Lista de obras - Massimo Serra - Dominio Público Uruguay

4-Demethoxy-3'-deamino-3'-aziridinyl-4'-methylsulphonyl-daunorubicin (PNU-159548): a promising new candidate for chemotherapeutic treatment of osteosarcoma patients.

artículo científico publicado en 2005

A Genome-Wide Scan Identifies Variants in NFIB Associated with Metastasis in Patients with Osteosarcoma

artículo científico publicado en 2015

ABCA1/ABCB1 Ratio Determines Chemo- and Immune-Sensitivity in Human Osteosarcoma

scientific article published on 06 March 2020

Adjuvant and neo-adjuvant chemotherapy for Ewing's sarcoma family tumors and osteosarcoma of the extremity: further outcome for patients event-free survivors 5 years from the beginning of treatment

artículo científico publicado en 2007

Adriamycin binding assay: a valuable chemosensitivity test in human osteosarcoma

artículo científico publicado en 1992

Advances in emerging drugs for osteosarcoma

artículo científico

Agave negatively regulates YAP and TAZ transcriptionally and post-translationally in osteosarcoma cell lines

scientific article published on 19 June 2018

Alendronate reduces adhesion of human osteoclast-like cells to bone and bone protein-coated surfaces

artículo científico publicado en 1998

An aza-macrocycle containing maltolic side-arms (maltonis) as potential drug against human pediatric sarcomas.

artículo científico publicado en 2014

An update on chemotherapy for osteosarcoma

artículo científico publicado en 2015

Analysis of P-glycoprotein expression in osteosarcoma

scientific article published on 01 November 1995

Analysis of dihydrofolate reductase and reduced folate carrier gene status in relation to methotrexate resistance in osteosarcoma cells

artículo científico publicado en 2004

Analysis of heritability and shared heritability based on genome-wide association studies for thirteen cancer types

artículo científico publicado en 2015

Anti-EGFR Antibody Cetuximab Enhances the Cytolytic Activity of Natural Killer Cells toward Osteosarcoma

artículo científico publicado en 2011

Antitumor activity of the insulin-like growth factor-I receptor kinase inhibitor NVP-AEW541 in musculoskeletal tumors.

artículo científico publicado en 2005

Array comparative genomic hybridization reveals frequent alterations of G1/S checkpoint genes in undifferentiated pleomorphic sarcoma of bone

artículo científico publicado en 2011

Biological indicators of prognosis in Ewing's sarcoma: an emerging role for lectin galactoside-binding soluble 3 binding protein (LGALS3BP).

artículo científico publicado en 2010

C-kit receptor expression in Ewing's sarcoma: lack of prognostic value but therapeutic targeting opportunities in appropriate conditions.

artículo científico publicado en 2003

CD99 acts as an oncosuppressor in osteosarcoma

artículo científico publicado en 2006

Candidate germline polymorphisms of genes belonging to the pathways of four drugs used in osteosarcoma standard chemotherapy associated with risk, survival and toxicity in non-metastatic high-grade osteosarcoma

scientific article published on 22 August 2016

Caveolin-1 reduces osteosarcoma metastases by inhibiting c-Src activity and met signaling.

artículo científico publicado en 2007

Caveolins in the development and diseases of musculoskeletal system.

artículo científico publicado en 2009

Chemotherapy-resistant osteosarcoma is highly susceptible to IL-15-activated allogeneic and autologous NK cells.

artículo científico publicado en 2011

Clinical impact of the methotrexate resistance-associated genes C-MYC and dihydrofolate reductase (DHFR) in high-grade osteosarcoma.

artículo científico publicado en 2008

Clinical relevance of Ki-67 expression in bone tumors

artículo científico publicado en 1995

Clinicopathological significance of cell cycle regulation markers in a large series of genetically confirmed Ewing's Sarcoma Family of Tumors

artículo científico publicado en 2011

Combined use of expression and CGH arrays pinpoints novel candidate genes in Ewing sarcoma family of tumors

artículo científico publicado en 2009

Contribution of MEK/MAPK and PI3-K signaling pathway to the malignant behavior of Ewing's sarcoma cells: therapeutic prospects

artículo científico publicado en 2004

Copy number alterations and neoplasia-specific mutations in MELK, PDCD1LG2, TLN1, and PAX5 at 9p in different neoplasias

artículo científico publicado en 2014

Different simian virus 40 genomic regions and sequences homologous with SV40 large T antigen in DNA of human brain and bone tumors and of leukocytes from blood donors.

artículo científico publicado en 2002

Doxorubicin-resistant osteosarcoma: novel therapeutic approaches in sight?

artículo científico publicado en 2017

Effect of TP53 Arg72Pro and MDM2 SNP309 polymorphisms on the risk of high-grade osteosarcoma development and survival

artículo científico publicado en 2009

Effectiveness of Type I interferons in the treatment of multidrug resistant osteosarcoma cells

artículo científico publicado en 2004

Emerging drugs for high-grade osteosarcoma

artículo científico publicado en 2010

Endoplasmic reticulum-targeting doxorubicin: a new tool effective against doxorubicin-resistant osteosarcoma

scientific article published on 14 November 2018

Establishment and characterization of in vivo orthotopic bioluminescent xenograft models from human osteosarcoma cell lines in Swiss nude and NSG mice.

artículo científico publicado en 2018

Evaluation of osteonectin as a diagnostic marker of osteogenic bone tumors

artículo científico publicado en 1992

Ewing's sarcoma family tumours. Differences in clinicopathological characteristics at presentation between localised and metastatic tumours

artículo científico publicado en 2007

Excision repair cross-complementation group 1 protein expression predicts survival in patients with high-grade, non-metastatic osteosarcoma treated with neoadjuvant chemotherapy.

artículo científico publicado en 2015

Expression of Met/hepatocyte growth factor receptor gene and malignant behavior of musculoskeletal tumors.

artículo científico publicado en 1996

Expression of an IGF-I receptor dominant negative mutant induces apoptosis, inhibits tumorigenesis and enhances chemosensitivity in Ewing's sarcoma cells.

artículo científico publicado en 2002

Expression of insulin-like growth factor system components in Ewing's sarcoma and their association with survival.

artículo científico publicado en 2011

Frequency and implications of chromosome 8 and 12 gains in Ewing sarcoma

artículo científico publicado en 1998

Frequent deletion of CDKN2A and recurrent coamplification of KIT, PDGFRA, and KDR in fibrosarcoma of bone--an array comparative genomic hybridization study.

artículo científico publicado en 2010

Functional characterization of osteosarcoma cell lines provides representative models to study the human disease

artículo científico publicado en 2011

Functionalized Keratin as Nanotechnology-Based Drug Delivery System for the Pharmacological Treatment of Osteosarcoma ⬇️

artículo científico publicado en 2018

Gene amplifications in osteosarcoma-CGH microarray analysis

artículo científico publicado en 2005

Genetic analysis of fibrosarcoma of bone, a rare tumour entity closely related to osteosarcoma and malignant fibrous histiocytoma of bone

article

Genetic testing for high-grade osteosarcoma: a guide for future tailored treatments?

artículo científico publicado en 2018

Genome-wide association study identifies the GLDC/IL33 locus associated with survival of osteosarcoma patients

artículo científico publicado en 2017

Genome-wide association study identifies two susceptibility loci for osteosarcoma

artículo científico publicado en 2013

Genomic imbalances associated with methotrexate resistance in human osteosarcoma cell lines detected by comparative genomic hybridization-based techniques.

artículo científico publicado en 2003

Genomics and Therapeutic Vulnerabilities of Primary Bone Tumors

artículo científico publicado en 2020

H2S-Donating Doxorubicins May Overcome Cardiotoxicity and Multidrug Resistance

artículo científico publicado en 2016

Identification of genetic variants in pharmacokinetic genes associated with Ewing Sarcoma treatment outcome.

artículo científico publicado en 2016

Immunostaining of the p30/32MIC2 antigen and molecular detection of EWS rearrangements for the diagnosis of Ewing's sarcoma and peripheral neuroectodermal tumor.

artículo científico

Impact of IGF-I/IGF-IR circuit on the angiogenetic properties of Ewing's sarcoma cells

artículo científico publicado en 2003

Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33

artículo científico publicado en 2014

In Ewing's sarcoma CCN3(NOV) inhibits proliferation while promoting migration and invasion of the same cell type

artículo científico publicado en 2005

Integrative analysis reveals relationships of genetic and epigenetic alterations in osteosarcoma

artículo científico publicado en 2012

Kinome and mRNA expression profiling of high-grade osteosarcoma cell lines implies Akt signaling as possible target for therapy.

artículo científico publicado en 2014

LSAMP, a novel candidate tumor suppressor gene in human osteosarcomas, identified by array comparative genomic hybridization

artículo científico publicado en 2009

Local recurrence and local control of non-metastatic osteosarcoma of the extremities: a 27-year experience in a single institution

article

Malignant fibrous histiocytoma of bone: Analysis of genomic imbalances by comparative genomic hybridisation and C-MYC expression by immunohistochemistry

scientific article published on 19 April 2006

Mechanisms of gene amplification and evidence of coamplification in drug-resistant human osteosarcoma cell lines.

artículo científico publicado en 2009

Mitochondria-Targeted Doxorubicin: A New Therapeutic Strategy against Doxorubicin-Resistant Osteosarcoma

artículo científico publicado en 2016

Modulation of the osteosarcoma expression phenotype by microRNAs

artículo científico publicado en 2012

Molecular characterization of commonly used cell lines for bone tumor research: a trans-European EuroBoNet effort

artículo científico publicado en 2010

Molecular profiling of chordoma

artículo científico publicado en 2014

Murine model for skeletal metastases of Ewing's sarcoma

artículo científico publicado en 2000

Neoadjuvant chemotherapy for osteosarcoma of the extremities in patients aged 41-60 years: outcome in 34 cases treated with adriamycin, cisplatinum and ifosfamide between 1984 and 1999

scientific article published on 01 June 2007

New model for bone resorption study in vitro: human osteoclast-like cells from giant cell tumors of bone.

artículo científico publicado en 1994

No correlation between methotrexate serum level and histologic response in the pre-operative treatment of extremity osteosarcoma

article

Nucleotide excision repair gene variants and association with survival in osteosarcoma patients treated with neoadjuvant chemotherapy.

artículo científico publicado en 2011

Overcoming glutathione S-transferase P1-related cisplatin resistance in osteosarcoma

artículo científico publicado en 2008

Overcoming resistance to conventional drugs in Ewing sarcoma and identification of molecular predictors of outcome

artículo científico publicado en 2009

P-glycoprotein expression in osteosarcoma: a basis for risk-adapted adjuvant chemotherapy.

artículo científico publicado en 1999

P53 oncosuppressor influences selection of genomic imbalances in response to ionizing radiations in human osteosarcoma cell line SAOS-2.

artículo científico publicado en 2008

Pharmacogenomics of genes involved in antifolate drug response and toxicity in osteosarcoma

artículo científico publicado en 2016

Pharmacogenomics of second-line drugs used for treatment of unresponsive or relapsed osteosarcoma patients.

artículo científico publicado en 2016

Polymorphisms of genes related to metotrexate response and toxicity in high-grade osteosarcoma

article

Polyomavirus latency and human tumors

artículo científico publicado en 1994

Positional cloning identifies a novel cyclophilin as a candidate amplified oncogene in 1q21.

artículo científico publicado en 2002

Pre-treatment of human osteosarcoma cells with N-methylformamide enhances P-glycoprotein expression and resistance to doxorubicin

artículo científico publicado en 1994

Preclinical validation of Aurora kinases-targeting drugs in osteosarcoma

artículo científico publicado en 2013

Production of interleukin-6 by human osteoclast-like cells from giant cell tumor of bone

artículo científico publicado en 1996

Prognostic and therapeutic relevance of HER2 expression in osteosarcoma and Ewing's sarcoma

artículo científico publicado en 2005

Prognostic value of CCN3 in osteosarcoma

artículo científico publicado en 2008

Prognostic value of P-glycoprotein in high-grade osteosarcoma.

artículo científico publicado en 2007

Reversal of malignant phenotype in human osteosarcoma cells transduced with the alkaline phosphatase gene

artículo científico publicado en 2000

Role of pharmacogenetics of drug-metabolizing enzymes in treating osteosarcoma

artículo científico

Simultaneous paired analysis of numerical chromosomal aberrations and DNA content in osteosarcoma.

artículo científico publicado en 2001

Small Nucleolar RNAs Determine Resistance to Doxorubicin in Human Osteosarcoma

artículo científico publicado en 2020

Targeting CDKs with Roscovitine Increases Sensitivity to DNA Damaging Drugs of Human Osteosarcoma Cells

artículo científico publicado en 2016

Targeting GSTP1-1 induces JNK activation and leads to apoptosis in cisplatin-sensitive and -resistant human osteosarcoma cell lines.

artículo científico publicado en 2011

Targeting glutathione-S transferase enzymes in musculoskeletal sarcomas: a promising therapeutic strategy.

artículo científico publicado en 2011

Targeting polo-like kinase 1 by NMS-P937 in osteosarcoma cell lines inhibits tumor cell growth and partially overcomes drug resistance

artículo científico publicado en 2014

The expression of P-glycoprotein is causally related to a less aggressive phenotype in human osteosarcoma cells.

artículo científico publicado en 1999

The expression of ccn3(nov) gene in musculoskeletal tumors

artículo científico publicado en 2002

The fine-tuning of TRAF2-GSTP1-1 interaction: effect of ligand binding and in situ detection of the complex

artículo científico publicado en 2014

The metastatic ability of Ewing's sarcoma cells is modulated by stem cell factor and by its receptor c-kit

artículo científico publicado en 2000

The molecular mechanisms responsible for resistance to ET-743 (Trabectidin; Yondelis) in the Ewing's sarcoma cell line, TC-71.

artículo científico publicado en 2005

The pharmacogenomics of osteosarcoma

artículo científico publicado en 2016

The role of basic research in clinical treatment of Ewing's sarcoma and osteosarcoma.

artículo científico publicado en 2003

Tumor-infiltrating macrophages are associated with metastasis suppression in high-grade osteosarcoma: a rationale for treatment with macrophage activating agents

artículo científico publicado en 2011

Value of P-glycoprotein and clinicopathologic factors as the basis for new treatment strategies in high-grade osteosarcoma of the extremities

artículo científico publicado en 2003

miR-34a predicts survival of Ewing's sarcoma patients and directly influences cell chemo-sensitivity and malignancy

artículo científico publicado en 2012

Lista de obras de Massimo Serra

4-Demethoxy-3'-deamino-3'-aziridinyl-4'-methylsulphonyl-daunorubicin (PNU-159548): a promising new candidate for chemotherapeutic treatment of osteosarcoma patients.

A Genome-Wide Scan Identifies Variants in NFIB Associated with Metastasis in Patients with Osteosarcoma

ABCA1/ABCB1 Ratio Determines Chemo- and Immune-Sensitivity in Human Osteosarcoma

Adjuvant and neo-adjuvant chemotherapy for Ewing's sarcoma family tumors and osteosarcoma of the extremity: further outcome for patients event-free survivors 5 years from the beginning of treatment

Adriamycin binding assay: a valuable chemosensitivity test in human osteosarcoma

Advances in emerging drugs for osteosarcoma

Agave negatively regulates YAP and TAZ transcriptionally and post-translationally in osteosarcoma cell lines

Alendronate reduces adhesion of human osteoclast-like cells to bone and bone protein-coated surfaces

An aza-macrocycle containing maltolic side-arms (maltonis) as potential drug against human pediatric sarcomas.

An update on chemotherapy for osteosarcoma

Analysis of P-glycoprotein expression in osteosarcoma

Analysis of dihydrofolate reductase and reduced folate carrier gene status in relation to methotrexate resistance in osteosarcoma cells

Analysis of heritability and shared heritability based on genome-wide association studies for thirteen cancer types

Anti-EGFR Antibody Cetuximab Enhances the Cytolytic Activity of Natural Killer Cells toward Osteosarcoma

Antitumor activity of the insulin-like growth factor-I receptor kinase inhibitor NVP-AEW541 in musculoskeletal tumors.

Array comparative genomic hybridization reveals frequent alterations of G1/S checkpoint genes in undifferentiated pleomorphic sarcoma of bone

Biological indicators of prognosis in Ewing's sarcoma: an emerging role for lectin galactoside-binding soluble 3 binding protein (LGALS3BP).

C-kit receptor expression in Ewing's sarcoma: lack of prognostic value but therapeutic targeting opportunities in appropriate conditions.

CD99 acts as an oncosuppressor in osteosarcoma

Candidate germline polymorphisms of genes belonging to the pathways of four drugs used in osteosarcoma standard chemotherapy associated with risk, survival and toxicity in non-metastatic high-grade osteosarcoma

Caveolin-1 reduces osteosarcoma metastases by inhibiting c-Src activity and met signaling.

Caveolins in the development and diseases of musculoskeletal system.

Chemotherapy-resistant osteosarcoma is highly susceptible to IL-15-activated allogeneic and autologous NK cells.

Clinical impact of the methotrexate resistance-associated genes C-MYC and dihydrofolate reductase (DHFR) in high-grade osteosarcoma.

Clinical relevance of Ki-67 expression in bone tumors

Clinicopathological significance of cell cycle regulation markers in a large series of genetically confirmed Ewing's Sarcoma Family of Tumors

Combined use of expression and CGH arrays pinpoints novel candidate genes in Ewing sarcoma family of tumors

Contribution of MEK/MAPK and PI3-K signaling pathway to the malignant behavior of Ewing's sarcoma cells: therapeutic prospects

Copy number alterations and neoplasia-specific mutations in MELK, PDCD1LG2, TLN1, and PAX5 at 9p in different neoplasias

Different simian virus 40 genomic regions and sequences homologous with SV40 large T antigen in DNA of human brain and bone tumors and of leukocytes from blood donors.

Doxorubicin-resistant osteosarcoma: novel therapeutic approaches in sight?

Effect of TP53 Arg72Pro and MDM2 SNP309 polymorphisms on the risk of high-grade osteosarcoma development and survival

Effectiveness of Type I interferons in the treatment of multidrug resistant osteosarcoma cells

Emerging drugs for high-grade osteosarcoma

Endoplasmic reticulum-targeting doxorubicin: a new tool effective against doxorubicin-resistant osteosarcoma

Establishment and characterization of in vivo orthotopic bioluminescent xenograft models from human osteosarcoma cell lines in Swiss nude and NSG mice.

Evaluation of osteonectin as a diagnostic marker of osteogenic bone tumors

Ewing's sarcoma family tumours. Differences in clinicopathological characteristics at presentation between localised and metastatic tumours

Excision repair cross-complementation group 1 protein expression predicts survival in patients with high-grade, non-metastatic osteosarcoma treated with neoadjuvant chemotherapy.

Expression of Met/hepatocyte growth factor receptor gene and malignant behavior of musculoskeletal tumors.

Expression of an IGF-I receptor dominant negative mutant induces apoptosis, inhibits tumorigenesis and enhances chemosensitivity in Ewing's sarcoma cells.

Expression of insulin-like growth factor system components in Ewing's sarcoma and their association with survival.

Frequency and implications of chromosome 8 and 12 gains in Ewing sarcoma

Frequent deletion of CDKN2A and recurrent coamplification of KIT, PDGFRA, and KDR in fibrosarcoma of bone--an array comparative genomic hybridization study.

Functional characterization of osteosarcoma cell lines provides representative models to study the human disease

Functionalized Keratin as Nanotechnology-Based Drug Delivery System for the Pharmacological Treatment of Osteosarcoma ⬇️

Gene amplifications in osteosarcoma-CGH microarray analysis

Genetic analysis of fibrosarcoma of bone, a rare tumour entity closely related to osteosarcoma and malignant fibrous histiocytoma of bone

Genetic testing for high-grade osteosarcoma: a guide for future tailored treatments?

Genome-wide association study identifies the GLDC/IL33 locus associated with survival of osteosarcoma patients

Genome-wide association study identifies two susceptibility loci for osteosarcoma

Genomic imbalances associated with methotrexate resistance in human osteosarcoma cell lines detected by comparative genomic hybridization-based techniques.

Genomics and Therapeutic Vulnerabilities of Primary Bone Tumors

H2S-Donating Doxorubicins May Overcome Cardiotoxicity and Multidrug Resistance

Identification of genetic variants in pharmacokinetic genes associated with Ewing Sarcoma treatment outcome.

Immunostaining of the p30/32MIC2 antigen and molecular detection of EWS rearrangements for the diagnosis of Ewing's sarcoma and peripheral neuroectodermal tumor.

Impact of IGF-I/IGF-IR circuit on the angiogenetic properties of Ewing's sarcoma cells

Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33

In Ewing's sarcoma CCN3(NOV) inhibits proliferation while promoting migration and invasion of the same cell type

Integrative analysis reveals relationships of genetic and epigenetic alterations in osteosarcoma

Kinome and mRNA expression profiling of high-grade osteosarcoma cell lines implies Akt signaling as possible target for therapy.

LSAMP, a novel candidate tumor suppressor gene in human osteosarcomas, identified by array comparative genomic hybridization

Local recurrence and local control of non-metastatic osteosarcoma of the extremities: a 27-year experience in a single institution

Malignant fibrous histiocytoma of bone: Analysis of genomic imbalances by comparative genomic hybridisation and C-MYC expression by immunohistochemistry

Mechanisms of gene amplification and evidence of coamplification in drug-resistant human osteosarcoma cell lines.

Mitochondria-Targeted Doxorubicin: A New Therapeutic Strategy against Doxorubicin-Resistant Osteosarcoma

Modulation of the osteosarcoma expression phenotype by microRNAs

Molecular characterization of commonly used cell lines for bone tumor research: a trans-European EuroBoNet effort

Molecular profiling of chordoma

Murine model for skeletal metastases of Ewing's sarcoma

Neoadjuvant chemotherapy for osteosarcoma of the extremities in patients aged 41-60 years: outcome in 34 cases treated with adriamycin, cisplatinum and ifosfamide between 1984 and 1999

New model for bone resorption study in vitro: human osteoclast-like cells from giant cell tumors of bone.

No correlation between methotrexate serum level and histologic response in the pre-operative treatment of extremity osteosarcoma

Nucleotide excision repair gene variants and association with survival in osteosarcoma patients treated with neoadjuvant chemotherapy.

Overcoming glutathione S-transferase P1-related cisplatin resistance in osteosarcoma

Overcoming resistance to conventional drugs in Ewing sarcoma and identification of molecular predictors of outcome

P-glycoprotein expression in osteosarcoma: a basis for risk-adapted adjuvant chemotherapy.

P53 oncosuppressor influences selection of genomic imbalances in response to ionizing radiations in human osteosarcoma cell line SAOS-2.

Pharmacogenomics of genes involved in antifolate drug response and toxicity in osteosarcoma