Lista de obras - Laura Belvisi - Dominio Público Uruguay

A 3D QSAR CoMFA study of non-peptide angiotensin II receptor antagonists

artículo científico publicado en 1996

A 3D QSAR approach to the search for geometrical similarity in a series of nonpeptide angiotensin II receptor antagonists

artículo científico publicado en 1994

A NMR and computational study of Smac mimics targeting both the BIR2 and BIR3 domains in XIAP protein.

artículo científico publicado en 2012

A critical assessment of force field accuracy against NMR data for cyclic peptides containing β-amino acids

scientific article published on 01 June 2018

A new optical imaging probe targeting αVβ3 integrin in glioblastoma xenografts.

artículo científico publicado en 2011

A potent integrin antagonist from a small library of cyclic RGD pentapeptide mimics including benzyl-substituted azabicycloalkane amino acids

artículo científico publicado en 2008

Antiangiogenic effect of dual/selective alpha(5)beta(1)/alpha(v)beta(3) integrin antagonists designed on partially modified retro-inverso cyclotetrapeptide mimetics

artículo científico publicado en 2010

Antitumor activity of a novel homodimeric SMAC mimetic in ovarian carcinoma.

artículo científico publicado en 2013

Biological and molecular properties of a new alpha(v)beta3/alpha(v)beta5 integrin antagonist

artículo científico publicado en 2005

Bromine-Promoted Glycosidation of Conformationally Superarmed Thioglycosides

scientific article published on 20 August 2019

Computational design of novel peptidomimetic inhibitors of cadherin homophilic interactions

artículo científico publicado en 2015

Crystal Structure of Human E-Cadherin-EC1EC2 in Complex with a Peptidomimetic Competitive Inhibitor of Cadherin Homophilic Interaction

artículo científico publicado en 2016

Cyclic RGD Peptidomimetics Containing Bifunctional Diketopiperazine Scaffolds as New Potent Integrin Ligands

Cyclic RGD and isoDGR Integrin Ligands Containing cis-2-amino-1-cyclopentanecarboxylic (cis-β-ACPC) Scaffolds

artículo científico publicado en 2020

Cyclic RGD-containing functionalized azabicycloalkane peptides as potent integrin antagonists for tumor targeting.

artículo científico publicado en 2009

Cyclic RGD-peptidomimetics containing bifunctional diketopiperazine scaffolds as new potent integrin ligands.

artículo científico publicado en 2009

Cyclic isoDGR and RGD peptidomimetics containing bifunctional diketopiperazine scaffolds are integrin antagonists.

artículo científico publicado en 2015

Cyclic isoDGR peptidomimetics as low-nanomolar αvβ3 integrin ligands.

artículo científico publicado en 2013

Design and synthesis of nonpeptide angiotensin II receptor antagonists featuring acyclic imidazole-mimicking structural units

artículo científico publicado en 1998

Design, synthesis, and biological evaluation of novel cRGD-paclitaxel conjugates for integrin-assisted drug delivery.

artículo científico publicado en 2012

Designing nanomolar antagonists of DC-SIGN-mediated HIV infection: ligand presentation using molecular rods

artículo científico publicado en 2015

Determination of the binding epitope of RGD-peptidomimetics to αvβ3 and α(IIb)β3 integrin-rich intact cells by NMR and computational studies.

artículo científico publicado en 2013

Development of isoxazoline-containing peptidomimetics as dual αvβ3 and α5β1 integrin ligands

artículo científico publicado en 2011

Dimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part II: Structural and biological characterization

artículo científico publicado en 2012

Fast Cyclization of a Proline-Derived Self-Immolative Spacer Improves the Efficacy of Carbamate Prodrugs

artículo científico publicado en 2020

First round of a focused library of cholera toxin inhibitors

artículo científico publicado en 2007

Functionalized azabicycloalkane amino acids by nitrone 1,3-dipolar intramolecular cycloaddition.

artículo científico publicado en 2005

Grafting aminocyclopentane carboxylic acids onto the RGD tripeptide sequence generates low nanomolar alphaVbeta3/alphaVbeta5 integrin dual binders.

artículo científico publicado en 2005

Homo- and heterodimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part I: Synthesis

artículo científico publicado en 2012

Innovative Linker Strategies for Tumor-Targeted Drug Conjugates

scientific article published on 20 September 2019

Insights into the Binding of Cyclic RGD Peptidomimetics to α5β1 Integrin by using Live-Cell NMR And Computational Studies

artículo científico publicado en 2016

Investigating the Interaction of Cyclic RGD Peptidomimetics with αVβ₆ Integrin by Biochemical and Molecular Docking Studies

artículo científico publicado en 2017

Metadynamics Simulations Rationalise the Conformational Effects Induced by N-Methylation of RGD Cyclic Hexapeptides

artículo científico publicado en 2015

Modulation of αvβ₃- and α₅β₁-integrin-mediated adhesion by dehydro-β-amino acids containing peptidomimetics.

artículo científico publicado en 2013

Multivalency Increases the Binding Strength of RGD Peptidomimetic-Paclitaxel Conjugates to Integrin αV β3.

artículo científico publicado en 2017

N-3-Substituted Pyrimidinones as Potent, Orally Active, AT1 Selective Angiotensin II Receptor Antagonists

artículo científico publicado en 1995

Neutrophil Elastase Promotes Linker Cleavage and Paclitaxel Release from an Integrin-Targeted Conjugate

scientific article published on 27 December 2018

New Insights into the Molecular Mechanism of E-Cadherin-Mediated Cell Adhesion by Free Energy Calculations

artículo científico publicado en 2015

New potent αvβ3 integrin ligands based on azabicycloalkane (γ,α)-dipeptide mimics

artículo científico publicado en 2016

New β-Lactam Derivatives Modulate Cell Adhesion and Signaling Mediated by RGD-Binding and Leukocyte Integrins

artículo científico publicado en 2016

Nonpeptide Angiotensin II Receptor Antagonists. Synthesis, in vitro Activity, and Molecular Modeling Studies of N-[(Heterobiaryl)methyl]imidazoles

scientific article published on 01 November 1994

Potent integrin antagonists from a small library of RGD-including cyclic pseudopeptides.

artículo científico publicado en 2001

Rational design, synthesis and characterization of potent, non-peptidic Smac mimics/XIAP inhibitors as proapoptotic agents for cancer therapy.

artículo científico publicado en 2009

STD and trNOESY NMR study of receptor-ligand interactions in living cancer cells.

artículo científico publicado en 2011

Second generation of fucose-based DC-SIGN ligands : affinity improvement and specificity versus Langerin

scientific article published on 07 July 2011

Simulation of carbohydrate-protein interactions: computer-aided design of a second generation GM1 mimic.

artículo científico

Stem-Like Cancer Cells in a Dynamic 3D Culture System: A Model to Study Metastatic Cell Adhesion and Anti-Cancer Drugs

artículo científico publicado en 2019

Structural investigations of isomeric oxidised forms of hyperforin by HPLC-NMR and HPLC-MSn

artículo científico publicado en 2003

Structure-activity relationship of Ca2+ channel blockers: A study using conformational analysis and chemometric methods

scientific article published on 01 December 1991

Synthesis and Biological Evaluation of RGD and isoDGR-Monomethyl Auristatin Conjugates Targeting Integrin αV β3

artículo científico publicado en 2019

Synthesis and biological evaluation of RGD peptidomimetic-paclitaxel conjugates bearing lysosomally cleavable linkers

artículo científico publicado en 2015

Synthesis and conformational analysis of an α-d-mannopyranosyl-(1→2)-α-d-mannopyranosyl-(1→6)-α-d-mannopyranose mimic

artículo científico publicado en 2007

Synthesis and conformational studies of peptidomimetics containing a new bifunctional diketopiperazine scaffold acting as a beta-hairpin inducer.

artículo científico publicado en 2007

Synthesis of Gd and (68)Ga complexes in conjugation with a conformationally optimized RGD sequence as potential MRI and PET tumor-imaging probes.

artículo científico publicado en 2012

Synthesis, Characterization, and Biological Evaluation of a Dual-Action Ligand Targeting αvβ3 Integrin and VEGF Receptors

artículo científico publicado en 2015

Targeting integrins: insights into structure and activity of cyclic RGD pentapeptide mimics containing azabicycloalkane amino acids

artículo científico publicado en 2005

Thermodynamically-Weighted Conformational Ensemble of Cyclic RGD Peptidomimetics from NOE Data.

artículo científico publicado en 2016

Transferred-NOE NMR experiments on intact human platelets: receptor-bound conformation of RGD-peptide mimics.

artículo científico publicado en 2007

Tumor Targeting with an isoDGR-Drug Conjugate

artículo científico publicado en 2017

αvβ3 Integrin-Targeted Peptide/Peptidomimetic-Drug Conjugates: In-Depth Analysis of the Linker Technology

artículo científico

Lista de obras de Laura Belvisi

A 3D QSAR CoMFA study of non-peptide angiotensin II receptor antagonists

A 3D QSAR approach to the search for geometrical similarity in a series of nonpeptide angiotensin II receptor antagonists

A NMR and computational study of Smac mimics targeting both the BIR2 and BIR3 domains in XIAP protein.

A critical assessment of force field accuracy against NMR data for cyclic peptides containing β-amino acids

A new optical imaging probe targeting αVβ3 integrin in glioblastoma xenografts.

A potent integrin antagonist from a small library of cyclic RGD pentapeptide mimics including benzyl-substituted azabicycloalkane amino acids

Antiangiogenic effect of dual/selective alpha(5)beta(1)/alpha(v)beta(3) integrin antagonists designed on partially modified retro-inverso cyclotetrapeptide mimetics

Antitumor activity of a novel homodimeric SMAC mimetic in ovarian carcinoma.

Biological and molecular properties of a new alpha(v)beta3/alpha(v)beta5 integrin antagonist

Bromine-Promoted Glycosidation of Conformationally Superarmed Thioglycosides

Computational design of novel peptidomimetic inhibitors of cadherin homophilic interactions

Crystal Structure of Human E-Cadherin-EC1EC2 in Complex with a Peptidomimetic Competitive Inhibitor of Cadherin Homophilic Interaction

Cyclic RGD Peptidomimetics Containing Bifunctional Diketopiperazine Scaffolds as New Potent Integrin Ligands

Cyclic RGD and <i>iso</i>DGR Integrin Ligands Containing <i>cis</i>-2-amino-1-cyclopentanecarboxylic (<i>cis</i>-β-ACPC) Scaffolds

Cyclic RGD-containing functionalized azabicycloalkane peptides as potent integrin antagonists for tumor targeting.

Cyclic RGD-peptidomimetics containing bifunctional diketopiperazine scaffolds as new potent integrin ligands.

Cyclic isoDGR and RGD peptidomimetics containing bifunctional diketopiperazine scaffolds are integrin antagonists.

Cyclic isoDGR peptidomimetics as low-nanomolar αvβ3 integrin ligands.

Design and synthesis of nonpeptide angiotensin II receptor antagonists featuring acyclic imidazole-mimicking structural units

Design, synthesis, and biological evaluation of novel cRGD-paclitaxel conjugates for integrin-assisted drug delivery.

Designing nanomolar antagonists of DC-SIGN-mediated HIV infection: ligand presentation using molecular rods

Determination of the binding epitope of RGD-peptidomimetics to αvβ3 and α(IIb)β3 integrin-rich intact cells by NMR and computational studies.

Development of isoxazoline-containing peptidomimetics as dual αvβ3 and α5β1 integrin ligands

Dimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part II: Structural and biological characterization

Fast Cyclization of a Proline-Derived Self-Immolative Spacer Improves the Efficacy of Carbamate Prodrugs

First round of a focused library of cholera toxin inhibitors

Functionalized azabicycloalkane amino acids by nitrone 1,3-dipolar intramolecular cycloaddition.

Grafting aminocyclopentane carboxylic acids onto the RGD tripeptide sequence generates low nanomolar alphaVbeta3/alphaVbeta5 integrin dual binders.

Homo- and heterodimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part I: Synthesis

Innovative Linker Strategies for Tumor-Targeted Drug Conjugates

Insights into the Binding of Cyclic RGD Peptidomimetics to α5β1 Integrin by using Live-Cell NMR And Computational Studies

Investigating the Interaction of Cyclic RGD Peptidomimetics with αVβ₆ Integrin by Biochemical and Molecular Docking Studies

Metadynamics Simulations Rationalise the Conformational Effects Induced by N-Methylation of RGD Cyclic Hexapeptides

Modulation of αvβ₃- and α₅β₁-integrin-mediated adhesion by dehydro-β-amino acids containing peptidomimetics.

Multivalency Increases the Binding Strength of RGD Peptidomimetic-Paclitaxel Conjugates to Integrin αV β3.

N-3-Substituted Pyrimidinones as Potent, Orally Active, AT1 Selective Angiotensin II Receptor Antagonists

Neutrophil Elastase Promotes Linker Cleavage and Paclitaxel Release from an Integrin-Targeted Conjugate

New Insights into the Molecular Mechanism of E-Cadherin-Mediated Cell Adhesion by Free Energy Calculations

New potent αvβ3 integrin ligands based on azabicycloalkane (γ,α)-dipeptide mimics

New β-Lactam Derivatives Modulate Cell Adhesion and Signaling Mediated by RGD-Binding and Leukocyte Integrins

Nonpeptide Angiotensin II Receptor Antagonists. Synthesis, in vitro Activity, and Molecular Modeling Studies of N-[(Heterobiaryl)methyl]imidazoles

Potent integrin antagonists from a small library of RGD-including cyclic pseudopeptides.

Rational design, synthesis and characterization of potent, non-peptidic Smac mimics/XIAP inhibitors as proapoptotic agents for cancer therapy.

STD and trNOESY NMR study of receptor-ligand interactions in living cancer cells.

Second generation of fucose-based DC-SIGN ligands : affinity improvement and specificity versus Langerin

Simulation of carbohydrate-protein interactions: computer-aided design of a second generation GM1 mimic.

Stem-Like Cancer Cells in a Dynamic 3D Culture System: A Model to Study Metastatic Cell Adhesion and Anti-Cancer Drugs

Structural investigations of isomeric oxidised forms of hyperforin by HPLC-NMR and HPLC-MSn

Structure-activity relationship of Ca2+ channel blockers: A study using conformational analysis and chemometric methods

Synthesis and Biological Evaluation of RGD and isoDGR-Monomethyl Auristatin Conjugates Targeting Integrin αV β3

Synthesis and biological evaluation of RGD peptidomimetic-paclitaxel conjugates bearing lysosomally cleavable linkers

Synthesis and conformational analysis of an α-d-mannopyranosyl-(1→2)-α-d-mannopyranosyl-(1→6)-α-d-mannopyranose mimic

Synthesis and conformational studies of peptidomimetics containing a new bifunctional diketopiperazine scaffold acting as a beta-hairpin inducer.

Synthesis of Gd and (68)Ga complexes in conjugation with a conformationally optimized RGD sequence as potential MRI and PET tumor-imaging probes.

Synthesis, Characterization, and Biological Evaluation of a Dual-Action Ligand Targeting αvβ3 Integrin and VEGF Receptors

Targeting integrins: insights into structure and activity of cyclic RGD pentapeptide mimics containing azabicycloalkane amino acids

Thermodynamically-Weighted Conformational Ensemble of Cyclic RGD Peptidomimetics from NOE Data.

Transferred-NOE NMR experiments on intact human platelets: receptor-bound conformation of RGD-peptide mimics.

Tumor Targeting with an isoDGR-Drug Conjugate

αvβ3 Integrin-Targeted Peptide/Peptidomimetic-Drug Conjugates: In-Depth Analysis of the Linker Technology