Lista de obras - Muralidhar L. Hegde - Dominio Público Uruguay

8-Oxoguanine DNA glycosylase-1 links DNA repair to cellular signaling via the activation of the small GTPase Rac1.

artículo científico publicado en 2013

8-Oxoguanine DNA glycosylase-1-mediated DNA repair is associated with Rho GTPase activation and α-smooth muscle actin polymerization.

artículo científico publicado en 2014

8-Oxoguanine DNA glycosylase1-driven DNA repair-A paradoxical role in lung aging.

artículo científico

A Commentary on TDP-43 and DNA Damage Response in Amyotrophic Lateral Sclerosis

scientific article published on 10 October 2019

A new evidence for DNA nicking property of amyloid beta-peptide (1-42): relevance to Alzheimer's disease

artículo científico publicado en 2007

Activation of Ras Signaling Pathway by 8-Oxoguanine DNA Glycosylase Bound to Its Excision Product, 8-Oxoguanine ⬇️

artículo científico publicado el 8 de mayo de 2012

Activation of cellular signaling by 8-oxoguanine DNA glycosylase-1-initiated DNA base excision repair

artículo científico publicado en 2013

Altered Mitochondrial Dynamics in Motor Neuron Disease: An Emerging Perspective

artículo científico publicado en 2020

Aluminium in Alzheimer's disease: are we still at a crossroad?

artículo científico publicado en 2005

Amyloid beta and neuromelanin--toxic or protective molecules? The cellular context makes the difference.

artículo científico publicado en 2006

An algorithmic approach to understand trace elemental homeostasis in serum samples of Parkinson disease

artículo científico publicado en 2005

Carotenoids as Novel Therapeutic Molecules Against Neurodegenerative Disorders: Chemistry and Molecular Docking Analysis

scientific article published on 07 November 2019

Challenges and complexities of alpha-synuclein toxicity: new postulates in unfolding the mystery associated with Parkinson's disease

artículo científico publicado en 2003

Challenges associated with metal chelation therapy in Alzheimer's disease

artículo científico publicado en 2009

Chronic oxidative damage together with genome repair deficiency in the neurons is a double whammy for neurodegeneration: Is damage response signaling a potential therapeutic target?

artículo científico publicado en 2016

Comprehensive mapping of the C-terminus of flap endonuclease-1 reveals distinct interaction sites for five proteins that represent different DNA replication and repair pathways

artículo científico publicado en 2007

DNA induced folding/fibrillation of alpha-synuclein: new insights in Parkinson's disease

artículo científico publicado en 2010

DNA induces folding in alpha-synuclein: understanding the mechanism using chaperone property of osmolytes

artículo científico publicado en 2007

Deficiency in classical nonhomologous end-joining-mediated repair of transcribed genes is linked to SCA3 pathogenesis

artículo científico publicado en 2020

Evidence of altered DNA integrity in the brain regions of suicidal victims of Bipolar Depression

artículo científico publicado en 2010

First evidence for helical transitions in supercoiled DNA by amyloid Beta Peptide (1-42) and aluminum: a new insight in understanding Alzheimer's disease.

artículo científico publicado en 2004

Hexahydropyrrolo[2,3-b]indole Compounds as Potential Therapeutics for Alzheimer's Disease

scientific article published on 07 October 2019

Interaction of the human DNA glycosylase NEIL1 with proliferating cell nuclear antigen. The potential for replication-associated repair of oxidized bases in mammalian genomes

artículo científico publicado en 2007

Ligand-induced gene activation is associated with oxidative genome damage whose repair is required for transcription

scientific article published on 21 August 2020

Loss of endosomal recycling factor RAB11 coupled with complex regulation of MAPK/ERK/AKT signaling in postmortem spinal cord specimens of sporadic amyotrophic lateral sclerosis patients.

artículo científico publicado en 2019

MOF phosphorylation by ATM regulates 53BP1-mediated double-strand break repair pathway choice.

artículo científico publicado en 2014

Mutant FUS causes DNA ligation defects to inhibit oxidative damage repair in Amyotrophic Lateral Sclerosis

artículo científico publicado en 2018

New Mechanisms of DNA Repair Defects in Fused in Sarcoma-Associated Neurodegeneration: Stage Set for DNA Repair-Based Therapeutics?

scientific article published on 10 June 2019

New evidence on α-synuclein and Tau binding to conformation and sequence specific GC* rich DNA: Relevance to neurological disorders

artículo científico publicado en 2012

New paradigms in the repair of oxidative damage in human genome: mechanisms ensuring repair of mutagenic base lesions during replication and involvement of accessory proteins.

artículo científico publicado en 2015

New perspectives on oxidized genome damage and repair inhibition by pro-oxidant metals in neurological diseases

artículo científico publicado en 2014

Oxidative Genome Damage and its Repair in Neurodegenerative Diseases: Function of Transition Metals as a Double-Edged Sword ⬇️

artículo científico publicado el 1 de enero de 2011

Oxidative genome damage and its repair: implications in aging and neurodegenerative diseases.

artículo científico publicado en 2012

Oxidized Guanine Base Lesions Function in 8-Oxoguanine DNA Glycosylase-1-mediated Epigenetic Regulation of Nuclear Factor κB-driven Gene Expression.

artículo científico publicado en 2016

Pervasive Genomic Damage in Experimental Intracerebral Hemorrhage: Therapeutic Potential of a Mechanistic-Based Carbon Nanoparticle

artículo científico publicado en 2020

Pre-Replicative Repair of Oxidized Bases Maintains Fidelity in Mammalian Genomes: The Cowcatcher Role of NEIL1 DNA Glycosylase

artículo científico publicado en 2017

Preferential repair of oxidized base damage in the transcribed genes of mammalian cells

artículo científico publicado en 2010

Prereplicative repair of oxidized bases in the human genome is mediated by NEIL1 DNA glycosylase together with replication proteins

artículo científico publicado en 2013

RPA physically interacts with the human DNA glycosylase NEIL1 to regulate excision of oxidative DNA base damage in primer-template structures

artículo científico publicado en 2010

RT2 PCR array screening reveals distinct perturbations in DNA damage response signaling in FUS-associated motor neuron disease

scientific article published on 04 December 2019

Recent advances in α-synuclein functions, advanced glycation, and toxicity: implications for Parkinson's disease

artículo científico publicado en 2012

Role of human DNA glycosylase Nei-like 2 (NEIL2) and single strand break repair protein polynucleotide kinase 3'-phosphatase in maintenance of mitochondrial genome

artículo científico publicado en 2011

Role of protein conformational dynamics and DNA integrity in relevance to neuronal cell death in neurodegeneration

artículo científico publicado en 2006

Serum trace element levels and the complexity of inter-element relations in patients with Parkinson's disease

scientific article published on 01 January 2004

Specific Inhibition of NEIL-initiated repair of oxidized base damage in human genome by copper and iron: potential etiological linkage to neurodegenerative diseases

artículo científico publicado en 2010

Studies on genomic DNA topology and stability in brain regions of Parkinson's disease

artículo científico publicado en 2006

The C-terminal Domain (CTD) of Human DNA Glycosylase NEIL1 Is Required for Forming BERosome Repair Complex with DNA Replication Proteins at the Replicating Genome: DOMINANT NEGATIVE FUNCTION OF THE CTD.

artículo científico publicado en 2015

The disordered C-terminal domain of human DNA glycosylase NEIL1 contributes to its stability via intramolecular interactions

artículo científico publicado en 2013

The human Werner syndrome protein stimulates repair of oxidative DNA base damage by the DNA glycosylase NEIL1

artículo científico publicado en 2007

The interaction between polynucleotide kinase phosphatase and the DNA repair protein XRCC1 is critical for repair of DNA alkylation damage and stable association at DNA damage sites

artículo científico publicado en 2012

The role of 8-oxoguanine DNA glycosylase-1 in inflammation

artículo científico publicado en 2014

The role of the mammalian DNA end-processing enzyme polynucleotide kinase 3'-phosphatase in spinocerebellar ataxia type 3 pathogenesis

artículo científico publicado en 2015

Whole transcriptome analysis reveals a role for OGG1-initiated DNA repair signaling in airway remodeling

scientific article published on 14 July 2015

XRCC1 promotes replication restart, nascent fork degradation and mutagenic DNA repair in BRCA2-deficient cells

artículo científico publicado en 2020

Lista de obras de Muralidhar L. Hegde

8-Oxoguanine DNA glycosylase-1 links DNA repair to cellular signaling via the activation of the small GTPase Rac1.

8-Oxoguanine DNA glycosylase-1-mediated DNA repair is associated with Rho GTPase activation and α-smooth muscle actin polymerization.

8-Oxoguanine DNA glycosylase1-driven DNA repair-A paradoxical role in lung aging.

A Commentary on TDP-43 and DNA Damage Response in Amyotrophic Lateral Sclerosis

A new evidence for DNA nicking property of amyloid beta-peptide (1-42): relevance to Alzheimer's disease

Activation of Ras Signaling Pathway by 8-Oxoguanine DNA Glycosylase Bound to Its Excision Product, 8-Oxoguanine ⬇️

Activation of cellular signaling by 8-oxoguanine DNA glycosylase-1-initiated DNA base excision repair

Altered Mitochondrial Dynamics in Motor Neuron Disease: An Emerging Perspective

Aluminium in Alzheimer's disease: are we still at a crossroad?

Amyloid beta and neuromelanin--toxic or protective molecules? The cellular context makes the difference.

An algorithmic approach to understand trace elemental homeostasis in serum samples of Parkinson disease

Carotenoids as Novel Therapeutic Molecules Against Neurodegenerative Disorders: Chemistry and Molecular Docking Analysis

Challenges and complexities of alpha-synuclein toxicity: new postulates in unfolding the mystery associated with Parkinson's disease

Challenges associated with metal chelation therapy in Alzheimer's disease

Chronic oxidative damage together with genome repair deficiency in the neurons is a double whammy for neurodegeneration: Is damage response signaling a potential therapeutic target?

Comprehensive mapping of the C-terminus of flap endonuclease-1 reveals distinct interaction sites for five proteins that represent different DNA replication and repair pathways

DNA induced folding/fibrillation of alpha-synuclein: new insights in Parkinson's disease

DNA induces folding in alpha-synuclein: understanding the mechanism using chaperone property of osmolytes

Deficiency in classical nonhomologous end-joining-mediated repair of transcribed genes is linked to SCA3 pathogenesis

Evidence of altered DNA integrity in the brain regions of suicidal victims of Bipolar Depression

First evidence for helical transitions in supercoiled DNA by amyloid Beta Peptide (1-42) and aluminum: a new insight in understanding Alzheimer's disease.

Hexahydropyrrolo[2,3-b]indole Compounds as Potential Therapeutics for Alzheimer's Disease

Interaction of the human DNA glycosylase NEIL1 with proliferating cell nuclear antigen. The potential for replication-associated repair of oxidized bases in mammalian genomes

Ligand-induced gene activation is associated with oxidative genome damage whose repair is required for transcription

Loss of endosomal recycling factor RAB11 coupled with complex regulation of MAPK/ERK/AKT signaling in postmortem spinal cord specimens of sporadic amyotrophic lateral sclerosis patients.

MOF phosphorylation by ATM regulates 53BP1-mediated double-strand break repair pathway choice.

Mutant FUS causes DNA ligation defects to inhibit oxidative damage repair in Amyotrophic Lateral Sclerosis

New Mechanisms of DNA Repair Defects in Fused in Sarcoma-Associated Neurodegeneration: Stage Set for DNA Repair-Based Therapeutics?

New evidence on α-synuclein and Tau binding to conformation and sequence specific GC* rich DNA: Relevance to neurological disorders

New paradigms in the repair of oxidative damage in human genome: mechanisms ensuring repair of mutagenic base lesions during replication and involvement of accessory proteins.

New perspectives on oxidized genome damage and repair inhibition by pro-oxidant metals in neurological diseases

Oxidative Genome Damage and its Repair in Neurodegenerative Diseases: Function of Transition Metals as a Double-Edged Sword ⬇️

Oxidative genome damage and its repair: implications in aging and neurodegenerative diseases.

Oxidized Guanine Base Lesions Function in 8-Oxoguanine DNA Glycosylase-1-mediated Epigenetic Regulation of Nuclear Factor κB-driven Gene Expression.

Pervasive Genomic Damage in Experimental Intracerebral Hemorrhage: Therapeutic Potential of a Mechanistic-Based Carbon Nanoparticle

Pre-Replicative Repair of Oxidized Bases Maintains Fidelity in Mammalian Genomes: The Cowcatcher Role of NEIL1 DNA Glycosylase

Preferential repair of oxidized base damage in the transcribed genes of mammalian cells

Prereplicative repair of oxidized bases in the human genome is mediated by NEIL1 DNA glycosylase together with replication proteins

RPA physically interacts with the human DNA glycosylase NEIL1 to regulate excision of oxidative DNA base damage in primer-template structures

RT2 PCR array screening reveals distinct perturbations in DNA damage response signaling in FUS-associated motor neuron disease

Recent advances in α-synuclein functions, advanced glycation, and toxicity: implications for Parkinson's disease

Role of human DNA glycosylase Nei-like 2 (NEIL2) and single strand break repair protein polynucleotide kinase 3'-phosphatase in maintenance of mitochondrial genome

Role of protein conformational dynamics and DNA integrity in relevance to neuronal cell death in neurodegeneration

Serum trace element levels and the complexity of inter-element relations in patients with Parkinson's disease

Specific Inhibition of NEIL-initiated repair of oxidized base damage in human genome by copper and iron: potential etiological linkage to neurodegenerative diseases

Studies on genomic DNA topology and stability in brain regions of Parkinson's disease

The C-terminal Domain (CTD) of Human DNA Glycosylase NEIL1 Is Required for Forming BERosome Repair Complex with DNA Replication Proteins at the Replicating Genome: DOMINANT NEGATIVE FUNCTION OF THE CTD.

The disordered C-terminal domain of human DNA glycosylase NEIL1 contributes to its stability via intramolecular interactions

The human Werner syndrome protein stimulates repair of oxidative DNA base damage by the DNA glycosylase NEIL1

The interaction between polynucleotide kinase phosphatase and the DNA repair protein XRCC1 is critical for repair of DNA alkylation damage and stable association at DNA damage sites

The role of 8-oxoguanine DNA glycosylase-1 in inflammation

The role of the mammalian DNA end-processing enzyme polynucleotide kinase 3'-phosphatase in spinocerebellar ataxia type 3 pathogenesis

Whole transcriptome analysis reveals a role for OGG1-initiated DNA repair signaling in airway remodeling

XRCC1 promotes replication restart, nascent fork degradation and mutagenic DNA repair in BRCA2-deficient cells