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Lista de obras de Xuejun Wang

A microRNA-mediated decrease in eukaryotic initiation factor 2α promotes cell survival during PS-341 treatment ⬇️

artículo científico publicado en 2016

A novel deubiquitinase inhibitor b-AP15 triggers apoptosis in both androgen receptor-dependent and -independent prostate cancers.

artículo científico publicado en 2017

A novel nickel complex works as a proteasomal deubiquitinase inhibitor for cancer therapy

artículo científico publicado en 2016

A novel proteasome inhibitor suppresses tumor growth via targeting both 19S proteasome deubiquitinases and 20S proteolytic peptidases

artículo científico publicado en 2014

A novel transgenic mouse model reveals deregulation of the ubiquitin-proteasome system in the heart by doxorubicin

artículo científico publicado en 2005

A therapeutic dose of doxorubicin activates ubiquitin-proteasome system-mediated proteolysis by acting on both the ubiquitination apparatus and proteasome.

artículo científico publicado en 2008

Aberrant protein aggregation is essential for a mutant desmin to impair the proteolytic function of the ubiquitin-proteasome system in cardiomyocytes

artículo científico publicado en 2006

Activation of the ubiquitin-proteasome system in doxorubicin cardiomyopathy.

artículo científico publicado en 2009

Alpha B-crystallin suppresses pressure overload cardiac hypertrophy

scientific journal article

AlphaB-crystallin modulates protein aggregation of abnormal desmin

artículo científico publicado en 2003

Altered ubiquitin-proteasome signaling in right ventricular hypertrophy and failure

artículo científico publicado en 2013

Anti-rheumatic agent auranofin induced apoptosis in chronic myeloid leukemia cells resistant to imatinib through both Bcr/Abl-dependent and -independent mechanisms

artículo científico publicado en 2014

Auranofin lethality to prostate cancer includes inhibition of proteasomal deubiquitinases and disrupted androgen receptor signaling

scientific article published on 09 January 2019

Autophagic-lysosomal inhibition compromises ubiquitin-proteasome system performance in a p62 dependent manner in cardiomyocytes

artículos científicos

Autophagy Controls Nrf2-Mediated Dichotomy in Pressure Overloaded Hearts

Autophagy Inhibition Enables Nrf2 to Exaggerate the Progression of Diabetic Cardiomyopathy in Mice

scientific article published on 18 September 2020

Autophagy and p62 in cardiac protein quality control

artículo científico publicado en 2011

Autophagy and p62 in cardiac proteinopathy.

artículo científico publicado en 2011

Autophagy and the ubiquitin-proteasome system in cardiac dysfunction.

artículo científico publicado en 2010

Autophagy modulation: a potential therapeutic approach in cardiac hypertrophy.

artículo científico publicado en 2017

Bilirubin neurotoxicity is associated with proteasome inhibition

artículo científico publicado en 2017

Bortezomib, a proteasome inhibitor, attenuates angiotensin II-induced hypertension and aortic remodeling in rats

artículo científico publicado en 2013

COP9 Signalosome Promotes Neointimal Hyperplasia via Deneddylation and CSN5-Mediated Nuclear Export

COP9 Signalosome Suppresses RIPK1-RIPK3 mediated Cardiomyocyte Necroptosis in Mice

artículo científico publicado en 2020

COP9 signalosome controls the degradation of cytosolic misfolded proteins and protects against cardiac proteotoxicity

artículo científico publicado en 2015

COP9 signalosome regulates autophagosome maturation

artículo científico publicado en 2011

COP9 signalosome subunit 8 is required for postnatal hepatocyte survival and effective proliferation.

artículo científico publicado en 2010

COP9 signalosome subunit Csn8 is involved in maintaining proper duration of the G1 phase

artículo científico publicado en 2013

CYLD exaggerates pressure overload-induced cardiomyopathy via suppressing autolysosome efflux in cardiomyocytes

scientific article published on 14 June 2020

Cadmium pyrithione suppresses tumor growth in vitro and in vivo through inhibition of proteasomal deubiquitinase.

artículo científico publicado en 2017

Cardiac proteasome functional insufficiency plays a pathogenic role in diabetic cardiomyopathy

artículo científico publicado en 2016

Cardiac-specific haploinsufficiency of beta-catenin attenuates cardiac hypertrophy but enhances fetal gene expression in response to aortic constriction.

artículo científico publicado en 2007

Catecholamine Surges Cause Cardiomyocyte Necroptosis a RIPK1-RIPK3-Dependent Pathway in Mice

Chronic pressure overload cardiac hypertrophy and failure in guinea pigs: I. Regional hemodynamics and myocyte remodeling

artículo científico publicado en 1999

Chronic pressure overload cardiac hypertrophy and failure in guinea pigs: II. Cytoskeletal remodeling

artículo científico publicado en 1999

Chronic pressure overload cardiac hypertrophy and failure in guinea pigs: III. Intercalated disc remodeling

artículo científico publicado en 1999

Clinically used antirheumatic agent auranofin is a proteasomal deubiquitinase inhibitor and inhibits tumor growth

artículo científico publicado en 2014

Cullin Deneddylation Suppresses the Necroptotic Pathway in Cardiomyocytes

Cytoplasmic RAP1 mediates cisplatin resistance of non-small cell lung cancer

artículo científico publicado en 2017

Desmin Filaments and Desmin-Related Myopathy

Desmin filaments and cardiac disease: establishing causality.

artículo científico publicado en 2002

Differential activities of the ubiquitin-proteasome system in neurons versus glia may account for the preferential accumulation of misfolded proteins in neurons

artículo científico publicado en 2008

Doxycycline attenuates protein aggregation in cardiomyocytes and improves survival of a mouse model of cardiac proteinopathy

artículo científico publicado en 2010

Editorial: Targeting Cardiac Proteotoxicity

Enhancement of proteasomal function protects against cardiac proteinopathy and ischemia/reperfusion injury in mice ⬇️

artículo científico publicado el 15 de agosto de 2011

Enhancement of proteasome function by PA28α overexpression protects against oxidative stress.

artículo científico publicado en 2010

Entangled in a heart-ailing quandary: could modified cofilin-2 be a culprit of Alzheimer's disease of the heart?

artículo científico publicado en 2015

Expression of R120G-alphaB-crystallin causes aberrant desmin and alphaB-crystallin aggregation and cardiomyopathy in mice

artículo científico publicado en 2001

Formation of binucleated cardiac myocytes in rat heart: I. Role of actin-myosin contractile ring

artículo científico publicado en 1997

Formation of binucleated cardiac myocytes in rat heart: II. Cytoskeletal organisation

artículo científico publicado en 1997

FoxO3 hastens autophagy and shrinks the heart but does not curtail pathological hypertrophy in adult mice

artículo científico publicado en 2011

GFP reporter mouse models of UPS proteolytic function

artículo científico publicado en 2006

Gambogic Acid Is a Tissue-Specific Proteasome Inhibitor In Vitro and In Vivo ⬇️

artículo científico publicado el 21 de diciembre de 2012

Gambogic acid induces apoptosis in diffuse large B-cell lymphoma cells via inducing proteasome inhibition

artículo científico publicado en 2015

Gambogic acid induces apoptosis in imatinib-resistant chronic myeloid leukemia cells via inducing proteasome inhibition and caspase-dependent Bcr-Abl downregulation

artículo científico publicado en 2013

Gambogic acid moderates cardiac responses to chronic hypoxia likely by acting on the proteasome and NF-κB pathway ⬇️

artículo científico publicado el 16 de agosto de 2013

Gambogic acid suppresses pressure overload cardiac hypertrophy in rats

artículo científico publicado en 2013

Genetically Induced Moderate Inhibition of the Proteasome in Cardiomyocytes Exacerbates Myocardial Ischemia-Reperfusion Injury in Mice ⬇️

artículo científico publicado el 26 de junio de 2012

Genetically induced moderate inhibition of 20S proteasomes in cardiomyocytes facilitates heart failure in mice during systolic overload

artículo científico publicado en 2015

Guidelines for the use and interpretation of assays for monitoring autophagy

artículo científico publicado en 2012

Heart failure and protein quality control

artículo científico publicado en 2006

Hepatic deficiency of COP9 signalosome subunit 8 induces ubiquitin-proteasome system impairment and Bim-mediated apoptosis in murine livers.

artículo científico publicado en 2013

Highly Dynamic Changes in the Activity and Regulation of Macroautophagy in Hearts Subjected to Increased Proteotoxic Stress

scientific article published on 26 June 2019

Hinokitiol copper complex inhibits proteasomal deubiquitination and induces paraptosis-like cell death in human cancer cells.

artículo científico publicado en 2017

In situ dynamically monitoring the proteolytic function of the ubiquitin-proteasome system in cultured cardiac myocytes

artículo científico publicado en 2004

Inadequate ubiquitination-proteasome coupling contributes to myocardial ischemia-reperfusion injury

scientific article published on 22 October 2018

Increased myocardial Rab GTPase expression: a consequence and cause of cardiomyopathy

artículo científico publicado en 2001

Inhibition of EGFR signaling with Spautin-1 represents a novel therapeutics for prostate cancer

scientific article published on 11 April 2019

Inhibition of Proteasomal Deubiquitinase by Silver Complex Induces Apoptosis in Non-Small Cell Lung Cancer Cells

artículo científico publicado en 2018

Inhibition of USP14 enhances the sensitivity of breast cancer to enzalutamide

scientific article published on 24 May 2019

Interplay between the ubiquitin-proteasome system and autophagy in proteinopathies.

artículo científico publicado en 2009

Intrasarcoplasmic amyloidosis impairs proteolytic function of proteasomes in cardiomyocytes by compromising substrate uptake

artículo científico publicado en 2005

L-carnitine is an endogenous HDAC inhibitor selectively inhibiting cancer cell growth in vivo and in vitro

artículo científico publicado en 2012

Low thyroid function leads to cardiac atrophy with chamber dilatation, impaired myocardial blood flow, loss of arterioles, and severe systolic dysfunction

artículo científico publicado en 2005

Mifepristone increases mRNA translation rate, triggers the unfolded protein response, increases autophagic flux, and kills ovarian cancer cells in combination with proteasome or lysosome inhibitors.

artículo científico publicado en 2016

Murine Myocardial Transcriptome Analysis Reveals a Critical Role of COPS8 in the Gene Expression of Cullin-RING Ligase Substrate Receptors and Redox and Vesicle Trafficking Pathways

artículo científico

Muscarinic 2 receptors modulate cardiac proteasome function in a protein kinase G-dependent manner

artículo científico publicado en 2014

Myocardial Upregulation of Cathepsin D by Ischemic Heart Disease Promotes Autophagic Flux and Protects Against Cardiac Remodeling and Heart Failure

artículo científico publicado en 2017

NEDD8 Ultimate Buster 1 Long (NUB1L) Protein Suppresses Atypical Neddylation and Promotes the Proteasomal Degradation of Misfolded Proteins

artículo científico publicado en 2015

Nickel pyrithione induces apoptosis in chronic myeloid leukemia cells resistant to imatinib via both Bcr/Abl-dependent and Bcr/Abl-independent mechanisms.

artículo científico publicado en 2016

Novel use of old drug: Anti-rheumatic agent auranofin overcomes imatinib-resistance of chronic myeloid leukemia cells

artículo científico publicado en 2014

Nrf2-Mediated Cardiac Maladaptive Remodeling and Dysfunction in a Setting of Autophagy Insufficiency

artículo científico publicado en 2015

Nuclear compartmentalization of FAK and FRNK in cardiac myocytes

scientific journal article

Nuclear factor erythroid-2 related factor 2 (Nrf2)-mediated protein quality control in cardiomyocytes.

artículo científico

PDE1 inhibition facilitates proteasomal degradation of misfolded proteins and protects against cardiac proteinopathy

artículo científico publicado en 2019

PKA-dependent phosphorylation of cardiac myosin binding protein C in transgenic mice

artículo científico publicado en 2001

Pathological Significance and Prognostic Roles of Indirect Bilirubin/Albumin Ratio in Hepatic Encephalopathy

Peripherally misfolded proteins exacerbate ischemic stroke-induced neuroinflammation and brain injury

artículo científico publicado en 2021

Perturbation of cullin deneddylation via conditional Csn8 ablation impairs the ubiquitin-proteasome system and causes cardiomyocyte necrosis and dilated cardiomyopathy in mice.

artículo científico publicado en 2010

Physiological levels of ATP negatively regulate proteasome function.

artículo científico publicado en 2010

Platinum pyrithione induces apoptosis in chronic myeloid leukemia cells resistant to imatinib via DUB inhibition-dependent caspase activation and Bcr-Abl downregulation.

artículo científico publicado en 2017

Platinum-containing compound platinum pyrithione is stronger and safer than cisplatin in cancer therapy.

artículo científico publicado en 2016

Posttranslational Modification and Quality Control ⬇️

artículo científico publicado el 18 de enero de 2013

Priming the Proteasome to Protect against Proteotoxicity

artículo científico publicado en 2020

Priming the proteasome by protein kinase G: a novel cardioprotective mechanism of sildenafil

artículo científico publicado en 2015

Proteasomal and lysosomal protein degradation and heart disease

artículo científico publicado en 2013

Proteasome functional insufficiency activates the calcineurin-NFAT pathway in cardiomyocytes and promotes maladaptive remodelling of stressed mouse hearts

artículo científico publicado en 2010

Proteasome malfunction activates the PPP3/calcineurin-TFEB-SQSTM1/p62 pathway to induce macroautophagy in the heart

scientific article published on 22 September 2020

Proteasome-associated deubiquitinase ubiquitin-specific protease 14 regulates prostate cancer proliferation by deubiquitinating and stabilizing androgen receptor

artículo científico publicado en 2017

Protein kinase g positively regulates proteasome-mediated degradation of misfolded proteins.

artículo científico publicado en 2013

Protein quality control and degradation in cardiomyocytes

artículo científico publicado en 2008

Protein quality control in protection against systolic overload cardiomyopathy: the long term role of small heat shock proteins

artículo científico publicado en 2010

Rapid transition of cardiac myocytes from hyperplasia to hypertrophy during postnatal development

artículo científico publicado en 1996

Remodeling of gap junctions and slow conduction in a mouse model of desmin-related cardiomyopathy

artículo científico publicado en 2005

Repeated intermittent administration of a ubiquitous proteasome inhibitor leads to restrictive cardiomyopathy ⬇️

artículo científico publicado el 2 de mayo de 2013

Repurposing an antidandruff agent to treating cancer: zinc pyrithione inhibits tumor growth via targeting proteasome-associated deubiquitinases.

artículo científico publicado en 2017

Sanggenon C decreases tumor cell viability associated with proteasome inhibition

artículo científico publicado en 2011

Ser14-RPN6 Phosphorylation Mediates the Activation of 26S Proteasomes by cAMP and Protects against Cardiac Proteotoxic Stress in Mice

Shikonin exerts antitumor activity via proteasome inhibition and cell death induction in vitro and in vivo.

artículo científico publicado en 2009

Shikonin extracted from medicinal Chinese herbs exerts anti-inflammatory effect via proteasome inhibition ⬇️

artículo científico publicado el 24 de marzo de 2011

Structural basis of ventricular remodeling: role of the myocyte.

artículo científico publicado en 2004

Subcellular redistribution of focal adhesion kinase and its related nonkinase in hypertrophic myocardium

artículo científico publicado en 2003

Sulforaphane enhances proteasomal and autophagic activities in mice and is a potential therapeutic reagent for Huntington's disease.

artículo científico publicado en 2014

Sumo E2 enzyme UBC9 is required for efficient protein quality control in cardiomyocytes

artículo científico publicado en 2014

Synergistic effects of gefitinib and thalidomide treatment on EGFR-TKI-sensitive and -resistant NSCLC

artículo científico publicado en 2019

Systemic inhibition of neddylation by 3-day MLN4924 treatment regime does not impair autophagic flux in mouse hearts and brains

artículo científico publicado en 2017

TFEB activation protects against cardiac proteotoxicity via increasing autophagic flux

artículo científico publicado en 2017

Targeting proteasome-associated deubiquitinases as a novel strategy for the treatment of estrogen receptor-positive breast cancer

scholarly article by Xiaohong Xia published in September 2018

The COP9 signalosome and cullin-RING ligases in the heart

artículo científico publicado en 2015

The COP9 signalosome and vascular function: intriguing possibilities?

artículo científico publicado en 2015

The COP9 signalosome coerces autophagy and the ubiquitin-proteasome system to police the heart

artículo científico publicado en 2016

The COP9 signalosome is required for autophagy, proteasome-mediated proteolysis, and cardiomyocyte survival in adult mice.

artículo científico publicado en 2013

The COP9 signalosome negatively regulates proteasome proteolytic function and is essential to transcription.

artículo científico publicado en 2008

The Calcineurin-TFEB-p62 Pathway Mediates the Activation of Cardiac Macroautophagy by Proteasomal Malfunction

artículo científico publicado en 2020

The Interplay Between Autophagy and Regulated Necrosis

The Ubiquitin–Proteasome System and Cardiovascular Disease ⬇️

artículo científico publicado el 1 de enero de 2012

The interplay between autophagy and the ubiquitin-proteasome system in cardiac proteotoxicity

artículo científico publicado en 2014

The role of the proteasome in heart disease

artículo científico publicado en 2010

The role of the ubiquitin-proteasome pathway in cardiovascular disease

artículo científico publicado en 2009

The ubiquitin-proteasome system in cardiac proteinopathy: a quality control perspective

artículo científico publicado en 2009

Transcription Factor 7-like 2 Mediates Canonical Wnt/β-Catenin Signaling and c-Myc Upregulation in Heart Failure.

artículo científico publicado en 2016

Two clinical drugs deubiquitinase inhibitor auranofin and aldehyde dehydrogenase inhibitor disulfiram trigger synergistic anti-tumor effects in vitro and in vivo

artículo científico publicado en 2015

UBXN2A enhances CHIP-mediated proteasomal degradation of oncoprotein mortalin-2 in cancer cells

scholarly article by Sanam Sane et al published October 2018 in Molecular Oncology

UCHL1 protects against ischemic heart injury via activating HIF-1α signal pathway

UCHL1 regulates muscle fibers and mTORC1 activity in skeletal muscle

artículo científico publicado en 2019

Ubiquilin-1 protects cells from oxidative stress and ischemic stroke caused tissue injury in mice.

artículo científico publicado en 2014

Ubiquitin Carboxyl-Terminal Hydrolase L1 of Cardiomyocytes Promotes Macroautophagy and Proteostasis and Protects Against Post-myocardial Infarction Cardiac Remodeling and Heart Failure

artículo científico publicado en 2022

Ubiquitin receptors and protein quality control

artículo científico publicado en 2012

Unraveling enigma in the z-disks

scientific article published on 01 August 2010

Upregulation of gamma-catenin compensates for the loss of beta-catenin in adult cardiomyocytes

artículo científico publicado en 2006

Vascular Spasm: A Newly Unraveled Cause for Cardiovascular Adversity of Proteasome Inhibition

artículo científico publicado en 2017

p62 Stages an interplay between the ubiquitin-proteasome system and autophagy in the heart of defense against proteotoxic stress

artículo científico publicado en 2011

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