Lista de obras - Bruno Ségui - Dominio Público Uruguay

Anti-TNF, a magic bullet in cancer immunotherapy?

artículo científico publicado en 2019

Apolipoprotein E-deficient mice develop an anti-Chlamydophila pneumoniae T helper 2 response and resist vascular infection.

artículo científico publicado en 2010

Blocking Tumor Necrosis Factor α Enhances CD8 T-cell-Dependent Immunity in Experimental Melanoma

artículo científico publicado en 2015

CD40 signals apoptosis through FAN-regulated activation of the sphingomyelin-ceramide pathway.

artículo científico publicado en 1999

CD95 triggers Orai1-mediated localized Ca2+ entry, regulates recruitment of protein kinase C (PKC) β2, and prevents death-inducing signaling complex formation

artículo científico publicado en 2011

Caspase-10 triggers Bid cleavage and caspase cascade activation in FasL-induced apoptosis.

artículo científico publicado en 2005

Caspase-10-dependent cell death in Fas/CD95 signalling is not abrogated by caspase inhibitor zVAD-fmk

artículo científico publicado en 2010

Caspase-dependent and -independent cell death of Jurkat human leukemia cells induced by novel synthetic ceramide analogs

artículo científico publicado en 2006

Caspase-mediated inhibition of sphingomyelin synthesis is involved in FasL-triggered cell death

artículo científico publicado en 2009

Ceramide in apoptosis: a revisited role.

artículo científico publicado en 2002

Chemotherapy with ceramide in TNBC.

artículo científico publicado en 2015

Chlamydia pneumoniae alters mildly oxidized low-density lipoprotein-induced cell death in human endothelial cells, leading to necrosis rather than apoptosis.

artículo científico publicado en 2005

Chronic vascular rejection: histologic comparison between two murine experimental models

scientific article published on 01 July 2005

Cleavage and cytoplasmic relocalization of histone deacetylase 3 are important for apoptosis progression

artículo científico publicado en 2006

Downregulation of ceramide synthase-6 during epithelial-to-mesenchymal transition reduces plasma membrane fluidity and cancer cell motility

artículo científico publicado en 2014

Downregulation of sphingosine kinase-1 induces protective tumor immunity by promoting M1 macrophage response in melanoma

scientific article published on 30 September 2016

Dual role of sphingosine kinase-1 in promoting the differentiation of dermal fibroblasts and the dissemination of melanoma cells

artículo científico publicado en 2013

Engraftment of human T, B and NK cells in CB.17 SCID/beige mice by transfer of human spleen cells

artículo científico publicado en 2005

Evidence for the lack of involvement of sphingomyelin hydrolysis in the tumor necrosis factor-induced secretion of nerve growth factor in primary astrocyte cultures.

artículo científico publicado en 1998

Expression of membrane-bound and soluble FasL in Fas- and FADD-dependent T lymphocyte apoptosis induced by mildly oxidized LDL

artículo científico publicado en 2003

FAN (factor associated with neutral sphingomyelinase activation), a moonlighting protein in TNF-R1 signaling

artículo científico publicado en 2010

FAN stimulates TNF(alpha)-induced gene expression, leukocyte recruitment, and humoral response.

artículo científico publicado en 2009

Genetic disorders of simple sphingolipid metabolism.

artículo científico

Glucosylceramidases and malignancies in mammals.

artículo científico publicado en 2015

Human genetic disorders of sphingolipid biosynthesis

artículo científico publicado en 2014

Human immune reconstitution with spleen cells in SCID/Beige mice

scientific article published on 01 July 2005

IL-6 deficiency attenuates murine diet-induced non-alcoholic steatohepatitis

artículo científico publicado en 2009

IL13-Mediated Dectin-1 and Mannose Receptor Overexpression Promotes Macrophage Antitumor Activities through Recognition of Sialylated Tumor Cells

scientific article published on 04 January 2019

Interleukin-6 deficiency fails to prevent chronic rejection after aortic allografts in apolipoprotein E-deficient mice

artículo científico publicado en 2008

Involvement of FAN in TNF-induced apoptosis

artículo científico publicado en 2001

Is active acid sphingomyelinase required for the antiproliferative response to rituximab?

artículo científico publicado en 2011

Liquid Chromatography-High Resolution Mass Spectrometry Method to Study Sphingolipid Metabolism Changes in Response to CD95L

artículo científico publicado en 2017

Lysosomal sphingomyelinase is not solicited for apoptosis signaling

artículo científico publicado en 2000

Method to Measure Sphingomyelin Synthase Activity Changes in Response to CD95L.

artículo científico publicado en 2017

Monogenic neurological disorders of sphingolipid metabolism

artículo científico

Morniga G: a plant lectin as an endocytic ligand for photosensitizer molecule targeting toward tumor-associated T/Tn antigens

artículo científico publicado en 2010

Morniga-G, a T/Tn-Specific Lectin, Induces Leukemic Cell Death via Caspase and DR5 Receptor-Dependent Pathways ⬇️

artículo científico publicado en 2019

Multiple human mesenteric arterial grafts from the same donor to study human chronic vascular rejection in humanized SCID/beige mice

scientific article published on 02 May 2006

OPA1 cleavage depends on decreased mitochondrial ATP level and bivalent metals

scientific article published on 19 August 2007

Ordering of ceramide formation and caspase-9 activation in CD95L-induced Jurkat leukemia T cell apoptosis

artículo científico publicado en 2012

Phosphatidylinositol transfer protein beta displays minimal sphingomyelin transfer activity and is not required for biosynthesis and trafficking of sphingomyelin

artículo científico publicado en 2002

Phosphorylation of a distinct structural form of phosphatidylinositol transfer protein alpha at Ser166 by protein kinase C disrupts receptor-mediated phospholipase C signaling by inhibiting delivery of phosphatidylinositol to membranes

artículo científico publicado en 2004

Phosphorylation of serine palmitoyltransferase long chain-1 (SPTLC1) on tyrosine 164 inhibits its activity and promotes cell survival.

artículo científico publicado en 2013

Regulation of death and growth signals at the plasma membrane by sphingomyelin synthesis: implications for hematological malignancies

artículo científico publicado en 2011

Resistance of melanoma to immune checkpoint inhibitors is overcome by targeting the sphingosine kinase-1

scientific article published on 23 January 2020

Retrovirus-mediated correction of the metabolic defect in cultured Farber disease cells.

artículo científico publicado en 1999

Role of FAN in tumor necrosis factor-alpha and lipopolysaccharide-induced interleukin-6 secretion and lethality in D-galactosamine-sensitized mice

artículo científico publicado en 2004

S1P: the elixir of life for naive T cells

scientific article published on 30 October 2017

Sphingolipid signalling: molecular basis and role in TNF-alpha-induced cell death.

artículo científico publicado en 2002

Sphingolipid-mediated apoptotic signaling pathways

artículo científico publicado en 2003

Sphingolipids modulate the epithelial-mesenchymal transition in cancer.

artículo científico publicado en 2015

Sphingomyelin Synthase 1 (SMS1) Downregulation Is Associated With Sphingolipid Reprogramming and a Worse Prognosis in Melanoma

artículo científico publicado en 2019

Stress-induced apoptosis is not mediated by endolysosomal ceramide

artículo científico publicado en 2000

TNF-R1, an immune checkpoint in melanoma?

artículo científico publicado en 2015

TNFα blockade overcomes resistance to anti-PD-1 in experimental melanoma.

artículo científico publicado en 2017

Targeting TNF alpha as a novel strategy to enhance CD8(+) T cell-dependent immune response in melanoma?

artículo científico

Targeting of T/Tn antigens with a plant lectin to kill human leukemia cells by photochemotherapy

artículo científico publicado en 2011

Targeting the Sphingosine 1-Phosphate Axis Exerts Potent Antitumor Activity in BRAFi-Resistant Melanomas

artículo científico publicado en 2018

The CB(1) cannabinoid receptor of astrocytes is coupled to sphingomyelin hydrolysis through the adaptor protein fan.

artículo científico publicado en 2001

The TNF Paradox in Cancer Progression and Immunotherapy

scientific article published on 31 July 2019

The nonlysosomal β-glucosidase GBA2 promotes endoplasmic reticulum stress and impairs tumorigenicity of human melanoma cells

artículo científico publicado en 2012

The pro-inflammatory action of tumour necrosis factor-α in non-alcoholic steatohepatitis is independent of the NSMAF gene product.

artículo científico publicado en 2012

The tricyclodecan-9-yl-xanthogenate D609 triggers ceramide increase and enhances FasL-induced caspase-dependent and -independent cell death in T lymphocytes

artículo científico publicado en 2012

Two structurally identical mannose-specific jacalin-related lectins display different effects on human T lymphocyte activation and cell death.

artículo científico publicado en 2009

Use of human mesenteric arteries to study chronic vascular rejection in SCID/beige mice reconstituted with human spleen cells

artículo científico publicado en 2005

[Anti-TNFα antibodies in melanoma immunotherapy]

artículo científico publicado en 2018

Lista de obras de Bruno Ségui

Anti-TNF, a magic bullet in cancer immunotherapy?

Apolipoprotein E-deficient mice develop an anti-Chlamydophila pneumoniae T helper 2 response and resist vascular infection.

Blocking Tumor Necrosis Factor α Enhances CD8 T-cell-Dependent Immunity in Experimental Melanoma

CD40 signals apoptosis through FAN-regulated activation of the sphingomyelin-ceramide pathway.

CD95 triggers Orai1-mediated localized Ca2+ entry, regulates recruitment of protein kinase C (PKC) β2, and prevents death-inducing signaling complex formation

Caspase-10 triggers Bid cleavage and caspase cascade activation in FasL-induced apoptosis.

Caspase-10-dependent cell death in Fas/CD95 signalling is not abrogated by caspase inhibitor zVAD-fmk

Caspase-dependent and -independent cell death of Jurkat human leukemia cells induced by novel synthetic ceramide analogs

Caspase-mediated inhibition of sphingomyelin synthesis is involved in FasL-triggered cell death

Ceramide in apoptosis: a revisited role.

Chemotherapy with ceramide in TNBC.

Chlamydia pneumoniae alters mildly oxidized low-density lipoprotein-induced cell death in human endothelial cells, leading to necrosis rather than apoptosis.

Chronic vascular rejection: histologic comparison between two murine experimental models

Cleavage and cytoplasmic relocalization of histone deacetylase 3 are important for apoptosis progression

Downregulation of ceramide synthase-6 during epithelial-to-mesenchymal transition reduces plasma membrane fluidity and cancer cell motility

Downregulation of sphingosine kinase-1 induces protective tumor immunity by promoting M1 macrophage response in melanoma

Dual role of sphingosine kinase-1 in promoting the differentiation of dermal fibroblasts and the dissemination of melanoma cells

Engraftment of human T, B and NK cells in CB.17 SCID/beige mice by transfer of human spleen cells

Evidence for the lack of involvement of sphingomyelin hydrolysis in the tumor necrosis factor-induced secretion of nerve growth factor in primary astrocyte cultures.

Expression of membrane-bound and soluble FasL in Fas- and FADD-dependent T lymphocyte apoptosis induced by mildly oxidized LDL

FAN (factor associated with neutral sphingomyelinase activation), a moonlighting protein in TNF-R1 signaling

FAN stimulates TNF(alpha)-induced gene expression, leukocyte recruitment, and humoral response.

Genetic disorders of simple sphingolipid metabolism.

Glucosylceramidases and malignancies in mammals.

Human genetic disorders of sphingolipid biosynthesis

Human immune reconstitution with spleen cells in SCID/Beige mice

IL-6 deficiency attenuates murine diet-induced non-alcoholic steatohepatitis

IL13-Mediated Dectin-1 and Mannose Receptor Overexpression Promotes Macrophage Antitumor Activities through Recognition of Sialylated Tumor Cells

Interleukin-6 deficiency fails to prevent chronic rejection after aortic allografts in apolipoprotein E-deficient mice

Involvement of FAN in TNF-induced apoptosis

Is active acid sphingomyelinase required for the antiproliferative response to rituximab?

Liquid Chromatography-High Resolution Mass Spectrometry Method to Study Sphingolipid Metabolism Changes in Response to CD95L

Lysosomal sphingomyelinase is not solicited for apoptosis signaling

Method to Measure Sphingomyelin Synthase Activity Changes in Response to CD95L.

Monogenic neurological disorders of sphingolipid metabolism

Morniga G: a plant lectin as an endocytic ligand for photosensitizer molecule targeting toward tumor-associated T/Tn antigens

Morniga-G, a T/Tn-Specific Lectin, Induces Leukemic Cell Death via Caspase and DR5 Receptor-Dependent Pathways ⬇️

Multiple human mesenteric arterial grafts from the same donor to study human chronic vascular rejection in humanized SCID/beige mice

OPA1 cleavage depends on decreased mitochondrial ATP level and bivalent metals

Ordering of ceramide formation and caspase-9 activation in CD95L-induced Jurkat leukemia T cell apoptosis

Phosphatidylinositol transfer protein beta displays minimal sphingomyelin transfer activity and is not required for biosynthesis and trafficking of sphingomyelin

Phosphorylation of a distinct structural form of phosphatidylinositol transfer protein alpha at Ser166 by protein kinase C disrupts receptor-mediated phospholipase C signaling by inhibiting delivery of phosphatidylinositol to membranes

Phosphorylation of serine palmitoyltransferase long chain-1 (SPTLC1) on tyrosine 164 inhibits its activity and promotes cell survival.

Regulation of death and growth signals at the plasma membrane by sphingomyelin synthesis: implications for hematological malignancies

Resistance of melanoma to immune checkpoint inhibitors is overcome by targeting the sphingosine kinase-1

Retrovirus-mediated correction of the metabolic defect in cultured Farber disease cells.

Role of FAN in tumor necrosis factor-alpha and lipopolysaccharide-induced interleukin-6 secretion and lethality in D-galactosamine-sensitized mice

S1P: the elixir of life for naive T cells

Sphingolipid signalling: molecular basis and role in TNF-alpha-induced cell death.

Sphingolipid-mediated apoptotic signaling pathways

Sphingolipids modulate the epithelial-mesenchymal transition in cancer.

Sphingomyelin Synthase 1 (SMS1) Downregulation Is Associated With Sphingolipid Reprogramming and a Worse Prognosis in Melanoma

Stress-induced apoptosis is not mediated by endolysosomal ceramide

TNF-R1, an immune checkpoint in melanoma?

TNFα blockade overcomes resistance to anti-PD-1 in experimental melanoma.

Targeting TNF alpha as a novel strategy to enhance CD8(+) T cell-dependent immune response in melanoma?

Targeting of T/Tn antigens with a plant lectin to kill human leukemia cells by photochemotherapy

Targeting the Sphingosine 1-Phosphate Axis Exerts Potent Antitumor Activity in BRAFi-Resistant Melanomas

The CB(1) cannabinoid receptor of astrocytes is coupled to sphingomyelin hydrolysis through the adaptor protein fan.

The TNF Paradox in Cancer Progression and Immunotherapy

The nonlysosomal β-glucosidase GBA2 promotes endoplasmic reticulum stress and impairs tumorigenicity of human melanoma cells

The pro-inflammatory action of tumour necrosis factor-α in non-alcoholic steatohepatitis is independent of the NSMAF gene product.

The tricyclodecan-9-yl-xanthogenate D609 triggers ceramide increase and enhances FasL-induced caspase-dependent and -independent cell death in T lymphocytes

Two structurally identical mannose-specific jacalin-related lectins display different effects on human T lymphocyte activation and cell death.

Use of human mesenteric arteries to study chronic vascular rejection in SCID/beige mice reconstituted with human spleen cells

[Anti-TNFα antibodies in melanoma immunotherapy]