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Lista de obras de Paola Perego

7-Azaindole-1-carboxamides as a new class of PARP-1 inhibitors.

artículo científico publicado en 2013

A proteomic approach for evaluating the cell response to a novel histone deacetylase inhibitor in colon cancer cells

artículo científico publicado en 2008

A proteomic approach to cisplatin resistance in the cervix squamous cell carcinoma cell line A431.

artículo científico publicado en 2004

A role for c-myc in DNA damage-induced apoptosis in a human TP53-mutant small-cell lung cancer cell line

artículo científico publicado en 2001

Activation of ATM and Chk2 kinases in relation to the amount of DNA strand breaks.

artículo científico publicado en 2004

Anionic glycolipids related to glucuronosyldiacylglycerol inhibit protein kinase Akt.

artículo científico publicado en 2014

Antisecretive and Antitumor Activity of Abiraterone Acetate in Human Adrenocortical Cancer: A Preclinical Study

artículo científico publicado en 2016

Antitumor activity of a novel homodimeric SMAC mimetic in ovarian carcinoma.

artículo científico publicado en 2013

Apoptosis and growth arrest induced by platinum compounds in U2-OS cells reflect a specific DNA damage recognition associated with a different p53-mediated response.

artículo científico publicado en 2002

Ascites Regression and Survival Increase in Mice Bearing Advanced-stage Human Ovarian Carcinomas and Repeatedly Treated Intraperitoneally With CpG-ODN

artículo científico publicado en 2010

Association of promoter polymorphism -765G>C in the PTGS2 gene with malignant melanoma in Italian patients and its correlation to gene expression in dermal fibroblasts.

artículo científico publicado en 2014

Axl molecular targeting counteracts aggressiveness but not platinum-resistance of ovarian carcinoma cells

artículo científico publicado en 2017

Bcl-2 phosphorylation in a human breast carcinoma xenograft: a common event in response to effective DNA-damaging drugs

artículo científico publicado en 2000

Biological properties of IDN5174, a new synthetic camptothecin with the open lactone ring

artículo científico publicado en 2006

Cellular bases of the antitumor activity of a 7-substituted camptothecin in hormone-refractory human prostate carcinoma models

artículo científico publicado en 2003

Cellular pharmacology of cisplatin in relation to the expression of human copper transporter CTR1 in different pairs of cisplatin-sensitive and -resistant cells

artículo científico publicado en 2004

Cellular pharmacology studies of anticancer agents: recommendations from the EORTC-PAMM group

artículo científico publicado en 2017

Cellular sensitivity to beta-diketonato complexes of ruthenium(III), chromium(III) and rhodium(III).

artículo científico publicado en 2006

Characterization of an established human, malignant, glioblastoma cell line (GBM) and its response to conventional drugs.

artículo científico publicado en 1994

Clinicopathological impact of ABCC1/MRP1 and ABCC4/MRP4 in epithelial ovarian carcinoma

artículo científico publicado en 2013

Cooperation between p53 and p73 in cisplatin-induced apoptosis in ovarian carcinoma cells

artículo científico publicado en 2008

Decreased drug accumulation and increased tolerance to DNA damage in tumor cells with a low level of cisplatin resistance

artículo científico publicado en 1998

Defining targets of modulation of human tumor cell response to cisplatin.

artículo científico publicado en 2008

Design, synthesis and biological evaluation of novel dimeric and tetrameric cRGD-paclitaxel conjugates for integrin-assisted drug delivery

artículo científico publicado en 2015

Design, synthesis, and biological evaluation of novel cRGD-paclitaxel conjugates for integrin-assisted drug delivery.

artículo científico publicado en 2012

Development of resistance to a trinuclear platinum complex in ovarian carcinoma cells.

artículo científico publicado en 2003

Different accumulation of cisplatin, oxaliplatin and JM216 in sensitive and cisplatin-resistant human cervical tumour cells

artículo científico publicado en 2006

Differential outcome of MEK1/2 inhibitor-platinum combinations in platinum-sensitive and -resistant ovarian carcinoma cells

artículo científico publicado en 2014

Dimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part II: Structural and biological characterization

artículo científico publicado en 2012

Drug combinations with proteasome inhibitors in antitumor therapy

artículo científico

Editorial: Targeting Drug-resistant and Metastatic Tumors by Interference with Tumor and Microenvironment-related Alterations

artículo científico publicado en 2017

Effect of modulation of protein kinase C activity on cisplatin cytotoxicity in cisplatin-resistant and cisplatin-sensitive human osteosarcoma cells

artículo científico publicado en 1993

Efficacy of a Selective Binder of αVβ3 Integrin Linked to the Tyrosine Kinase Inhibitor Sunitinib in Ovarian Carcinoma Preclinical Models

artículo científico publicado en 2019

Electron microscopy analysis of early localization of cisplatin in ovarian carcinoma cells.

artículo científico publicado en 2002

Enhanced antitumour efficacy of gimatecan in combination with Bcl-2 antisense oligonucleotide in human melanoma xenografts.

artículo científico publicado en 2005

Expression of the anti-apoptotic gene survivin correlates with taxol resistance in human ovarian cancer

artículo científico publicado en 2002

Extra-cellular thiol metabolism in clones of human metastatic melanoma with different gamma-glutamyl transpeptidase expression: implications for cell response to platinum-based drugs

artículo científico publicado en 2002

Fas/CD95-mediated apoptosis in human glioblastoma cells: a target for sensitisation to topoisomerase I inhibitors

artículo científico publicado en 2002

Fast Cyclization of a Proline-Derived Self-Immolative Spacer Improves the Efficacy of Carbamate Prodrugs

artículo científico publicado en 2020

FoxO-1 contributes to the efficacy of the combination of the XPO1 inhibitor selinexor and cisplatin in ovarian carcinoma preclinical models.

artículo científico publicado en 2017

Gene expression profiles in the cellular response to a multinuclear platinum complex

artículo científico publicado en 2004

Global gene expression of fission yeast in response to cisplatin.

artículo científico publicado en 2004

Growth inhibition and sensitization to cisplatin by zoledronic acid in osteosarcoma cells

artículo científico publicado en 2006

Highly tumorigenic lung cancer CD133+ cells display stem-like features and are spared by cisplatin treatment

artículo científico publicado en 2009

Homo- and heterodimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part I: Synthesis

artículo científico publicado en 2012

Identification of MET and SRC activation in melanoma cell lines showing primary resistance to PLX4032.

artículo científico publicado en 2011

Improved apoptotic cell death in drug-resistant non-small-cell lung cancer cells by tumor necrosis factor-related apoptosis-inducing ligand-based treatment.

artículo científico publicado en 2013

In vitro and in vivo interaction between cisplatin and topotecan in ovarian carcinoma systems

artículo científico publicado en 1998

Increased levels and defective glycosylation of MRPs in ovarian carcinoma cells resistant to oxaliplatin.

artículo científico

Increased sensitivity to cisplatin in non-small cell lung cancer cell lines after FHIT gene transfer

artículo científico publicado en 2006

Induction of lymphocyte apoptosis by tumor cell secretion of FasL-bearing microvesicles.

artículo científico publicado en 2002

Inhibition of proteasome deubiquitinating activity as a new cancer therapy

artículo científico publicado en 2011

Integrin-Targeted Peptide- and Peptidomimetic-Drug Conjugates for the Treatment of Tumors

artículo científico publicado en 2017

KiSS1 in regulation of metastasis and response to antitumor drugs

scientific article published on 01 January 2019

Mechanisms controlling sensitivity to platinum complexes: role of p53 and DNA mismatch repair.

artículo científico publicado en 2003

Metabolic approach to the enhancement of antitumor effect of chemotherapy: a key role of acetyl-L-carnitine

artículo científico publicado en 2010

Microenvironment-Modulated Metastatic CD133+/CXCR4+/EpCAM- Lung Cancer-Initiating Cells Sustain Tumor Dissemination and Correlate with Poor Prognosis

artículo científico publicado en 2015

Modulation of cell growth and cisplatin sensitivity by membrane gamma-glutamyltransferase in melanoma cells.

artículo científico publicado en 2006

Modulation of cell sensitivity to antitumor agents by targeting survival pathways.

artículo científico publicado en 2010

Modulation of epidermal growth factor receptor tyrosine phosphorylation by tumor necrosis factor

artículo científico publicado en 1991

Modulation of pro- and anti-apoptotic factors in human melanoma cells exposed to histone deacetylase inhibitors.

artículo científico publicado en 2004

Modulation of survival pathways in ovarian carcinoma cell lines resistant to platinum compounds

artículo científico publicado en 2008

Molecular alterations of cells resistant to platinum drugs: role of PKCalpha

artículo científico publicado en 2006

Molecular basis for the DNA damage induction and anticancer activity of asymmetrically substituted anthrapyridazone PDZ-7.

artículo científico publicado en 2017

Molecular mechanisms controlling sensitivity to toxic metal ions in yeast

artículo científico publicado en 1997

New mechanisms for old drugs: Insights into DNA-unrelated effects of platinum compounds and drug resistance determinants

artículo científico

Novel 7-oxyiminomethyl derivatives of camptothecin with potent in vitro and in vivo antitumor activity

artículo científico publicado en 2001

Novel 7-substituted camptothecins with potent antitumor activity

artículo científico publicado en 2000

Novel bis-platinum complexes endowed with an improved pharmacological profile

artículo científico publicado en 2010

Novel cytotoxic 7-iminomethyl and 7-aminomethyl derivatives of camptothecin.

artículo científico publicado en 2001

Nucleolar targeting by platinum: p53-independent apoptosis follows rRNA inhibition, cell-cycle arrest, and DNA compaction.

artículo científico publicado en 2014

Orchestration of DSB repair: a novel BRCA2 connection

artículo científico publicado en 2015

Ovarian cancer cisplatin-resistant cell lines: multiple changes including collateral sensitivity to Taxol.

artículo científico publicado en 1998

Oxaliplatin in the era of personalized medicine: from mechanistic studies to clinical efficacy

artículo científico publicado en 2015

PKC-alpha modulation by miR-483-3p in platinum-resistant ovarian carcinoma cells

artículo científico publicado en 2016

PP2A: more than a reset switch to activate pRB proteins during the cell cycle and in response to signaling cues

artículo científico publicado en 2015

Preface: Histone Deacetylases as Therapeutic Targets

artículo científico publicado en 2015

Protein kinase C activation by anthracyclines in Swiss 3T3 cells

artículo científico publicado en 1991

Proteomic analysis of cellular response to novel proapoptotic agents related to atypical retinoids in human IGROV-1 ovarian carcinoma cells

artículo científico publicado en 2011

RECQL4 Modulates MDR1 Expression and Chemoresistance-Letter

artículo científico publicado en 2016

Relationship between folate-binding protein expression and cisplatin sensitivity in ovarian carcinoma cell lines

artículo científico publicado el 1 de enero de 1997

Role of Bcl-2 and its post-transcriptional modification in response to antitumor therapy.

artículo científico publicado en 2001

Role of FoxO Proteins in Cellular Response to Antitumor Agents

artículo científico publicado en 2019

Role of apoptotic response in cellular resistance to cytotoxic agents

artículo científico publicado en 1997

Role of the Receptor Tyrosine Kinase Axl and its Targeting in Cancer Cells

artículo científico publicado en 2016

Role of the sugar moiety in the pharmacological activity of anthracyclines: development of a novel series of disaccharide analogs.

artículo científico publicado en 2001

Role of tyrosyl-DNA phosphodiesterase 1 and inter-players in regulation of tumor cell sensitivity to topoisomerase I inhibition.

artículo científico publicado en 2011

Sensitization of tumor cells by targeting histone deacetylases

artículo científico publicado en 2011

Sensitization to gimatecan-induced apoptosis by tumor necrosis factor-related apoptosis inducing ligand in prostate carcinoma cells

artículo científico publicado en 2006

Smac mimetics induce inflammation and necrotic tumour cell death by modulating macrophage activity

artículo científico publicado en 2013

Synergistic cooperation between sunitinib and cisplatin promotes apoptotic cell death in human medullary thyroid cancer

artículo científico publicado en 2013

Synergistic interaction between the novel histone deacetylase inhibitor ST2782 and the proteasome inhibitor bortezomib in platinum-sensitive and resistant ovarian carcinoma cells

artículo científico publicado en 2012

Synthetic sulfoglycolipids targeting the serine-threonine protein kinase Akt.

artículo científico publicado en 2016

Targeting DNA topoisomerase I with non-camptothecin poisons.

artículo científico

Targeting peptidyl-prolyl isomerase pin1 to inhibit tumor cell aggressiveness.

artículo científico publicado en 2016

Targeting the Akt kinase to modulate survival, invasiveness and drug resistance of cancer cells

artículo científico publicado en 2013

Targeting the invasive phenotype of cisplatin-resistant non-small cell lung cancer cells by a novel histone deacetylase inhibitor.

artículo científico publicado en 2015

Targeting topoisomerase I: molecular mechanisms and cellular determinants of response to topoisomerase I inhibitors

artículo científico publicado en 2008

Tau Mutations Serve as a Novel Risk Factor for Cancer

artículo científico publicado en 2018

Tau Mutations as a Novel Risk Factor for Cancer-Response

artículo científico publicado en 2018

The ABC of glycosylation

artículo científico publicado en 2010

The cellular basis of the efficacy of the trinuclear platinum complex BBR 3464 against cisplatin-resistant cells

scientific article published on 01 October 1999

The human homolog of fission yeast Rad17 is implicated in tumor growth

artículo científico publicado en 2008

The rediscovery of platinum-based cancer therapy

artículo científico publicado en 2020

Tyrosyl-DNA phosphodiesterase 1 targeting for modulation of camptothecin-based treatment.

scientific article published on January 2010

Ubiquitin-proteasome genes as targets for modulation of cisplatin sensitivity in fission yeast.

artículo científico publicado en 2011

[Pharmacologic basis of the effectiveness of topotecan in the treatment of ovarian carcinoma]

artículo científico publicado en 1999

gamma-Glutamyl transpeptidase catalyses the extracellular detoxification of cisplatin in a human cell line derived from the proximal convoluted tubule of the kidney

artículo científico publicado en 2003

p53-dependent activation of microRNA-34a in response to etoposide-induced DNA damage in osteosarcoma cell lines not impaired by dominant negative p53 expression

artículo científico publicado en 2014