Lista de obras - Marival Bermejo - Dominio Público Uruguay

"Development of Fixed Dose Combination Products" Workshop Report: Considerations of Gastrointestinal Physiology and Overall Development Strategy

scientific article published on 06 June 2019

A Mechanistic Physiologically-Based Biopharmaceutics Modeling (PBBM) Approach to Assess the In Vivo Performance of an Orally Administered Drug Product: From IVIVC to IVIVP

scientific article published on 17 January 2020

A new mathematical approach for the estimation of the AUC and its variability under different experimental designs in preclinical studies.

artículo científico publicado en 2011

A promising camptothecin derivative: Semisynthesis, antitumor activity and intestinal permeability.

artículo científico publicado en 2014

A provisional biopharmaceutical classification of the top 200 oral drug products in the United States, Great Britain, Spain, and Japan

artículo científico publicado en 2006

An exploratory study of two Caco-2 cell models for oral absorption: a report on their within-laboratory and between-laboratory variability, and their predictive capacity.

artículo científico publicado en 2010

Assessment of the Regulatory Methods for the Comparison of Highly Variable Dissolution Profiles.

artículo científico publicado en 2016

Availability of Authorizations from EMA and FDA for Age-Appropriate Medicines Contained in the WHO Essential Medicines List for Children 2019

scientific article published on 01 April 2020

Bias in estimation of transporter kinetic parameters from overexpression systems: Interplay of transporter expression level and substrate affinity.

artículo científico publicado en 2006

Biomimetic Artificial Membrane Permeability Assay over Franz Cell Apparatus Using BCS Model Drugs

scientific article published on 19 October 2020

Biopharmaceutical optimization in neglected diseases for paediatric patients by applying the provisional paediatric biopharmaceutical classification system

scientific article published on 17 July 2018

Candesartan Cilexetil In Vitro-In Vivo Correlation: Predictive Dissolution as a Development Tool

artículo científico publicado en 2020

Classification of WHO Essential Oral Medicines for Children Applying a Provisional Pediatric Biopharmaceutics Classification System

scientific article published on 31 October 2019

Closed-Loop Doluisio (Colon, Small Intestine) and Single-Pass Intestinal Perfusion (Colon, Jejunum) in Rat-Biophysical Model and Predictions Based on Caco-2.

artículo científico publicado en 2017

Comparison of segmental-dependent permeability in human and in situ perfusion model in rat.

artículo científico publicado en 2017

Computer simulations for bioequivalence trials: Selection of analyte in BCS class II and IV drugs with first-pass metabolism, two metabolic pathways and intestinal efflux transporter

artículo científico publicado en 2018

Computer simulations for bioequivalence trials: selection of analyte in BCS drugs with first-pass metabolism and two metabolic pathways

artículo científico publicado en 2010

Computer simulations of bioequivalence trials: selection of design and analyte in BCS drugs with first-pass hepatic metabolism: Part II. Non-linear kinetics.

artículo científico publicado en 2008

Covalently crosslinked organophosphorous derivatives-chitosan hydrogel as a drug delivery system for oral administration of camptothecin

scientific article published on 14 January 2019

Defining level A IVIVC dissolution specifications based on individual in vitro dissolution profiles of a controlled release formulation.

artículo científico publicado en 2018

Determination of intestinal permeability using in situ perfusion model in rats: Challenges and advantages to BCS classification applied to digoxin

artículo científico publicado en 2018

Development of an ion-pair to improve the colon permeability of a low permeability drug: Atenolol

artículo científico publicado en 2016

Drug gastrointestinal absorption in rat: Strain and gender differences

artículo científico publicado en 2015

Effect of antiinflammatory agents on the accumulation of ofloxacin in human polymorphonuclear leukocytes

artículo científico publicado en 1999

Effects of ethanol on intestinal absorption of drugs: in situ studies with ciprofloxacin analogs in acute and chronic alcohol-fed rats

artículo científico publicado en 1999

Enhancing Oral Absorption of β-Lapachone: Progress Till Date.

artículo científico publicado en 2016

Erratum: Hens, B.; et al. Application of the Gastrointestinal Simulator (GIS) Coupled with In Silico Modeling to Measure the Impact of Coca-Cola<sup>®</sup> on the Luminal and Systemic Behavior of Loratadine (BCS Class 2b). <i>Pharmaceutics</i>, 202

artículo científico publicado en 2020

Evaluation and optimized selection of supersaturating drug delivery systems of posaconazole (BCS class 2b) in the gastrointestinal simulator (GIS): An in vitro-in silico-in vivo approach.

artículo científico publicado en 2018

Evaluation of the intestinal permeability of rosemary (Rosmarinus officinalis L.) extract polyphenols and terpenoids in Caco-2 cell monolayers.

artículo científico publicado en 2017

Exploring Bioequivalence of Dexketoprofen Trometamol Drug Products with the Gastrointestinal Simulator (GIS) and Precipitation Pathways Analyses

scientific article published on 15 March 2019

Exploring different strategies for imbalanced ADME data problem: case study on Caco-2 permeability modeling.

artículo científico publicado en 2015

Formulation predictive dissolution (fPD) testing to advance oral drug product development: An introduction to the US FDA funded '21st Century BA/BE' project

artículo científico publicado en 2018

Gastric emptying and intestinal appearance of nonabsorbable drugs phenol red and paromomycin in human subjects: A multi-compartment stomach approach

artículo científico publicado en 2018

Gated Mesoporous Silica Nanocarriers for a "Two-Step" Targeted System to Colonic Tissue

artículo científico publicado en 2017

Giardiasis: characteristics, pathogenesis and new insights about treatment

artículo científico publicado en 2018

Hydrogels: an interesting strategy for smart drug delivery

artículo científico publicado en 2013

IVIVC approach based on carbamazepine bioequivalence studies combination

artículo científico publicado en 2017

Impact on intestinal permeability of pediatric hyperosmolar formulations after dilution: Studies with rat perfusion method

scientific article published on 27 December 2018

In Silico Prediction of Caco-2 Cell Permeability by a Classification QSAR Approach

artículo científico publicado en 2011

In Situ Perfusion Model in Rat Colon for Drug Absorption Studies: Comparison with Small Intestine and Caco-2 Cell Model.

artículo científico publicado en 2015

In Vitro Dissolution as a Tool for Formulation Selection: Telmisartan Two-Step IVIVC

scientific article published on 17 May 2018

In Vivo Predictive Dissolution and Simulation Workshop Report: Facilitating the Development of Oral Drug Formulation and the Prediction of Oral Bioperformance

artículo científico publicado en 2018

In vitro-in situ permeability and dissolution of fexofenadine with kinetic modeling in the presence of sodium dodecyl sulfate

scientific article published on 11 August 2011

In vitro-in vivo correlations: general concepts, methodologies and regulatory applications

artículo científico

In-situ intestinal rat perfusions for human Fabs prediction and BCS permeability class determination: Investigation of the single-pass vs. the Doluisio experimental approaches

artículo científico publicado en 2015

Influence of polyunsaturated fatty acids on Cortisol transport through MDCK and MDCK-MDR1 cells as blood-brain barrier in vitro model.

artículo científico publicado en 2010

Innovative in vitro method to predict rate and extent of drug delivery to the brain across the blood-brain barrier

artículo científico publicado en 2013

Intestinal Permeability Study of Clinically Relevant Formulations of Silibinin in Caco-2 Cell Monolayers ⬇️

artículo científico

Intestinal Permeability of β-Lapachone and Its Cyclodextrin Complexes and Physical Mixtures

artículo científico publicado en 2015

Intrinsic absolute bioavailability prediction in rats based on in situ absorption rate constants and/or in vitro partition coefficients: 6-fluoroquinolones.

artículo científico publicado en 2000

Investigating drug absorption from the colon: Single-pass vs. Doluisio approaches to in-situ rat large-intestinal perfusion.

artículo científico publicado en 2017

Investigating the Discriminatory Power of BCS-Biowaiver in Vitro Methodology to Detect Bioavailability Differences between Immediate Release Products Containing a Class I Drug.

artículo científico publicado en 2015

Investigation to Explain Bioequivalence Failure in Pravastatin Immediate-Release Products

scientific article published on 09 December 2019

Ion-pair approach coupled with nanoparticle formation to increase bioavailability of a low permeability charged drug

artículo científico publicado en 2018

Ion-pair strategy for enabling amifostine oral absorption: rat in situ and in vivo experiments.

artículo científico publicado en 2013

Ionic Hydrogel Based on Chitosan Cross-Linked with 6-Phosphogluconic Trisodium Salt as a Drug Delivery System.

artículo científico publicado en 2018

Kinetic Modeling of Triamterene Intestinal Absorption and its Inhibition by Folic Acid and Methotrexate

artículo científico publicado el 1 de mayo de 2003

Kinetic modelling of the intestinal transport of sarafloxacin. Studies in situ in rat and in vitro in Caco-2 cells.

artículo científico publicado en 2005

Linking the Gastrointestinal Behavior of Ibuprofen with The Systemic Exposure Between and Within Humans - Part 1: Fasted State

artículo científico publicado en 2018

Linking the Gastrointestinal Behavior of Ibuprofen with the Systemic Exposure between and within Humans-Part 2: Fed State

artículo científico publicado en 2018

Long-Circulating Hyaluronan-Based Nanohydrogels as Carriers of Hydrophobic Drugs

artículo científico publicado en 2018

Low Buffer Capacity and Alternating Motility along the Human Gastrointestinal Tract: Implications for in Vivo Dissolution and Absorption of Ionizable Drugs

artículo científico publicado en 2017

Mass Transport Analysis of the Enhanced Buffer Capacity of the Bicarbonate-CO Buffer in a Phase-Heterogenous System: Physiological and Pharmaceutical Significance

scientific article published on 26 October 2018

Mathematical modeling of oral absorption and bioavailability of a fluoroquinolone after its precipitation in the gastrointestinal tract

artículo científico publicado en 2013

Mathematical modelling of in situ and in vitro efflux of ciprofloxacin and grepafloxacin.

artículo científico publicado en 2005

Measuring the Impact of Gastrointestinal Variables on the Systemic Outcome of Two Suspensions of Posaconazole by a PBPK Model

scientific article published on 29 March 2018

Mechanistic analysis and experimental verification of bicarbonate-controlled enteric coat dissolution: Potential in vivo implications

artículo científico publicado en 2019

Modified nonsink equation for permeability estimation in cell monolayers: comparison with standard methods.

artículo científico publicado en 2014

PAMPA--a drug absorption in vitro model 7. Comparing rat in situ, Caco-2, and PAMPA permeability of fluoroquinolones.

artículo científico publicado en 2004

PLGA nanoparticles are effective to control the colonic release and absorption on ibuprofen

artículo científico publicado en 2017

Permeability Study of Polyphenols Derived from a Phenolic-Enriched Hibiscus sabdariffa Extract by UHPLC-ESI-UHR-Qq-TOF-MS.

artículo científico publicado en 2015

Population pharmacokinetic model of lithium and drug compliance assessment

artículo científico publicado en 2016

Preclinical models for colonic absorption, application to controlled release formulation development

scientific article published on 06 July 2018

Progress in the development of early diagnosis and a drug with unique pharmacology to improve cancer therapy

scientific article published on October 2008

Provisional Classification and in Silico Study of Biopharmaceutical System Based on Caco-2 Cell Permeability and Dose Number

artículo científico publicado en 2013

Purely in silico BCS classification: science based quality standards for the world's drugs

artículo científico publicado en 2013

Segmental-dependent permeability throughout the small intestine following oral drug administration: Single-pass vs. Doluisio approach to in-situ rat perfusion

artículo científico publicado en 2016

Semi-mechanistic Pharmacokinetic/Pharmacodynamic model of three pegylated rHuEPO and ior®EPOCIM in New Zealand rabbits.

artículo científico publicado en 2018

Semi-physiologic model validation and bioequivalence trials simulation to select the best analyte for acetylsalicylic acid.

artículo científico publicado en 2015

Semisynthesis, cytotoxic activity, and oral availability of new lipophilic 9-substituted camptothecin derivatives.

artículo científico publicado en 2013

TOPS-MODE approach for the prediction of blood-brain barrier permeation

artículo científico publicado en 2004

The Use of Rule-Based and QSPR Approaches in ADME Profiling: A Case Study on Caco-2 Permeability.

artículo científico publicado en 2013

Tubulin acetylation promoting potency and absorption efficacy of deacetylase inhibitors.

artículo científico publicado en 2014

Unique pharmacology of KAR-2, a potential anti-cancer agent: absorption modelling and selective mitotic spindle targeting.

artículo científico publicado en 2008

Usefulness of Caco-2/HT29-MTX and Caco-2/HT29-MTX/Raji B Coculture Models To Predict Intestinal and Colonic Permeability Compared to Caco-2 Monoculture

artículo científico publicado en 2017

Validation of a biophysical drug absorption model by the PATQSAR system.

artículo científico publicado en 1999

Validation of a semi-physiological model for caffeine in healthy subjects and cirrhotic patients.

artículo científico publicado en 2015

Validation of phenol red versus gravimetric method for water reabsorption correction and study of gender differences in Doluisio's absorption technique

artículo científico publicado en 2014

Variability of permeability estimation from different protocols of subculture and transport experiments in cell monolayers.

artículo científico publicado en 2014

Lista de obras de Marival Bermejo

"Development of Fixed Dose Combination Products" Workshop Report: Considerations of Gastrointestinal Physiology and Overall Development Strategy

A Mechanistic Physiologically-Based Biopharmaceutics Modeling (PBBM) Approach to Assess the In Vivo Performance of an Orally Administered Drug Product: From IVIVC to IVIVP

A new mathematical approach for the estimation of the AUC and its variability under different experimental designs in preclinical studies.

A promising camptothecin derivative: Semisynthesis, antitumor activity and intestinal permeability.

A provisional biopharmaceutical classification of the top 200 oral drug products in the United States, Great Britain, Spain, and Japan

An exploratory study of two Caco-2 cell models for oral absorption: a report on their within-laboratory and between-laboratory variability, and their predictive capacity.

Assessment of the Regulatory Methods for the Comparison of Highly Variable Dissolution Profiles.

Availability of Authorizations from EMA and FDA for Age-Appropriate Medicines Contained in the WHO Essential Medicines List for Children 2019

Bias in estimation of transporter kinetic parameters from overexpression systems: Interplay of transporter expression level and substrate affinity.

Biomimetic Artificial Membrane Permeability Assay over Franz Cell Apparatus Using BCS Model Drugs

Biopharmaceutical optimization in neglected diseases for paediatric patients by applying the provisional paediatric biopharmaceutical classification system

Candesartan Cilexetil In Vitro-In Vivo Correlation: Predictive Dissolution as a Development Tool

Classification of WHO Essential Oral Medicines for Children Applying a Provisional Pediatric Biopharmaceutics Classification System

Closed-Loop Doluisio (Colon, Small Intestine) and Single-Pass Intestinal Perfusion (Colon, Jejunum) in Rat-Biophysical Model and Predictions Based on Caco-2.

Comparison of segmental-dependent permeability in human and in situ perfusion model in rat.

Computer simulations for bioequivalence trials: Selection of analyte in BCS class II and IV drugs with first-pass metabolism, two metabolic pathways and intestinal efflux transporter

Computer simulations for bioequivalence trials: selection of analyte in BCS drugs with first-pass metabolism and two metabolic pathways

Computer simulations of bioequivalence trials: selection of design and analyte in BCS drugs with first-pass hepatic metabolism: Part II. Non-linear kinetics.

Covalently crosslinked organophosphorous derivatives-chitosan hydrogel as a drug delivery system for oral administration of camptothecin

Defining level A IVIVC dissolution specifications based on individual in vitro dissolution profiles of a controlled release formulation.

Determination of intestinal permeability using in situ perfusion model in rats: Challenges and advantages to BCS classification applied to digoxin

Development of an ion-pair to improve the colon permeability of a low permeability drug: Atenolol

Drug gastrointestinal absorption in rat: Strain and gender differences

Effect of antiinflammatory agents on the accumulation of ofloxacin in human polymorphonuclear leukocytes

Effects of ethanol on intestinal absorption of drugs: in situ studies with ciprofloxacin analogs in acute and chronic alcohol-fed rats

Enhancing Oral Absorption of β-Lapachone: Progress Till Date.

Erratum: Hens, B.; et al. Application of the Gastrointestinal Simulator (GIS) Coupled with In Silico Modeling to Measure the Impact of Coca-Cola<sup>®</sup> on the Luminal and Systemic Behavior of Loratadine (BCS Class 2b). <i>Pharmaceutics</i>, 202

Evaluation and optimized selection of supersaturating drug delivery systems of posaconazole (BCS class 2b) in the gastrointestinal simulator (GIS): An in vitro-in silico-in vivo approach.

Evaluation of the intestinal permeability of rosemary (Rosmarinus officinalis L.) extract polyphenols and terpenoids in Caco-2 cell monolayers.

Exploring Bioequivalence of Dexketoprofen Trometamol Drug Products with the Gastrointestinal Simulator (GIS) and Precipitation Pathways Analyses

Exploring different strategies for imbalanced ADME data problem: case study on Caco-2 permeability modeling.

Formulation predictive dissolution (fPD) testing to advance oral drug product development: An introduction to the US FDA funded '21st Century BA/BE' project

Gastric emptying and intestinal appearance of nonabsorbable drugs phenol red and paromomycin in human subjects: A multi-compartment stomach approach

Gated Mesoporous Silica Nanocarriers for a "Two-Step" Targeted System to Colonic Tissue

Giardiasis: characteristics, pathogenesis and new insights about treatment

Hydrogels: an interesting strategy for smart drug delivery

IVIVC approach based on carbamazepine bioequivalence studies combination

Impact on intestinal permeability of pediatric hyperosmolar formulations after dilution: Studies with rat perfusion method

In Silico Prediction of Caco-2 Cell Permeability by a Classification QSAR Approach

In Situ Perfusion Model in Rat Colon for Drug Absorption Studies: Comparison with Small Intestine and Caco-2 Cell Model.

In Vitro Dissolution as a Tool for Formulation Selection: Telmisartan Two-Step IVIVC

In Vivo Predictive Dissolution and Simulation Workshop Report: Facilitating the Development of Oral Drug Formulation and the Prediction of Oral Bioperformance

In vitro-in situ permeability and dissolution of fexofenadine with kinetic modeling in the presence of sodium dodecyl sulfate

In vitro-in vivo correlations: general concepts, methodologies and regulatory applications

In-situ intestinal rat perfusions for human Fabs prediction and BCS permeability class determination: Investigation of the single-pass vs. the Doluisio experimental approaches

Influence of polyunsaturated fatty acids on Cortisol transport through MDCK and MDCK-MDR1 cells as blood-brain barrier in vitro model.

Innovative in vitro method to predict rate and extent of drug delivery to the brain across the blood-brain barrier

Intestinal Permeability Study of Clinically Relevant Formulations of Silibinin in Caco-2 Cell Monolayers ⬇️

Intestinal Permeability of β-Lapachone and Its Cyclodextrin Complexes and Physical Mixtures

Intrinsic absolute bioavailability prediction in rats based on in situ absorption rate constants and/or in vitro partition coefficients: 6-fluoroquinolones.

Investigating drug absorption from the colon: Single-pass vs. Doluisio approaches to in-situ rat large-intestinal perfusion.

Investigating the Discriminatory Power of BCS-Biowaiver in Vitro Methodology to Detect Bioavailability Differences between Immediate Release Products Containing a Class I Drug.

Investigation to Explain Bioequivalence Failure in Pravastatin Immediate-Release Products

Ion-pair approach coupled with nanoparticle formation to increase bioavailability of a low permeability charged drug

Ion-pair strategy for enabling amifostine oral absorption: rat in situ and in vivo experiments.

Ionic Hydrogel Based on Chitosan Cross-Linked with 6-Phosphogluconic Trisodium Salt as a Drug Delivery System.

Kinetic Modeling of Triamterene Intestinal Absorption and its Inhibition by Folic Acid and Methotrexate

Kinetic modelling of the intestinal transport of sarafloxacin. Studies in situ in rat and in vitro in Caco-2 cells.

Linking the Gastrointestinal Behavior of Ibuprofen with The Systemic Exposure Between and Within Humans - Part 1: Fasted State

Linking the Gastrointestinal Behavior of Ibuprofen with the Systemic Exposure between and within Humans-Part 2: Fed State

Long-Circulating Hyaluronan-Based Nanohydrogels as Carriers of Hydrophobic Drugs

Low Buffer Capacity and Alternating Motility along the Human Gastrointestinal Tract: Implications for in Vivo Dissolution and Absorption of Ionizable Drugs

Mass Transport Analysis of the Enhanced Buffer Capacity of the Bicarbonate-CO Buffer in a Phase-Heterogenous System: Physiological and Pharmaceutical Significance

Mathematical modeling of oral absorption and bioavailability of a fluoroquinolone after its precipitation in the gastrointestinal tract

Mathematical modelling of in situ and in vitro efflux of ciprofloxacin and grepafloxacin.

Measuring the Impact of Gastrointestinal Variables on the Systemic Outcome of Two Suspensions of Posaconazole by a PBPK Model

Mechanistic analysis and experimental verification of bicarbonate-controlled enteric coat dissolution: Potential in vivo implications

Modified nonsink equation for permeability estimation in cell monolayers: comparison with standard methods.

PAMPA--a drug absorption in vitro model 7. Comparing rat in situ, Caco-2, and PAMPA permeability of fluoroquinolones.

PLGA nanoparticles are effective to control the colonic release and absorption on ibuprofen

Permeability Study of Polyphenols Derived from a Phenolic-Enriched Hibiscus sabdariffa Extract by UHPLC-ESI-UHR-Qq-TOF-MS.

Population pharmacokinetic model of lithium and drug compliance assessment

Preclinical models for colonic absorption, application to controlled release formulation development

Progress in the development of early diagnosis and a drug with unique pharmacology to improve cancer therapy

Provisional Classification and in Silico Study of Biopharmaceutical System Based on Caco-2 Cell Permeability and Dose Number

Purely in silico BCS classification: science based quality standards for the world's drugs

Segmental-dependent permeability throughout the small intestine following oral drug administration: Single-pass vs. Doluisio approach to in-situ rat perfusion

Semi-mechanistic Pharmacokinetic/Pharmacodynamic model of three pegylated rHuEPO and ior®EPOCIM in New Zealand rabbits.

Semi-physiologic model validation and bioequivalence trials simulation to select the best analyte for acetylsalicylic acid.