Lista de obras - Klaus Okkenhaug - Dominio Público Uruguay

A point mutation in CD28 distinguishes proliferative signals from survival signals

artículo científico publicado en 2001

A protocol for construction of gene targeting vectors and generation of homologous recombinant embryonic stem cells.

artículo científico publicado en 2013

Antigen receptor signalling: a distinctive role for the p110delta isoform of PI3K.

artículo científico publicado en 2007

BACH2 regulates CD8(+) T cell differentiation by controlling access of AP-1 factors to enhancers

artículo científico publicado en 2016

Blockade of phosphatidylinositol 3-kinase PI3Kδ or PI3Kγ reduces IL-17 and ameliorates imiquimod-induced psoriasis-like dermatitis

artículo científico publicado en 2012

CCL21 mediates CD4+ T-cell costimulation via a DOCK2/Rac-dependent pathway

artículo científico publicado en 2009

CD28 provides T-cell costimulation and enhances PI3K activity at the immune synapse independently of its capacity to interact with the p85/p110 heterodimer.

artículo científico publicado en 2007

CD28 regulates the translation of Bcl-xL via the phosphatidylinositol 3-kinase/mammalian target of rapamycin pathway

artículo científico publicado en 2005

Cellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer.

artículo científico publicado en 2001

Cholesterol metabolism drives regulatory B cell IL-10 through provision of geranylgeranyl pyrophosphate

scientific article published on 08 July 2020

Class I phosphoinositide 3-kinase p110beta is required for apoptotic cell and Fcgamma receptor-mediated phagocytosis by macrophages

artículo científico publicado en 2003

Class IA PI3Ks regulate subcellular and functional dynamics of IDO1

artículo científico publicado en 2020

Clinical spectrum and features of activated phosphoinositide 3-kinase δ syndrome: A large patient cohort study ⬇️

artículo científico publicado en 2016

Compensation between CSF1R+ macrophages and Foxp3+ Treg cells drives resistance to tumor immunotherapy

artículo científico publicado en 2018

Cowden's syndrome with immunodeficiency

artículo científico publicado en 2015

Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation

scientific journal article

Cross talk between phosphatidylinositol 3-kinase and cyclic AMP (cAMP)-protein kinase a signaling pathways at the level of a protein kinase B/beta-arrestin/cAMP phosphodiesterase 4 complex

artículo científico publicado en 2010

Cutting edge: differential roles for phosphoinositide 3-kinases, p110gamma and p110delta, in lymphocyte chemotaxis and homing

artículo científico publicado en 2004

Cutting edge: the Foxp3 target miR-155 contributes to the development of regulatory T cells.

artículo científico publicado en 2009

Cutting edge: the phosphoinositide 3-kinase p110 delta is critical for the function of CD4+CD25+Foxp3+ regulatory T cells

artículo científico publicado en 2006

Does the PI3K pathway promote or antagonize regulatory T cell development and function?

artículo científico publicado en 2012

Editorial: Lipid Signaling in T Cell Development and Function

artículo científico publicado en 2015

Essential role for the p110delta phosphoinositide 3-kinase in the allergic response

artículo científico publicado en 2004

Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice

artículo científico publicado en 2008

Firefly luciferin-activated rose bengal: in vitro photodynamic therapy by intracellular chemiluminescence in transgenic NIH 3T3 cells.

artículo científico publicado en 2003

Gene targeting in mice: a review

artículo científico publicado en 2013

Gene-targeting reveals physiological roles and complex regulation of the phosphoinositide 3-kinases

artículo científico publicado en 2003

Genetic or pharmaceutical blockade of p110delta phosphoinositide 3-kinase enhances IgE production

artículo científico publicado en 2008

Genetic or pharmaceutical blockade of phosphoinositide 3-kinase p110δ prevents chronic rejection of heart allografts

artículo científico publicado en 2012

Grb2 Forms an Inducible Protein Complex with CD28 through a Src Homology 3 Domain-Proline Interaction ⬇️

artículo científico publicado el 14 de agosto de 1998

Haematological cancer: idelalisib-targeting PI3Kδ in patients with B-cell malignancies

artículo científico publicado en 2014

IL-21 promotes CD4 T cell responses by phosphatidylinositol 3-kinase-dependent upregulation of CD86 on B cells

artículo científico publicado en 2014

Ig gene-like molecule CD31 plays a nonredundant role in the regulation of T-cell immunity and tolerance

artículo científico publicado en 2010

Immunomodulation of Selective Naive T Cell Functions by p110δ Inactivation Improves the Outcome of Mismatched Cell Transplantation

artículo científico publicado en 2015

Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant mice

artículo científico publicado en 2002

Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer

artículo científico publicado en 2014

Inactivation of PI3Kgamma and PI3Kdelta distorts T-cell development and causes multiple organ inflammation.

artículo científico publicado en 2007

Inhibition of Phosphoinositide 3-Kinase p110delta Does Not Affect T Cell Driven Development of Type 1 Diabetes Despite Significant Effects on Cytokine Production

artículo científico publicado en 2016

Integrity in Scientific Research: Creating an Environment that Promotes Responsible Conduct

artículo científico publicado en 2003

Ionic immune suppression within the tumour microenvironment limits T cell effector function.

artículo científico publicado en 2016

Key role of the p110delta isoform of PI3K in B-cell antigen and IL-4 receptor signaling: comparative analysis of genetic and pharmacologic interference with p110delta function in B cells

artículo científico publicado en 2005

Loss of Phosphatidylinositol 3-Kinase Activity in Regulatory T Cells Leads to Neuronal Inflammation

artículo científico publicado en 2020

MAPK, phosphatidylinositol 3-kinase, and mammalian target of rapamycin pathways converge at the level of ribosomal protein S6 phosphorylation to control metabolic signaling in CD8 T cells

artículo científico publicado en 2009

Multi-tissue DNA methylation age predictor in mouse

artículo científico publicado en 2017

New responsibilities for the PI3K regulatory subunit p85 alpha.

artículo científico publicado en 2001

Obesity-Induced Metabolic Stress Leads to Biased Effector Memory CD4+ T Cell Differentiation via PI3K p110δ-Akt-Mediated Signals.

scientific article published on 30 January 2017

Oncogenic PI3Kα promotes multipotency in breast epithelial cells

artículo científico publicado en 2015

P-Rex1 regulates neutrophil function

artículo científico publicado en 2005

PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells

artículo científico publicado en 2012

PI 3-kinase delta enhances axonal PIP3 to support axon regeneration in the adult CNS

scientific article published on 17 June 2020

PI3K Signaling in B Cell and T Cell Biology.

artículo científico publicado en 2014

PI3K Signaling in Normal B Cells and Chronic Lymphocytic Leukemia (CLL)

artículo científico publicado en 2016

PI3K in lymphocyte development, differentiation and activation

artículo científico publicado en 2003

PI3K induces B-cell development and regulates B cell identity

artículo científico publicado en 2018

PI3K inhibitors in inflammation, autoimmunity and cancer.

artículo científico

PI3K p110delta regulates T-cell cytokine production during primary and secondary immune responses in mice and humans

artículo científico publicado en 2010

PI3K p110δ is expressed by gp38(-)CD31(+) and gp38(+)CD31(+) spleen stromal cells and regulates their CCL19, CCL21, and LTβR mRNA levels

scientific journal article

PI3K-signalling in B- and T-cells: insights from gene-targeted mice

artículo científico publicado en 2003

PI3Ks in lymphocyte signaling and development

artículo científico publicado en 2010

PI3Kβ plays a critical role in neutrophil activation by immune complexes.

artículo científico publicado en 2011

PI3Kδ Regulates the Magnitude of CD8+ T Cell Responses after Challenge with Listeria monocytogenes

artículo científico publicado en 2015

PI3Kδ and primary immunodeficiencies.

artículo científico publicado en 2016

PI3Kδ hyper-activation promotes development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner

artículo científico publicado en 2018

PI3Kδ promotes CD4(+) T-cell interactions with antigen-presenting cells by increasing LFA-1 binding to ICAM-1.

artículo científico publicado en 2016

Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking

artículo científico publicado en 2008

Phosphoinositide 3-kinase activity in T cells regulates the magnitude of the germinal center reaction

artículo científico publicado en 2010

Phosphoinositide 3-kinase in T cell activation and survival.

artículo científico publicado en 2004

Phosphoinositide 3-kinase δ gene mutation predisposes to respiratory infection and airway damage

artículo científico publicado en 2013

Phosphoinositide 3-kinase δ inhibition promotes antitumor responses but antagonizes checkpoint inhibitors.

artículo científico publicado en 2018

Phosphoinositide 3-kinase δ is a regulatory T-cell target in cancer immunotherapy

scientific article published on 01 July 2019

Physiologic and aberrant regulation of memory T-cell trafficking by the costimulatory molecule CD28

artículo científico publicado en 2006

Proliferative signals mediated by CD28 superagonists require the exchange factor Vav1 but not phosphoinositide 3-kinase in primary peripheral T cells

scientific article published on 01 September 2008

Protein kinase B controls transcriptional programs that direct cytotoxic T cell fate but is dispensable for T cell metabolism

artículo científico publicado en 2011

Pten loss in CD4 T cells enhances their helper function but does not lead to autoimmunity or lymphoma.

artículo científico publicado en 2012

Regulatory T Cell Migration Is Dependent on Glucokinase-Mediated Glycolysis

artículo científico publicado en 2017

Requirement for phosphoinositide 3-kinase p110delta signaling in B cell antigen receptor-mediated antigen presentation

scientific article published on 01 February 2007

Requirement of bic/microRNA-155 for normal immune function

artículo científico publicado en 2007

Ribosomal protein S6 kinase 1 signaling regulates mammalian life span

artículo científico publicado en 2009

Role of the p110delta PI 3-kinase in integrin and ITAM receptor signalling in platelets

artículo científico publicado en 2005

Role of the phosphoinositide 3-kinase p110delta in generation of type 2 cytokine responses and allergic airway inflammation

artículo científico publicado en 2007

Rules of engagement: distinct functions for the four class I PI3K catalytic isoforms in immunity ⬇️

artículo científico publicado el 1 de marzo de 2013

Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils

artículo científico publicado en 2005

Signaling by the phosphoinositide 3-kinase family in immune cells

artículo científico publicado en 2013

Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation

artículo científico publicado en 1999

T cell receptor-induced phosphoinositide-3-kinase p110delta activity is required for T cell localization to antigenic tissue in mice

artículo científico publicado en 2008

Targeting PI3K in cancer: impact on tumor cells, their protective stroma, angiogenesis and immunotherapy

artículo científico publicado en 2016

The PI3K isoforms p110alpha and p110delta are essential for pre-B cell receptor signaling and B cell development.

artículo científico publicado en 2010

The PI3K p110δ Isoform Inhibitor Idelalisib Preferentially Inhibits Human Regulatory T Cell Function

scientific article published on 28 January 2019

The PI3K p110δ regulates expression of CD38 on regulatory T cells

artículo científico publicado en 2011

The SH3 domain of Itk/Emt binds to proline-rich sequences in the cytoplasmic domain of the T cell costimulatory receptor CD28

scientific article published on 01 October 1997

The Therapeutic Potential for PI3K Inhibitors in Autoimmune Rheumatic Diseases

artículo científico publicado en 2012

The p110beta isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110gamma.

artículo científico publicado en 2008

The p110delta isoform of phosphatidylinositol 3-kinase controls susceptibility to Leishmania major by regulating expansion and tissue homing of regulatory T cells.

artículo científico publicado en 2009

The p110delta isoform of phosphoinositide 3-kinase controls clonal expansion and differentiation of Th cells

scientific article published on 01 October 2006

The transcription factor BACH2 promotes tumor immunosuppression.

artículo científico publicado en 2016

Tumors induce de novo steroid biosynthesis in T cells to evade immunity

artículo científico publicado en 2020

Two birds with one stone: dual p110δ and p110γ inhibition

artículo científico publicado en 2013

p110δ is required for innate immunity to transplantable lymphomas

scientific article published on 01 April 2007

Lista de obras de Klaus Okkenhaug

A point mutation in CD28 distinguishes proliferative signals from survival signals

A protocol for construction of gene targeting vectors and generation of homologous recombinant embryonic stem cells.

Antigen receptor signalling: a distinctive role for the p110delta isoform of PI3K.

BACH2 regulates CD8(+) T cell differentiation by controlling access of AP-1 factors to enhancers

Blockade of phosphatidylinositol 3-kinase PI3Kδ or PI3Kγ reduces IL-17 and ameliorates imiquimod-induced psoriasis-like dermatitis

CCL21 mediates CD4+ T-cell costimulation via a DOCK2/Rac-dependent pathway

CD28 provides T-cell costimulation and enhances PI3K activity at the immune synapse independently of its capacity to interact with the p85/p110 heterodimer.

CD28 regulates the translation of Bcl-xL via the phosphatidylinositol 3-kinase/mammalian target of rapamycin pathway

Cellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer.

Cholesterol metabolism drives regulatory B cell IL-10 through provision of geranylgeranyl pyrophosphate

Class I phosphoinositide 3-kinase p110beta is required for apoptotic cell and Fcgamma receptor-mediated phagocytosis by macrophages

Class IA PI3Ks regulate subcellular and functional dynamics of IDO1

Clinical spectrum and features of activated phosphoinositide 3-kinase δ syndrome: A large patient cohort study ⬇️

Compensation between CSF1R+ macrophages and Foxp3+ Treg cells drives resistance to tumor immunotherapy

Cowden's syndrome with immunodeficiency

Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation

Cross talk between phosphatidylinositol 3-kinase and cyclic AMP (cAMP)-protein kinase a signaling pathways at the level of a protein kinase B/beta-arrestin/cAMP phosphodiesterase 4 complex

Cutting edge: differential roles for phosphoinositide 3-kinases, p110gamma and p110delta, in lymphocyte chemotaxis and homing

Cutting edge: the Foxp3 target miR-155 contributes to the development of regulatory T cells.

Cutting edge: the phosphoinositide 3-kinase p110 delta is critical for the function of CD4+CD25+Foxp3+ regulatory T cells

Does the PI3K pathway promote or antagonize regulatory T cell development and function?

Editorial: Lipid Signaling in T Cell Development and Function

Essential role for the p110delta phosphoinositide 3-kinase in the allergic response

Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice

Firefly luciferin-activated rose bengal: in vitro photodynamic therapy by intracellular chemiluminescence in transgenic NIH 3T3 cells.

Gene targeting in mice: a review

Gene-targeting reveals physiological roles and complex regulation of the phosphoinositide 3-kinases

Genetic or pharmaceutical blockade of p110delta phosphoinositide 3-kinase enhances IgE production

Genetic or pharmaceutical blockade of phosphoinositide 3-kinase p110δ prevents chronic rejection of heart allografts

Grb2 Forms an Inducible Protein Complex with CD28 through a Src Homology 3 Domain-Proline Interaction ⬇️

Haematological cancer: idelalisib-targeting PI3Kδ in patients with B-cell malignancies

IL-21 promotes CD4 T cell responses by phosphatidylinositol 3-kinase-dependent upregulation of CD86 on B cells

Ig gene-like molecule CD31 plays a nonredundant role in the regulation of T-cell immunity and tolerance

Immunomodulation of Selective Naive T Cell Functions by p110δ Inactivation Improves the Outcome of Mismatched Cell Transplantation

Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant mice

Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer

Inactivation of PI3Kgamma and PI3Kdelta distorts T-cell development and causes multiple organ inflammation.

Inhibition of Phosphoinositide 3-Kinase p110delta Does Not Affect T Cell Driven Development of Type 1 Diabetes Despite Significant Effects on Cytokine Production

Integrity in Scientific Research: Creating an Environment that Promotes Responsible Conduct

Ionic immune suppression within the tumour microenvironment limits T cell effector function.

Key role of the p110delta isoform of PI3K in B-cell antigen and IL-4 receptor signaling: comparative analysis of genetic and pharmacologic interference with p110delta function in B cells

Loss of Phosphatidylinositol 3-Kinase Activity in Regulatory T Cells Leads to Neuronal Inflammation

MAPK, phosphatidylinositol 3-kinase, and mammalian target of rapamycin pathways converge at the level of ribosomal protein S6 phosphorylation to control metabolic signaling in CD8 T cells

Multi-tissue DNA methylation age predictor in mouse

New responsibilities for the PI3K regulatory subunit p85 alpha.

Obesity-Induced Metabolic Stress Leads to Biased Effector Memory CD4+ T Cell Differentiation via PI3K p110δ-Akt-Mediated Signals.

Oncogenic PI3Kα promotes multipotency in breast epithelial cells

P-Rex1 regulates neutrophil function

PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells

PI 3-kinase delta enhances axonal PIP3 to support axon regeneration in the adult CNS

PI3K Signaling in B Cell and T Cell Biology.

PI3K Signaling in Normal B Cells and Chronic Lymphocytic Leukemia (CLL)

PI3K in lymphocyte development, differentiation and activation

PI3K induces B-cell development and regulates B cell identity

PI3K inhibitors in inflammation, autoimmunity and cancer.

PI3K p110delta regulates T-cell cytokine production during primary and secondary immune responses in mice and humans

PI3K p110δ is expressed by gp38(-)CD31(+) and gp38(+)CD31(+) spleen stromal cells and regulates their CCL19, CCL21, and LTβR mRNA levels

PI3K-signalling in B- and T-cells: insights from gene-targeted mice

PI3Ks in lymphocyte signaling and development

PI3Kβ plays a critical role in neutrophil activation by immune complexes.

PI3Kδ Regulates the Magnitude of CD8+ T Cell Responses after Challenge with Listeria monocytogenes

PI3Kδ and primary immunodeficiencies.

PI3Kδ hyper-activation promotes development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner

PI3Kδ promotes CD4(+) T-cell interactions with antigen-presenting cells by increasing LFA-1 binding to ICAM-1.

Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking

Phosphoinositide 3-kinase activity in T cells regulates the magnitude of the germinal center reaction

Phosphoinositide 3-kinase in T cell activation and survival.

Phosphoinositide 3-kinase δ gene mutation predisposes to respiratory infection and airway damage

Phosphoinositide 3-kinase δ inhibition promotes antitumor responses but antagonizes checkpoint inhibitors.

Phosphoinositide 3-kinase δ is a regulatory T-cell target in cancer immunotherapy

Physiologic and aberrant regulation of memory T-cell trafficking by the costimulatory molecule CD28

Proliferative signals mediated by CD28 superagonists require the exchange factor Vav1 but not phosphoinositide 3-kinase in primary peripheral T cells

Protein kinase B controls transcriptional programs that direct cytotoxic T cell fate but is dispensable for T cell metabolism

Pten loss in CD4 T cells enhances their helper function but does not lead to autoimmunity or lymphoma.

Regulatory T Cell Migration Is Dependent on Glucokinase-Mediated Glycolysis

Requirement for phosphoinositide 3-kinase p110delta signaling in B cell antigen receptor-mediated antigen presentation

Requirement of bic/microRNA-155 for normal immune function

Ribosomal protein S6 kinase 1 signaling regulates mammalian life span

Role of the p110delta PI 3-kinase in integrin and ITAM receptor signalling in platelets