Lista de obras - Alessandro Datti - Dominio Público Uruguay

A chemical biology screen identifies glucocorticoids that regulate c-maf expression by increasing its proteasomal degradation through up-regulation of ubiquitin.

artículo científico publicado en 2007

A chemical screen identifies anisomycin as an anoikis sensitizer that functions by decreasing FLIP protein synthesis

artículo científico publicado en 2007

A coupled assay for UDP-GlcNAc:Gal beta 1-3GalNAc-R beta 1,6-N-acetylglucosaminyltransferase (GlcNAc to GalNAc).

artículo científico publicado en 1992

A fluorescent assay for the determination of UDP-GlcNAc: Gal beta 1,3GalNAc-R (GlcNAc to GalNAc) beta 1,6-N-acetylglucosaminyltransferase activity

artículo científico publicado en 1995

A high-content chemical screen identifies ellipticine as a modulator of p53 nuclear localization

artículo científico publicado en 2008

A homogeneous cell-based assay to identify N-linked carbohydrate processing inhibitors

scientific article published on 01 April 2000

A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities

scientific article published on 08 October 2013

A repurposing strategy identifies novel synergistic inhibitors of Plasmodium falciparum heat shock protein 90.

artículo científico publicado en 2010

A small molecule screening strategy with validation on human leukemia stem cells uncovers the therapeutic efficacy of kinetin riboside

artículo científico publicado en 2011

A small-molecule inhibitor of D-cyclin transactivation displays preclinical efficacy in myeloma and leukemia via phosphoinositide 3-kinase pathway.

artículo científico publicado en 2010

A solid-phase glycosyltransferase assay for high-throughput screening in drug discovery research

artículo científico publicado en 1999

A systematic approach to identify novel cancer drug targets using machine learning, inhibitor design and high-throughput screening.

artículo científico publicado en 2014

Activators of cylindrical proteases as antimicrobials: identification and development of small molecule activators of ClpP protease

artículo científico publicado en 2011

Activity levels of a β1,6 N-acetylglucosaminyltransferase in lymphomonocytes from multiple sclerosis patients

artículo científico publicado en 1997

An endogenous PI3K interactome promoting astrocyte mediated neuroprotection identifies a novel association with RNA binding protein ZC3H14

artículo científico publicado en 2020

Anticancer activity of pyrithione zinc in oral cancer cells identified in small molecule screens and xenograft model: Implications for oral cancer therapy

artículo científico publicado en 2015

Application of an integrated physical and functional screening approach to identify inhibitors of the Wnt pathway

artículo científico publicado en 2009

COX inhibitors and bone: A safer impact on osteoblasts by NO-releasing NSAIDs

artículo científico publicado en 2018

Cell-based high-throughput screen for small molecule inhibitors of Bax translocation

artículo científico publicado en 2018

Chelation of intracellular iron with the antifungal agent ciclopirox olamine induces cell death in leukemia and myeloma cells.

artículo científico publicado en 2009

Clinical validation of a link between TNF-alpha and the glycosylation enzyme core 2 GlcNAc-T and the relationship of this link to diabetic retinopathy

artículo científico publicado en 2006

Combined deletion of Pten and p53 in mammary epithelium accelerates triple-negative breast cancer with dependency on eEF2K

artículo científico publicado en 2014

Complex N-glycan and metabolic control in tumor cells.

artículo científico publicado en 2007

Coordinated involvement of cathepsins S, D and cystatin C in the commitment of hematopoietic stem cells to dendritic cells.

artículo científico publicado en 2011

Cyproheptadine displays preclinical activity in myeloma and leukemia

artículo científico publicado en 2008

Digitoxin-induced cytotoxicity in cancer cells is mediated through distinct kinase and interferon signaling networks

artículo científico publicado en 2011

Disulfiram when Combined with Copper Enhances the Therapeutic Effects of Temozolomide for the Treatment of Glioblastoma

artículo científico publicado en 2016

Drug-mediated inhibition of Fli-1 for the treatment of leukemia

artículo científico publicado en 2012

Efficient siRNA delivery by the cationic liposome DOTAP in human hematopoietic stem cells differentiating into dendritic cells

artículo científico publicado en 2009

Erlotinib synergizes with the poly(ADP-ribose) glycohydrolase inhibitor ethacridine in acute myeloid leukemia cells

artículo científico publicado en 2016

Essential gene profiles in breast, pancreatic, and ovarian cancer cells.

artículo científico publicado en 2011

Excess Polθ functions in response to replicative stress in homologous recombination-proficient cancer cells

artículo científico publicado en 2016

Expression of cathepsins S and D signals a distinctive biochemical trait in CD34+ hematopoietic stem cells of relapsing-remitting multiple sclerosis patients

artículo científico publicado en 2013

Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogramming

artículo científico publicado en 2010

High throughput kinase inhibitor screens reveal TRB3 and MAPK-ERK/TGFβ pathways as fundamental Notch regulators in breast cancer.

artículo científico publicado en 2013

High-throughput drug library screening identifies colchicine as a thyroid cancer inhibitor

artículo científico publicado en 2016

High-throughput screen identifies disulfiram as a potential therapeutic for triple-negative breast cancer cells: Interaction with IQ motif-containing factors ⬇️

artículo científico publicado el 12 de agosto de 2013

High-throughput screening identifies cardiac glycosides as potent inhibitors of human tissue kallikrein expression: implications for cancer therapies

artículo científico publicado en 2008

High-throughput testing in head and neck squamous cell carcinoma identifies agents with preferential activity in human papillomavirus-positive or negative cell lines.

artículo científico publicado en 2018

Highly conserved cysteines of mouse core 2 beta1,6-N-acetylglucosaminyltransferase I form a network of disulfide bonds and include a thiol that affects enzyme activity

artículo científico publicado en 2003

Hypophosphorylated pRb knock-in mice exhibit hallmarks of aging and vitamin C-preventable diabetes

artículo científico publicado en 2022

Ibrutinib synergizes with poly(ADP-ribose) glycohydrolase inhibitors to induce cell death in AML cells via a BTK-independent mechanism

artículo científico publicado en 2015

Identification of CDC25 as a Common Therapeutic Target for Triple-Negative Breast Cancer

artículo científico publicado en 2018

Identification of Drugs that Regulate Dermal Stem Cells and Enhance Skin Repair.

artículo científico publicado en 2015

Identification of a non-phosphorylated, cell permeable, small molecule ligand for the Stat3 SH2 domain

artículo científico publicado en 2011

Inhibition of intracellular dipeptidyl peptidases 8 and 9 enhances parthenolide's anti-leukemic activity.

artículo científico publicado en 2013

Inhibition of mitochondrial translation as a therapeutic strategy for human acute myeloid leukemia

artículo científico publicado en 2011

Inhibition of osteoclast bone resorption by disrupting vacuolar H+-ATPase a3-B2 subunit interaction.

artículo científico publicado en 2010

Inhibition of the sodium potassium adenosine triphosphatase pump sensitizes cancer cells to anoikis and prevents distant tumor formation

artículo científico publicado en 2009

Inhibition of the sodium/potassium ATPase impairs N-glycan expression and function

artículo científico publicado en 2008

Integrating high-throughput genetic interaction mapping and high-content screening to explore yeast spindle morphogenesis

artículo científico publicado en 2010

Lestaurtinib is a potent inhibitor of anaplastic thyroid cancer cell line models

artículo científico publicado en 2018

Luteolin inhibition of V-ATPase a3-d2 interaction decreases osteoclast resorptive activity.

artículo científico publicado en 2013

Lysosomal disruption preferentially targets acute myeloid leukemia cells and progenitors

artículo científico publicado en 2012

Lysosomal β-galactosidase and β-hexosaminidase activities correlate with clinical stages of dementia associated with Alzheimer's disease and type 2 diabetes mellitus

artículo científico publicado en 2011

MicroRNA implications across neurodevelopment and neuropathology

artículo científico publicado en 2009

Multilayered Control of Alternative Splicing Regulatory Networks by Transcription Factors

artículo científico publicado en 2017

Myc and SAGA rewire an alternative splicing network during early somatic cell reprogramming

artículo científico publicado en 2015

PI3K/AKT/mTOR inhibition in combination with doxorubicin is an effective therapy for leiomyosarcoma.

artículo científico publicado en 2016

PhenoM: a database of morphological phenotypes caused by mutation of essential genes in Saccharomyces cerevisiae

artículo científico

RB1 deficiency in triple-negative breast cancer induces mitochondrial protein translation

artículo científico publicado en 2016

RB1 status in triple negative breast cancer cells dictates response to radiation treatment and selective therapeutic drugs

artículo científico publicado en 2013

ROCK inhibitors upregulate the neuroprotective Parkin-mediated mitophagy pathway

artículo científico publicado en 2020

Repurposing Albendazole: new potential as a chemotherapeutic agent with preferential activity against HPV-negative head and neck squamous cell cancer

artículo científico publicado en 2017

Select microtubule inhibitors increase lysosome acidity and promote lysosomal disruption in acute myeloid leukemia (AML) cells

artículo científico publicado en 2015

Selenium maintains cytosolic Ca2+ homeostasis and preserves germination rates of maize pollen under H2O2-induced oxidative stress

artículo científico publicado en 2019

Small molecule kinase inhibitor screen identifies polo-like kinase 1 as a target for neuroblastoma tumor-initiating cells

artículo científico publicado en 2011

Sorafenib as an Inhibitor of RUVBL2

scientific article published on 14 April 2020

Systematic exploration of essential yeast gene function with temperature-sensitive mutants

artículo científico publicado en 2011

Targeted Pten deletion plus p53-R270H mutation in mouse mammary epithelium induces aggressive claudin-low and basal-like breast cancer

artículo científico publicado en 2016

Targeting Mitochondria with Avocatin B Induces Selective Leukemia Cell Death

artículo científico publicado en 2015

The MMS22L-TONSL complex mediates recovery from replication stress and homologous recombination

artículo científico publicado en 2010

The RNF146 and tankyrase pathway maintains the junctional Crumbs complex through regulation of angiomotin

artículo científico publicado en 2016

The antiparasitic agent ivermectin induces chloride-dependent membrane hyperpolarization and cell death in leukemia cells

artículo científico publicado en 2010

Tumor necrosis factor-alpha in diabetic plasma increases the activity of core 2 GlcNAc-T and adherence of human leukocytes to retinal endothelial cells: significance of core 2 GlcNAc-T in diabetic retinopathy

artículo científico publicado en 2004

Uroporphyrinogen decarboxylase is a radiosensitizing target for head and neck cancer

artículo científico publicado en 2011

beta1,6 N-acetylglucosaminyltransferase (core 2 GlcNAc-T) expression in normal rat tissues and different cell lines: evidence for complex mechanisms of regulation

scientific journal article

β-N-Acetylhexosaminadases in human cerebrospinal fluid and serum of patients with multiple sclerosis

artículo científico publicado en 1991

Lista de obras de Alessandro Datti

A chemical biology screen identifies glucocorticoids that regulate c-maf expression by increasing its proteasomal degradation through up-regulation of ubiquitin.

A chemical screen identifies anisomycin as an anoikis sensitizer that functions by decreasing FLIP protein synthesis

A coupled assay for UDP-GlcNAc:Gal beta 1-3GalNAc-R beta 1,6-N-acetylglucosaminyltransferase (GlcNAc to GalNAc).

A fluorescent assay for the determination of UDP-GlcNAc: Gal beta 1,3GalNAc-R (GlcNAc to GalNAc) beta 1,6-N-acetylglucosaminyltransferase activity

A high-content chemical screen identifies ellipticine as a modulator of p53 nuclear localization

A homogeneous cell-based assay to identify N-linked carbohydrate processing inhibitors

A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities

A repurposing strategy identifies novel synergistic inhibitors of Plasmodium falciparum heat shock protein 90.

A small molecule screening strategy with validation on human leukemia stem cells uncovers the therapeutic efficacy of kinetin riboside

A small-molecule inhibitor of D-cyclin transactivation displays preclinical efficacy in myeloma and leukemia via phosphoinositide 3-kinase pathway.

A solid-phase glycosyltransferase assay for high-throughput screening in drug discovery research

A systematic approach to identify novel cancer drug targets using machine learning, inhibitor design and high-throughput screening.

Activators of cylindrical proteases as antimicrobials: identification and development of small molecule activators of ClpP protease

Activity levels of a β1,6 N-acetylglucosaminyltransferase in lymphomonocytes from multiple sclerosis patients

An endogenous PI3K interactome promoting astrocyte mediated neuroprotection identifies a novel association with RNA binding protein ZC3H14

Anticancer activity of pyrithione zinc in oral cancer cells identified in small molecule screens and xenograft model: Implications for oral cancer therapy

Application of an integrated physical and functional screening approach to identify inhibitors of the Wnt pathway

COX inhibitors and bone: A safer impact on osteoblasts by NO-releasing NSAIDs

Cell-based high-throughput screen for small molecule inhibitors of Bax translocation

Chelation of intracellular iron with the antifungal agent ciclopirox olamine induces cell death in leukemia and myeloma cells.

Clinical validation of a link between TNF-alpha and the glycosylation enzyme core 2 GlcNAc-T and the relationship of this link to diabetic retinopathy

Combined deletion of Pten and p53 in mammary epithelium accelerates triple-negative breast cancer with dependency on eEF2K

Complex N-glycan and metabolic control in tumor cells.

Coordinated involvement of cathepsins S, D and cystatin C in the commitment of hematopoietic stem cells to dendritic cells.

Cyproheptadine displays preclinical activity in myeloma and leukemia

Digitoxin-induced cytotoxicity in cancer cells is mediated through distinct kinase and interferon signaling networks

Disulfiram when Combined with Copper Enhances the Therapeutic Effects of Temozolomide for the Treatment of Glioblastoma

Drug-mediated inhibition of Fli-1 for the treatment of leukemia

Efficient siRNA delivery by the cationic liposome DOTAP in human hematopoietic stem cells differentiating into dendritic cells

Erlotinib synergizes with the poly(ADP-ribose) glycohydrolase inhibitor ethacridine in acute myeloid leukemia cells

Essential gene profiles in breast, pancreatic, and ovarian cancer cells.

Excess Polθ functions in response to replicative stress in homologous recombination-proficient cancer cells

Expression of cathepsins S and D signals a distinctive biochemical trait in CD34+ hematopoietic stem cells of relapsing-remitting multiple sclerosis patients

Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogramming

High throughput kinase inhibitor screens reveal TRB3 and MAPK-ERK/TGFβ pathways as fundamental Notch regulators in breast cancer.

High-throughput drug library screening identifies colchicine as a thyroid cancer inhibitor

High-throughput screen identifies disulfiram as a potential therapeutic for triple-negative breast cancer cells: Interaction with IQ motif-containing factors ⬇️

High-throughput screening identifies cardiac glycosides as potent inhibitors of human tissue kallikrein expression: implications for cancer therapies

High-throughput testing in head and neck squamous cell carcinoma identifies agents with preferential activity in human papillomavirus-positive or negative cell lines.

Highly conserved cysteines of mouse core 2 beta1,6-N-acetylglucosaminyltransferase I form a network of disulfide bonds and include a thiol that affects enzyme activity

Hypophosphorylated pRb knock-in mice exhibit hallmarks of aging and vitamin C-preventable diabetes

Ibrutinib synergizes with poly(ADP-ribose) glycohydrolase inhibitors to induce cell death in AML cells via a BTK-independent mechanism

Identification of CDC25 as a Common Therapeutic Target for Triple-Negative Breast Cancer

Identification of Drugs that Regulate Dermal Stem Cells and Enhance Skin Repair.

Identification of a non-phosphorylated, cell permeable, small molecule ligand for the Stat3 SH2 domain

Inhibition of intracellular dipeptidyl peptidases 8 and 9 enhances parthenolide's anti-leukemic activity.

Inhibition of mitochondrial translation as a therapeutic strategy for human acute myeloid leukemia

Inhibition of osteoclast bone resorption by disrupting vacuolar H+-ATPase a3-B2 subunit interaction.

Inhibition of the sodium potassium adenosine triphosphatase pump sensitizes cancer cells to anoikis and prevents distant tumor formation

Inhibition of the sodium/potassium ATPase impairs N-glycan expression and function

Integrating high-throughput genetic interaction mapping and high-content screening to explore yeast spindle morphogenesis

Lestaurtinib is a potent inhibitor of anaplastic thyroid cancer cell line models

Luteolin inhibition of V-ATPase a3-d2 interaction decreases osteoclast resorptive activity.

Lysosomal disruption preferentially targets acute myeloid leukemia cells and progenitors

Lysosomal β-galactosidase and β-hexosaminidase activities correlate with clinical stages of dementia associated with Alzheimer's disease and type 2 diabetes mellitus

MicroRNA implications across neurodevelopment and neuropathology

Multilayered Control of Alternative Splicing Regulatory Networks by Transcription Factors

Myc and SAGA rewire an alternative splicing network during early somatic cell reprogramming

PI3K/AKT/mTOR inhibition in combination with doxorubicin is an effective therapy for leiomyosarcoma.

PhenoM: a database of morphological phenotypes caused by mutation of essential genes in Saccharomyces cerevisiae

RB1 deficiency in triple-negative breast cancer induces mitochondrial protein translation

RB1 status in triple negative breast cancer cells dictates response to radiation treatment and selective therapeutic drugs

ROCK inhibitors upregulate the neuroprotective Parkin-mediated mitophagy pathway

Repurposing Albendazole: new potential as a chemotherapeutic agent with preferential activity against HPV-negative head and neck squamous cell cancer

Select microtubule inhibitors increase lysosome acidity and promote lysosomal disruption in acute myeloid leukemia (AML) cells

Selenium maintains cytosolic Ca2+ homeostasis and preserves germination rates of maize pollen under H2O2-induced oxidative stress

Small molecule kinase inhibitor screen identifies polo-like kinase 1 as a target for neuroblastoma tumor-initiating cells

Sorafenib as an Inhibitor of RUVBL2

Systematic exploration of essential yeast gene function with temperature-sensitive mutants

Targeted Pten deletion plus p53-R270H mutation in mouse mammary epithelium induces aggressive claudin-low and basal-like breast cancer

Targeting Mitochondria with Avocatin B Induces Selective Leukemia Cell Death

The MMS22L-TONSL complex mediates recovery from replication stress and homologous recombination

The RNF146 and tankyrase pathway maintains the junctional Crumbs complex through regulation of angiomotin

The antiparasitic agent ivermectin induces chloride-dependent membrane hyperpolarization and cell death in leukemia cells

Tumor necrosis factor-alpha in diabetic plasma increases the activity of core 2 GlcNAc-T and adherence of human leukocytes to retinal endothelial cells: significance of core 2 GlcNAc-T in diabetic retinopathy

Uroporphyrinogen decarboxylase is a radiosensitizing target for head and neck cancer

beta1,6 N-acetylglucosaminyltransferase (core 2 GlcNAc-T) expression in normal rat tissues and different cell lines: evidence for complex mechanisms of regulation

β-N-Acetylhexosaminadases in human cerebrospinal fluid and serum of patients with multiple sclerosis