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Lista de obras de Roger Schibli

"Click-to-chelate": design and incorporation of triazole-containing metal-chelating systems into biomolecules of diagnostic and therapeutic interest

artículo científico publicado en 2008

"Click-to-chelate": in vitro and in vivo comparison of a 99mTc(CO)3-labeled N(tau)-histidine folate derivative with its isostructural, clicked 1,2,3-triazole analogue

artículo científico publicado en 2008

(64)Cu- and (68)Ga-Based PET Imaging of Folate Receptor-Positive Tumors: Development and Evaluation of an Albumin-Binding NODAGA-Folate

artículo científico publicado en 2016

165Er: A new candidate for Auger electron therapy and its possible cyclotron production from natural holmium targets

scientific article published on 12 February 2020

18F-AzaFol for Detection of Folate Receptor-β Positive Macrophages in Experimental Interstitial Lung Disease-A Proof-of-Concept Study

scientific article published on 22 November 2019

44Sc-PSMA-617 for radiotheragnostics in tandem with 177Lu-PSMA-617-preclinical investigations in comparison with 68Ga-PSMA-11 and 68Ga-PSMA-617.

artículo científico publicado en 2017

5-(2-18F-fluoroethoxy)-L-tryptophan as a substrate of system L transport for tumor imaging by PET.

artículo científico publicado en 2012

99mTc-labeling and in vivo studies of a bombesin analogue with a novel water-soluble dithiadiphosphine-based bifunctional chelating agent

artículo científico publicado en 1999

A "click chemistry" approach to the efficient synthesis of multiple imaging probes derived from a single precursor

artículo científico publicado en 2009

A 99mTc(I)-postlabeled high affinity bombesin analogue as a potential tumor imaging agent

artículo científico publicado en 2002

A Novel Organometallic Aqua Complex of Technetium for the Labeling of Biomolecules:  Synthesis of [99mTc(OH2)3(CO)3]+from [99mTcO4]-in Aqueous Solution and Its Reaction with a Bifunctional Ligand

artículo científico publicado en 1998

A Short-Term Biological Indicator for Long-Term Kidney Damage after Radionuclide Therapy in Mice

artículo científico publicado en 2017

A click approach to structurally diverse conjugates containing a central di-1,2,3-triazole metal chelate

artículo científico publicado en 2009

A comparison of three (67/68)Ga-labelled exendin-4 derivatives for β-cell imaging on the GLP-1 receptor: the influence of the conjugation site of NODAGA as chelator

artículo científico publicado en 2014

A first-in-man PET study of [18F]PSS232, a fluorinated ABP688 derivative for imaging metabotropic glutamate receptor subtype 5.

artículo científico publicado en 2017

A new 18F-labeled folic acid derivative with improved properties for the PET imaging of folate receptor-positive tumors

artículo científico publicado en 2010

A unique matched quadruplet of terbium radioisotopes for PET and SPECT and for α- and β- radionuclide therapy: an in vivo proof-of-concept study with a new receptor-targeted folate derivative

artículo científico publicado en 2012

Albumin-Binding PSMA Ligands: Optimization of the Tissue Distribution Profile

artículo científico publicado en 2018

Albumin-Binding PSMA Radioligands: Impact of Minimal Structural Changes on the Tissue Distribution Profile

artículo científico publicado en 2020

Alpha-PET for Prostate Cancer: Preclinical investigation using 149Tb-PSMA-617

scientific article published on 28 November 2019

Alpha-PET with terbium-149: evidence and perspectives for radiotheragnostics

Anti-L1CAM radioimmunotherapy is more effective with the radiolanthanide terbium-161 compared to lutetium-177 in an ovarian cancer model.

artículo científico publicado en 2014

Assessment of an elastin binding molecule for PET imaging of atherosclerotic plaques

artículo científico publicado en 2013

Biodistribution and dosimetry of a single dose of albumin-binding ligand [177Lu]Lu-PSMA-ALB-56 in patients with mCRPC

artículo científico publicado en 2020

Bis(thiosemicarbazones) as bifunctional chelators for the room temperature 64-copper labeling of peptides

artículo científico publicado en 2010

Brain glucose transport and phosphorylation under acute insulin-induced hypoglycemia in mice: an 18F-FDG PET study

artículo científico publicado en 2013

CD80 Is Upregulated in a Mouse Model with Shear Stress-Induced Atherosclerosis and Allows for Evaluating CD80-Targeting PET Tracers

artículo científico publicado en 2016

Can Nuclear Imaging of Activated Macrophages with Folic Acid-Based Radiotracers Serve as a Prognostic Means to Identify COVID-19 Patients at Risk?

scientific article published on 09 September 2020

Can animal data predict human outcome? Problems and pitfalls of translational animal research

artículo científico publicado en 2012

Cannabinoid receptor type 2 (CB2) as one of the candidate genes in human carotid plaque imaging: Evaluation of the novel radiotracer [11C]RS-016 targeting CB2 in atherosclerosis.

artículo científico publicado en 2017

Catabolism of neurotensins. Implications for the design of radiolabeling strategies of peptides

artículo científico publicado en 1999

Characterization of different osteosarcoma phenotypes by PET imaging in preclinical animal models

artículo científico publicado en 2013

Charge dependent substrate activity of C3' and N3 functionalized, organometallic technetium and rhenium-labeled thymidine derivatives toward human thymidine kinase 1.

artículo científico publicado en 2010

Chemoselective 18F-incorporation into pyridyl acyltrifluoroborates for rapid radiolabelling of peptides and proteins at room temperature

artículo científico publicado en 2020

Cholecystokinin 2 Receptor Agonist 177Lu-PP-F11N for Radionuclide Therapy of Medullary Thyroid Carcinoma: Results of the Lumed Phase 0a Study

artículo científico publicado en 2019

Clinical evaluation of the radiolanthanide terbium-152: first-in-human PET/CT with 152Tb-DOTATOC.

artículo científico publicado en 2017

Combination of Proton Therapy and Radionuclide Therapy in Mice: Preclinical Pilot Study at the Paul Scherrer Institute

scientific article published on 02 September 2019

Combination of lutetium-177 labelled anti-L1CAM antibody chCE7 with the clinically relevant protein kinase inhibitor MK1775: a novel combination against human ovarian carcinoma

Combination of terbium-161 with somatostatin receptor antagonists-a potential paradigm shift for the treatment of neuroendocrine neoplasms

artículo científico publicado en 2021

Combined Application of Albumin-Binding [177Lu]Lu-PSMA-ALB-56 and Fast-Cleared PSMA Inhibitors: Optimization of the Pharmacokinetics

scientific article published on 08 May 2020

Combining Albumin-Binding Properties and Interaction with Pemetrexed to Improve the Tissue Distribution of Radiofolates

artículo científico publicado en 2018

Comparative Studies of Three Pairs of α- and γ-Conjugated Folic Acid Derivatives Labeled with Fluorine-18.

artículo científico publicado en 2015

Comparative studies of substitution reactions of rhenium(I) dicarbonyl-nitrosyl and tricarbonyl complexes in aqueous media

artículo científico publicado en 2005

Comparison of desferrioxamine and NODAGA for the gallium-68 labeling of exendin-4

scientific article published on 16 May 2019

Comparison of recombinant human haptocorrin expressed in human embryonic kidney cells and native haptocorrin

artículo científico publicado en 2012

Complete Carbonylation of fac-

scientific article published on 01 January 2000

Contribution of Auger/conversion electrons to renal side effects after radionuclide therapy: preclinical comparison of (161)Tb-folate and (177)Lu-folate.

artículo científico publicado en 2016

Corrigendum concerning "Methoxinine-An alternative stable amino acid substitute for oxidation-sensitive methionine in radiolabelled peptide conjugates"

scientific article published on 26 January 2020

Cu(I)-catalyzed intramolecular cyclization of alkynoic acids in aqueous media: a "click side reaction".

artículo científico publicado en 2007

Current use and future potential of organometallic radiopharmaceuticals.

artículo científico publicado en 2002

Cyclotron production of (44)Sc: From bench to bedside.

artículo científico publicado en 2015

DOTA conjugate with an albumin-binding entity enables the first folic acid-targeted 177Lu-radionuclide tumor therapy in mice

artículo científico publicado en 2012

DOTA-functionalized polylysine: a high number of DOTA chelates positively influences the biodistribution of enzymatic conjugated anti-tumor antibody chCE7agl

artículo científico publicado en 2013

Delivery of BMP-2 by two clinically available apatite materials: in vitro and in vivo comparison

artículo científico publicado en 2014

Design and Preclinical Evaluation of an Albumin-Binding PSMA Ligand for Cu-Based PET Imaging

scientific article published on 30 October 2018

Design of Radiolabeled Analogs of Minigastrin by Multiple Amide-to-Triazole Substitutions

artículo científico publicado en 2020

Design, synthesis, and initial evaluation of a high affinity positron emission tomography probe for imaging matrix metalloproteinases 2 and 9.

artículo científico publicado en 2013

Development and evaluation of novel PET tracers for imaging cannabinoid receptor type 2 in brain

artículo científico publicado en 2014

Development of 3,4-dihydroisoquinolin-1(2H)-one derivatives for the Positron Emission Tomography (PET) imaging of σ₂ receptors

artículo científico publicado en 2013

Development of [(18)F]-PSS223 as a PET tracer for imaging of metabotropic glutamate receptor subtype 5 (mGluR5).

artículo científico publicado en 2012

Development of a new class of PSMA radioligands comprising ibuprofen as an albumin-binding entity

artículo científico publicado en 2020

Diastereomerically Pure 6R- and 6S-3'-Aza-2'-18F-Fluoro-5-Methyltetrahydrofolates Show Unprecedentedly High Uptake in Folate Receptor-Positive KB Tumors

artículo científico publicado en 2018

Direct in vitro and in vivo comparison of (161)Tb and (177)Lu using a tumour-targeting folate conjugate

artículo científico publicado en 2013

Discovery of a fluorinated 4-oxo-quinoline derivative as a potential positron emission tomography radiotracer for imaging cannabinoid receptor type 2.

artículo científico publicado en 2016

Discovery of a high affinity and selective pyridine analog as a potential positron emission tomography imaging agent for cannabinoid type 2 receptor.

artículo científico publicado en 2015

Distance-Dependent Cellular Uptake of Oligoproline-Based Homobivalent Ligands Targeting GPCRs-An Experimental and Computational Analysis

artículo científico publicado en 2020

Dose-dependent effects of (anti)folate preinjection on 99mTc-radiofolate uptake in tumors and kidneys

artículo científico publicado en 2007

Dosimetry and first clinical evaluation of the new 18F-radiolabeled bombesin analogue BAY 864367 in patients with prostate cancer.

artículo científico publicado en 2015

Dual, Site-Specific Modification of Antibodies by Using Solid-Phase Immobilized Microbial Transglutaminase

artículo científico publicado en 2017

Effects of antifolate drugs on the cellular uptake of radiofolates in vitro and in vivo.

artículo científico publicado en 2006

Effects of the antifolates pemetrexed and CB3717 on the tissue distribution of (99m)Tc-EC20 in xenografted and syngeneic tumor-bearing mice

artículo científico publicado en 2010

Efficient tumor targeting with high-affinity designed ankyrin repeat proteins: effects of affinity and molecular size

artículo científico publicado en 2010

Elucidating the Structure-Activity Relationship of the Pentaglutamic Acid Sequence of Minigastrin with Cholecystokinin Receptor Subtype 2

artículo científico publicado en 2019

Enzymatic antibody modification by bacterial transglutaminase

artículo científico publicado en 2013

Erratum: Longitudinal in vivo evaluation of bone regeneration by combined measurement of multi-pinhole SPECT and micro-CT for tissue engineering

artículo científico publicado en 2015

Evaluation of 4-oxo-quinoline-based CB2 PET radioligands in R6/2 chorea huntington mouse model and human ALS spinal cord tissue

artículo científico publicado en 2018

Evaluation of 5H-thiazolo[3,2-a]pyrimidin-5-ones as potential GluN2A PET tracers

artículo científico publicado en 2020

Evaluation of Actinium-225 Labeled Minigastrin Analogue [225Ac]Ac-DOTA-PP-F11N for Targeted Alpha Particle Therapy

scientific article published on 12 November 2020

Evaluation of Tc-rhAnnexin V-128 SPECT/CT as a diagnostic tool for early stages of interstitial lung disease associated with systemic sclerosis

artículo científico publicado en 2018

Evaluation of [11C]Me-NB1 as a potential PET radioligand for measuring GluN2B-containing NMDA receptors, drug occupancy and receptor crosstalk

artículo científico publicado en 2017

Evaluation of a Novel Tc-99m Labelled Vitamin B12 Derivative for Targeting Escherichia coli and Staphylococcus aureus In Vitro and in an Experimental Foreign-Body Infection Model

artículo científico publicado en 2015

Evaluation of a novel radiofolate in tumour-bearing mice: promising prospects for folate-based radionuclide therapy

artículo científico publicado en 2009

Evaluation of anti-VEGFR-3 specific scFv antibodies as potential therapeutic and diagnostic tools for tumor lymph-angiogenesis.

artículo científico publicado en 2007

Evaluation of the first 44Sc-labeled Affibody molecule for imaging of HER2-expressing tumors

artículo científico publicado en 2016

Evaluation of the radiolabeled boronic acid-based FAP inhibitor MIP-1232 for atherosclerotic plaque imaging.

artículo científico publicado en 2015

Evaluation of ¹¹¹in-labelled exendin-4 derivatives containing different meprin β-specific cleavable linkers

artículo científico publicado en 2015

Ex vivo differential phase contrast and magnetic resonance imaging for characterization of human carotid atherosclerotic plaques

artículo científico publicado en 2015

Exendin-4 Derivatives with an Albumin-Binding Moiety Show Decreased Renal Retention and Improved GLP-1 Receptor Targeting

artículo científico publicado en 2019

Expression of functional folate receptors by human parathyroid cells.

artículo científico publicado en 2013

FDG kinetic modeling in small rodent brain PET: optimization of data acquisition and analysis

artículo científico publicado en 2013

Facile and Improved Precursor Synthesis for the Next Generation Cardiac Positron Emission Tomography Imaging Agent [18F]Flurpiridaz

scientific article published on 23 April 2020

First Clinicopathologic Evidence of a Non-PSMA-Related Uptake Mechanism for 68Ga-PSMA-11 in Salivary Glands

artículo científico publicado en 2019

First clinical results of (D)-18F-Fluoromethyltyrosine (BAY 86-9596) PET/CT in patients with non-small cell lung cancer and head and neck squamous cell carcinoma

artículo científico

First-in-Human PET/CT Imaging of Metastatic Neuroendocrine Neoplasms with Cyclotron-Produced 44Sc-DOTATOC: A Proof-of-Concept Study

artículo científico publicado en 2017

Fluorinated quinazolinones as potential radiotracers for imaging kinesin spindle protein expression.

artículo científico publicado en 2012

Fluorine-18 click radiosynthesis and preclinical evaluation of a new 18F-labeled folic acid derivative

artículo científico publicado en 2008

Folate Receptor-Positive Gynecological Cancer Cells: In Vitro and In Vivo Characterization

artículo científico publicado en 2017

Folate receptor targeted alpha-therapy using terbium-149.

artículo científico publicado en 2014

Folate receptor-targeted multimodality imaging of ovarian cancer in a novel syngeneic mouse model

artículo científico publicado en 2015

Folate receptor-targeted radionuclide therapy: preclinical investigation of anti-tumor effects and potential radionephropathy

artículo científico publicado en 2015

Folic acid conjugates for nuclear imaging of folate receptor-positive cancer

artículo científico publicado en 2010

Functionalization of glucose at position C-3 for transition metal coordination: organo-rhenium complexes with carbohydrate skeletons

artículo científico publicado en 2005

Future prospects for SPECT imaging using the radiolanthanide terbium-155 - production and preclinical evaluation in tumor-bearing mice

artículo científico publicado en 2013

GABAA receptor subtypes in the mouse brain: Regional mapping and diazepam receptor occupancy by in vivo [18F]flumazenil PET.

artículo científico publicado en 2017

Gene expression levels of matrix metalloproteinases in human atherosclerotic plaques and evaluation of radiolabeled inhibitors as imaging agents for plaque vulnerability

artículo científico publicado en 2014

Glycation methods for bombesin analogs containing the (NalphaHis)Ac chelator for 99mTc(CO)3 radiolabeling

artículo científico publicado en 2008

HAX1 deficiency: Impact on lymphopoiesis and B-cell development

article

High-Resolution SPECT Imaging of Stimuli-Responsive Soft Microrobots

scientific article published on 15 July 2019

High-sensitivity ICP-MS – an alternative for in vitro and in vivo characterization of future radiometal-based theranostic candidates

scientific article published in 2022

Identification and Preclinical Development of a 2,5,6-Trisubstituted Fluorinated Pyridine Derivative as a Radioligand for the Positron Emission Tomography Imaging of Cannabinoid Type 2 Receptors

artículo científico publicado en 2020

Identification and Preclinical Evaluation of a Radiofluorinated Benzazepine Derivative for Imaging the GluN2B Subunit of the Ionotropic NMDA Receptor

artículo científico publicado en 2018

Identification, characterization and suppression of side-products formed during the synthesis of high dose ⁶⁸Ga-DOTA-TATE

artículo científico publicado en 2012

Imaging atherosclerotic plaque inflammation via folate receptor targeting using a novel 18F-folate radiotracer

artículo científico publicado en 2014

Imaging of activated macrophages in experimental osteoarthritis using folate-targeted animal single-photon-emission computed tomography/computed tomography

artículo científico publicado en 2011

Imaging quality of (44)Sc in comparison with five other PET radionuclides using Derenzo phantoms and preclinical PET.

artículo científico publicado en 2016

Imaging tumour ATB0,+ transport activity by PET with the cationic amino acid O-2((2-[18F]fluoroethyl)methyl-amino)ethyltyrosine.

artículo científico publicado en 2013

ImmunoPET/MR imaging allows specific detection of Aspergillus fumigatus lung infection in vivo

artículo científico publicado en 2016

Implementation of a new separation method to produce qualitatively improved 64 Cu

artículo científico publicado en 2019

Improved PET imaging of tumors in mice using a novel (18) F-folate conjugate with an albumin-binding entity

artículo científico publicado en 2013

Improved Syntheses of the Mglu₅ Antagonists MMPEP and MTEP Using Sonogashira Cross-Coupling

artículo científico publicado en 2018

In Vivo Imaging of Local Inflammation: Monitoring LPS-Induced CD80/CD86 Upregulation by PET

artículo científico publicado en 2020

In Vivo Labeling of Plasma Proteins for Imaging of Enhanced Vascular Permeability in the Lungs

scientific article published on 28 September 2018

In vitro and in vivo evaluation of an innocuous drug cocktail to improve the quality of folic acid targeted nuclear imaging in preclinical research.

artículo científico publicado en 2013

In vitro and in vivo evaluation of bidentate, water-soluble phosphine ligands as anchor groups for the organometallic fac-[99mTc(CO)3]+-core

artículo científico publicado en 1999

In vitro and in vivo targeting of different folate receptor-positive cancer cell lines with a novel 99mTc-radiofolate tracer

artículo científico publicado en 2006

In vivo imaging of inflammation- and tumor-induced lymph node lymphangiogenesis by immuno-positron emission tomography

artículo científico publicado en 2010

In vivo imaging of prostate cancer using [68Ga]-labeled bombesin analog BAY86-7548.

artículo científico publicado en 2013

Influence of the denticity of ligand systems on the in vitro and in vivo behavior of (99m)Tc(I)-tricarbonyl complexes: a hint for the future functionalization of biomolecules

artículo científico publicado en 2000

Influence of the molecular charge on the biodistribution of bombesin analogues labeled with the [99mTc(CO)3]-core

artículo científico publicado en 2008

Inhibition of MNK pathways enhances cancer cell response to chemotherapy with temozolomide and targeted radionuclide therapy

artículo científico publicado en 2016

Injected Human Muscle Precursor Cells Overexpressing PGC-1α Enhance Functional Muscle Regeneration after Trauma.

artículo científico publicado en 2018

Investigation of the chick embryo as a potential alternative to the mouse for evaluation of radiopharmaceuticals

artículo científico publicado en 2014

Isostructural folate conjugates radiolabeled with the matched pair 99mTc/188Re: a potential strategy for diagnosis and therapy of folate receptor-positive tumors

artículo científico publicado en 2007

Ketamine and Ceftriaxone-Induced Alterations in Glutamate Levels Do Not Impact the Specific Binding of Metabotropic Glutamate Receptor Subtype 5 Radioligand [F]PSS232 in the Rat Brain

artículo científico publicado en 2018

L1 Cell Adhesion Molecule Confers Radioresistance to Ovarian Cancer and Defines a New Cancer Stem Cell Population

scientific article published on 15 January 2020

L1-CAM-targeted antibody therapy and 177Lu-radioimmunotherapy of disseminated ovarian cancer

artículo científico publicado en 2011

Liquid Chromatography ICP-MS to Assess the Stability of 175Lu- and natGa-Based Tumor-Targeting Agents towards the Development of 177Lu- and 68Ga-Labeled Radiopharmaceuticals

artículo científico publicado en 2024

Longitudinal in vivo evaluation of bone regeneration by combined measurement of multi-pinhole SPECT and micro-CT for tissue engineering

artículo científico publicado en 2015

MRS glucose mapping and PET joining forces: re-evaluation of the lumped constant in the rat brain under isoflurane anaesthesia

artículo científico publicado en 2014

Management of chronic obstructive pulmonary disease: the Swiss guidelines. Official Guidelines of the Swiss Respiratory Society.

artículo científico publicado en 2002

Metabotropic glutamate receptor subtype 5 is altered in LPS-induced murine neuroinflammation model and in the brains of AD and ALS patients

artículo científico publicado en 2018

Metal chelating systems synthesized using the copper(I) catalyzed azide-alkyne cycloaddition.

artículo científico publicado en 2009

Methoxinine - an alternative stable amino acid substitute for oxidation-sensitive methionine in radiolabelled peptide conjugates

artículo científico publicado en 2017

Microbial transglutaminase and c-myc-tag: a strong couple for the functionalization of antibody-like protein scaffolds from discovery platforms.

artículo científico publicado en 2015

Modification of different IgG1 antibodies via glutamine and lysine using bacterial and human tissue transglutaminase

artículo científico publicado en 2007

Molecular assembly of multifunctional ⁹⁹(m)Tc radiopharmaceuticals using "clickable" amino acid derivatives.

artículo científico publicado en 2010

Multi-parameter optimization: Development of a morpholin-3-one derivative with an improved kinetic profile for imaging monoacylglycerol lipase in the brain

artículo científico publicado en 2022

Multimodal imaging of pancreatic beta cells in vivo by targeting transmembrane protein 27 (TMEM27).

artículo científico publicado en 2012

Neuroimaging with Radiopharmaceuticals Targeting the Glutamatergic System

artículo científico publicado en 2020

New derivatives of vitamin B12 show preferential targeting of tumors

artículo científico publicado en 2008

Noninvasive PET Imaging and Tracking of Engineered Human Muscle Precursor Cells for Skeletal Muscle Tissue Engineering

artículo científico publicado en 2016

Novel chemoselective (18)F-radiolabeling of thiol-containing biomolecules under mild aqueous conditions.

artículo científico publicado en 2016

Novel glycated [99mTc(CO)3]-labeled bombesin analogues for improved targeting of gastrin-releasing peptide receptor-positive tumors

artículo científico publicado en 2008

Novel peptide probes to assess the tensional state of fibronectin fibers in cancer

artículo científico publicado en 2017

On the consensus nomenclature rules for radiopharmaceutical chemistry - Reconsideration of radiochemical conversion

artículo científico publicado en 2020

Organometallic 99mTc-aquaion labels peptide to an unprecedented high specific activity

artículo científico publicado en 1999

Organometallic [Re(CO)3]+ and [Re(CO)2(NO)]2+ labeled substrates for human thymidine kinase 1.

artículo científico publicado en 2009

PEGylation of (99m)Tc-labeled bombesin analogues improves their pharmacokinetic properties

artículo científico publicado en 2011

PEGylation, increasing specific activity and multiple dosing as strategies to improve the risk-benefit profile of targeted radionuclide therapy with 177Lu-DOTA-bombesin analogues.

artículo científico publicado en 2012

Paclitaxel improved anti-L1CAM lutetium-177 radioimmunotherapy in an ovarian cancer xenograft model

artículo científico publicado en 2014

Pemetrexed improves tumor selectivity of 111In-DTPA-folate in mice with folate receptor-positive ovarian cancer

artículo científico publicado en 2008

Pharmacological inhibition of mTORC1 increases CCKBR-specific tumor uptake of radiolabeled minigastrin analogue [177Lu]Lu-PP-F11N

artículo científico publicado en 2020

Physiologically Based Pharmacokinetic Modelling with Dynamic PET Data to Study the In Vivo Effects of Transporter Inhibition on Hepatobiliary Clearance in Mice.

artículo científico publicado en 2018

Preclinical Comparison of Albumin-Binding Radiofolates: Impact of Linker Entities on the in Vitro and in Vivo Properties

artículo científico publicado en 2017

Preclinical Development of 18F-OF-NB1 for Imaging GluN2B-Containing N-Methyl-D-Aspartate Receptors and its Utility as a Biomarker for Amyotrophic Lateral Sclerosis

artículo científico publicado en 2020

Preclinical Development of Novel PSMA-Targeting Radioligands: Modulation of Albumin-Binding Properties To Improve Prostate Cancer Therapy.

artículo científico publicado en 2018

Preclinical Evaluation of Benzazepine-Based PET Radioligands (R)- and (S)-11C-Me-NB1 Reveals Distinct Enantiomeric Binding Patterns and a Tightrope Walk Between GluN2B- and σ1-Receptor-Targeted PET Imaging

artículo científico publicado en 2019

Preclinical evaluation and test-retest studies of [(18)F]PSS232, a novel radioligand for targeting metabotropic glutamate receptor 5 (mGlu5).

artículo científico publicado en 2014

Preclinical evaluation of 5-methyltetrahydrofolate-based radioconjugates-new perspectives for folate receptor-targeted radionuclide therapy

artículo científico publicado en 2020

Preclinical evaluation of novel organometallic 99mTc-folate and 99mTc-pteroate radiotracers for folate receptor-positive tumour targeting

artículo científico publicado en 2006

Preclinical imaging of the co-stimulatory molecules CD80 and CD86 with indium-111-labeled belatacept in atherosclerosis.

artículo científico publicado en 2016

Preclinical investigations and first-in-human application of 152Tb-PSMA-617 for PET/CT imaging of prostate cancer

artículo científico publicado en 2019

Production and characterization of no-carrier-added 161Tb as an alternative to the clinically-applied 177Lu for radionuclide therapy

artículo científico publicado en 2019

Production and separation of Sc for radiopharmaceutical purposes

article published in 2017

Promises of cyclotron-produced 44Sc as a diagnostic match for trivalent β--emitters: in vitro and in vivo study of a 44Sc-DOTA-folate conjugate

artículo científico publicado en 2013

Promising potential of [177Lu]Lu-DOTA-folate to enhance tumor response to immunotherapy-a preclinical study using a syngeneic breast cancer model

artículo científico publicado en 2020

Promising prospects for 44Sc-/47Sc-based theragnostics: application of 47Sc for radionuclide tumor therapy in mice.

artículo científico publicado en 2014

Prospects in folate receptor-targeted radionuclide therapy

scientific article published on 24 September 2013

Quantification of brain glucose metabolism by 18F-FDG PET with real-time arterial and image-derived input function in mice

artículo científico publicado en 2012

Quantitative positron emission tomography of mGluR5 in rat brain with [(18) F]PSS232 at minimal invasiveness and reduced model complexity

artículo científico publicado en 2015

Radiation dosimetry of 18F-AzaFol: A first in-human use of a folate receptor PET tracer

scientific article published on 08 April 2020

Radiation dosimetry of [18F]-PSS232-a PET radioligand for imaging mGlu5 receptors in humans

scientific article published on 25 June 2019

Radioimmunotherapy of fibroblast activation protein positive tumors by rapidly internalizing antibodies.

artículo científico publicado en 2012

Radioiodinated folic acid conjugates: evaluation of a valuable concept to improve tumor-to-background contrast

artículo científico publicado en 2012

Radiolabeled 111In-FGF-2 Is Suitable for In Vitro/Ex Vivo Evaluations and In Vivo Imaging.

artículo científico publicado en 2017

Radiolabeling and in vitro /in vivo evaluation of N-(1-adamantyl)-8-methoxy-4-oxo-1-phenyl-1,4-dihydroquinoline-3-carboxamide as a PET probe for imaging cannabinoid type 2 receptor.

artículo científico publicado en 2013

Radiolabeling of rituximab with (188)Re and (99m)Tc using the tricarbonyl technology

artículo científico publicado en 2010

Radiometal labeling of antibodies and antibody fragments for imaging and therapy.

artículo científico publicado en 2004

Radiosynthesis and evaluation of an 18F-labeled silicon containing exendin-4 peptide as a PET probe for imaging insulinoma

artículo científico publicado en 2018

Radiosynthesis and preclinical evaluation of 3'-Aza-2'-[(18)F]fluorofolic acid: a novel PET radiotracer for folate receptor targeting

artículo científico publicado en 2013

Recent progress in allosteric modulators for GluN2A subunit and development of GluN2A-selective nuclear imaging probes

scientific article published on 01 June 2019

Recording intracellular molecular events from the outside: glycosylphosphatidylinositol-anchored avidin as a reporter protein for in vivo imaging

artículo científico publicado en 2011

Reduced 18F-Folate Conjugates as a New Class of PET Tracers for Folate Receptor Imaging.

artículo científico publicado en 2018

Regional cerebral blood flow estimated by early PiB uptake is reduced in mild cognitive impairment and associated with age in an amyloid-dependent manner

artículo científico publicado en 2015

SPECT study of folate receptor-positive malignant and normal tissues in mice using a novel 99mTc-radiofolate

artículo científico publicado en 2008

SUN-334 Evaluation of the CCK-2 Receptor Agonist 177Lu-PP-F11N for PRRT of Medullary Thyroid Carcinoma: Results of a Phase 0 "Lumed" Study.

artículo científico publicado en 2019

Sc as useful β-emitter for the radiotheragnostic paradigm: a comparative study of feasible production routes

article published in 2017

Sc for labeling of DOTA- and NODAGA-functionalized peptides: preclinical in vitro and in vivo investigations

Simultaneous Visualization of 161Tb- and 177Lu-Labeled Somatostatin Analogues Using Dual-Isotope SPECT Imaging

artículo científico publicado en 2021

Single Photon Emission Computed Tomography Tracer

artículo científico publicado en 2020

Single photon emission computed tomography tracer.

artículo científico

Single-step radiofluorination of peptides using continuous flow microreactor

artículo científico publicado en 2012

Site-Specific Conjugation of Monomethyl Auristatin E to Anti-CD30 Antibodies Improves Their Pharmacokinetics and Therapeutic Index in Rodent Models

artículo científico publicado en 2015

Site-specific and stoichiometric modification of antibodies by bacterial transglutaminase

artículo científico publicado en 2010

Stable one-step technetium-99m labeling of His-tagged recombinant proteins with a novel Tc(I)-carbonyl complex

artículo científico publicado en 1999

Steps toward high specific activity labeling of biomolecules for therapeutic application: preparation of precursor [(188)Re(H(2)O)(3)(CO)(3)](+) and synthesis of tailor-made bifunctional ligand systems

artículo científico publicado en 2002

Strategies for the Development of Novel Tumor Targeting Technetium and Rhenium Radiopharmaceuticals

article

Structural Basis for Universal Corrinoid Recognition by the Cobalamin Transport Protein Haptocorrin

artículo científico publicado en 2013

Structural and (99)Tc NMR Investigations of Complexes with fac-[Tc(CO)(3)](+) Moieties and Macrocyclic Thioethers of Various Ring Sizes: Synthesis and X-ray Structure of the Complexes fac-[Tc(9-ane-S(3))(CO)(3)]Br, fac-[Tc(2)(tosylate)(2)(18-ane-S(6

artículo científico publicado en 1998

Structure-Activity Relationship Studies of Pyridine-Based Ligands and Identification of a Fluorinated Derivative for Positron Emission Tomography Imaging of Cannabinoid Type 2 Receptors

scientific article published on 05 December 2019

Structure-Affinity Relationships of 2,3,4,5-Tetrahydro-1H-3-benzazepine and 6,7,8,9-Tetrahydro-5H-benzo[7]annulen-7-amine Analogues and the Discovery of a Radiofluorinated 2,3,4,5-Tetrahydro-1H-3-benzazepine Congener for Imaging GluN2B Subunit-Conta

scientific article published on 28 October 2019

Studies toward the development of new silicon-containing building blocks for the direct (18)F-labeling of peptides

artículo científico publicado en 2013

Syntheses and characterization of dicarbonyl-nitrosyl complexes of technetium(I) and rhenium(I) in aqueous media: spectroscopic, structural, and DFT analyses.

artículo científico publicado en 2005

Synthesis and Biological Evaluation of Thiophene-Based Cannabinoid Receptor Type 2 Radiotracers for PET Imaging

artículo científico publicado en 2016

Synthesis and In Vitro Evaluation of E- and Z-Geometrical Isomers of PSS232 as Potential Metabotropic Glutamate Receptors Subtype 5 (mGlu5) Binders

Synthesis and Pharmacological Evaluation of [11C]Granisetron and [18F]Fluoropalonosetron as PET Probes for 5-HT3 Receptor Imaging

artículo científico publicado en 2016

Synthesis and Preliminary Evaluation of a 2-Oxoquinoline Carboxylic Acid Derivative for PET Imaging the Cannabinoid Type 2 Receptor

artículo científico publicado en 2014

Synthesis and Structure-Affinity Relationship of Small Molecules for Imaging Human CD80 by Positron Emission Tomography

scientific article published on 29 August 2019

Synthesis and biological evaluation of (18)F-labeled Fluoroethoxy tryptophan analogues as potential PET tumor imaging agents.

artículo científico publicado en 2014

Synthesis and biological evaluation of ¹⁸F-labeled fluoropropyl tryptophan analogs as potential PET probes for tumor imaging.

artículo científico publicado en 2013

Synthesis and evaluation of biphenyl compounds as kinesin spindle protein inhibitors

artículo científico publicado en 2013

Synthesis and evaluation of bombesin analogues conjugated to two different triazolyl-derived chelators for (99m)Tc labeling

artículo científico publicado en 2010

Synthesis and evaluation of novel α-fluorinated (E)-3-((6-methylpyridin-2-yl)ethynyl)cyclohex-2-enone-O-methyl oxime (ABP688) derivatives as metabotropic glutamate receptor subtype 5 PET radiotracers

artículo científico publicado en 2012

Synthesis and in vitro characterization of organometallic rhenium and technetium glucose complexes against Glut 1 and hexokinase.

artículo científico publicado en 2005

Synthesis and in vitro/in vivo evaluation of novel 99mTc(CO)3-folates

artículo científico publicado en 2006

Synthesis and in vitro/in vivo pharmacological evaluation of [11C]-ThioABP, a novel radiotracer for imaging mGluR5 with PET

scholarly article by Selena Milicevic Sephton et al published 2013 in MedChemComm

Synthesis and pharmacological evaluation of ¹¹C-labeled piperazine derivative as a PET probe for sigma-2 receptor imaging.

artículo científico publicado en 2015

Synthesis and preclinical evaluation of a folic acid derivative labeled with 18F for PET imaging of folate receptor-positive tumors.

artículo científico publicado en 2006

Synthesis and preliminary biological evaluation of O-2((2-[(18)F]fluoroethyl)methylamino)ethyltyrosine ([(18)F]FEMAET) as a potential cationic amino acid PET tracer for tumor imaging.

artículo científico publicado en 2014

Synthesis and properties of boranocarbonate: a convenient in situ CO source for the aqueous preparation of [(99m)Tc(OH(2))3(CO)3]+.

artículo científico publicado en 2001

Synthesis of a Novel γ-Folic Acid-N τ-Histidine Conjugate Suitable for Labeling with 99mTc and 188Re

Synthesis, Radiolabeling, and Biological Evaluation of 5-Hydroxy-2-[(18)F]fluoroalkyl-tryptophan Analogues as Potential PET Radiotracers for Tumor Imaging.

artículo científico publicado en 2016

Synthesis, Radiolabeling, and Characterization of Plasma Protein-Binding Ligands: Potential Tools for Modulation of the Pharmacokinetic Properties of (Radio)Pharmaceuticals.

artículo científico publicado en 2017

Synthesis, in vitro, and in silico evaluation of organometallic technetium and rhenium thymidine complexes with retained substrate activity toward human thymidine kinase type 1.

artículo científico publicado en 2008

Synthesis, radiolabeling and evaluation of novel 4-oxo-quinoline derivatives as PET tracers for imaging cannabinoid type 2 receptor

artículo científico publicado en 2015

Synthesis, radiolabelling and in vitro and in vivo evaluation of a novel fluorinated ABP688 derivative for the PET imaging of metabotropic glutamate receptor subtype 5.

artículo científico publicado en 2011

Targeted 64 Cu-labeled gold nanoparticles for dual imaging with positron emission tomography and optical imaging

scientific article published on 28 May 2019

Targeted Radiotherapeutics from 'Bench-to-Bedside'

artículo científico publicado en 2020

Targeting Cancer Stem Cells with Radioimmunotherapy: The Case of the Ovarian Cancer Stemness-Associated Biomarker L1CAM

artículo científico publicado en 2024

Targets and probes for non-invasive imaging of β-cells

artículo científico publicado en 2017

Terbium-161 for PSMA-targeted radionuclide therapy of prostate cancer

artículo científico publicado en 2019

The biodistribution of self-assembling protein nanoparticles shows they are promising vaccine platforms

artículo científico publicado en 2013

The influence of physical work upon decompression time after simulated oxy-helium dives

artículo científico publicado en 1972

The low-energy β− and electron emitter 161Tb as an alternative to 177Lu for targeted radionuclide therapy

artículo científico publicado en 2011

The soluble form of the cancer-associated L1 cell adhesion molecule is a pro-angiogenic factor.

artículo científico publicado en 2009

Therapeutic Potential of 47Sc in Comparison to 177Lu and 90Y: Preclinical Investigations

scientific article published on 20 August 2019

Therapeutic Radiometals Beyond 177Lu and 90Y: Production and Application of Promising α-Particle, β--Particle, and Auger Electron Emitters.

artículo científico publicado en 2017

Towards Translational ImmunoPET/MR Imaging of Invasive Pulmonary Aspergillosis: The Humanised Monoclonal Antibody JF5 Detects Aspergillus Lung Infections In Vivo.

artículo científico publicado en 2017

Towards non-invasive imaging of vulnerable atherosclerotic plaques by targeting co-stimulatory molecules.

artículo científico publicado en 2014

Transglutaminase-based chemo-enzymatic conjugation approach yields homogeneous antibody-drug conjugates.

artículo científico publicado en 2014

Transplantation and tracking of human-induced pluripotent stem cells in a pig model of myocardial infarction: assessment of cell survival, engraftment, and distribution by hybrid single photon emission computed tomography/computed tomography of sodi

artículo científico publicado en 2012

Triazolo-Peptidomimetics: Novel Radiolabeled Minigastrin Analogs for Improved Tumor Targeting

artículo científico publicado en 2020

Tumor imaging in patients with advanced tumors using a new (99m) Tc-radiolabeled vitamin B12 derivative

artículo científico publicado en 2013

Tumor targeting using 67Ga-DOTA-Bz-folate--investigations of methods to improve the tissue distribution of radiofolates

scientific article published on 03 March 2011

Unexpected reactivity of cyclic perfluorinated iodanes with electrophiles

scientific article published on 01 August 2018

Versatile routes to C-2- and C-6-functionalized glucose derivatives of iminodiacetic acid

artículo científico publicado en 2003

Versatile synthetic approach to new bifunctional chelating agents tailor made for labeling with the fac-[M(CO)(3)](+) core (M = Tc, (99m)Tc, Re): synthesis, in vitro, and in vivo behavior of the model complex [M(APPA)(CO)(3)] (APPA = [(5-amino-penty

artículo científico publicado en 2003

Visualisation of interstitial lung disease by molecular imaging of integrin αvβ3 and somatostatin receptor 2

scientific article published on 17 November 2018

Water-exchange study revealed unexpected substitution behavior of [(CO)2(NO)Re(H2O)3]2+ in aqueous media.

artículo científico publicado en 2006

[(3)H]metyrapol and 4-[(131)i]iodometomidate label overlapping, but not identical, binding sites on rat adrenal membranes

artículo científico publicado en 2013

[11C]mHED PET follows a two-tissue compartment model in mouse myocardium with norepinephrine transporter (NET)-dependent uptake, while [18F]LMI1195 uptake is NET-independent

artículo científico publicado en 2020

[18F]Fluoro-Deoxy-Glucose Folate: A Novel PET Radiotracer with Improved in Vivo Properties for Folate Receptor Targeting

artículo científico publicado en 2012

“Click to Chelate”: Synthesis and Installation of Metal Chelates into Biomolecules in a Single Step

artículo científico publicado en 2006

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