Lista de obras - Paul Whi Parren - Dominio Público Uruguay

A Novel Bispecific Antibody Targeting EGFR and cMet Is Effective against EGFR Inhibitor-Resistant Lung Tumors.

artículo científico publicado en 2016

A Novel Platform for the Potentiation of Therapeutic Antibodies Based on Antigen-Dependent Formation of IgG Hexamers at the Cell Surface

artículo científico publicado en 2016

A bispecific antibody antagonizes pro-survival CD40 signaling and promotes Vγ9Vδ2 T cell-mediated antitumor responses in human B-cell malignancies

scientific article published on 11 November 2020

A human CD4 monoclonal antibody for the treatment of T-cell lymphoma combines inhibition of T-cell signaling by a dual mechanism with potent Fc-dependent effector activity

artículo científico publicado en 2007

A novel human antibody against human immunodeficiency virus type 1 gp120 is V1, V2, and V3 loop dependent and helps delimit the epitope of the broadly neutralizing antibody immunoglobulin G1 b12.

artículo científico publicado en 2003

A novel label-free cell-based assay technology using biolayer interferometry

artículo científico publicado en 2016

A quantitative flow cytometric assay for determining binding characteristics of chimeric, humanized and human antibodies in whole blood: proof of principle with rituximab and ofatumumab

artículo científico publicado en 2012

A structure-based approach to a synthetic vaccine for HIV-1.

artículo científico publicado en 2000

ADCT-301, a Pyrrolobenzodiazepine (PBD) Dimer-Containing Antibody-Drug Conjugate (ADC) Targeting CD25-Expressing Hematological Malignancies.

artículo científico publicado en 2016

Absence of specific mucosal antibody responses in HIV-exposed uninfected sex workers from the Gambia

artículo científico publicado en 2000

An antibody-drug conjugate that targets tissue factor exhibits potent therapeutic activity against a broad range of solid tumors

artículo científico publicado en 2013

An integrated science-based approach to drug development

article

Anti-Inflammatory Activity of Human IgG4 Antibodies by Dynamic Fab Arm Exchange

artículo científico publicado en 2007

Antibodies That Efficiently Form Hexamers upon Antigen Binding Can Induce Complement-Dependent Cytotoxicity under Complement-Limiting Conditions.

artículo científico publicado en 2016

Antibody C Region Influences TGN1412-like Functional Activity In Vitro

scientific article published on 12 November 2012

Antibody Engineering & Therapeutics 2015: The Antibody Society's annual meeting December 7-10, 2015, San Diego, CA.

artículo científico publicado en 2015

Antibody Engineering & Therapeutics 2016: The Antibody Society's annual meeting, December 11-15, 2016, San Diego, CA

artículo científico publicado en 2016

Antibody Engineering and Therapeutics Conference: The Annual Meeting of the Antibody Society, December 8–12, 2013, Huntington Beach, CA.

artículo científico publicado en 2013

Antibody engineering and therapeutics conference. The annual meeting of the antibody society, Huntington Beach, CA, December 7-11, 2014.

artículo científico publicado en 2014

Antibody engineering and therapeutics, The Annual Meeting of the Antibody Society: December 8-12, 2013, Huntington Beach, CA

artículo científico publicado en 2014

Antibody-mediated phagocytosis contributes to the anti-tumor activity of the therapeutic antibody daratumumab in lymphoma and multiple myeloma

artículo científico publicado en 2015

Assorted mutations in the envelope gene of simian immunodeficiency virus lead to loss of neutralization resistance against antibodies representing a broad spectrum of specificities

artículo científico publicado en 2003

B-cell depletion attenuates white and gray matter pathology in marmoset experimental autoimmune encephalomyelitis.

artículo científico publicado en 2011

Binding of submaximal C1q promotes complement-dependent cytotoxicity (CDC) of B cells opsonized with anti-CD20 mAbs ofatumumab (OFA) or rituximab (RTX): considerably higher levels of CDC are induced by OFA than by RTX.

artículo científico publicado en 2009

Bispecific antibodies: a mechanistic review of the pipeline

scientific article published on 01 August 2019

Broadly cross-reactive HIV-1-neutralizing human monoclonal Fab selected for binding to gp120-CD4-CCR5 complexes

artículo científico publicado en 2002

Broadly neutralizing antibodies targeted to the membrane-proximal external region of human immunodeficiency virus type 1 glycoprotein gp41.

artículo científico publicado en 2001

CD20-Specific Immunoligands Engaging NKG2D Enhance γδ T Cell-Mediated Lysis of Lymphoma Cells.

artículo científico publicado en 2017

Celebrating Antibody Therapeutics.

artículo científico publicado en 2017

Changes to International Nonproprietary Names for antibody therapeutics 2017 and beyond: of mice, men and more

artículo científico

Characterization of a fully human IgG1 reconstructed from an anti-AChR Fab.

artículo científico publicado en 2003

Characterization of new human CD20 monoclonal antibodies with potent cytolytic activity against non-Hodgkin lymphomas

artículo científico publicado en 2004

Combined Fc-protein- and Fc-glyco-engineering of scFv-Fc fusion proteins synergistically enhances CD16a binding but does not further enhance NK-cell mediated ADCC.

artículo científico publicado en 2011

Complement activation impacts B-cell depletion by both type I and type II CD20 monoclonal antibodies

artículo científico publicado en 2008

Complement in therapy and disease: Regulating the complement system with antibody-based therapeutics

artículo científico publicado en 2015

Complement is activated by IgG hexamers assembled at the cell surface

artículo científico publicado en 2014

Complement-Dependent Tumor Cell Lysis Triggered by Combinations of Epidermal Growth Factor Receptor Antibodies

artículo científico publicado en 2008

Complement-mediated tumor-specific cell lysis by antibody combinations targeting epidermal growth factor receptor (EGFR) and its variant III (EGFRvIII).

artículo científico publicado en 2011

Contrasting IgG Structures Reveal Extreme Asymmetry and Flexibility

artículo científico publicado en 2002

Controlled Fab-arm exchange for the generation of stable bispecific IgG1.

artículo científico publicado en 2014

Cooperative targeting of melanoma heterogeneity with an AXL antibody-drug conjugate and BRAF/MEK inhibitors.

artículo científico publicado en 2018

Crosstalk between human IgG isotypes and murine effector cells

artículo científico publicado en 2012

Crystal structure of a neutralizing human IGG against HIV-1: a template for vaccine design

artículo científico publicado en 2001

Crystallization and preliminary structure determination of an intact human immunoglobulin, b12: an antibody that broadly neutralizes primary isolates of HIV-1

article

Cysteine-SILAC Mass Spectrometry Enabling the Identification and Quantitation of Scrambled Interchain Disulfide Bonds: Preservation of Native Heavy-Light Chain Pairing in Bispecific IgGs Generated by Controlled Fab-arm Exchange.

artículo científico publicado en 2017

Daratumumab, a novel therapeutic human CD38 monoclonal antibody, induces killing of multiple myeloma and other hematological tumors.

artículo científico publicado en 2010

Daratumumab-mediated lysis of primary multiple myeloma cells is enhanced in combination with the human anti-KIR antibody IPH2102 and lenalidomide

artículo científico publicado en 2014

Detection of antibodies against the four subtypes of ebola virus in sera from any species using a novel antibody-phage indicator assay.

artículo científico publicado en 2002

Differences in responsiveness to CD3 stimulation between naive and memory CD4+ T cells cannot be overcome by CD28 costimulation.

artículo científico publicado en 1994

Discovery of amivantamab (JNJ-61186372), a bispecific antibody targeting EGFR and MET

artículo científico publicado en 2021

Dual epitope targeting and enhanced hexamerization by DR5 antibodies as a novel approach to induce potent anti-tumor activity through DR5 agonism

artículo científico publicado en 2020

Editorial overview: Special section: New concepts in antibody therapeutics: What's in store for antibody therapy?

scholarly article by Janine Schuurman & Paul Whi Parren published June 2016 in Current Opinion in Immunology

Effect of Target Dynamics on Pharmacokinetics of a Novel Therapeutic Antibody against the Epidermal Growth Factor Receptor: Implications for the Mechanisms of Action

article

Effector function activities of a panel of mutants of a broadly neutralizing antibody against human immunodeficiency virus type 1

artículo científico publicado en 2001

Efficient Generation of Bispecific Murine Antibodies for Pre-Clinical Investigations in Syngeneic Rodent Models

artículo científico publicado en 2017

Efficient Payload Delivery by a Bispecific Antibody-Drug Conjugate Targeting HER2 and CD63.

artículo científico publicado en 2016

Efficient generation of stable bispecific IgG1 by controlled Fab-arm exchange.

artículo científico publicado en 2013

Enhancing Accuracy in Molecular Weight Determination of Highly Heterogeneously Glycosylated Proteins by Native Tandem Mass Spectrometry

artículo científico publicado en 2017

Enhancing natural killer cell-mediated lysis of lymphoma cells by combining therapeutic antibodies with CD20-specific immunoligands engaging NKG2D or NKp30.

artículo científico

Epidermal growth factor receptor (EGFR) antibody-induced antibody-dependent cellular cytotoxicity plays a prominent role in inhibiting tumorigenesis, even of tumor cells insensitive to EGFR signaling inhibition.

artículo científico publicado en 2011

Erratum to “Relevance of the antibody response against human immunodeficiency virus type 1 envelope to vaccine design” [Immunol. Lett. 57 (1997) 105–112] ⬇️

artículo científico publicado el 1 de julio de 1997

Evidence for the involvement of the 16kD gene promoter in initiation of chromosomal replication of Escherichia coli strains carrying a B/r-derived replication origin

artículo científico publicado en 1987

Exhaustion of cytotoxic effector systems may limit monoclonal antibody-based immunotherapy in cancer patients

artículo científico publicado en 2012

Fab-arm exchange: what's in a name?

artículo científico publicado en 2012

Fc receptor but not complement binding is important in antibody protection against HIV.

artículo científico publicado en 2007

Fc-Fc interactions of human IgG4 require dissociation of heavy chains and are formed predominantly by the intra-chain hinge isomer

artículo científico publicado en 2012

Fighting the Ebola virus

artículo científico publicado en 2000

Functional characterization of a novel anti-B7 monoclonal antibody

article

Fusion proteins between ligands for NKG2D and CD20-directed single-chain variable fragments sensitize lymphoma cells for natural killer cell-mediated lysis and enhance antibody-dependent cellular cytotoxicity

artículo científico publicado en 2011

Genetic Vaccination: One-Shot Shopping for Immediate and Sustained Protection

HER2 monoclonal antibodies that do not interfere with receptor heterodimerization-mediated signaling induce effective internalization and represent valuable components for rational antibody-drug conjugate design

artículo científico publicado en 2014

Heterogeneity of envelope molecules expressed on primary human immunodeficiency virus type 1 particles as probed by the binding of neutralizing and nonneutralizing antibodies

artículo científico publicado en 2003

Hexamerization-enhanced CD20 antibody mediates complement-dependent cytotoxicity in serum genetically deficient in C9.

artículo científico publicado en 2017

High throughput screening for antibody induced complement-dependent cytotoxicity in early antibody discovery using homogeneous macroconfocal fluorescence imaging.

artículo científico publicado en 2009

High turnover of tissue factor enables efficient intracellular delivery of antibody-drug conjugates

artículo científico publicado en 2015

High-Throughput Screening for Internalizing Antibodies by Homogeneous Fluorescence Imaging of a pH-Activated Probe.

artículo científico publicado en 2015

Hinge-deleted IgG4 blocker therapy for acetylcholine receptor myasthenia gravis in rhesus monkeys

artículo científico publicado en 2017

Hitting Ebola, to the power of two.

artículo científico publicado en 2016

HuMab-7D8, a monoclonal antibody directed against the membrane-proximal small loop epitope of CD20 can effectively eliminate CD20 low expressing tumor cells that resist rituximab-mediated lysis.

artículo científico publicado en 2010

Human IgG is produced in a pro-form that requires clipping of C-terminal lysines for maximal complement activation

artículo científico publicado en 2015

Human IgG2 Antibodies against Epidermal Growth Factor Receptor Effectively Trigger Antibody-Dependent Cellular Cytotoxicity but, in Contrast to IgG1, Only by Cells of Myeloid Lineage

artículo científico publicado en 2009

Human kappa light chain targeted Pseudomonas exotoxin A--identifying human antibodies and Fab fragments with favorable characteristics for antibody-drug conjugate development

artículo científico publicado en 2011

Human recombinant antimannan immunoglobulin G1 antibody confers resistance to hematogenously disseminated candidiasis in mice

artículo científico publicado en 2006

Ibrutinib interferes with the cell-mediated anti-tumor activities of therapeutic CD20 antibodies: implications for combination therapy

artículo científico publicado en 2014

Identification and characterization of a peptide that specifically binds the human, broadly neutralizing anti-human immunodeficiency virus type 1 antibody b12

artículo científico publicado en 2001

IgA EGFR antibodies mediate tumour killing in vivo

artículo científico publicado en 2013

Immunogenicity screening in protein drug development

artículo científico publicado en 2007

Immunology. Two-in-one designer antibodies

artículo científico publicado en 2009

Impact of Fc gamma receptor polymorphisms on efficacy and safety of daratumumab in relapsed/refractory multiple myeloma.

artículo científico publicado en 2018

In situ depletion of CD4+ T cells in human skin by Zanolimumab

scientific article published on 08 November 2006

In vitro characterization of five humanized OKT3 effector function variant antibodies.

artículo científico publicado en 2000

In vivo cytotoxicity of type I CD20 antibodies critically depends on Fc receptor ITAM signaling.

artículo científico publicado en 2010

In-depth qualitative and quantitative analysis of composite glycosylation profiles and other micro-heterogeneity on intact monoclonal antibodies by high-resolution native mass spectrometry using a modified Orbitrap

artículo científico publicado en 2013

Induction of T-cell proliferation by recombinant mouse and chimeric mouse/human anti-CD3 monoclonal antibodies.

artículo científico publicado en 1991

Inhibition of virus attachment to CD4+ target cells is a major mechanism of T cell line-adapted HIV-1 neutralization

artículo científico publicado en 1997

Late B Cell Depletion with a Human Anti-Human CD20 IgG1 Monoclonal Antibody Halts the Development of Experimental Autoimmune Encephalomyelitis in Marmosets

article

Listening for viral infection

scholarly article by Erica Ollmann Saphire & Paul Whi Parren published September 2001 in Nature Biotechnology

Loss of CD20 and bound CD20 antibody from opsonized B cells occurs more rapidly because of trogocytosis mediated by Fc receptor-expressing effector cells than direct internalization by the B cells.

artículo científico publicado en 2011

Mimicking an induced self phenotype by coating lymphomas with the NKp30 ligand B7-H6 promotes NK cell cytotoxicity

artículo científico publicado en 2012

Mind the gap

Molecular Basis of Assembly and Activation of Complement Component C1 in Complex with Immunoglobulin G1 and Antigen

artículo científico publicado en 2016

Molecular features of the broadly neutralizing immunoglobulin G1 b12 required for recognition of human immunodeficiency virus type 1 gp120.

artículo científico publicado en 2003

Monoclonal Antibodies against Epidermal Growth Factor Receptor Acquire an Ability To Kill Tumor Cells through Complement Activation by Mutations That Selectively Facilitate the Hexamerization of IgG on Opsonized Cells.

artículo científico publicado en 2017

Monoclonal antibodies targeting CD38 in hematological malignancies and beyond

artículo científico publicado en 2016

Mouse/Human Chimeric IgE Antibodies Directed to the House Dust Mite Allergen Der p 2

artículo científico publicado en 1995

N-linked glycosylation is an important parameter for optimal selection of cell lines producing biopharmaceutical human IgG.

artículo científico publicado en 2009

Neutralization synergy of human immunodeficiency virus type 1 primary isolates by cocktails of broadly neutralizing antibodies.

artículo científico publicado en 2001

Neutralizing antibodies have limited effects on the control of established HIV-1 infection in vivo.

artículo científico publicado en 1999

Neutralizing antibody affords comparable protection against vaginal and rectal simian/human immunodeficiency virus challenge in macaques.

artículo científico publicado en 2016

Neutralizing human Fab fragments against measles virus recovered by phage display

artículo científico publicado en 2002

Ofatumumab (Arzerra®): a Next-Generation Human Therapeutic CD20 Antibody with Potent Complement-Dependent Cytotoxicity

Oligomeric and conformational properties of a proteolytically mature, disulfide-stabilized human immunodeficiency virus type 1 gp140 envelope glycoprotein

artículo científico publicado en 2002

Oncogenic KRAS impairs EGFR antibodies' efficiency by C/EBPβ-dependent suppression of EGFR expression

artículo científico publicado en 2012

Online nanoliquid chromatography–mass spectrometry and nanofluorescence detection for high-resolution quantitative N-glycan analysis

article

Opening the door to innovation

artículo científico publicado en 2014

Passive immunization with a human monoclonal antibody protects hu-PBL-SCID mice against challenge by primary isolates of HIV-1.

artículo científico publicado en 1997

Polymorphism of the human Fc gamma receptor II (CD32): molecular basis and functional aspects

artículo científico publicado el 1 de agosto de 1992

Pre- and postexposure prophylaxis of Ebola virus infection in an animal model by passive transfer of a neutralizing human antibody

artículo científico publicado en 2002

Pre-clinical evaluation of CD38 chimeric antigen receptor engineered T cells for the treatment of multiple myeloma.

artículo científico publicado en 2016

Preclinical Evidence for the Therapeutic Potential of CD38-Targeted Immuno-Chemotherapy in Multiple Myeloma Patients Refractory to Lenalidomide and Bortezomib

artículo científico publicado en 2014

Production of a mouse/human chimeric IgE monoclonal antibody to the house dust mite allergen Der p 2 and its use for the absolute quantification of allergen-specific IgE

article

Production of stable bispecific IgG1 by controlled Fab-arm exchange: scalability from bench to large-scale manufacturing by application of standard approaches.

artículo científico publicado en 2013

Quantitative Analysis of the Interaction Strength and Dynamics of Human IgG4 Half Molecules by Native Mass Spectrometry

article

Rapid production of recombinant human IgG With improved ADCC effector function in a transient expression system

artículo científico publicado en 2010

Real-time analysis of the detailed sequence of cellular events in mAb-mediated complement-dependent cytotoxicity of B-cell lines and of chronic lymphocytic leukemia B-cells.

artículo científico publicado en 2015

Recognition properties of a sequence-specific DNA binding antibody

artículo científico publicado en 1998

Relevance of the antibody response against human immunodeficiency virus type 1 envelope to vaccine design ⬇️

artículo científico publicado el 1 de junio de 1997

Resolution of psoriasis upon blockade of IL-15 biological activity in a xenograft mouse model

artículo científico publicado en 2003

Response to Comment on "Type I CD20 Antibodies Recruit the B Cell Receptor for Complement-Dependent Lysis of Malignant B Cells".

artículo científico publicado en 2018

Retraction for Lammerts van Bueren et al. The antibody zalutumumab inhibits epidermal growth factor receptor signaling by limiting intra- and intermolecular flexibility

artículo científico publicado en 2012

Role of IgG Fc Receptors in Monoclonal Antibody Therapy of Cancer

article

Species-Specific Determinants in the IgG CH3 Domain Enable Fab-Arm Exchange by Affecting the Noncovalent CH3-CH3 Interaction Strength

article

Statins impair antitumor effects of rituximab by inducing conformational changes of CD20

artículo científico publicado en 2008

Structures of C1-IgG1 provide insights into how danger pattern recognition activates complement

artículo científico publicado en 2018

Tandem Native Mass-Spectrometry on Antibody-Drug Conjugates and Submillion Da Antibody-Antigen Protein Assemblies on an Orbitrap EMR Equipped with a High-Mass Quadrupole Mass Selector

artículo científico publicado en 2015

Targeting interleukin-15 in patients with rheumatoid arthritis: a proof-of-concept study

artículo científico publicado en 2005

The Human CD38 Monoclonal Antibody Daratumumab Shows Antitumor Activity and Hampers Leukemia-Microenvironment Interactions in Chronic Lymphocytic Leukemia.

artículo científico publicado en 2016

The INNs and outs of antibody nonproprietary names

artículo científico publicado en 2016

The Therapeutic CD38 Monoclonal Antibody Daratumumab Induces Programmed Cell Death via Fcγ Receptor-Mediated Cross-Linking

artículo científico publicado en 2016

The antiviral activity of antibodies in vitro and in vivo.

artículo científico publicado en 2001

The in vivo mechanism of action of CD20 monoclonal antibodies depends on local tumor burden.

artículo científico publicado en 2011

The novel tribody [(CD20)(2)xCD16] efficiently triggers effector cell-mediated lysis of malignant B cells

artículo científico publicado en 2012

The therapeutic human CD38 antibody daratumumab improves the anti-myeloma effect of newly emerging multi-drug therapies

artículo científico publicado en 2011

Therapeutic IgG4 antibodies engage in Fab-arm exchange with endogenous human IgG4 in vivo

artículo científico publicado en 2009

Towards effective immunotherapy of myeloma: enhanced elimination of myeloma cells by combination of lenalidomide with the human CD38 monoclonal antibody daratumumab

artículo científico publicado en 2010

Type I CD20 Antibodies Recruit the B Cell Receptor for Complement-Dependent Lysis of Malignant B Cells.

artículo científico publicado en 2016

Vaccines and the induction of functional antibodies: time to look beyond the molecules of natural infection?

artículo científico publicado en 2000

When blood transfusion medicine becomes complicated due to interference by monoclonal antibody therapy

artículo científico publicado en 2015

gp120: Biologic aspects of structural features

artículo científico publicado en 2001

Lista de obras de Paul Whi Parren

A Novel Bispecific Antibody Targeting EGFR and cMet Is Effective against EGFR Inhibitor-Resistant Lung Tumors.

A Novel Platform for the Potentiation of Therapeutic Antibodies Based on Antigen-Dependent Formation of IgG Hexamers at the Cell Surface

A bispecific antibody antagonizes pro-survival CD40 signaling and promotes Vγ9Vδ2 T cell-mediated antitumor responses in human B-cell malignancies

A human CD4 monoclonal antibody for the treatment of T-cell lymphoma combines inhibition of T-cell signaling by a dual mechanism with potent Fc-dependent effector activity

A novel human antibody against human immunodeficiency virus type 1 gp120 is V1, V2, and V3 loop dependent and helps delimit the epitope of the broadly neutralizing antibody immunoglobulin G1 b12.

A novel label-free cell-based assay technology using biolayer interferometry

A quantitative flow cytometric assay for determining binding characteristics of chimeric, humanized and human antibodies in whole blood: proof of principle with rituximab and ofatumumab

A structure-based approach to a synthetic vaccine for HIV-1.

ADCT-301, a Pyrrolobenzodiazepine (PBD) Dimer-Containing Antibody-Drug Conjugate (ADC) Targeting CD25-Expressing Hematological Malignancies.

Absence of specific mucosal antibody responses in HIV-exposed uninfected sex workers from the Gambia

An antibody-drug conjugate that targets tissue factor exhibits potent therapeutic activity against a broad range of solid tumors

An integrated science-based approach to drug development

Anti-Inflammatory Activity of Human IgG4 Antibodies by Dynamic Fab Arm Exchange

Antibodies That Efficiently Form Hexamers upon Antigen Binding Can Induce Complement-Dependent Cytotoxicity under Complement-Limiting Conditions.

Antibody C Region Influences TGN1412-like Functional Activity In Vitro

Antibody Engineering & Therapeutics 2015: The Antibody Society's annual meeting December 7-10, 2015, San Diego, CA.

Antibody Engineering & Therapeutics 2016: The Antibody Society's annual meeting, December 11-15, 2016, San Diego, CA

Antibody Engineering and Therapeutics Conference: The Annual Meeting of the Antibody Society, December 8–12, 2013, Huntington Beach, CA.

Antibody engineering and therapeutics conference. The annual meeting of the antibody society, Huntington Beach, CA, December 7-11, 2014.

Antibody engineering and therapeutics, The Annual Meeting of the Antibody Society: December 8-12, 2013, Huntington Beach, CA

Antibody-mediated phagocytosis contributes to the anti-tumor activity of the therapeutic antibody daratumumab in lymphoma and multiple myeloma

Assorted mutations in the envelope gene of simian immunodeficiency virus lead to loss of neutralization resistance against antibodies representing a broad spectrum of specificities

B-cell depletion attenuates white and gray matter pathology in marmoset experimental autoimmune encephalomyelitis.

Binding of submaximal C1q promotes complement-dependent cytotoxicity (CDC) of B cells opsonized with anti-CD20 mAbs ofatumumab (OFA) or rituximab (RTX): considerably higher levels of CDC are induced by OFA than by RTX.

Bispecific antibodies: a mechanistic review of the pipeline

Broadly cross-reactive HIV-1-neutralizing human monoclonal Fab selected for binding to gp120-CD4-CCR5 complexes

Broadly neutralizing antibodies targeted to the membrane-proximal external region of human immunodeficiency virus type 1 glycoprotein gp41.

CD20-Specific Immunoligands Engaging NKG2D Enhance γδ T Cell-Mediated Lysis of Lymphoma Cells.

Celebrating Antibody Therapeutics.

Changes to International Nonproprietary Names for antibody therapeutics 2017 and beyond: of mice, men and more

Characterization of a fully human IgG1 reconstructed from an anti-AChR Fab.

Characterization of new human CD20 monoclonal antibodies with potent cytolytic activity against non-Hodgkin lymphomas

Combined Fc-protein- and Fc-glyco-engineering of scFv-Fc fusion proteins synergistically enhances CD16a binding but does not further enhance NK-cell mediated ADCC.

Complement activation impacts B-cell depletion by both type I and type II CD20 monoclonal antibodies

Complement in therapy and disease: Regulating the complement system with antibody-based therapeutics

Complement is activated by IgG hexamers assembled at the cell surface

Complement-Dependent Tumor Cell Lysis Triggered by Combinations of Epidermal Growth Factor Receptor Antibodies

Complement-mediated tumor-specific cell lysis by antibody combinations targeting epidermal growth factor receptor (EGFR) and its variant III (EGFRvIII).

Contrasting IgG Structures Reveal Extreme Asymmetry and Flexibility

Controlled Fab-arm exchange for the generation of stable bispecific IgG1.

Cooperative targeting of melanoma heterogeneity with an AXL antibody-drug conjugate and BRAF/MEK inhibitors.

Crosstalk between human IgG isotypes and murine effector cells

Crystal structure of a neutralizing human IGG against HIV-1: a template for vaccine design

Crystallization and preliminary structure determination of an intact human immunoglobulin, b12: an antibody that broadly neutralizes primary isolates of HIV-1

Cysteine-SILAC Mass Spectrometry Enabling the Identification and Quantitation of Scrambled Interchain Disulfide Bonds: Preservation of Native Heavy-Light Chain Pairing in Bispecific IgGs Generated by Controlled Fab-arm Exchange.

Daratumumab, a novel therapeutic human CD38 monoclonal antibody, induces killing of multiple myeloma and other hematological tumors.

Daratumumab-mediated lysis of primary multiple myeloma cells is enhanced in combination with the human anti-KIR antibody IPH2102 and lenalidomide

Detection of antibodies against the four subtypes of ebola virus in sera from any species using a novel antibody-phage indicator assay.

Differences in responsiveness to CD3 stimulation between naive and memory CD4+ T cells cannot be overcome by CD28 costimulation.

Discovery of amivantamab (JNJ-61186372), a bispecific antibody targeting EGFR and MET

Dual epitope targeting and enhanced hexamerization by DR5 antibodies as a novel approach to induce potent anti-tumor activity through DR5 agonism

Editorial overview: Special section: New concepts in antibody therapeutics: What's in store for antibody therapy?

Effect of Target Dynamics on Pharmacokinetics of a Novel Therapeutic Antibody against the Epidermal Growth Factor Receptor: Implications for the Mechanisms of Action

Effector function activities of a panel of mutants of a broadly neutralizing antibody against human immunodeficiency virus type 1

Efficient Generation of Bispecific Murine Antibodies for Pre-Clinical Investigations in Syngeneic Rodent Models

Efficient Payload Delivery by a Bispecific Antibody-Drug Conjugate Targeting HER2 and CD63.

Efficient generation of stable bispecific IgG1 by controlled Fab-arm exchange.

Enhancing Accuracy in Molecular Weight Determination of Highly Heterogeneously Glycosylated Proteins by Native Tandem Mass Spectrometry

Enhancing natural killer cell-mediated lysis of lymphoma cells by combining therapeutic antibodies with CD20-specific immunoligands engaging NKG2D or NKp30.

Epidermal growth factor receptor (EGFR) antibody-induced antibody-dependent cellular cytotoxicity plays a prominent role in inhibiting tumorigenesis, even of tumor cells insensitive to EGFR signaling inhibition.

Erratum to “Relevance of the antibody response against human immunodeficiency virus type 1 envelope to vaccine design” [Immunol. Lett. 57 (1997) 105–112] ⬇️

Evidence for the involvement of the 16kD gene promoter in initiation of chromosomal replication of Escherichia coli strains carrying a B/r-derived replication origin

Exhaustion of cytotoxic effector systems may limit monoclonal antibody-based immunotherapy in cancer patients

Fab-arm exchange: what's in a name?

Fc receptor but not complement binding is important in antibody protection against HIV.

Fc-Fc interactions of human IgG4 require dissociation of heavy chains and are formed predominantly by the intra-chain hinge isomer

Fighting the Ebola virus

Functional characterization of a novel anti-B7 monoclonal antibody

Fusion proteins between ligands for NKG2D and CD20-directed single-chain variable fragments sensitize lymphoma cells for natural killer cell-mediated lysis and enhance antibody-dependent cellular cytotoxicity

Genetic Vaccination: One-Shot Shopping for Immediate and Sustained Protection

HER2 monoclonal antibodies that do not interfere with receptor heterodimerization-mediated signaling induce effective internalization and represent valuable components for rational antibody-drug conjugate design

Heterogeneity of envelope molecules expressed on primary human immunodeficiency virus type 1 particles as probed by the binding of neutralizing and nonneutralizing antibodies

Hexamerization-enhanced CD20 antibody mediates complement-dependent cytotoxicity in serum genetically deficient in C9.

High throughput screening for antibody induced complement-dependent cytotoxicity in early antibody discovery using homogeneous macroconfocal fluorescence imaging.

High turnover of tissue factor enables efficient intracellular delivery of antibody-drug conjugates

High-Throughput Screening for Internalizing Antibodies by Homogeneous Fluorescence Imaging of a pH-Activated Probe.

Hinge-deleted IgG4 blocker therapy for acetylcholine receptor myasthenia gravis in rhesus monkeys

Hitting Ebola, to the power of two.

HuMab-7D8, a monoclonal antibody directed against the membrane-proximal small loop epitope of CD20 can effectively eliminate CD20 low expressing tumor cells that resist rituximab-mediated lysis.