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Lista de obras de Namasivayam Ambalavanan

A Comparison of 3 Vitamin D Dosing Regimens in Extremely Preterm Infants: A Randomized Controlled Trial

artículo científico publicado en 2016

A Nitric Oxide-Releasing Self-Assembled Peptide Amphiphile Nanomatrix for Improving the Biocompatibility of Microporous Hollow Fibers

artículo científico publicado en 2015

A Shared Pattern of β-catenin Activation in Bronchopulmonary Dysplasia and Idiopathic Pulmonary Fibrosis.

artículo científico publicado en 2018

A comparison of three vitamin A dosing regimens in extremely-low-birth-weight infants

artículo científico publicado en 2003

A functional ATG16L1 (T300A) variant is associated with necrotizing enterocolitis in premature infants

artículo científico publicado en 2016

A pumpless lung assist device reduces mechanical ventilation-induced lung injury in juvenile piglets

artículo científico publicado en 2009

A randomised trial of re-feeding gastric residuals in preterm infants

artículo científico publicado en 2014

ABO blood group is associated with response to inhaled nitric oxide in neonates with respiratory failure

artículo científico publicado en 2012

Accuracy of a novel system for oxygen delivery to small children

artículo científico publicado en 2011

Acute Kidney Injury Urine Biomarkers in Very Low-Birth-Weight Infants

artículo científico publicado en 2016

Acute Kidney Injury in Neonates

Acute changes in fluid status affect the incidence, associative clinical outcomes, and urine biomarker performance in premature infants with acute kidney injury

artículo científico publicado en 2015

Acute kidney injury and renal replacement therapy independently predict mortality in neonatal and pediatric noncardiac patients on extracorporeal membrane oxygenation

artículo científico publicado en 2011

Acute kidney injury in critically ill newborns: what do we know? What do we need to learn?

artículo científico publicado en 2009

Acute kidney injury is associated with bronchopulmonary dysplasia/mortality in premature infants

artículo científico publicado en 2015

Acute kidney injury is independently associated with mortality in very low birthweight infants: a matched case-control analysis

artículo científico publicado en 2009

Acute kidney injury reduces survival in very low birth weight infants

artículo científico publicado en 2011

Adjunctive Azithromycin Prophylaxis for Cesarean Delivery

artículo científico publicado en 2016

Airway Microbiome and Development of Bronchopulmonary Dysplasia in Preterm Infants: A Systematic Review

article

Alterations in gene expression and DNA methylation during murine and human lung alveolar septation

artículo científico publicado en 2015

Altered DNA methylation profile in idiopathic pulmonary fibrosis

artículo científico publicado en 2012

Analgesia for ventilated neonates: where do we stand?

scientific article published on 01 October 1999

Approach to infants born at 22 to 24 weeks' gestation: relationship to outcomes of more-mature infants

artículo científico publicado en 2012

Array comparative genomic hybridisation testing in CHD

Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates: Design of a Retrospective Cohort Study

artículo científico publicado en 2016

Association of Chorioamnionitis with Aberrant Neonatal Gut Colonization and Adverse Clinical Outcomes

artículo científico publicado en 2016

Atrial natriuretic peptide-dependent modulation of hypoxia-induced pulmonary vascular remodeling.

artículo científico publicado en 2006

Baseline values of candidate urine acute kidney injury biomarkers vary by gestational age in premature infants

artículo científico publicado en 2011

Basic Principles of Mechanical Ventilation

article

Bias in reported neurodevelopmental outcomes among extremely low birth weight survivors

artículo científico publicado en 2004

Biomarkers associated with bronchopulmonary dysplasia/mortality in premature infants

artículo científico publicado en 2016

Biomarkers, Early Diagnosis, and Clinical Predictors of Bronchopulmonary Dysplasia

artículo científico publicado en 2015

Blood Cytokine Profiles Associated with Distinct Patterns of Bronchopulmonary Dysplasia among Extremely Low Birth Weight Infants

artículo científico publicado en 2016

Blood Gases

Both Extremes of Arterial Carbon Dioxide Pressure and the Magnitude of Fluctuations in Arterial Carbon Dioxide Pressure Are Associated With Severe Intraventricular Hemorrhage in Preterm Infants: In Reply

Both extremes of arterial carbon dioxide pressure and the magnitude of fluctuations in arterial carbon dioxide pressure are associated with severe intraventricular hemorrhage in preterm infants

artículo científico publicado en 2007

Bronchopulmonary dysplasia: new insights

artículo científico publicado en 2004

CFTR dysfunction increases endoglin and TGF-β signaling in airway epithelia

artículo científico publicado en 2019

Cellular and humoral biomarkers of Bronchopulmonary Dysplasia

artículo científico publicado en 2016

Center Variation in Intestinal Microbiota Prior to Late-Onset Sepsis in Preterm Infants

artículo científico publicado en 2015

Challenges, priorities and novel therapies for hypoxemic respiratory failure and pulmonary hypertension in the neonate

artículo científico publicado en 2016

Chronic exposure to cigarette smoke extract impairs endothelium-dependent relaxation of chicken embryo pulmonary arteries

artículo científico publicado en 2001

Classification of Mechanical Ventilation Devices

Comparison of the prediction of extremely low birth weight neonatal mortality by regression analysis and by neural networks

artículo científico publicado en 2001

Correction: Myofibroblast Differentiation and Enhanced Tgf-B Signaling in Cystic Fibrosis Lung Disease

artículo científico publicado en 2013

Cytokines and neurodevelopmental outcomes in extremely low birth weight infants

artículo científico publicado en 2011

Cytokines and posthemorrhagic ventricular dilation in premature infants

artículo científico publicado en 2012

Cytokines associated with bronchopulmonary dysplasia or death in extremely low birth weight infants

artículo científico publicado en 2009

Developing a neonatal acute kidney injury research definition: a report from the NIDDK neonatal AKI workshop

artículo científico publicado en 2017

Developmental regulation of NO-mediated VEGF-induced effects in the lung

artículo científico publicado en 2008

Disseminated Ureaplasma infection as a cause of fatal hyperammonemia in humans.

artículo científico publicado en 2015

Dominant negative mutation of the TGF-beta receptor blocks hypoxia-induced pulmonary vascular remodeling.

artículo científico publicado en 2005

Dose-Response Effects of Early Vitamin D Supplementation on Neurodevelopmental and Respiratory Outcomes of Extremely Preterm Infants at 2 Years of Age: A Randomized Trial.

artículo científico publicado en 2018

Early CPAP versus surfactant in extremely preterm infants

artículo científico publicado en 2010

Early Life Supraphysiological Levels of Oxygen Exposure Permanently Impairs Hippocampal Mitochondrial Function

scientific article published on 16 September 2019

Early airway microbial metagenomic and metabolomic signatures are associated with development of severe bronchopulmonary dysplasia

scientific article published on 16 August 2018

Early exposure to hyperoxia or hypoxia adversely impacts cardiopulmonary development

artículo científico publicado en 2015

Early prediction of poor outcome in extremely low birth weight infants by classification tree analysis

article

Effect of Depth and Duration of Cooling on Death or Disability at Age 18 Months Among Neonates With Hypoxic-Ischemic Encephalopathy: A Randomized Clinical Trial.

artículo científico publicado en 2017

Effect of Prenatal versus Postnatal Vitamin D Deficiency on Pulmonary Structure and Function in Mice

artículo científico publicado en 2017

Effect of Therapeutic Hypothermia Initiated After 6 Hours of Age on Death or Disability Among Newborns With Hypoxic-Ischemic Encephalopathy: A Randomized Clinical Trial.

artículo científico publicado en 2017

Effect of cigarette smoke extract on neonatal porcine vascular smooth muscle cells.

artículo científico publicado en 2001

Effects of Myo-inositol on Type 1 Retinopathy of Prematurity Among Preterm Infants <28 Weeks' Gestational Age: A Randomized Clinical Trial

scientific article published in The Journal of the American Medical Association

Endothelial Cell Bioenergetics and Mitochondrial DNA Damage Differ in Humans Having African or West Eurasian Maternal Ancestry.

artículo científico publicado en 2016

Endothelin-1 mediates hypoxia-induced increases in vascular collagen in the newborn mouse lung

artículo científico publicado en 2007

Endothelin-A Receptor Blockade in Porcine Pulmonary Hypertension

Endothelin-A receptor blockade in porcine pulmonary hypertension

artículo científico publicado en 2002

Endothelin-A receptor blockade inhibits the effects of hypoxia on the newborn lung vasculature.

artículo científico publicado en 2006

Endothelin-A receptor blockade prevents and partially reverses neonatal hypoxic pulmonary vascular remodeling

artículo científico publicado en 2005

Environmental or Nasal Cannula Supplemental Oxygen for Preterm Infants: A Randomized Cross-Over Trial

Epidemiology of readmissions in early infancy following nonelective cesarean delivery

artículo científico publicado en 2020

Evaluation of a pumpless lung assist device in hypoxia-induced pulmonary hypertension in juvenile piglets

artículo científico publicado en 2009

Exosomal microRNA predicts and protects against severe bronchopulmonary dysplasia in extremely premature infants

artículo científico publicado en 2018

Exposure of neonatal mice to bromine impairs their alveolar development and lung function.

artículo científico publicado en 2017

Extracellular matrix in lung development, homeostasis and disease

artículo científico publicado en 2018

Extremely low birth weight and infant mortality rates in the United States

artículo científico publicado en 2013

Feasibility of Mid-Frequency Ventilation Among Infants With Respiratory Distress Syndrome

artículo científico publicado en 2017

Feeding practices and necrotizing enterocolitis

artículo científico publicado en 2013

Fluid overload and mortality are associated with acute kidney injury in sick near-term/term neonate

artículo científico publicado en 2012

Gastric residuals and their relationship to necrotizing enterocolitis in very low birth weight infants

artículo científico publicado en 2004

Genetic polymorphisms of heme-oxygenase 1 (HO-1) may impact on acute kidney injury, bronchopulmonary dysplasia, and mortality in premature infants

artículo científico publicado en 2015

Genetic predisposition to bronchopulmonary dysplasia

artículo científico publicado en 2015

Genomics, microbiomics, proteomics, and metabolomics in bronchopulmonary dysplasia

scientific article published on 02 October 2018

Gestational age and birthweight for risk assessment of neurodevelopmental impairment or death in extremely preterm infants

artículo científico publicado en 2016

Hemodynamic effects of levcromakalim in neonatal porcine pulmonary hypertension

artículo científico publicado en 2001

High-Magnitude and/or High-Frequency Mechanical Strain Promotes Peripapillary Scleral Myofibroblast Differentiation.

artículo científico publicado en 2015

Histological characteristics of the fetal inflammatory response associated with neurodevelopmental impairment and death in extremely preterm infants

artículo científico publicado en 2013

Histone deacetylase inhibition promotes fibroblast apoptosis and ameliorates pulmonary fibrosis in mice

artículo científico publicado en 2014

Home Oxygen Use and 1-Year Readmission among Infants Born Preterm with Bronchopulmonary Dysplasia Discharged from Children's Hospital Neonatal Intensive Care Units

artículo científico publicado en 2020

How can we prevent early death in preterm infants?

artículo científico publicado en 2008

Hyperoxia Induces Intracellular Acidification in Neonatal Mouse Lung Fibroblasts: Real-Time Investigation Using Plasmonically Enhanced Raman Spectroscopy

artículo científico publicado en 2016

Hyperoxia causes miR-34a-mediated injury via angiopoietin-1 in neonatal lungs

artículo científico publicado en 2017

Hyperoxia-induced neonatal rat lung injury involves activation of TGF-{beta} and Wnt signaling and is protected by rosiglitazone

artículo científico publicado en 2009

Hypoxia induces downregulation of PPAR-γ in isolated pulmonary arterial smooth muscle cells and in rat lung via transforming growth factor-β signaling

artículo científico publicado en 2011

Hypoxia-induced inhibition of lung development is attenuated by the peroxisome proliferator-activated receptor-γ agonist rosiglitazone

artículo científico publicado en 2011

Hypoxia-induced release of peptide growth factors from neonatal porcine pulmonary artery smooth muscle cells

artículo científico publicado en 1999

Identification of extremely premature infants at high risk of rehospitalization

artículo científico publicado en 2011

Iloprost attenuates hyperoxia-mediated impairment of lung development in newborn mice

artículo científico publicado en 2018

Impact of early surfactant and inhaled nitric oxide therapies on outcomes in term/late preterm neonates with moderate hypoxic respiratory failure.

artículo científico publicado en 2013

Impact of gestational age, sex, and postnatal age on urine biomarkers in premature neonates

artículo científico publicado en 2015

Impact of timing of birth and resident duty-hour restrictions on outcomes for small preterm infants.

artículo científico publicado en 2010

In utero exposure to second-hand smoke aggravates adult responses to irritants: adult second-hand smoke

artículo científico publicado en 2012

In utero exposure to second-hand smoke aggravates the response to ovalbumin in adult mice

artículo científico publicado en 2013

In vitro studies on the effect of particle size on macrophage responses to nanodiamond wear debris

artículo científico publicado en 2012

Incidence and Risk Factors of Early Onset Neonatal AKI

artículo científico publicado en 2019

Incidence and outcomes of neonatal acute kidney injury (AWAKEN): a multicentre, multinational, observational cohort study

article

Individual and center-level factors affecting mortality among extremely low birth weight infants

artículo científico publicado en 2013

Inflammatory signals that regulate intestinal epithelial renewal, differentiation, migration and cell death: Implications for necrotizing enterocolitis

artículo científico publicado en 2014

Inhaled PGE1 in neonates with hypoxemic respiratory failure: two pilot feasibility randomized clinical trials

artículo científico publicado en 2014

Integrated genomic analyses in bronchopulmonary dysplasia

artículo científico publicado en 2014

Intercenter Differences in Bronchopulmonary Dysplasia or Death Among Very Low Birth Weight Infants

artículo científico publicado el 13 de diciembre de 2010

Intestinal microbiota of preterm infants differ over time and between hospitals

artículo científico publicado en 2014

Kangaroo mother care for the prevention of neonatal hypothermia: a randomised controlled trial in term neonates.

artículo científico publicado en 2018

Loss of Thy-1 inhibits alveolar development in the newborn mouse lung

scientific article published on 06 March 2009

LungMAP: The Molecular Atlas of Lung Development Program.

artículo científico

Management of hypoxemic respiratory failure and pulmonary hypertension in preterm infants

artículo científico publicado en 2016

Markers of Successful Extubation in Extremely Preterm Infants, and Morbidity After Failed Extubation

artículo científico publicado en 2017

Matrix Metalloproteinase-9 Mediates RSV Infection in Vitro and in Vivo

artículo científico publicado en 2015

Mechanisms and Treatment of Halogen Inhalation-Induced Pulmonary and Systemic Injuries in Pregnant Mice.

artículo científico publicado en 2017

Mechanisms of Ventilator-induced Lung Injury: Is the Elafin in the Room?

artículo científico publicado en 2018

Medical and Surgical Interventions for Respiratory Distress and Airway Management

Mortality and Morbidity by Month of Birth of Neonates Admitted to an Academic Neonatal Intensive Care Unit

article by T. D. Soltau et al published 31 October 2008 in Pediatrics

Mortality and Pulmonary Outcomes of Extremely Preterm Infants Exposed to Antenatal Corticosteroids.

artículo científico publicado en 2017

Myofibroblast differentiation and enhanced TGF-B signaling in cystic fibrosis lung disease

artículo científico publicado en 2013

Nano-TiO₂ particles impair adhesion of airway epithelial cells to fibronectin

artículo científico publicado en 2013

Neonatal mortality among low birth weight infants during the initial months of the academic year

artículo científico publicado en 2008

Neurodevelopmental impairment following neonatal hyperoxia in the mouse

artículo científico publicado en 2012

Nitric oxide administration using an oxygen hood: a pilot trial

artículo científico publicado en 2009

Noninvasive imaging of experimental lung fibrosis

artículo científico publicado en 2015

Optimizing the AKI definition during first postnatal week using Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates (AWAKEN) cohort

scientific article published on 13 December 2018

Oronasopharyngeal suction versus wiping of the mouth and nose at birth: a randomised equivalency trial.

artículo científico publicado en 2013

Outcome of Preterm Infants with Transient Cystic Periventricular Leukomalacia on Serial Cranial Imaging Up to Term Equivalent Age.

artículo científico publicado en 2018

Outcome of Term Infants Using Apgar Scores at 10 Minutes Following Hypoxic-Ischemic Encephalopathy

Outcome of term infants using apgar scores at 10 minutes following hypoxic-ischemic encephalopathy

artículo científico publicado en 2009

Outcome trajectories in extremely preterm infants

artículo científico publicado en 2012

Outcomes of extremely low birthweight infants with acidosis at birth

artículo científico publicado en 2014

Outcomes of extremely preterm infants following severe intracranial hemorrhage.

artículo científico publicado en 2013

PaCO2 and neurodevelopment in extremely low birth weight infants

artículo científico publicado en 2009

PaCO2 in surfactant, positive pressure, and oxygenation randomised trial (SUPPORT).

artículo científico publicado en 2014

Pathogenetics of alveolar capillary dysplasia with misalignment of pulmonary veins

artículo científico publicado en 2016

Peptide growth factors in tracheal aspirates of mechanically ventilated preterm neonates

artículo científico publicado en 2003

Peptide-directed highly selective targeting of pulmonary arterial hypertension

artículo científico publicado en 2011

Permissive hypercapnia to decrease lung injury in ventilated preterm neonates

artículo científico publicado en 2008

Pharmacokinetics, microbial response, and pulmonary outcomes of multidose intravenous azithromycin in preterm infants at risk for Ureaplasma respiratory colonization

artículo científico publicado en 2014

Population pharmacokinetics of sildenafil in extremely premature infants

scientific article published on 15 December 2019

Pre-Vent: the prematurity-related ventilatory control study

scientific article published on 01 February 2019

Predicting outcomes of neonates diagnosed with hypoxemic-ischemic encephalopathy

artículo científico publicado en 2006

Predicting time to hospital discharge for extremely preterm infants

artículo científico publicado en 2009

Prediction of bronchopulmonary dysplasia by postnatal age in extremely premature infants

artículo científico publicado en 2011

Prediction of death for extremely low birth weight neonates

artículo científico publicado en 2005

Predictors of death or bronchopulmonary dysplasia in preterm infants with respiratory failure.

artículo científico publicado en 2008

Prematurity and race account for much of the interstate variation in infant mortality rates in the United States

scientific article published on 09 March 2020

Prolonged duration of initial empirical antibiotic treatment is associated with increased rates of necrotizing enterocolitis and death for extremely low birth weight infants

artículo científico publicado en 2009

Prophylactic indomethacin and intestinal perforation in extremely low birth weight infants

artículo científico publicado en 2014

Prophylactic phenobarbital and whole-body cooling for neonatal hypoxic-ischemic encephalopathy

artículo científico publicado en 2010

Prospective analysis of pulmonary hypertension in extremely low birth weight infants

artículo científico publicado en 2012

Pulmonary hypertension in bronchopulmonary dysplasia

Pulmonary matrix metalloproteinase-9 activity in mechanically ventilated children with respiratory syncytial virus

artículo científico publicado en 2013

Randomized trial of plastic bags to prevent term neonatal hypothermia in a resource-poor setting

artículo científico publicado en 2013

Reconstructing dynamic microRNA-regulated interaction networks

artículo científico publicado en 2013

Regulation of alveolar septation by microRNA-489.

artículo científico publicado en 2015

Reply

Reply to Shah et al.: Mitochondrial Dysfunction in Bronchopulmonary Dysplasia

artículo científico publicado en 2018

Respiratory syncytial virus infection increases chlorine-induced airway hyperresponsiveness

artículo científico publicado en 2015

Response to a different view concerning the NICHD neonatal research network late hypothermia trial

scientific article published on 10 February 2019

Retinoic acid combined with vitamin A synergizes to increase retinyl ester storage in the lungs of newborn and dexamethasone-treated neonatal rats

artículo científico publicado en 2007

Retinol-binding protein, transthyretin, and C-reactive protein in extremely low birth weight (ELBW) infants

artículo científico publicado en 2005

Role of matrix metalloproteinase-2 in newborn mouse lungs under hypoxic conditions

artículo científico publicado en 2008

Role of nitric oxide in regulating neonatal porcine pulmonary artery smooth muscle cell proliferation.

artículo científico publicado en 1999

SNO-hemoglobin is not essential for red blood cell-dependent hypoxic vasodilation

artículo científico publicado en 2008

Searching for better animal models of BPD: a perspective

artículo científico publicado en 2016

Seasonal Variation in Solar Ultra Violet Radiation and Early Mortality in Extremely Preterm Infants

artículo científico publicado en 2015

Selecting the most appropriate time points to profile in high-throughput studies

artículo científico publicado en 2017

Serum eotaxin-1 is increased in extremely-low-birth-weight infants with bronchopulmonary dysplasia or death

artículo científico publicado en 2015

Setting research priorities to improve global newborn health and prevent stillbirths by 2025.

artículo científico publicado en 2016

Short versus Extended Duration of Trophic Feeding to Reduce Time to Achieve Full Enteral Feeding in Extremely Preterm Infants: An Observational Study

artículo científico publicado en 2017

Spatially-Resolved Proteomics: Rapid Quantitative Analysis of Laser Capture Microdissected Alveolar Tissue Samples

artículo científico publicado en 2016

Supraphysiological Levels of Oxygen Exposure During the Neonatal Period Impairs Signaling Pathways Required for Learning and Memory.

artículo científico publicado en 2018

Surgical necrotizing enterocolitis in extremely premature neonates is associated with genetic variations in an intergenic region of chromosome eight.

artículo científico publicado en 2018

Survey of vitamin A supplementation for extremely-low-birth-weight infants: is clinical practice consistent with the evidence?

artículo científico publicado en 2004

Systems biology of lung development and regeneration: current knowledge and recommendations for future research

artículo científico publicado en 2013

TGF-β2 suppresses macrophage cytokine production and mucosal inflammatory responses in the developing intestine

artículo científico publicado en 2011

Target ranges of oxygen saturation in extremely preterm infants

artículo científico publicado en 2010

Temporary fetal tracheal occlusion using a gel plug in a rabbit model of congenital diaphragmatic hernia

article

Term and Preterm Infants

artículo científico publicado en 2016

The Airway Microbiome at Birth

artículo científico publicado en 2016

The Impact of Maternal Antibiotics on Neonatal Disease.

artículo científico publicado en 2018

The value of Pa(CO2) in relation to outcome in congenital diaphragmatic hernia

artículo científico publicado en 2014

Thy-1 signals through PPARγ to promote lipofibroblast differentiation in the developing lung

artículo científico publicado en 2012

Titanium oxide nanoparticle instillation induces inflammation and inhibits lung development in mice

artículo científico publicado en 2012

Transforming growth factor-beta signaling mediates hypoxia-induced pulmonary arterial remodeling and inhibition of alveolar development in newborn mouse lung

artículo científico publicado en 2008

Transforming growth factor-β regulates endothelin-1 signaling in the newborn mouse lung during hypoxia exposure

artículo científico publicado en 2012

Ureaplasma infection-mediated release of matrix metalloproteinase-9 and PGP: a novel mechanism of preterm rupture of membranes and chorioamnionitis

artículo científico publicado en 2016

Urine biomarkers predict acute kidney injury and mortality in very low birth weight infants

artículo científico publicado en 2011

Urine biomarkers predict acute kidney injury in newborns

artículo científico publicado en 2012

VARA attenuates hyperoxia-induced impaired alveolar development and lung function in newborn mice

artículo científico publicado en 2013

VENTILATORY STRATEGIES

article

Vascular Endothelial Mitochondrial Function Predicts Death or Pulmonary Outcomes in Preterm Infants.

artículo científico publicado en 2017

Ventilation Strategies

article

Ventilator Parameters

scholarly article published 1988

Ventilatory strategies in the prevention and management of bronchopulmonary dysplasia

artículo científico publicado en 2006

Vitamin A and retinoic acid act synergistically to increase lung retinyl esters during normoxia and reduce hyperoxic lung injury in newborn mice

artículo científico publicado en 2010

Vitamin A and retinoic acid combination attenuates neonatal hyperoxia-induced neurobehavioral impairment in adult mice

artículo científico publicado en 2017

Vitamin A combined with retinoic acid increases retinol uptake and lung retinyl ester formation in a synergistic manner in neonatal rats.

artículo científico publicado en 2006

Vitamin A supplementation for extremely low birth weight infants: outcome at 18 to 22 months

artículo científico publicado en 2005

iDREM: Interactive visualization of dynamic regulatory networks.

artículo científico publicado en 2018

microRNA-145 Antagonism Reverses TGF-β Inhibition of F508del CFTR Correction in Airway Epithelia.

artículo científico publicado en 2017