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Lista de obras de Patricia T. Bozza

A PPARγ AGONIST ENHANCES BACTERIAL CLEARANCE THROUGH NEUTROPHIL EXTRACELLULAR TRAP FORMATION AND IMPROVES SURVIVAL IN SEPSIS.

artículo científico publicado en 2015

A role for adrenoceptors in the regulation of pleural neutrophilia induced by LPS

article

Adipose-derived Mesenchymal Stromal Cells Modulate Lipid Metabolism and Lipid Droplet Biogenesis via AKT/mTOR -PPARγ Signalling in Macrophages

artículo científico publicado en 2019

Adrenal response in severe community-acquired pneumonia: impact on outcomes and disease severity

artículo científico publicado en 2008

Adrenergic modulation of the blood neutrophilia induced by platelet activating factor in rats

artículo científico publicado en 1994

Allergic challenge-elicited lipid bodies compartmentalize in vivo leukotriene C4 synthesis within eosinophils

artículo científico publicado en 2005

An observational clinical case of Zika virus-associated neurological disease is associated with primary IgG response and enhanced TNF levels

artículo científico publicado en 2018

Analgesic and anti-inflammatory activity of the aqueous extract of Rheedia longifolia Planch & Triana

artículo científico publicado en 2007

Anti-allergic properties of Cissampelos sympodialis and its isolated alkaloid warifteine

artículo científico publicado en 2006

Anti-allergic properties of curine, a bisbenzylisoquinoline alkaloid.

artículo científico

Anti-allergic properties of the bromeliaceae Nidularium procerum: inhibition of eosinophil activation and influx

artículo científico publicado en 2005

Anti-inflammatory activity in the aqueous crude extract of the leaves of Nidularium procerum: A bromeliaceae from the Brazilian coastal rain forest

artículo científico publicado en 2005

Anti-parasite therapy drives changes in human visceral leishmaniasis-associated inflammatory balance

artículo científico publicado en 2017

Antinociceptive effect of Nidularium procerum: a Bromeliaceae from the Brazilian coastal rain forest

artículo científico publicado en 2005

Apoptotic mimicry by an obligate intracellular parasite downregulates macrophage microbicidal activity

artículo científico publicado en 2001

Arginase I, Polyamine, and Prostaglandin E2Pathways Suppress the Inflammatory Response and Contribute to Diffuse Cutaneous Leishmaniasis

article

Arrest of oogenesis in the bug Rhodnius prolixus challenged with the fungus Aspergillus niger is mediated by immune response-derived PGE2.

artículo científico publicado en 2008

Bacterial clearance in septic mice is modulated by MCP-1/CCL2 and nitric oxide

artículo científico publicado en 2013

Bacterial clearance is improved in septic mice by platelet-activating factor-acetylhydrolase (PAF-AH) administration

artículo científico publicado en 2013

Biomarkers of sepsis: Lost in translation?*

artículo científico publicado en 2008

Breast-cancer extracellular vesicles induce platelet activation and aggregation by tissue factor-independent and -dependent mechanisms

artículo científico publicado en 2017

Cell Cycle Progression Regulates Biogenesis and Cellular Localization of Lipid Droplets

artículo científico publicado en 2019

Circulating Biomarkers of Immune Activation, Oxidative Stress and Inflammation Characterize Severe Canine Visceral Leishmaniasis

artículo científico publicado en 2016

Circulating levels of macrophage migration inhibitory factor are associated with mild pulmonary dysfunction after cardiopulmonary bypass

artículo científico publicado en 2004

Clinical and immunopathological findings during long term follow-up in Leishmania infantum experimentally infected dogs

artículo científico publicado en 2017

Co-operative signalling through DP(1) and DP(2) prostanoid receptors is required to enhance leukotriene C(4) synthesis induced by prostaglandin D(2) in eosinophils.

artículo científico publicado en 2011

Cognitive dysfunction is sustained after rescue therapy in experimental cerebral malaria, and is reduced by additive antioxidant therapy

artículo científico publicado en 2010

Combination of antiviral drugs inhibits SARS-CoV-2 polymerase and exonuclease and demonstrates COVID-19 therapeutic potential in viral cell culture

artículo científico publicado en 2022

Contribution of macrophage migration inhibitory factor to the pathogenesis of dengue virus infection

artículo científico publicado en 2009

Corrigendum: The clinically approved antiviral drug sofosbuvir inhibits Zika virus replication

artículo científico publicado en 2017

Cortisol levels and adrenal response in severe community-acquired pneumonia: a systematic review of the literature

artículo científico publicado en 2010

Culture of mouse peritoneal macrophages with mouse serum induces lipid bodies that associate with the parasitophorous vacuole and decrease their microbicidal capacity against Toxoplasma gondii

artículo científico publicado en 2014

Curine inhibits eosinophil activation and airway hyper-responsiveness in a mouse model of allergic asthma

artículo científico publicado en 2013

Curine inhibits mast cell-dependent responses in mice

artículo científico publicado en 2014

Curine, an alkaloid isolated from Chondrodendron platyphyllum inhibits prostaglandin E2 in experimental models of inflammation and pain

artículo científico publicado en 2014

Current perspectives for the use of corticosteroids in sepsis: patient selection is the key

Cutting Edge: Lipoxin (LX) A4 and Aspirin-Triggered 15-Epi-LXA4 Block Allergen-Induced Eosinophil Trafficking

artículo científico publicado en 2000

Cutting edge: prostaglandin D2 enhances leukotriene C4 synthesis by eosinophils during allergic inflammation: synergistic in vivo role of endogenous eotaxin

artículo científico publicado en 2006

Cyclosporin A inhibits colon cancer cell growth independently of the calcineurin pathway.

artículo científico publicado en 2012

Cytokine profiles as markers of disease severity in sepsis: a multiplex analysis

artículo científico publicado en 2007

Cytoplasmic lipid bodies in eosinophils: Central roles in eicosanoid generation

Cytosolic phospholipase A2-driven PGE2 synthesis within unsaturated fatty acids-induced lipid bodies of epithelial cells

artículo científico publicado en 2009

Deciphering the contribution of lipid droplets in leprosy: multifunctional organelles with roles in Mycobacterium leprae pathogenesis

artículo científico

Dengue Virus Capsid Protein Usurps Lipid Droplets for Viral Particle Formation

artículo científico publicado en 2009

Dengue virus capsid protein binding to hepatic lipid droplets (LD) is potassium ion dependent and is mediated by LD surface proteins

artículo científico publicado en 2011

Dengue virus-activated platelets modulate monocyte immunometabolic response through lipid droplet biogenesis and cytokine signaling

artículo científico publicado en 2020

Differential Expression of the Eicosanoid Pathway in Patients With Localized or Mucosal Cutaneous Leishmaniasis

artículo científico publicado en 2015

Differential Shedding and Antibody Kinetics of Zika and Chikungunya Viruses, Brazil

article

Differential TLR2 downstream signaling regulates lipid metabolism and cytokine production triggered by Mycobacterium bovis BCG infection

artículo científico publicado en 2013

Early short-term versus prolonged low-dose methylprednisolone therapy in acute lung injury

artículo científico publicado en 2008

Effectiveness of Cissampelos sympodialis and its isolated alkaloid warifteine in airway hyperreactivity and lung remodeling in a mouse model of asthma

artículo científico publicado en 2012

EicosaCell: An Imaging-Based Assay to Identify Spatiotemporal Eicosanoid Synthesis

artículo científico publicado en 2017

Eicosanoid-mediated proinflammatory activity of Pseudomonas aeruginosa ExoU.

artículo científico publicado en 2005

Emergence of the East-Central-South-African genotype of Chikungunya virus in Brazil and the city of Rio de Janeiro may have occurred years before surveillance detection

article

Eosinophil Lipid Bodies: Specific, Inducible Intracellular Sites for Enhanced Eicosanoid Formation ⬇️

artículo científico publicado el 15 de septiembre de 1997

Eosinophil recruitment and activation: the role of lipid mediators

artículo científico

Eosinophils as a novel cell source of prostaglandin D2: autocrine role in allergic inflammation.

artículo científico publicado en 2011

Exogenous platelet-activating factor acetylhydrolase reduces mortality in mice with systemic inflammatory response syndrome and sepsis

artículo científico publicado en 2006

Fat, fight, and beyond: The multiple roles of lipid droplets in infections and inflammation

artículo científico publicado en 2019

Genome sequencing reveals Zika virus diversity and spread in the Americas

artículo científico publicado en 2017

Heme-oxygenases during erythropoiesis in K562 and human bone marrow cells

artículo científico publicado en 2011

Hepatic myofibroblasts derived from Schistosoma mansoni-infected mice are a source of IL-5 and eotaxin: controls of eosinophil populations in vitro

artículo científico publicado en 2015

High Vascular Endothelial Growth Factor Levels in NZW Mice Do Not Correlate with Collagen Deposition in Allergic Asthma

artículo científico publicado en 2006

Histopathological analysis of initial cellular response in TLR-2 deficient mice experimentally infected by Leishmania (L.) amazonensis.

artículo científico publicado en 2010

Histoplasma capsulatum cell wall {beta}-glucan induces lipid body formation through CD18, TLR2, and dectin-1 receptors: correlation with leukotriene B4 generation and role in HIV-1 infection

artículo científico publicado en 2009

Homologous tachyphylaxis to bradykinin and its interference with allergic pleurisy in actively sensitized rats

article

Host cell lipid bodies triggered by Trypanosoma cruzi infection and enhanced by the uptake of apoptotic cells are associated with prostaglandin E₂ generation and increased parasite growth

artículo científico publicado en 2011

IL-5 accounts for the mouse pleural eosinophil accumulation triggered by antigen but not by LPS.

artículo científico publicado en 1994

Identifying intracellular sites of eicosanoid lipid mediator synthesis with EicosaCell assays

artículo científico publicado en 2011

Immunization of Experimental Dogs With Salivary Proteins From , Using DNA and Recombinant Canarypox Virus Induces Immune Responses Consistent With Protection Against

article

In vitro and in vivo responses of murine granulocytes to human complement-derived, haemolytically inactive C5b67 (iC5b67)

article

In vivo and in vitro antimalarial effect and toxicological evaluation of the chloroquine analogue PQUI08001/06

IncreasedLeishmaniaReplication in HIV‐1–Infected Macrophages Is Mediated by Tat Protein through Cyclooxygenase‐2 Expression and Prostaglandin E2Synthesis

article

Induction of autophagy correlates with increased parasite load of Leishmania amazonensis in BALB/c but not C57BL/6 macrophages

artículo científico publicado en 2008

Infection by HTLV-1 Is Associated With High Levels of Proinflammatory Cytokines in HIV-HCV-Coinfected Patients

artículo científico publicado en 2017

Inflammatory response and bacterial dissemination after laparotomy and abdominal CO2 insufflation in a murine model of peritonitis

artículo científico publicado en 2006

Influence of murine Toxocara canis infection on plasma and bronchoalveolar lavage fluid eosinophil numbers and its correlation with cytokine levels

artículo científico publicado en 2005

Integrin αDβ2 (CD11d/CD18) Modulates Leukocyte Accumulation, Pathogen Clearance, and Pyroptosis in Experimental Salmonella Typhimurium Infection

artículo científico publicado en 2018

Integrin αDβ2 (CD11d/CD18) mediates experimental malaria-associated acute respiratory distress syndrome (MA-ARDS).

artículo científico publicado en 2016

Interaction of Macrophages with Apoptotic Cells Enhances HIV Type 1 Replication Through PGE2, PAF, and Vitronectin Receptor

article

Intererence of the PAF receptor antagonist, PCA 4248, with the rat pleurisy evoked by inflammatory mediators or allergen

artículo científico publicado en 1993

Interplay of cysteinyl leukotrienes and TGF-β in the activation of hepatic stellate cells from Schistosoma mansoni granulomas

artículo científico publicado en 2010

Intravenous glutamine decreases lung and distal organ injury in an experimental model of abdominal sepsis

artículo científico publicado en 2009

Involvement of TLR6 in the induction of COX-2, PGE 2 and IL-10 in macrophages by lipids from virulent S2P and attenuated R1A Babesia bovis strains

artículo científico publicado en 2016

Leishmania infantum lipophosphoglycan induced-Prostaglandin E2 production in association with PPAR-γ expression via activation of Toll like receptors-1 and 2.

artículo científico publicado en 2017

Leprosy and its reactional episodes: Serum levels and possible roles of omega-3 and omega-6-derived lipid mediators

artículo científico publicado en 2018

Leptin Elicits LTC Synthesis by Eosinophils Mediated by Sequential Two-Step Autocrine Activation of CCR3 and PGD Receptors

article by Natália R T Amorim et al published 2018 in Frontiers in Immunology

Leptin Mediates In Vivo Neutrophil Migration: Involvement of Tumor Necrosis Factor-Alpha and CXCL1.

artículo científico publicado en 2018

Leptin activation of mTOR pathway in intestinal epithelial cell triggers lipid droplet formation, cytokine production and increased cell proliferation.

artículo científico publicado en 2015

Leptin induces macrophage lipid body formation by a phosphatidylinositol 3-kinase- and mammalian target of rapamycin-dependent mechanism

artículo científico publicado en 2007

Leukocyte lipid bodies - Biogenesis and functions in inflammation

artículo científico publicado en 2009

Leukocyte lipid bodies regulation and function: contribution to allergy and host defense

artículo científico publicado en 2006

Lipid Body Organelles within the Parasite Trypanosoma cruzi: A Role for Intracellular Arachidonic Acid Metabolism

artículo científico publicado en 2016

Lipid Droplet, a Key Player in Host-Parasite Interactions

artículo científico publicado en 2018

Lipid bodies accumulation in Leishmania infantum-infected C57BL/6 macrophages

artículo científico publicado en 2017

Lipid bodies are reservoirs of cyclooxygenase-2 and sites of prostaglandin-E2 synthesis in colon cancer cells

artículo científico publicado en 2008

Lipid bodies in inflammatory cells: structure, function, and current imaging techniques.

artículo científico publicado en 2011

Lipid bodies in innate immune response to bacterial and parasite infections

artículo científico publicado en 2008

Lipid bodies in oxidized LDL-induced foam cells are leukotriene-synthesizing organelles: a MCP-1/CCL2 regulated phenomenon.

artículo científico publicado en 2009

Lipid body function in eicosanoid synthesis: an update

artículo científico publicado en 2011

Lipid body mobilization in the ExoU-induced release of inflammatory mediators by airway epithelial cells

artículo científico publicado en 2008

Lipid droplet formation in leprosy: Toll-like receptor-regulated organelles involved in eicosanoid formation and Mycobacterium leprae pathogenesis

artículo científico publicado en 2009

Lipid droplets fuel SARS-CoV-2 replication and production of inflammatory mediators

artículo científico publicado en 2020

Lipid droplets in host–pathogen interactions

Lipid droplets in inflammation and cancer.

artículo científico publicado en 2010

Lipid droplets: platforms with multiple functions in cancer hallmarks

artículo científico publicado en 2020

Lipids From Trypanosoma cruzi Amastigotes of RA and K98 Strains Generate a Pro-inflammatory Response via TLR2/6.

artículo científico publicado en 2018

Lipids from attenuated and virulent Babesia bovis strains induce differential TLR2-mediated macrophage activation.

artículo científico publicado en 2009

Lipopolysaccharide-induced pleural neutrophil accumulation depends on marrow neutrophils and platelet-activating factor

artículo científico publicado en 1994

Lutzomyia longipalpis saliva drives apoptosis and enhances parasite burden in neutrophils

artículo científico publicado en 2011

Lutzomyia longipalpis saliva triggers lipid body formation and prostaglandin E₂ production in murine macrophages

artículo científico publicado en 2010

Lysophosphatidylcholine triggers TLR2- and TLR4-mediated signaling pathways but counteracts LPS-induced NO synthesis in peritoneal macrophages by inhibiting NF-κB translocation and MAPK/ERK phosphorylation

artículo científico publicado en 2013

Macrophage lipid body induction by Chagas disease in vivo: putative intracellular domains for eicosanoid formation during infection.

artículo científico publicado en 2003

Mammalian lipid droplets are innate immune hubs integrating cell metabolism and host defense

scientific article published on 01 October 2020

Mechanisms of increased survival after lipopolysaccharide-induced endotoxic shock in mice consuming olive oil-enriched diet

artículo científico publicado en 2005

Metabonomics reveals drastic changes in anti-inflammatory/pro-resolving polyunsaturated fatty acids-derived lipid mediators in leprosy disease

artículo científico publicado en 2013

Methylprednisolone improves lung mechanics and reduces the inflammatory response in pulmonary but not in extrapulmonary mild acute lung injury in mice

artículo científico publicado en 2008

Modulation of lipid droplets by Mycobacterium leprae in Schwann cells: a putative mechanism for host lipid acquisition and bacterial survival in phagosomes.

artículo científico publicado en 2010

Multiplex cytokine profile from dengue patients: MIP-1beta and IFN-gamma as predictive factors for severity

artículo científico publicado en 2008

Murine lung injury caused by Leptospira interrogans glycolipoprotein, a specific Na/K-ATPase inhibitor.

artículo científico publicado en 2014

Mycobacterium bovis bacillus Calmette-Guérin infection induces TLR2-dependent peroxisome proliferator-activated receptor gamma expression and activation: functions in inflammation, lipid metabolism, and pathogenesis.

artículo científico publicado en 2009

Mycobacterium leprae intracellular survival relies on cholesterol accumulation in infected macrophages: a potential target for new drugs for leprosy treatment

artículo científico publicado en 2014

NS-398: cyclooxygenase-2 independent inhibition of leukocyte priming for lipid body formation and enhanced leukotriene generation

artículo científico publicado en 2002

Neutrophils increase or reduce parasite burden in Trypanosoma cruzi-infected macrophages, depending on host strain: role of neutrophil elastase

artículo científico publicado en 2014

Neutrophils recruited to the site of Mycobacterium bovis BCG infection undergo apoptosis and modulate lipid body biogenesis and prostaglandin E production by macrophages.

artículo científico publicado en 2008

Oleic acid induces lung injury in mice through activation of the ERK pathway

artículo científico publicado en 2012

Oleic acid inhibits lung Na/K-ATPase in mice and induces injury with lipid body formation in leukocytes and eicosanoid production

artículo científico publicado en 2013

Omega-9 Oleic Acid Induces Fatty Acid Oxidation and Decreases Organ Dysfunction and Mortality in Experimental Sepsis

artículo científico publicado en 2016

Omega-9 Oleic Acid, the Main Compound of Olive Oil, Mitigates Inflammation during Experimental Sepsis

artículo científico publicado en 2018

Outer membrane vesicles (OMVs) and detoxified lipooligosaccharide (dLOS) obtained from Brazilian prevalent N. meningitidis serogroup B strains protect mice against homologous and heterologous meningococcal infection and septic shock

artículo científico publicado en 2004

PGL I expression in live bacteria allows activation of a CD206/PPARγ cross-talk that may contribute to successful Mycobacterium leprae colonization of peripheral nerves

artículo científico publicado en 2018

PPAR gamma activation protects the brain against microvascular dysfunction in sepsis

artículo científico publicado en 2012

PPARγ Expression and Function in Mycobacterial Infection: Roles in Lipid Metabolism, Immunity, and Bacterial Killing

artículo científico publicado en 2012

Paradise revealed: first-class science rocked by the sound of the waves

artículo científico publicado en 2010

Patterns of c-reactive protein RATIO response in severe community-acquired pneumonia: a cohort study

artículo científico publicado en 2012

Peripheral leptin signaling persists in innate immune cells during diet-induced obesity

artículo científico publicado en 2020

Persistent platelet activation and apoptosis in virologically suppressed HIV-infected individuals

artículo científico publicado en 2018

Pharmacological modulation of Paf-induced rat pleurisy and its role in inflammation by zymosan

artículo científico publicado en 1989

Pharmacological modulation of lipopolysaccharide-induced pleural eosinophilia in the rat; a role for a newly generated protein

artículo científico publicado en 1993

Phenolic constituents from Wissadula periplocifolia (L.) C. Presl. and anti-inflammatory activity of 7,4'-di-O-methylisoscutellarein

artículo científico publicado en 2015

Platelet activation and apoptosis modulate monocyte inflammatory responses in dengue

artículo científico publicado en 2014

Platelet proteome reveals novel pathways of platelet activation and platelet-mediated immunoregulation in dengue

artículo científico publicado en 2017

Platelet-monocyte interaction amplifies thromboinflammation through tissue factor signaling in COVID-19

artículo científico publicado en 2022

Platelets mediate increased endothelium permeability in dengue through NLRP3-inflammasome activation

artículo científico publicado en 2013

Pro-inflammatory activity of enterolobin: A haemolytic protein purified from seeds of the Brazilian tree Enterolobium contortisiliquum

article

Prostaglandin E2/leukotriene B4 balance induced by Lutzomyia longipalpis saliva favors Leishmania infantum infection

artículo científico publicado en 2014

Pulmonary and extrapulmonary acute lung injury: inflammatory and ultrastructural analyses

artículo científico publicado en 2005

Rapid antigen tests for dengue virus serotypes and Zika virus in patient serum.

artículo científico publicado en 2017

Reduced plasma nonesterified fatty acid levels and the advent of an acute lung injury in mice after intravenous or enteral oleic acid administration

artículo científico publicado en 2012

Resolvin D1 drives establishment of Leishmania amazonensis infection

artículo científico publicado en 2017

Role of prostaglandin F2α production in lipid bodies from Leishmania infantum chagasi: insights on virulence.

artículo científico publicado en 2014

Schistosomal Lipids Activate Human Eosinophils via Toll-Like Receptor 2 and PGD Receptors: 15-LO Role in Cytokine Secretion

artículo científico publicado en 2018

Schistosomal-derived lysophosphatidylcholine triggers M2 polarization of macrophages through PPARγ dependent mechanisms.

artículo científico publicado en 2016

Schistosome infection-derived Hepatic Stellate Cells are cellular source of prostaglandin D₂: role in TGF-β-stimulated VEGF production

artículo científico publicado en 2015

Sofosbuvir protects Zika virus-infected mice from mortality, preventing short- and long-term sequelae

artículo científico publicado en 2017

Statins decrease neuroinflammation and prevent cognitive impairment after cerebral malaria

artículo científico publicado en 2012

TLR6-driven lipid droplets in Mycobacterium leprae-infected Schwann cells: immunoinflammatory platforms associated with bacterial persistence

artículo científico publicado en 2011

The cellular biology of eosinophil eicosanoid formation and function

artículo científico publicado en 2002

The clinically approved antiviral drug sofosbuvir impairs Brazilian zika virus replication

artículo científico publicado en 2016

The disordered N-terminal region of dengue virus capsid protein contains a lipid-droplet-binding motif

artículo científico publicado en 2012

The effect of thiamine deficiency on inflammation, oxidative stress and cellular migration in an experimental model of sepsis

artículo científico publicado en 2014

The impact of coagulation parameters on the outcomes of patients with severe community-acquired pneumonia requiring intensive care unit admission ⬇️

artículo científico publicado el 30 de marzo de 2011

The innate immune response in HIV/AIDS septic shock patients: a comparative study

artículo científico publicado en 2013

The role of corticosteroids in severe community-acquired pneumonia: a systematic review

scientific article published on 11 June 2008

The role of corticosteroids in severe community-acquired pneumonia: a systematic review

artículo científico publicado en 2008

The role of forced swim test on neutrophil leukocytosis observed during inflammation induced by LPS in rodents

artículo científico publicado en 2002

Time course of pulmonary burden in mice exposed to residual oil fly ash

artículo científico publicado en 2014

Toll-like receptor-2-mediated C-C chemokine receptor 3 and eotaxin-driven eosinophil influx induced by Mycobacterium bovis BCG pleurisy

artículo científico publicado en 2006

Toxoplasma gondii-skeletal muscle cells interaction increases lipid droplet biogenesis and positively modulates the production of IL-12, IFN-g and PGE2.

artículo científico publicado en 2014

Turnover of Neutrophils Mediated by Fas Ligand Drives Leishmania major Infection

artículo científico publicado en 2005

Two-dimensional difference gel electrophoresis (DiGE) analysis of plasmas from dengue fever patients

artículo científico publicado en 2009

Understanding the mechanisms controlling Leishmania amazonensis infection in vitro: the role of LTB4 derived from human neutrophils

artículo científico publicado en 2014

WASP deficiency leads to global defects of directed leukocyte migration in vitro and in vivo

artículo científico publicado en 2005

Yangambin: A New Naturally-Occurring Platelet-Activating Factor Receptor Antagonist: Binding andIn VitroFunctional Studies

Yangambin: a new naturally-occurring platelet-activating factor receptor antagonist: in vivo pharmacological studies.

artículo científico publicado en 1995

Yellow fever virus is susceptible to sofosbuvir both in vitro and in vivo

artículo científico publicado en 2019

Zika virus evolution and spread in the Americas

artículo científico publicado en 2017

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