Lista de obras - David J. Segal - Dominio Público Uruguay

A zinc finger protein array for the visual detection of specific DNA sequences for diagnostic applications

artículo científico publicado en 2010

Active integration: new strategies for transgenesis.

artículo científico publicado en 2007

Adding fingers to an engineered zinc finger nuclease can reduce activity

artículo científico publicado en 2011

Attenuation of HIV-1 replication in primary human cells with a designed zinc finger transcription factor.

artículo científico publicado en 2004

Author Correction: Methods for Scarless, Selection-Free Generation of Human Cells and Allele-Specific Functional Analysis of Disease-Associated SNPs and Variants of Uncertain Significance.

artículo científico publicado en 2018

Bacteria herald a new era of gene editing ⬇️

artículo científico publicado el 29 de enero de 2013

Beyond the genome and into the clinic.

artículo científico publicado en 2012

Bind-n-Seq: high-throughput analysis of in vitro protein-DNA interactions using massively parallel sequencing.

artículo científico publicado en 2009

Conformational elasticity can facilitate TALE-DNA recognition

artículo científico

Custom zinc-finger nucleases for use in human cells

artículo científico publicado en 2005

DNA sequence-enabled reassembly of the green fluorescent protein

artículo científico publicado en 2005

Design, construction and in vitro testing of zinc finger nucleases

artículo científico publicado en 2006

Designing transcription factor architectures for drug discovery.

artículo científico publicado en 2004

Determinants of heritable gene silencing for KRAB-dCas9 + DNMT3 and Ezh2-dCas9 + DNMT3 hit-and-run epigenome editing

artículo científico publicado en 2022

Development of zinc finger domains for recognition of the 5'-ANN-3' family of DNA sequences and their use in the construction of artificial transcription factors

artículo científico publicado en 2001

Development of zinc finger domains for recognition of the 5'-CNN-3' family DNA sequences and their use in the construction of artificial transcription factors

artículo científico publicado en 2005

Endonuclease-induced, targeted homologous extrachromosomal recombination in Xenopus oocytes.

artículo científico publicado en 1995

Evaluation of a modular strategy for the construction of novel polydactyl zinc finger DNA-binding proteins

artículo científico publicado en 2003

Exploring the suitability of RanBP2-type Zinc Fingers for RNA-binding protein design

artículo científico publicado en 2019

Fusion proteins consisting of human immunodeficiency virus type 1 integrase and the designed polydactyl zinc finger protein E2C direct integration of viral DNA into specific sites

artículo científico publicado en 2004

Genome engineering at the dawn of the golden age.

artículo científico

Guiding the design of synthetic DNA-binding molecules with massively parallel sequencing

artículo científico publicado en 2012

Is there a telltale RH fingerprint in zinc fingers that recognizes methylated CpG dinucleotides?

artículo científico publicado en 2013

Live-Animal Epigenome Editing: Convergence of Novel Techniques

artículo científico publicado en 2019

Methods for Scarless, Selection-Free Generation of Human Cells and Allele-Specific Functional Analysis of Disease-Associated SNPs and Variants of Uncertain Significance

artículo científico publicado en 2017

Modular Assembly of RanBP2-Type Zinc Finger Domains to Target Single-Stranded RNA

artículo científico publicado en 2012

New Insights into DNA Recognition by Zinc Fingers Revealed by Structural Analysis of the Oncoprotein ZNF217

artículo científico publicado en 2013

Positron emission tomography imaging of novel AAV capsids maps rapid brain accumulation

scientific article published on 30 April 2020

Quantitative analysis of TALE-DNA interactions suggests polarity effects.

artículo científico publicado en 2013

Restricted spacer tolerance of a zinc finger nuclease with a six amino acid linker

artículo científico publicado en 2009

SRA- and SET-domain-containing proteins link RNA polymerase V occupancy to DNA methylation

artículo científico publicado en 2014

Seeing genetic and epigenetic information without DNA denaturation using sequence-enabled reassembly (SEER).

artículo científico publicado en 2010

Sequence-enabled reassembly of beta-lactamase (SEER-LAC): a sensitive method for the detection of double-stranded DNA.

artículo científico publicado en 2006

Site-directed genome modification: nucleic acid and protein modules for targeted integration and gene correction.

artículo científico publicado en 2005

Site-specific detection of DNA methylation utilizing mCpG-SEER.

artículo científico publicado en 2006

Split beta-lactamase sensor for the sequence-specific detection of DNA methylation

artículo científico publicado en 2007

Structure of Aart, a designed six-finger zinc finger peptide, bound to DNA.

artículo científico publicado en 2006

Structure-based redesign of the dimerization interface reduces the toxicity of zinc-finger nucleases

artículo científico publicado en 2007

Systematic evaluation of split-fluorescent proteins for the direct detection of native and methylated DNA.

artículo científico publicado en 2009

Targeted DNA demethylation of the Arabidopsis genome using the human TET1 catalytic domain

artículo científico publicado en 2018

The functional significance of common polymorphisms in zinc finger transcription factors

artículo científico publicado en 2014

The generation of zinc finger proteins by modular assembly.

artículo científico publicado en 2010

The prospect of molecular therapy for Angelman syndrome and other monogenic neurologic disorders

artículo científico publicado en 2014

The prospects for designer single-stranded RNA-binding proteins ⬇️

artículo científico publicado el 27 de febrero de 2011

The protein-binding potential of C2H2 zinc finger domains

artículo científico publicado en 2008

The use of zinc finger peptides to study the role of specific factor binding sites in the chromatin environment.

artículo científico publicado en 2002

Toward a general approach for RNA-templated hierarchical assembly of split-proteins

artículo científico publicado en 2010

Toward controlling gene expression at will: specific regulation of the erbB-2/HER-2 promoter by using polydactyl zinc finger proteins constructed from modular building blocks

artículo científico publicado en 1998

Translational outcomes in a full gene deletion of ubiquitin protein ligase E3A rat model of Angelman syndrome

scientific article published on 27 January 2020

Uranyl acetate as a direct inhibitor of DNA-binding proteins

artículo científico publicado en 2007

Zinc-finger nucleases transition to the CoDA ⬇️

artículo científico publicado el 1 de enero de 2011

dCas9-based epigenome editing suggests acquisition of histone methylation is not sufficient for target gene repression.

artículo científico publicado en 2017

Lista de obras de David J. Segal

A zinc finger protein array for the visual detection of specific DNA sequences for diagnostic applications

Active integration: new strategies for transgenesis.

Adding fingers to an engineered zinc finger nuclease can reduce activity

Attenuation of HIV-1 replication in primary human cells with a designed zinc finger transcription factor.

Author Correction: Methods for Scarless, Selection-Free Generation of Human Cells and Allele-Specific Functional Analysis of Disease-Associated SNPs and Variants of Uncertain Significance.

Bacteria herald a new era of gene editing ⬇️

Beyond the genome and into the clinic.

Bind-n-Seq: high-throughput analysis of in vitro protein-DNA interactions using massively parallel sequencing.

Conformational elasticity can facilitate TALE-DNA recognition

Custom zinc-finger nucleases for use in human cells

DNA sequence-enabled reassembly of the green fluorescent protein

Design, construction and in vitro testing of zinc finger nucleases

Designing transcription factor architectures for drug discovery.

Determinants of heritable gene silencing for KRAB-dCas9 + DNMT3 and Ezh2-dCas9 + DNMT3 hit-and-run epigenome editing

Development of zinc finger domains for recognition of the 5'-ANN-3' family of DNA sequences and their use in the construction of artificial transcription factors

Development of zinc finger domains for recognition of the 5'-CNN-3' family DNA sequences and their use in the construction of artificial transcription factors

Endonuclease-induced, targeted homologous extrachromosomal recombination in Xenopus oocytes.

Evaluation of a modular strategy for the construction of novel polydactyl zinc finger DNA-binding proteins

Exploring the suitability of RanBP2-type Zinc Fingers for RNA-binding protein design

Fusion proteins consisting of human immunodeficiency virus type 1 integrase and the designed polydactyl zinc finger protein E2C direct integration of viral DNA into specific sites

Genome engineering at the dawn of the golden age.

Guiding the design of synthetic DNA-binding molecules with massively parallel sequencing

Is there a telltale RH fingerprint in zinc fingers that recognizes methylated CpG dinucleotides?

Live-Animal Epigenome Editing: Convergence of Novel Techniques

Methods for Scarless, Selection-Free Generation of Human Cells and Allele-Specific Functional Analysis of Disease-Associated SNPs and Variants of Uncertain Significance

Modular Assembly of RanBP2-Type Zinc Finger Domains to Target Single-Stranded RNA

New Insights into DNA Recognition by Zinc Fingers Revealed by Structural Analysis of the Oncoprotein ZNF217

Positron emission tomography imaging of novel AAV capsids maps rapid brain accumulation

Quantitative analysis of TALE-DNA interactions suggests polarity effects.

Restricted spacer tolerance of a zinc finger nuclease with a six amino acid linker

SRA- and SET-domain-containing proteins link RNA polymerase V occupancy to DNA methylation

Seeing genetic and epigenetic information without DNA denaturation using sequence-enabled reassembly (SEER).

Sequence-enabled reassembly of beta-lactamase (SEER-LAC): a sensitive method for the detection of double-stranded DNA.

Site-directed genome modification: nucleic acid and protein modules for targeted integration and gene correction.

Site-specific detection of DNA methylation utilizing mCpG-SEER.

Split beta-lactamase sensor for the sequence-specific detection of DNA methylation

Structure of Aart, a designed six-finger zinc finger peptide, bound to DNA.

Structure-based redesign of the dimerization interface reduces the toxicity of zinc-finger nucleases

Systematic evaluation of split-fluorescent proteins for the direct detection of native and methylated DNA.

Targeted DNA demethylation of the Arabidopsis genome using the human TET1 catalytic domain

The functional significance of common polymorphisms in zinc finger transcription factors

The generation of zinc finger proteins by modular assembly.

The prospect of molecular therapy for Angelman syndrome and other monogenic neurologic disorders

The prospects for designer single-stranded RNA-binding proteins ⬇️

The protein-binding potential of C2H2 zinc finger domains

The use of zinc finger peptides to study the role of specific factor binding sites in the chromatin environment.

Toward a general approach for RNA-templated hierarchical assembly of split-proteins

Toward controlling gene expression at will: specific regulation of the erbB-2/HER-2 promoter by using polydactyl zinc finger proteins constructed from modular building blocks

Translational outcomes in a full gene deletion of ubiquitin protein ligase E3A rat model of Angelman syndrome

Uranyl acetate as a direct inhibitor of DNA-binding proteins

Zinc-finger nucleases transition to the CoDA ⬇️

dCas9-based epigenome editing suggests acquisition of histone methylation is not sufficient for target gene repression.