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Lista de obras de Jerzy Adamski

12-months metabolic changes among gender dysphoric individuals under cross-sex hormone treatment: a targeted metabolomics study

artículo científico publicado en 2016

17β-Hydroxysteroid dehydrogenases (17β-HSDs) as therapeutic targets: protein structures, functions, and recent progress in inhibitor development.

artículo científico publicado en 2010

2nd congress on steroid research

artículo científico publicado en 2013

A Functional and Putative Physiological Role of Calcitriol in Patched1/Smoothened Interaction.

artículo científico publicado en 2015

A Metabolome-Wide Association Study of Kidney Function and Disease in the General Population ⬇️

artículo científico publicado en 2015

A Thyroid Hormone-Independent Molecular Fingerprint of 3,5-Diiodothyronine Suggests a Strong Relationship with Coffee Metabolism in Humans

artículo científico publicado en 2019

A genome-wide metabolic QTL analysis in Europeans implicates two loci shaped by recent positive selection

artículo científico publicado en 2011

A genome-wide perspective of genetic variation in human metabolism

artículo científico publicado en 2009

A mouse model for intellectual disability caused by mutations in the X-linked 2′‑O‑methyltransferase Ftsj1 gene

article

A network-based conditional genetic association analysis of the human metabolome

artículo científico publicado en 2018

A novel N-ethyl-N-nitrosourea-induced mutation in phospholipase Cγ2 causes inflammatory arthritis, metabolic defects, and male infertility in vitro in a murine model

article

A reference map of potential determinants for the human serum metabolome

artículo científico publicado en 2020

A semi-automated method for isolating functionally intact mitochondria from cultured cells and tissue biopsies

artículo científico publicado en 2013

A single night of sleep curtailment increases plasma acylcarnitines: Novel insights in the relationship between sleep and insulin resistance

artículo científico publicado en 2015

APOA5 variants and metabolic syndrome in Caucasians

artículo científico publicado en 2007

Absence of 11-keto reduction of cortisone and 11-ketotestosterone in the model organism zebrafish

artículo científico publicado en 2016

Ageing Investigation Using Two-Time-Point Metabolomics Data from KORA and CARLA Studies

article published in 2019

Aldo-keto Reductase 1B15 (AKR1B15): a mitochondrial human aldo-keto reductase with activity toward steroids and 3-keto-acyl-CoA conjugates

artículo científico publicado en 2015

Alterations in Lipid and Inositol Metabolisms in Two Dopaminergic Disorders

artículo científico publicado en 2016

Alterations of plasma metabolite profiles related to adipose tissue distribution and cardiometabolic risk.

artículo científico publicado en 2015

Alterations of the acylcarnitine profiles in blood serum and in muscle from periparturient cows with normal or elevated body condition

artículo científico publicado en 2020

Altered levels of acylcarnitines, phosphatidylcholines, and sphingomyelins in peritoneal fluid from ovarian endometriosis patients.

artículo científico publicado en 2016

Altered metabolism distinguishes high-risk from stable carotid atherosclerotic plaques.

artículo científico publicado en 2018

Amino acids, lipid metabolites, and ferritin as potential mediators linking red meat consumption to type 2 diabetes

artículo científico publicado en 2015

An IgE-associated polymorphism in STAT6 alters NF-kappaB binding, STAT6 promoter activity, and mRNA expression

artículo científico publicado en 2009

Analysis of the 5' flanking regions of human and murine HSD17B7: identification of a cholesterol dependent enhancer region.

artículo científico publicado en 2005

Assay Tools for Metabolomics

Association of Atopic Dermatitis with Cardiovascular Risk Factors and Diseases

artículo científico publicado en 2016

Associations between adipose tissue volume and small molecules in plasma and urine among asymptomatic subjects from the general population

artículo científico publicado en 2020

Associations between fecal bile acids, neutral sterols, and serum lipids in the KORA FF4 study

scientific article published on 22 June 2019

Associations between thyroid hormones and serum metabolite profiles in an euthyroid population

artículo científico publicado en 2013

Associations between usual food intake and faecal sterols and bile acids: results from the Cooperative Health Research in the Augsburg Region (KORA FF4) study

artículo científico publicado en 2019

Associations of anthropometric markers with serum metabolites using a targeted metabolomics approach: results of the EPIC-potsdam study

scientific article published on 27 June 2016

Atlas of Circadian Metabolism Reveals System-wide Coordination and Communication between Clocks

scientific article published on 01 September 2018

Automated workflow-based exploitation of pathway databases provides new insights into genetic associations of metabolite profiles

artículo científico publicado en 2013

BEMER Electromagnetic Field Therapy Reduces Cancer Cell Radioresistance by Enhanced ROS Formation and Induced DNA Damage

artículo científico publicado en 2016

Bayesian independent component analysis recovers pathway signatures from blood metabolomics data

artículo científico publicado en 2012

Bezafibrate Improves Insulin Sensitivity and Metabolic Flexibility in STZ-Induced Diabetic Mice

artículo científico publicado en 2016

Body fat free mass is associated with the serum metabolite profile in a population-based study

artículo científico publicado en 2012

Cardiovascular Risk Factors Associated With Blood Metabolite Concentrations and Their Alterations During a 4-Year Period in a Population-Based Cohort

artículo científico publicado en 2016

Cellular signaling of amino acids towards mTORC1 activation in impaired human leucine catabolism

artículo científico publicado en 2012

Changes in metabolite profiles caused by genetically determined obesity in mice

artículo científico publicado en 2013

Changes in the serum metabolite profile in obese children with weight loss

artículo científico publicado en 2014

Changing metabolic signatures of amino acids and lipids during the prediabetic period in a pig model with impaired incretin function and reduced β-cell mass

artículo científico publicado en 2012

Characterization of AKR1B16, a novel mouse aldo-keto reductase.

artículo científico publicado en 2017

Characterization of Bulk Phosphatidylcholine Compositions in Human Plasma Using Side-Chain Resolving Lipidomics

artículo científico publicado en 2019

Characterization of human DHRS6, an orphan short chain dehydrogenase/reductase enzyme: a novel, cytosolic type 2 R-beta-hydroxybutyrate dehydrogenase

artículo científico publicado en 2006

Characterization of missing values in untargeted MS-based metabolomics data and evaluation of missing data handling strategies

artículo científico publicado en 2018

Childhood obesity is associated with changes in the serum metabolite profile

artículo científico publicado en 2012

Cholesterol metabolism promotes B-cell positioning during immune pathogenesis of chronic obstructive pulmonary disease.

artículo científico publicado en 2018

Circadian expression of steroidogenic cytochromes P450 in the mouse adrenal gland--involvement of cAMP-responsive element modulator in epigenetic regulation of Cyp17a1.

artículo científico publicado en 2011

Circulating glutamate concentration as a biomarker of visceral obesity and associated metabolic alterations

scientific article published on 06 November 2018

Circulating metabolites differentiate acute ischemic stroke from stroke mimics

artículo científico publicado en 2020

Circulating steroid levels as correlates of adipose tissue phenotype in premenopausal women

scientific article published on 11 May 2018

Clinical Chemistry and Other Laboratory Tests on Mouse Plasma or Serum

artículo científico publicado en 2013

Closing the gap: identification of human 3-ketosteroid reductase, the last unknown enzyme of mammalian cholesterol biosynthesis

scientific journal article

Coenzyme specificity in fungal 17beta-hydroxysteroid dehydrogenase

artículo científico publicado en 2005

Combined liquid chromatography-tandem mass spectrometry analysis of progesterone metabolites

artículo científico publicado en 2015

Common Muscle Metabolic Signatures Highlight Arginine and Lysine Metabolism as Potential Therapeutic Targets to Combat Unhealthy Aging ⬇️

artículo científico

Comparative analysis of plasma metabolomics response to metabolic challenge tests in healthy subjects and influence of the FTO obesity risk allele

article

Comparison of metabolite networks from four German population-based studies

article

Comparison of predicted and experimental subcellular localization of two putative rat steroid dehydrogenases from the short-chain dehydrogenase/reductase protein superfamily

artículo científico publicado en 2008

Comprehensive Metabolic Profiling Reveals a Lipid-Rich Fingerprint of Free Thyroxine Far Beyond Classic Parameters

scientific article published on 01 May 2018

Comprehensive metabolic characterization of serum osteocalcin action in a large non-diabetic sample

artículo científico publicado en 2017

Comprehensive metabolic profiling of chronic low-grade inflammation among generally healthy individuals

artículo científico publicado en 2017

Cord Blood Lysophosphatidylcholine 16: 1 is Positively Associated with Birth Weight

artículo científico publicado en 2018

Correction to: The role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes: an IMI DIRECT study

artículo científico publicado en 2020

Correlation guided Network Integration (CoNI) reveals novel genes affecting hepatic metabolism

artículo científico publicado en 2021

Cortisol-related metabolic alterations assessed by mass spectrometry assay in patients with Cushing's syndrome

artículo científico publicado en 2017

Cross-omics analysis revealed gut microbiome-related metabolic pathways underlying atherosclerosis development after antibiotics treatment

scientific article published on 13 March 2020

Cytochrome c oxidase subunit 4 isoform 2-knockout mice show reduced enzyme activity, airway hyporeactivity, and lung pathology

artículo científico publicado en 2012

DNA methylation of lipid-related genes affects blood lipid levels

scientific article published on 12 January 2015

Deep molecular phenotypes link complex disorders and physiological insult to CpG methylation.

artículo científico publicado en 2018

Deletion of deoxyribonucleic acid binding domain of the vitamin D receptor abrogates genomic and nongenomic functions of vitamin D.

artículo científico publicado en 2002

Diagnosing fatty liver disease: a comparative evaluation of metabolic markers, phenotypes, genotypes and established biomarkers

artículo científico publicado en 2013

Diagnostic and Prognostic Metabolites Identified for Joint Symptoms in the KORA Population

artículo científico publicado en 2015

Dietary metabolite profiling brings new insight into the relationship between nutrition and metabolic risk: An IMI DIRECT study

artículo científico publicado en 2020

Differences between human plasma and serum metabolite profiles

artículo científico publicado en 2011

Dimerization and enzymatic activity of fungal 17beta-hydroxysteroid dehydrogenase from the short-chain dehydrogenase/reductase superfamily

artículo científico publicado en 2005

Discovery of a novel enzyme mediating glucocorticoid catabolism in fish: 20beta-hydroxysteroid dehydrogenase type 2.

artículo científico publicado en 2011

Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: an overview of the data from the epidemiological studies within the IMI DIRECT Consortium

Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: descriptive characteristics of the epidemiological studies within the IMI DIRECT Consortium

scientific article published on 15 June 2019

Discovery of sexual dimorphisms in metabolic and genetic biomarkers

artículo científico publicado en 2011

Disruption of glucagon receptor signaling causes hyperaminoacidemia exposing a possible liver-alpha-cell axis

artículo científico publicado en 2017

Down-regulation by nuclear factor kappaB of human 25-hydroxyvitamin D3 1alpha-hydroxylase promoter

artículo científico publicado en 2004

Dual Inhibitory Action of a Novel AKR1C3 Inhibitor on Both Full-Length AR and the Variant AR-V7 in Enzalutamide Resistant Metastatic Castration Resistant Prostate Cancer

artículo científico publicado en 2020

Early metabolic markers of the development of dysglycemia and type 2 diabetes and their physiological significance

artículo científico publicado en 2013

Effect of Empagliflozin on the Metabolic Signature of Patients With Type 2 Diabetes Mellitus and Cardiovascular Disease

artículo científico publicado en 2017

Effects of metformin on metabolite profiles and LDL cholesterol in patients with type 2 diabetes

artículo científico publicado en 2015

Effects of smoking and smoking cessation on human serum metabolite profile: results from the KORA cohort study

artículo científico publicado en 2013

Embryonic expression of cholesterogenic genes is restricted to distinct domains and colocalizes with apoptotic regions in mice

artículo científico publicado en 2003

Empagliflozin improves left ventricular diastolic function of db/db mice

artículo científico publicado en 2020

Endocrinology Meets Metabolomics: Achievements, Pitfalls, and Challenges.

artículo científico

Endothelin-1 Overexpression Improves Renal Function in eNOS Knockout Mice.

artículo científico publicado en 2015

Engineering aldo-keto reductase 1B10 to mimic the distinct 1B15 topology and specificity towards inhibitors and substrates, including retinoids and steroids

scientific article published on 24 April 2019

Epigenetic alterations in longevity regulators, reduced life span, and exacerbated aging-related pathology in old father offspring mice.

artículo científico publicado en 2018

Epigenetics meets metabolomics: an epigenome-wide association study with blood serum metabolic traits

artículo científico publicado en 2013

Eukaryotic GCP1 is a conserved mitochondrial protein required for progression of embryo development beyond the globular stage in Arabidopsis thaliana

artículo científico publicado en 2009

Evaluation of Metabolic Profiles of Patients with Anorexia Nervosa at Inpatient Admission, Short- and Long-Term Weight Regain-Descriptive and Pattern Analysis

artículo científico publicado en 2020

Evaluation of various biomarkers as potential mediators of the association between coffee consumption and incident type 2 diabetes in the EPIC-Potsdam Study.

artículo científico publicado en 2014

Evidence Supporting a Key Role of Lp-PLA2-Generated Lysophosphatidylcholine in Human Atherosclerotic Plaque Inflammation

article

Evidence for Stress-like Alterations in the HPA-Axis in Women Taking Oral Contraceptives

artículo científico publicado en 2017

Exposure to disinfection byproducts and risk of type 2 diabetes: a nested case-control study in the HUNT and Lifelines cohorts

scientific article published on 08 April 2019

Expression analysis of estrogen-metabolizing enzymes in human endometrial cancer

artículo científico publicado en 2005

Extracellular citrate affects critical elements of cancer cell metabolism and supports cancer development in vivo.

artículo científico publicado en 2018

Familial resemblance for serum metabolite concentrations

artículo científico publicado en 2013

Fetal Serum Metabolites Are Independently Associated with Gestational Diabetes Mellitus

artículo científico publicado en 2018

Fgf9 (Y162C) Mutation Alters Information Processing and Social Memory in Mice

artículo científico publicado en 2017

Finding New Molecular Targets of Familiar Natural Products Using In Silico Target Prediction

artículo científico publicado en 2020

First Structure-Activity Relationship of 17β-Hydroxysteroid Dehydrogenase Type 14 Nonsteroidal Inhibitors and Crystal Structures in Complex with the Enzyme.

artículo científico publicado en 2016

Flavonoids and cinnamic acid derivatives as inhibitors of 17beta-hydroxysteroid dehydrogenase type 1.

artículo científico publicado en 2008

Fourteenth Workshop on Vitamin D.

artículo científico publicado en 2010

Functional analysis of cholesterol biosynthesis by RNA interference

artículo científico publicado en 2007

Functional changes of the liver in the absence of growth hormone (GH) action - Proteomic and metabolomic insights from a GH receptor deficient pig model

scientific article published on 18 March 2020

Gaussian graphical modeling reconstructs pathway reactions from high-throughput metabolomics data

artículo científico publicado en 2011

Gender-specific pathway differences in the human serum metabolome

artículo científico publicado en 2015

Genetic Influences on Metabolite Levels: A Comparison across Metabolomic Platforms

artículo científico publicado en 2016

Genetic associations with lipoprotein subfractions provide information on their biological nature

artículo científico publicado en 2011

Genetic diagnosis of Mendelian disorders via RNA sequencing

artículo científico publicado en 2017

Genetic diagnosis of Mendelian disorders via RNA sequencing

article

Genetic variants in the GATA3 gene are not associated with asthma and atopic diseases in German children.

artículo científico publicado en 2009

Genetic variants including markers from the exome chip and metabolite traits of type 2 diabetes

artículo científico publicado en 2017

Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum

artículo científico publicado en 2008

Genome-wide association studies with metabolomics

artículo científico publicado en 2012

Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels

artículo científico publicado en 2015

Genome-wide association study of caffeine metabolites provides new insights to caffeine metabolism and dietary caffeine-consumption behavior

artículo científico publicado en 2016

Guest Editorial: Special issue on metabolomics

artículo científico publicado en 2015

HLX1 gene variants influence the development of childhood asthma

artículo científico publicado en 2008

HSD17B4 overexpression, an independent biomarker of poor patient outcome in prostate cancer

scientific article published on 28 November 2008

Heart-Specific Knockout of the Mitochondrial Thioredoxin Reductase (Txnrd2) Induces Metabolic and Contractile Dysfunction in the Aging Myocardium

artículo científico publicado en 2015

Hepatic Steatosis Is Associated With Adverse Molecular Signatures in Subjects Without Diabetes

artículo científico publicado en 2018

High levels of modified ceramides are a defining feature of murine and human cancer cachexia

scientific article published on 08 October 2020

High mobility group N proteins modulate the fidelity of the cellular transcriptional profile in a tissue- and variant-specific manner

artículo científico publicado en 2013

High-throughput extraction and quantification method for targeted metabolomics in murine tissues.

artículo científico publicado en 2017

His164 regulates accessibility to the active site in fungal 17beta-hydroxysteroid dehydrogenase

scientific article published on 26 September 2006

Homology modeling meets site-directed mutagenesis: an ideal combination to elucidate the topology of 17β-HSD2

artículo científico publicado en 2020

House dust mite drives proinflammatory eicosanoid reprogramming and macrophage effector functions

scientific article published on 08 January 2019

Huge splicing frequency in human Y chromosomal UTY gene

artículo científico publicado en 2011

Human and zebrafish hydroxysteroid dehydrogenase like 1 (HSDL1) proteins are inactive enzymes but conserved among species

artículo científico publicado en 2008

Human metabolic individuality in biomedical and pharmaceutical research

artículo científico publicado en 2011

Human serum metabolic profiles are age dependent

artículo científico publicado en 2012

IKK(α) controls canonical TGF(ß)-SMAD signaling to regulate genes expressing SNAIL and SLUG during EMT in panc1 cells

artículo científico publicado en 2010

IL-6 promoter polymorphisms and quantitative traits related to the metabolic syndrome in KORA S4.

artículo científico publicado en 2006

Identification and MS-assisted interpretation of genetically influenced NMR signals in human plasma

artículo científico publicado en 2013

Identification of a potential biomarker for FABP4 inhibition: the power of lipidomics in preclinical drug testing

artículo científico publicado en 2011

Identification of chemically diverse, novel inhibitors of 17β-hydroxysteroid dehydrogenase type 3 and 5 by pharmacophore-based virtual screening.

artículo científico publicado en 2011

Identification of putative biomarkers for type 2 diabetes using metabolomics in the Korea Association REsource (KARE) cohort

Identification of serum metabolites associated with risk of type 2 diabetes using a targeted metabolomic approach

artículo científico publicado en 2012

Immediate reduction of serum citrulline but no change of steroid profile after initiation of metformin in individuals with type 2 diabetes

artículo científico publicado en 2017

Impact of maternal smoking associated lyso-phosphatidylcholine 20:3 on offspring brain development

artículo científico publicado en 2020

Impaired autophagy induces chronic atrophic pancreatitis in mice via sex- and nutrition-dependent processes

artículo científico publicado en 2014

Important roles of the AKR1C2 and SRD5A1 enzymes in progesterone metabolism in endometrial cancer model cell lines

artículo científico publicado en 2014

Improvement of myocardial infarction risk prediction via inflammation-associated metabolite biomarkers

artículo científico publicado en 2017

In search for function of two human orphan SDR enzymes: hydroxysteroid dehydrogenase like 2 (HSDL2) and short-chain dehydrogenase/reductase-orphan (SDR-O)

artículo científico publicado en 2009

Increased amino acids levels and the risk of developing of hypertriglyceridemia in a 7-year follow-up

artículo científico publicado en 2014

Induction of the nicotinamide riboside kinase NAD+ salvage pathway in a model of sarcoplasmic reticulum dysfunction

artículo científico publicado en 2020

Inflammatory macrophage memory in NSAID-exacerbated respiratory disease

artículo científico publicado en 2020

Inhibitory effects of fluorine-substituted estrogens on the activity of 17beta-hydroxysteroid dehydrogenases

artículo científico publicado en 2006

Initial characterization of human DHRS1 (SDR19C1), a member of the short-chain dehydrogenase/reductase superfamily

artículo científico publicado en 2019

Innovations in phenotyping of mouse models in the German Mouse Clinic

artículo científico publicado en 2012

Instability of personal human metabotype is linked to all-cause mortality.

artículo científico publicado en 2018

Integrated view on 17beta-hydroxysteroid dehydrogenases

artículo científico publicado en 2008

Integration of steroid research: perspectives on environment factors, homeostasis in health, and disease treatment

artículo científico publicado en 2011

Integration of targeted metabolomics and transcriptomics identifies deregulation of phosphatidylcholine metabolism in Huntington's disease peripheral blood samples

artículo científico publicado en 2016

Interaction of the MAGUK family member Acvrinp1 and the cytoplasmic domain of the Notch ligand Delta1

scientific journal article

Intergenerational Metabolomic Analysis of Mothers with a History of Gestational Diabetes Mellitus and Their Offspring

artículo científico publicado en 2020

Interlaboratory Reproducibility of a Targeted Metabolomics Platform for Analysis of Human Serum and Plasma.

artículo científico publicado en 2016

International Ring Trial of a High Resolution Targeted Metabolomics and Lipidomics Platform for Serum and Plasma Analysis

scientific article published on 08 November 2019

Interrogating causal pathways linking genetic variants, small molecule metabolites, and circulating lipids

artículo científico publicado en 2014

Introducing the German Mouse Clinic: open access platform for standardized phenotyping.

artículo científico publicado en 2005

Introduction of an electron withdrawing group on the hydroxyphenylnaphthol scaffold improves the potency of 17β-hydroxysteroid dehydrogenase type 2 (17β-HSD2) inhibitors

artículo científico publicado en 2011

Investigation of Adiposity Measures and Operational Taxonomic unit (OTU) Data Transformation Procedures in Stool Samples from a German Cohort Study Using Machine Learning Algorithms

scientific article published on 10 April 2020

Isopentenyl-diphosphate isomerases in human and mouse: evolutionary analysis of a mammalian gene duplication

artículo científico publicado en 2003

It is high time to discontinue use of misidentified and contaminated cells: Guidelines for description and authentication of cell lines

artículo científico publicado en 2017

Key elements of metabolomics in the study of biomarkers of diabetes

artículo científico publicado en 2016

LC-MS/MS-Based Metabolomics for Cell Cultures

artículo científico publicado en 2019

Lactation is associated with altered metabolomic signatures in women with gestational diabetes.

artículo científico publicado en 2016

Ldlr and ApoE mice better mimic the human metabolite signature of increased carotid intima media thickness compared to other animal models of cardiovascular disease

Levels of the Autophagy Related 5 Protein Affect Progression and Metastasis of Pancreatic Tumors in Mice

artículo científico publicado en 2018

Ligand-based NMR spectra demonstrate an additional phytoestrogen binding site for 17beta-hydroxysteroid dehydrogenase type 1.

artículo científico publicado en 2009

Lipidomic Phenotyping Reveals Extensive Lipid Remodeling during Adipogenesis in Human Adipocytes

artículo científico publicado en 2020

Liver lipid metabolism is altered by increased circulating estrogen to androgen ratio in male mouse

artículo científico publicado en 2015

Long term conservation of human metabolic phenotypes and link to heritability

artículo científico publicado en 2014

Long-Term Stability of Human Plasma Metabolites during Storage at -80 °C.

artículo científico publicado en 2017

Low-level mitochondrial heteroplasmy modulates DNA replication, glucose metabolism and lifespan in mice

Low-level mitochondrial heteroplasmy modulates DNA replication, glucose metabolism and lifespan in mice.

artículo científico publicado en 2018

Low-parachor solvents extraction and thermostated micro-thin-layer chromatography separation for fast screening and classification of spirulina from pharmaceutical formulations and food samples.

artículo científico publicado en 2011

LysoPC-acyl C16:0 is associated with brown adipose tissue activity in men

scientific article published on 03 March 2017

Machine Learning Approaches Revealed Metabolic Signatures of Incident Chronic Kidney Disease in Persons With Pre-and Type 2 Diabetes

artículo científico publicado en 2020

Maternal PCaaC38:6 is Associated With Preterm Birth - a Risk Factor for Early and Late Adverse Outcome of the Offspring

artículo científico publicado en 2016

Mendelian Randomization Study on Amino Acid Metabolism Suggests Tyrosine as Causal Trait for Type 2 Diabetes

scientific article published on 19 December 2020

Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations

artículo científico publicado en 2009

Metabolic Fingerprints of Circulating IGF-1 and the IGF-1/IGFBP-3 Ratio: A Multifluid Metabolomics Study

artículo científico publicado en 2016

Metabolic Signatures in Apoptotic Human Cancer Cell Lines ⬇️

artículo científico publicado el 19 de febrero de 2011

Metabolic Signatures of Healthy Lifestyle Patterns and Colorectal Cancer Risk in a European Cohort

artículo científico publicado en 2020

Metabolic footprint of diabetes: a multiplatform metabolomics study in an epidemiological setting

artículo científico publicado en 2010

Metabolic impact of pheochromocytoma/paraganglioma: targeted metabolomics in patients before and after tumor removal

scientific article published on 01 December 2019

Metabolic profiling reveals distinct variations linked to nicotine consumption in humans--first results from the KORA study

artículo científico publicado en 2008

Metabolic signature associated with parameters of the complete blood count in apparently healthy individuals

scientific article published on 19 June 2019

Metabolic signatures of cultured human adipocytes from metabolically healthy versus unhealthy obese individuals

artículo científico publicado en 2014

Metabolic switch during adipogenesis: From branched chain amino acid catabolism to lipid synthesis.

artículo científico publicado en 2015

Metabolite Shifts Induced by Marathon Race Competition Differ between Athletes Based on Level of Fitness and Performance: A Substudy of the Enzy-MagIC Study

scientific article published on 01 March 2020

Metabolite profiling and cardiovascular event risk: a prospective study of 3 population-based cohorts

artículo científico publicado en 2015

Metabolite profiling reveals new insights into the regulation of serum urate in humans

artículo científico publicado en 2013

Metabolite ratios as potential biomarkers for type 2 diabetes: a DIRECT study.

artículo científico publicado en 2017

Metabolites associate with kidney function decline and incident chronic kidney disease in the general population

artículo científico publicado en 2013

Metabolomic Signature of Coronary Artery Disease in Type 2 Diabetes Mellitus

artículo científico publicado en 2017

Metabolomic profiles in individuals with negative affectivity and social inhibition: a population-based study of Type D personality

artículo científico publicado en 2012

Metabolomic profiling implicates adiponectin as mediator of a favorable lipoprotein profile associated with NT-proBNP

artículo científico publicado en 2018

Metabolomics approach reveals effects of antihypertensives and lipid-lowering drugs on the human metabolism

artículo científico publicado en 2014

Metabolomics for Diagnosis and Prognosis of Uterine Diseases? A Systematic Review

artículo científico publicado en 2020

Metabolomics for clinical use and research in chronic kidney disease

artículo científico publicado en 2017

Metabolomics meets machine learning: Longitudinal metabolite profiling in serum of normal versus overconditioned cows and pathway analysis

scientific article published on 20 September 2019

Metabolomics of Ramadan fasting: an opportunity for the controlled study of physiological responses to food intake

artículo científico publicado en 2014

Metabolomics platforms for genome wide association studies--linking the genome to the metabolome

artículo científico publicado en 2012

Metabolomics reveals determinants of weight loss during lifestyle intervention in obese children

Metabolomics screening identifies reduced L-carnitine to be associated with progressive emphysema

artículo científico publicado en 2015

Metabolomics signature associated with circulating serum selenoprotein P levels

scientific article published on 17 November 2018

Metformin Effect on Nontargeted Metabolite Profiles in Patients With Type 2 Diabetes and in Multiple Murine Tissues

artículo científico publicado en 2016

Methanobactin reverses acute liver failure in a rat model of Wilson disease

artículo científico publicado en 2016

Mild maternal hyperglycemia in INS C93S transgenic pigs causes impaired glucose tolerance and metabolic alterations in neonatal offspring

artículo científico publicado en 2019

Mining the unknown: a systems approach to metabolite identification combining genetic and metabolic information

artículo científico publicado en 2012

Mission to steroids

artículo científico publicado en 2008

Mitochondrial Regulation of the 26S Proteasome

artículo científico publicado en 2020

Mitochondrial gene polymorphisms alter hepatic cellular energy metabolism and aggravate diet-induced non-alcoholic steatohepatitis.

artículo científico publicado en 2016

Models including plasma levels of sphingomyelins and phosphatidylcholines as diagnostic and prognostic biomarkers of endometrial cancer

artículo científico publicado en 2018

Molecular Fingerprints of Iron Parameters among a Population-Based Sample

scientific article published on 19 November 2018

Molecular characterization of Patched-associated rhabdomyosarcoma.

artículo científico publicado en 2003

Molecular framework of steroid/retinoid discrimination in 17beta-hydroxysteroid dehydrogenase type 1 and photoreceptor-associated retinol dehydrogenase.

artículo científico publicado en 2010

Mouse Age Matters: How Age Affects the Murine Plasma Metabolome

scientific article published on 19 November 2020

Mouse Genetics and Metabolic Mouse Phenotyping

article

Mouse phenotyping

artículo científico publicado en 2010

Multi-omics insights into functional alterations of the liver in insulin-deficient diabetes mellitus

scientific article published on 04 June 2019

Multifunctionality of human 17beta-hydroxysteroid dehydrogenases

artículo científico publicado en 2006

Mutation analysis of congenital cataracts in Indian families: identification of SNPS and a new causative allele in CRYBB2 gene.

artículo científico publicado en 2004

Network based conditional genome wide association analysis of human metabolomics

Neutral endopeptidase inhibitors blunt kidney fibrosis by reducing myofibroblast formation

artículo científico publicado en 2019

New Insights into Human 17β-Hydroxysteroid Dehydrogenase Type 14: First Crystal Structures in Complex with a Steroidal Ligand and with a Potent Nonsteroidal Inhibitor

artículo científico publicado en 2016

Night Shift Work Affects Urine Metabolite Profiles of Nurses with Early Chronotype

scholarly article by Markus Rotter published in August 2018

Nonadditive Effects of Genes in Human Metabolomics

artículo científico publicado en 2015

Novel biomarkers for pre-diabetes identified by metabolomics

artículo científico publicado en 2012

Novel estrogen-related genes and potential biomarkers of ovarian endometriosis identified by differential expression analysis

artículo científico publicado en 2011

Novel genetic associations with serum level metabolites identified by phenotype set enrichment analyses

artículo científico publicado en 2014

Paramount importance of sample quality in pre-clinical and clinical research-Need for standard operating procedures (SOPs)

artículo científico publicado en 2018

Perspectives in steroid research

artículo científico publicado en 2015

Perspectives in understanding the role of human 17beta-hydroxysteroid dehydrogenases in health and disease.

artículo científico publicado en 2009

Pharmacokinetics of metformin in patients with gastrointestinal intolerance

artículo científico publicado en 2018

Physiological changes due to mild cooling in healthy lean males of white Caucasian and South Asian descent: A metabolomics study.

artículo científico publicado en 2015

Physiological relevance of the neuronal isoform of inositol-1,4,5-trisphosphate 3-kinases in mice

scientific article published on 25 June 2020

Plasma Metabolomics to Identify and Stratify Patients With Impaired Glucose Tolerance

artículo científico publicado en 2019

Plasma metabolomics reveal alterations of sphingo- and glycerophospholipid levels in non-diabetic carriers of the transcription factor 7-like 2 polymorphism rs7903146

artículo científico publicado en 2013

Pleiotropic functions for transcription factor zscan10.

artículo científico publicado en 2014

Posterior subcapsular cataracts are a late effect after acute exposure to 0.5 Gy ionizing radiation in mice

artículo científico

Postprandial metabolite profiles associated with type 2 diabetes clearly stratify individuals with impaired fasting glucose

artículo científico publicado en 2017

Potential Use of Gluconate in Cancer Therapy

scientific article published on 19 June 2019

Pre-analytical sample quality: metabolite ratios as an intrinsic marker for prolonged room temperature exposure of serum samples

artículo científico publicado en 2015

Pre-receptor steroid metabolism as target for pharmacological treatment.

artículo científico publicado en 2009

Predicting and elucidating the etiology of fatty liver disease: A machine learning modeling and validation study in the IMI DIRECT cohorts

scientific article published on 19 June 2020

Preservation of metabolic flexibility in skeletal muscle by a combined use of n-3 PUFA and rosiglitazone in dietary obese mice

artículo científico publicado en 2012

Procedure for tissue sample preparation and metabolite extraction for high-throughput targeted metabolomics

article published in 2011

Processes Underlying Glycemic Deterioration in Type 2 Diabetes: An IMI DIRECT Study

scientific article published on 15 December 2020

Progressive loss of PAX9 expression correlates with increasing malignancy of dysplastic and cancerous epithelium of the human oesophagus

artículo científico publicado en 2002

Promoter analyses of human and mouse 17beta-hydroxysteroid dehydrogenase type 7.

artículo científico publicado en 2005

Proteomics and metabolomics as tools to unravel novel culprits and mechanisms of uremic toxicity: instrument or hype?

artículo científico

Purification and properties of oestradiol 17 beta-dehydrogenase extracted from cytoplasmic vesicles of porcine endometrial cells ⬇️

artículo científico publicado el 1 de diciembre de 1992

Questionnaire-based self-reported nutrition habits associate with serum metabolism as revealed by quantitative targeted metabolomics

artículo científico publicado en 2010

RDH12, a retinol dehydrogenase causing Leber's congenital amaurosis, is also involved in steroid metabolism

artículo científico publicado en 2007

Random Survival Forest in practice: a method for modelling complex metabolomics data in time to event analysis

artículo científico publicado en 2016

Rapamycin extends murine lifespan but has limited effects on aging

artículo científico publicado en 2013

Rational design of novel mutants of fungal 17beta-hydroxysteroid dehydrogenase

artículo científico publicado en 2006

Recent advances in 17beta-hydroxysteroid dehydrogenases

artículo científico publicado en 2009

Recommendations for description and validation of antibodies for research use

artículo científico publicado en 2015

Release of lysophospholipid 'find-me' signals during apoptosis requires the ATP-binding cassette transporter A1.

artículo científico publicado en 2012

Reliability of serum metabolite concentrations over a 4-month period using a targeted metabolomic approach ⬇️

artículo científico publicado en 2011

Removing the bottlenecks of cell culture metabolomics: fast normalization procedure, correlation of metabolites to cell number, and impact of the cell harvesting method

artículo científico publicado en 2016

Reproducibility of Molecular Phenotypes after Long-Term Differentiation to Human iPSC-Derived Neurons: A Multi-Site Omics Study

article

Requirement of the RNA-editing enzyme ADAR2 for normal physiology in mice

artículo científico publicado en 2011

Response to Comment on Adam et al. Metformin Effect on Nontargeted Metabolite Profiles in Patients With Type 2 Diabetes and in Multiple Murine Tissues. Diabetes 2016;65:3776–3785

artículo científico publicado en 2017

Response to Comment on Xu et al. Effects of Metformin on Metabolite Profiles and LDL Cholesterol in Patients With Type 2 Diabetes. Diabetes Care 2015;38:1858–1867

scientific article published on 01 December 2015

Retinal proteome alterations in a mouse model of type 2 diabetes

artículo científico publicado en 2014

Serum Response Factor (SRF) Ablation Interferes with Acute Stress-Associated Immediate and Long-Term Coping Mechanisms

artículo científico publicado en 2016

Serum metabolite concentrations and decreased GFR in the general population

artículo científico publicado en 2012

Serum metabolites and risk of myocardial infarction and ischemic stroke: a targeted metabolomic approach in two German prospective cohorts

artículo científico publicado en 2017

Serum metabolites related to cardiorespiratory fitness, physical activity energy expenditure, sedentary time and vigorous activity

artículo científico publicado en 2013

Serum metabolomic profiling highlights pathways associated with liver fat content in a general population sample

artículo científico publicado en 2017

Sex hormone-binding globulin, androgens and mortality: the KORA-F4 cohort study

scientific article published on 01 March 2020

Sex-specific metabolic profiles of androgens and its main binding protein SHBG in a middle aged population without diabetes

artículo científico publicado en 2017

Short-term glucocorticoid treatment increases insulin secretion in islets derived from lean mice through multiple pathways and mechanisms

artículo científico publicado en 2008

Significance of individual amino acid residues for coenzyme and substrate specificity of 17beta-hydroxysteroid dehydrogenase from the fungus Cochliobolus lunatus

artículo científico publicado en 2003

Species used for drug testing reveal different inhibition susceptibility for 17beta-hydroxysteroid dehydrogenase type 1

artículo científico publicado en 2010

Specific Metabolic Markers Are Associated with Future Waist-Gaining Phenotype in Women

artículo científico publicado en 2016

Srgap3⁻/⁻ mice present a neurodevelopmental disorder with schizophrenia-related intermediate phenotypes

artículo científico publicado en 2012

Stability of targeted metabolite profiles of urine samples under different storage conditions

artículo científico publicado en 2016

Steroid metabolism in cnidarians: insights from Nematostella vectensis

artículo científico publicado en 2008

Steroid profiling and analytics: going towards sterome

artículo científico publicado en 2010

Steroids in teleost fishes: A functional point of view

artículo científico

Stiff-man syndrome: identification of 17 beta-hydroxysteroid dehydrogenase type 4 as a novel 80-kDa antineuronal antigen

scientific journal article

Structural and biochemical characterization of human orphan DHRS10 reveals a novel cytosolic enzyme with steroid dehydrogenase activity

artículo científico publicado en 2007

Structural optimization of 2,5-thiophene amides as highly potent and selective 17β-hydroxysteroid dehydrogenase type 2 inhibitors for the treatment of osteoporosis

artículo científico publicado en 2012

Structure-based design and profiling of novel 17β-HSD14 inhibitors

artículo científico publicado en 2018

Structure-based design, synthesis and in vitro characterization of potent 17beta-hydroxysteroid dehydrogenase type 1 inhibitors based on 2-substitutions of estrone and D-homo-estrone

artículo científico publicado en 2009

Substrate multispecificity among 20β-hydroxysteroid dehydrogenase type 2 members

artículo científico publicado en 2020

Systemic Regulation of Host Energy and Oogenesis by Microbiome-Derived Mitochondrial Coenzymes

artículo científico publicado en 2021

Systemic first-line phenotyping

artículo científico

TBX21 gene variants increase childhood asthma risk in combination with HLX1 variants

artículo científico publicado en 2009

Targeted Metabolomics of Dried Blood Spot Extracts

Targeted metabolomics as a tool in discriminating endocrine from primary hypertension

scientific article published on 31 December 2020

Targeted metabolomics identifies reliable and stable metabolites in human serum and plasma samples

artículo científico publicado en 2014

Targeted metabolomics profiles are strongly correlated with nutritional patterns in women

artículo científico publicado en 2012

Testosterone increases susceptibility to amebic liver abscess in mice and mediates inhibition of IFNγ secretion in natural killer T cells

artículo científico publicado en 2013

The Epoxyeicosatrienoic Acid Pathway Enhances Hepatic Insulin Signaling and is Repressed in Insulin-Resistant Mouse Liver

artículo científico publicado en 2015

The First Scube3 Mutant Mouse Line with Pleiotropic Phenotypic Alterations.

artículo científico publicado en 2016

The German Mouse Clinic – Running an Open Access Platform

article

The Human Blood Metabolome-Transcriptome Interface

artículo científico publicado en 2015

The Human Proteosome

The Hydroxysteroid (17β) Dehydrogenase Family Gene HSD17B12 Is Involved in the Prostaglandin Synthesis Pathway, the Ovarian Function, and Regulation of Fertility.

artículo científico publicado en 2016

The Munich MIDY Pig Biobank - A unique resource for studying organ crosstalk in diabetes

artículo científico publicado en 2017

The Pharmacogenetic Footprint of ACE Inhibition: A Population-Based Metabolomics Study

artículo científico publicado en 2016

The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative

artículo científico publicado en 2009

The dynamic range of the human metabolome revealed by challenges

artículo científico publicado en 2012

The exceptional sensitivity of brain mitochondria to copper

artículo científico publicado en 2018

The human metabolic profile reflects macro- and micronutrient intake distinctly according to fasting time

scientific article published in Scientific Reports

The liver-alpha cell axis associates with liver fat and insulin resistance: a validation study in women with non-steatotic liver fat levels

artículo científico publicado en 2020

The mitochondrial transporter SLC25A25 links ciliary TRPP2 signaling and cellular metabolism

artículo científico publicado en 2018

The pathologic effect of a novel neomorphic Fgf9(Y162C) allele is restricted to decreased vision and retarded lens growth

scientific journal article

The role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes: an IMI DIRECT study

artículo científico publicado en 2020

The search for predictive metabolic biomarkers for incident T2DM

artículo científico publicado en 2018

Time-resolved phosphoproteomic analysis elucidates hepatic 11,12-Epoxyeicosatrienoic acid signaling pathways

artículo científico publicado en 2019

Tobacco smoking leads to extensive genome-wide changes in DNA methylation

artículo científico publicado en 2013

Toll-like receptor heterodimer variants protect from childhood asthma

artículo científico publicado en 2008

Trans-right ventricle and transpulmonary metabolite gradients in human pulmonary arterial hypertension

scientific article published on 20 February 2020

Transcriptional regulation of human and murine 17beta-hydroxysteroid dehydrogenase type-7 confers its participation in cholesterol biosynthesis

artículo científico publicado en 2006

Treatment with beta-blockers is associated with lower levels of Lp-PLA2 and suPAR in carotid plaques

artículo científico publicado en 2013

Type 2 diabetes is associated with postprandial amino acid measures

artículo científico publicado en 2015

Variation in the human lipidome associated with coffee consumption as revealed by quantitative targeted metabolomics

artículo científico publicado en 2009

Vitamin D signaling is modulated on multiple levels in health and disease.

artículo científico publicado en 2006

Whole blood co-expression modules associate with metabolic traits and type 2 diabetes: an IMI-DIRECT study

artículo científico publicado en 2020

Zebrafish 20β-hydroxysteroid dehydrogenase type 2 is important for glucocorticoid catabolism in stress response

artículo científico publicado en 2013

Zebrafish and steroids: what do we know and what do we need to know?

artículo científico publicado en 2013

pulver: an R package for parallel ultra-rapid p-value computation for linear regression interaction terms

artículo científico publicado en 2017

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