Lista de obras - Melanie H. Cobb - Dominio Público Uruguay

A Kinase Divided.

artículo científico publicado en 2015

A similar ribosomal protein S6 kinase activity is found in insulin-treated 3T3-L1 cells and chick embryo fibroblasts transformed by Rous sarcoma virus

artículo científico publicado en 1986

A small molecule differentiation inducer increases insulin production by pancreatic β cells

artículo científico publicado en 2011

ASCL1 is a lineage oncogene providing therapeutic targets for high-grade neuroendocrine lung cancers

artículo científico publicado en 2014

Actions of the protein kinase WNK1 on endothelial cells are differentially mediated by its substrate kinases OSR1 and SPAK.

artículo científico publicado en 2014

Activated MEK5 induces serial assembly of sarcomeres and eccentric cardiac hypertrophy.

artículo científico publicado en 2001

Activation mechanism of the MAP kinase ERK2 by dual phosphorylation

artículo científico publicado en 1997

Activation of MEKK1 by Rho GTPases

artículo científico publicado en 2006

Activation of mitogen-activated protein kinase cascades by p21-activated protein kinases in cell-free extracts of Xenopus oocytes.

artículo científico publicado en 1995

Activation of mitogen-activating protein kinase by glucose is not required for insulin secretion

artículo científico publicado en 1997

Activity of the MAP kinase ERK2 is controlled by a flexible surface loop

artículo científico publicado en 1995

Amino acid regulation of autophagy through the GPCR TAS1R1-TAS1R3.

artículo científico publicado en 2012

Bacterial expression of activated mitogen-activated protein kinases

artículo científico publicado en 2001

Binding of JNK/SAPK to MEKK1 is regulated by phosphorylation

artículo científico publicado en 2002

Biological Cross-talk between WNK1 and the Transforming Growth Factor β-Smad Signaling Pathway

scientific article published in Journal of Biological Chemistry

Calcineurin increases glucose activation of ERK1/2 by reversing negative feedback ⬇️

artículo científico publicado el 6 de diciembre de 2010

Catalytic reaction pathway for the mitogen-activated protein kinase ERK2.

artículo científico publicado en 2000

Cell condition-dependent regulation of ERK5 by cAMP.

artículo científico publicado en 2002

Characterization of a Protein Kinase that Phosphorylates Serine 189 of the Mitogen-activated Protein Kinase Homolog ERK3

artículo científico publicado en 1996

Characterization of mitogen-activated protein kinase (MAPK) dimers

artículo científico publicado en 2006

Chloride Sensing by WNK1 Involves Inhibition of Autophosphorylation

artículo científico publicado en 2014

Chromatin-tethered MAPKs ⬇️

artículo científico publicado el 20 de febrero de 2013

Cloning of rat MEK kinase 1 cDNA reveals an endogenous membrane-associated 195-kDa protein with a large regulatory domain

scientific journal article

Context-dependent regulation of NeuroD activity and protein accumulation.

artículo científico publicado en 2005

Contributions of the Mitogen-activated Protein (MAP) Kinase Backbone and Phosphorylation Loop to MEK Specificity

artículo científico publicado en 1996

Control of Podocyte and Glomerular Capillary Wall Structure and Elasticity by WNK1 Kinase

artículo científico publicado en 2020

Correction to Insulin Promoter-Driven Gaussia Luciferase-Based Insulin Secretion Biosensor Assay for Discovery of β-Cell Glucose-Sensing Pathways

artículo científico publicado en 2017

Cross-cascade activation of ERKs and ternary complex factors by Rho family proteins ⬇️

artículo científico publicado el 3 de noviembre de 1997

Crystal structure of domain-swapped STE20 OSR1 kinase domain

artículo científico publicado en 2009

Crystal structure of the TAO2 kinase domain: activation and specificity of a Ste20p MAP3K

scientific journal article

Crystal structure of the kinase domain of WNK1, a kinase that causes a hereditary form of hypertension

artículo científico publicado en 2004

Crystal structures of MAP kinase p38 complexed to the docking sites on its nuclear substrate MEF2A and activator MKK3b

artículo científico publicado en 2002

Cyclic AMP selectively uncouples mitogen-activated protein kinase cascades from activating signals

artículo científico publicado en 2006

Different Domains of the Mitogen-activated Protein Kinases ERK3 and ERK2 Direct Subcellular Localization and Upstream Specificityin Vivo ⬇️

artículo científico publicado el 6 de diciembre de 2001

Differential Effects of PAK1-activating Mutations Reveal Activity-dependent and -independent Effects on Cytoskeletal Regulation ⬇️

artículo científico publicado el 23 de octubre de 1998

Differential Regulation of ERK1/2 and mTORC1 Through T1R1/T1R3 in MIN6 Cells

artículo científico publicado en 2015

Differential abundance of CK1α provides selectivity for pharmacological CK1α activators to target WNT-dependent tumors

artículo científico publicado en 2017

Differential regulation of CHOP-10/GADD153 gene expression by MAPK signaling in pancreatic beta-cells.

artículo científico publicado en 2007

Differential regulation of mitogen-activated protein/ERK kinase (MEK)1 and MEK2 and activation by a Ras-independent mechanism

artículo científico publicado en 1997

Domain-Swapping Switch Point in Ste20 Protein Kinase SPAK

artículo científico publicado en 2015

Dual MAP kinase pathways mediate opposing forms of long-term plasticity at CA3–CA1 synapses

artículo científico publicado en 2000

ERK1/2-dependent activation of transcription factors required for acute and chronic effects of glucose on the insulin gene promoter

artículo científico publicado en 2005

ERK2 enters the nucleus by a carrier-independent mechanism

artículo científico publicado en 2002

ERK5 signaling gets XIAPed: a role for ubiquitin in the disassembly of a MAPK cascade

artículo científico publicado en 2014

ERKs Weigh in on Ribosome Mass

artículo científico publicado en 2001

ERKs, extracellular signal-regulated MAP-2 kinases ⬇️

artículo científico publicado el 1 de diciembre de 1991

Exposing Contingency Plans for Kinase Networks

artículo científico publicado en 2010

Expression and characterization of MAP kinases in bacteria

artículo científico publicado en 2006

Extracellular signal-regulated kinases in T cells: characterization of human ERK1 and ERK2 cDNAs

artículo científico publicado el 14 de febrero de 1992

FAK phosphorylation by ERK primes ras-induced tyrosine dephosphorylation of FAK mediated by PIN1 and PTP-PEST

scientific article published on July 2009

Functional divergence caused by mutations in an energetic hotspot in ERK2

scientific article published on 11 July 2019

G protein-coupled receptors and the regulation of autophagy

artículo científico publicado en 2014

HTLV-I Tax protein binds to MEKK1 to stimulate IkappaB kinase activity and NF-kappaB activation

artículo científico publicado en 1998

Hydrophobic as well as charged residues in both MEK1 and ERK2 are important for their proper docking

artículo científico publicado en 2001

Identification of novel point mutations in ERK2 that selectively disrupt binding to MEK1

artículo científico publicado en 2002

Identification of substrates and regulators of the mitogen-activated protein kinase ERK5 using chimeric protein kinases.

artículo científico publicado en 1998

Inhibition of glucose-stimulated activation of extracellular signal-regulated protein kinases 1 and 2 by epinephrine in pancreatic beta-cells

artículo científico publicado en 2006

Insulin activates a tyrosine-specific protein kinase in extracts of 3T3-L1 adipocytes and human placenta.

artículo científico publicado en 1982

Insulin-stimulated sodium transport in toad urinary bladder

artículo científico publicado en 1986

Interactions with WNK (with no lysine) family members regulate oxidative stress response 1 and ion co-transporter activity

artículo científico publicado en 2012

Irreversible inhibition of sodium transport by the toad urinary bladder following photolysis of amiloride analogs

scientific article published on 01 January 1981

Isolation and characterization of pmk-(1-3): three p38 homologs in Caenorhabditis elegans.

artículo científico publicado en 2001

Isolation of TAO1, a protein kinase that activates MEKs in stress-activated protein kinase cascades

scientific journal article

Isolation of the protein kinase TAO2 and identification of its mitogen-activated protein kinase/extracellular signal-regulated kinase kinase binding domain

scientific journal article

Isoxazole Alters Metabolites and Gene Expression, Decreasing Proliferation and Promoting a Neuroendocrine Phenotype in β-Cells

scientific article published on February 2016

Lipopolysaccharide-induced tumor necrosis factor-alpha promoter activity is inhibitor of nuclear factor-kappaB kinase-dependent

artículo científico publicado en 1999

MAP kinase modules: many roads home.

artículo científico publicado en 2003

MAP kinases

scientific journal article

MAP-ping unconventional protein-DNA interactions.

artículo científico publicado en 2009

MEKK1 Binds Directly to the c-Jun N-terminal Kinases/Stress-activated Protein Kinases ⬇️

artículo científico publicado el 19 de diciembre de 1997

MEKK1 phosphorylates MEK1 and MEK2 but does not cause activation of mitogen-activated protein kinase

scientific journal article

Menin determines K-RAS proliferative outputs in endocrine cells

scientific journal article

Mineralocorticoid-induced membrane proteins in MDCK cells

artículo científico publicado en 1982

Minireview: Nutrient sensing by G protein-coupled receptors

artículo científico publicado en 2013

Mitogen-activated protein kinase pathways

artículo científico publicado en 1997

Multiple chromatin-bound protein kinases assemble factors that regulate insulin gene transcription

artículo científico publicado en 2009

Muscarinic control of MIN6 pancreatic β cells is enhanced by impaired amino acid signaling.

artículo científico publicado en 2014

Mutations in ERK2 Binding Sites Affect Nuclear Entry

scientific article published in Journal of Biological Chemistry

Mxi2 promotes stimulus-independent ERK nuclear translocation

artículo científico publicado en 2007

NGF and other growth factors induce an association between ERK1 and the NGF receptor, gp140prototrk

scientific article published on 01 December 1992

NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain

artículo científico publicado en 1997

NeuroD1 mediates nicotine-induced migration and invasion via regulation of the nicotinic acetylcholine receptor subunits in a subset of neural and neuroendocrine carcinomas

artículo científico publicado en 2014

NeuroD1 regulates survival and migration of neuroendocrine lung carcinomas via signaling molecules TrkB and NCAM.

artículo científico publicado en 2013

NeuroD1 regulation of migration accompanies the differential sensitivity of neuroendocrine carcinomas to TrkB inhibition ⬇️

artículo científico publicado el 19 de agosto de 2013

Off-target effects of MEK inhibitors

artículo científico publicado en 2013

Oncogenic Ras activates c-Jun via a separate pathway from the activation of extracellular signal-regulated kinases

artículo científico publicado en 1994

Overview of the Alliance for Cellular Signaling

artículo científico publicado en 2002

PTMap--a sequence alignment software for unrestricted, accurate, and full-spectrum identification of post-translational modification sites.

scholarly article

Pharmacological inhibitors of MAPK pathways.

artículo científico publicado en 2002

Phosphatidylinositol 3-kinase regulates Raf1 through Pak phosphorylation of serine 338

scientific article published on 01 May 2000

Phosphorylation of MAP Kinases by MAP/ERK Involves Multiple Regions of MAP Kinases

artículo científico publicado en 1999

Phosphorylation of the MAP Kinase ERK2 Promotes Its Homodimerization and Nuclear Translocation ⬇️

artículo científico publicado el 15 de mayo de 1998

Phosphorylation or Mutation of the ERK2 Activation Loop Alters Oligonucleotide Binding.

artículo científico publicado en 2016

Properties of WNK1 and implications for other family members

artículo científico publicado en 2005

Protein kinase WNK3 regulates the neuronal splicing factor Fox-1

artículo científico publicado en 2012

Protein kinases

scientific article published on 01 December 1994

Ras regulates kinesin 13 family members to control cell migration pathways in transformed human bronchial epithelial cells.

artículo científico publicado en 2013

Ras transformation uncouples the kinesin-coordinated cellular nutrient response

artículo científico publicado en 2014

Reciprocal Signaling between Heterotrimeric G Proteins and the p21-stimulated Protein Kinase

artículo científico publicado en 1999

Regulation of CCAAT/enhancer-binding protein homologous protein (CHOP) expression by interleukin-1 beta in pancreatic beta cells

artículo científico publicado en 2010

Regulation of ERK1 and ERK2 by glucose and peptide hormones in pancreatic beta cells

artículo científico publicado en 2003

Regulation of OSR1 and the sodium, potassium, two chloride cotransporter by convergent signals.

artículo científico publicado en 2013

Regulation of a third conserved phosphorylation site in SGK1

artículo científico publicado en 2008

Regulation of insulin gene transcription by ERK1 and ERK2 in pancreatic beta cells

artículo científico publicado en 2003

RhoA binds to the amino terminus of MEKK1 and regulates its kinase activity

artículo científico publicado en 2003

Role of with-no-lysine [K] kinases in the pathogenesis of Gordon's syndrome.

artículo científico publicado en 2006

Scaffolding and protein interactions in MAP kinase modules.

artículo científico publicado en 1999

Serum and glucocorticoid-induced kinase (SGK) 1 and the epithelial sodium channel are regulated by multiple with no lysine (WNK) family members

artículo científico publicado en 2010

Signal control through Raf: in sickness and in health

artículo científico

Small Cell Lung Cancer: Can Recent Advances in Biology and Molecular Biology Be Translated into Improved Outcomes?

artículo científico publicado en 2016

Starvation activates MAP kinase through the muscarinic acetylcholine pathway in Caenorhabditis elegans pharynx

artículo científico publicado en 2006

Stimulation of NFkappa B activity by multiple signaling pathways requires PAK1.

artículo científico publicado en 2000

Stimulus-specific requirements for MAP3 kinases in activating the JNK pathway

artículo científico publicado en 2002

Substrate Recognition Domains within Extracellular Signal-regulated Kinase Mediate Binding and Catalytic Activation of Mitogen-activated Protein Kinase Phosphatase-3

artículo científico publicado en 2000

Sumoylation regulates the transcriptional activity of MafA in pancreatic beta cells

artículo científico publicado en 2008

TAO (thousand-and-one amino acid) protein kinases mediate signaling from carbachol to p38 mitogen-activated protein kinase and ternary complex factors.

artículo científico publicado en 2003

TGF-β Regulation by Emilin1: New Links in the Etiology of Hypertension

artículo científico publicado en 2006

The CK1α Activator Pyrvinium Enhances the Catalytic Efficiency (kcat/Km) of CK1α

artículo científico publicado en 2019

The G protein-coupled taste receptor T1R1/T1R3 regulates mTORC1 and autophagy.

artículo científico publicado en 2012

The MAP kinase ERK5 binds to and phosphorylates p90 RSK.

artículo científico publicado en 2006

The MEK1 proline-rich insert is required for efficient activation of the mitogen-activated protein kinases ERK1 and ERK2 in mammalian cells

artículo científico publicado en 1998

The N-terminal ERK-binding site of MEK1 is required for efficient feedback phosphorylation by ERK2 in vitro and ERK activation in vivo

scientific journal article

The Structure of the MAP2K MEK6 Reveals an Autoinhibitory Dimer

artículo científico publicado en 2009

The death effector domain protein PEA-15 prevents nuclear entry of ERK2 by inhibiting required interactions

artículo científico publicado en 2004

The insulin receptor and tyrosine protein kinase activity

artículo científico publicado en 1984

The interaction of SV40 small tumor antigen with protein phosphatase 2A stimulates the map kinase pathway and induces cell proliferation.

artículo científico publicado en 1993

The nuclear localization of ERK2 occurs by mechanisms both independent of and dependent on energy

artículo científico publicado en 2006

The transcriptional ETS2 repressor factor associates with active and inactive Erks through distinct FXF motifs

artículo científico publicado en 2006

Uncoupling Raf1 from MEK1/2 impairs only a subset of cellular responses to Raf activation

artículo científico publicado en 2000

WNK1 activates SGK1 by a phosphatidylinositol 3-kinase-dependent and non-catalytic mechanism

artículo científico publicado en 2005

WNK1 activates SGK1 to regulate the epithelial sodium channel.

artículo científico publicado en 2005

WNK1 and OSR1 regulate the Na+, K+, 2Cl- cotransporter in HeLa cells

artículo científico publicado en 2006

WNK1 is a novel regulator of Munc18c-syntaxin 4 complex formation in soluble NSF attachment protein receptor (SNARE)-mediated vesicle exocytosis.

artículo científico publicado en 2007

WNK1 is required for mitosis and abscission.

artículo científico publicado en 2011

WNK1 phosphorylates synaptotagmin 2 and modulates its membrane binding

artículo científico publicado en 2004

kin-18, a C. elegans protein kinase involved in feeding

artículo científico publicado en 2001

p115 Rho GTPase activating protein interacts with MEKK1.

artículo científico publicado en 2002

WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II

artículo científico publicado en el año 2000

Lista de obras de Melanie H. Cobb

A Kinase Divided.

A similar ribosomal protein S6 kinase activity is found in insulin-treated 3T3-L1 cells and chick embryo fibroblasts transformed by Rous sarcoma virus

A small molecule differentiation inducer increases insulin production by pancreatic β cells

ASCL1 is a lineage oncogene providing therapeutic targets for high-grade neuroendocrine lung cancers

Actions of the protein kinase WNK1 on endothelial cells are differentially mediated by its substrate kinases OSR1 and SPAK.

Activated MEK5 induces serial assembly of sarcomeres and eccentric cardiac hypertrophy.

Activation mechanism of the MAP kinase ERK2 by dual phosphorylation

Activation of MEKK1 by Rho GTPases

Activation of mitogen-activated protein kinase cascades by p21-activated protein kinases in cell-free extracts of Xenopus oocytes.

Activation of mitogen-activating protein kinase by glucose is not required for insulin secretion

Activity of the MAP kinase ERK2 is controlled by a flexible surface loop

Amino acid regulation of autophagy through the GPCR TAS1R1-TAS1R3.

Bacterial expression of activated mitogen-activated protein kinases

Binding of JNK/SAPK to MEKK1 is regulated by phosphorylation

Biological Cross-talk between WNK1 and the Transforming Growth Factor β-Smad Signaling Pathway

Calcineurin increases glucose activation of ERK1/2 by reversing negative feedback ⬇️

Catalytic reaction pathway for the mitogen-activated protein kinase ERK2.

Cell condition-dependent regulation of ERK5 by cAMP.

Characterization of a Protein Kinase that Phosphorylates Serine 189 of the Mitogen-activated Protein Kinase Homolog ERK3

Characterization of mitogen-activated protein kinase (MAPK) dimers

Chloride Sensing by WNK1 Involves Inhibition of Autophosphorylation

Chromatin-tethered MAPKs ⬇️

Cloning of rat MEK kinase 1 cDNA reveals an endogenous membrane-associated 195-kDa protein with a large regulatory domain

Context-dependent regulation of NeuroD activity and protein accumulation.

Contributions of the Mitogen-activated Protein (MAP) Kinase Backbone and Phosphorylation Loop to MEK Specificity

Control of Podocyte and Glomerular Capillary Wall Structure and Elasticity by WNK1 Kinase

Correction to Insulin Promoter-Driven Gaussia Luciferase-Based Insulin Secretion Biosensor Assay for Discovery of β-Cell Glucose-Sensing Pathways

Cross-cascade activation of ERKs and ternary complex factors by Rho family proteins ⬇️

Crystal structure of domain-swapped STE20 OSR1 kinase domain

Crystal structure of the TAO2 kinase domain: activation and specificity of a Ste20p MAP3K

Crystal structure of the kinase domain of WNK1, a kinase that causes a hereditary form of hypertension

Crystal structures of MAP kinase p38 complexed to the docking sites on its nuclear substrate MEF2A and activator MKK3b

Cyclic AMP selectively uncouples mitogen-activated protein kinase cascades from activating signals

Different Domains of the Mitogen-activated Protein Kinases ERK3 and ERK2 Direct Subcellular Localization and Upstream Specificityin Vivo ⬇️

Differential Effects of PAK1-activating Mutations Reveal Activity-dependent and -independent Effects on Cytoskeletal Regulation ⬇️

Differential Regulation of ERK1/2 and mTORC1 Through T1R1/T1R3 in MIN6 Cells

Differential abundance of CK1α provides selectivity for pharmacological CK1α activators to target WNT-dependent tumors

Differential regulation of CHOP-10/GADD153 gene expression by MAPK signaling in pancreatic beta-cells.

Differential regulation of mitogen-activated protein/ERK kinase (MEK)1 and MEK2 and activation by a Ras-independent mechanism

Domain-Swapping Switch Point in Ste20 Protein Kinase SPAK

Dual MAP kinase pathways mediate opposing forms of long-term plasticity at CA3–CA1 synapses

ERK1/2-dependent activation of transcription factors required for acute and chronic effects of glucose on the insulin gene promoter

ERK2 enters the nucleus by a carrier-independent mechanism

ERK5 signaling gets XIAPed: a role for ubiquitin in the disassembly of a MAPK cascade

ERKs Weigh in on Ribosome Mass

ERKs, extracellular signal-regulated MAP-2 kinases ⬇️

Exposing Contingency Plans for Kinase Networks

Expression and characterization of MAP kinases in bacteria

Extracellular signal-regulated kinases in T cells: characterization of human ERK1 and ERK2 cDNAs

FAK phosphorylation by ERK primes ras-induced tyrosine dephosphorylation of FAK mediated by PIN1 and PTP-PEST

Functional divergence caused by mutations in an energetic hotspot in ERK2

G protein-coupled receptors and the regulation of autophagy

HTLV-I Tax protein binds to MEKK1 to stimulate IkappaB kinase activity and NF-kappaB activation

Hydrophobic as well as charged residues in both MEK1 and ERK2 are important for their proper docking

Identification of novel point mutations in ERK2 that selectively disrupt binding to MEK1

Identification of substrates and regulators of the mitogen-activated protein kinase ERK5 using chimeric protein kinases.

Inhibition of glucose-stimulated activation of extracellular signal-regulated protein kinases 1 and 2 by epinephrine in pancreatic beta-cells

Insulin activates a tyrosine-specific protein kinase in extracts of 3T3-L1 adipocytes and human placenta.

Insulin-stimulated sodium transport in toad urinary bladder

Interactions with WNK (with no lysine) family members regulate oxidative stress response 1 and ion co-transporter activity

Irreversible inhibition of sodium transport by the toad urinary bladder following photolysis of amiloride analogs

Isolation and characterization of pmk-(1-3): three p38 homologs in Caenorhabditis elegans.

Isolation of TAO1, a protein kinase that activates MEKs in stress-activated protein kinase cascades

Isolation of the protein kinase TAO2 and identification of its mitogen-activated protein kinase/extracellular signal-regulated kinase kinase binding domain

Isoxazole Alters Metabolites and Gene Expression, Decreasing Proliferation and Promoting a Neuroendocrine Phenotype in β-Cells

Lipopolysaccharide-induced tumor necrosis factor-alpha promoter activity is inhibitor of nuclear factor-kappaB kinase-dependent

MAP kinase modules: many roads home.

MAP kinases

MAP-ping unconventional protein-DNA interactions.

MEKK1 Binds Directly to the c-Jun N-terminal Kinases/Stress-activated Protein Kinases ⬇️

MEKK1 phosphorylates MEK1 and MEK2 but does not cause activation of mitogen-activated protein kinase

Menin determines K-RAS proliferative outputs in endocrine cells

Mineralocorticoid-induced membrane proteins in MDCK cells

Minireview: Nutrient sensing by G protein-coupled receptors

Mitogen-activated protein kinase pathways

Multiple chromatin-bound protein kinases assemble factors that regulate insulin gene transcription

Muscarinic control of MIN6 pancreatic β cells is enhanced by impaired amino acid signaling.

Mutations in ERK2 Binding Sites Affect Nuclear Entry

Mxi2 promotes stimulus-independent ERK nuclear translocation