Reduction of heart failure by pharmacological inhibition or gene deletion of protein tyrosine phosphatase 1B.

Sap-1/PTPRH activity is regulated by reversible dimerization

Selecting protein tyrosine phosphatases as drug targets

Structural Basis for Selective Inhibition of Mycobacterium tuberculosis Protein Tyrosine Phosphatase PtpB

The SPOT technique as a tool for studying protein tyrosine phosphatase substrate specificities

The antimalarial pipeline

The protein tyrosine phosphatase PTPN4/PTP-MEG1, an enzyme capable of dephosphorylating the TCR ITAMs and regulating NF-kappaB, is dispensable for T cell development and/or T cell effector functions

Tumor suppressor density-enhanced phosphatase-1 (DEP-1) inhibits the RAS pathway by direct dephosphorylation of ERK1/2 kinases

Two distinct NF-kappa B complexes differing in their larger subunit bind the E-selectin promoter kappa B element ⬇️