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Lista de obras de Michel Bouvier

A Perspective on Studying G-Protein-Coupled Receptor Signaling with Resonance Energy Transfer Biosensors in Living Organisms

artículo científico publicado en 2015

A Pluridimensional View of Biased Agonism

artículo científico publicado en 2016

A biosensor to monitor dynamic regulation and function of tumour suppressor PTEN in living cells

artículo científico publicado en 2014

A cyclic peptide mimicking the third intracellular loop of the V2 vasopressin receptor inhibits signaling through its interaction with receptor dimer and G protein

scientific journal article

A human immunodeficiency virus type 1 protease biosensor assay using bioluminescence resonance energy transfer

artículo científico publicado en 2005

A new inhibitor of the β-arrestin/AP2 endocytic complex reveals interplay between GPCR internalization and signalling

artículo científico publicado en 2017

A novel biased allosteric compound inhibitor of parturition selectively impedes the prostaglandin F2alpha-mediated Rho/ROCK signaling pathway

artículo científico publicado en 2010

A peptide derived from a beta2-adrenergic receptor transmembrane domain inhibits both receptor dimerization and activation.

artículo científico publicado en 1996

A synthetic biology approach reveals a CXCR4-G13-Rho signaling axis driving transendothelial migration of metastatic breast cancer cells

artículo científico publicado en 2011

Abnormal regulation of the sympathoadrenal system in deoxycorticosterone acetate – salt hypertensive rats

article

Activation of the beta(2)-adrenergic receptor-Galpha(s) complex leads to rapid depalmitoylation and inhibition of repalmitoylation of both the receptor and Galpha(s).

artículo científico publicado en 1999

Activity of the interferon-induced 2',5'-oligoadenylate synthetase in patients with chronic hepatitis C.

artículo científico publicado en 1995

Adenosine A2A-dopamine D2 receptor-receptor heteromerization: qualitative and quantitative assessment by fluorescence and bioluminescence energy transfer

artículo científico publicado en 2003

Adenosine A2A-dopamine D2 receptor-receptor heteromers. Targets for neuro-psychiatric disorders

artículo científico publicado en 2004

Agonist stimulation increases the turnover rate of beta 2AR-bound palmitate and promotes receptor depalmitoylation

artículo científico publicado en 1996

Agonist-biased signaling via proteinase activated receptor-2: differential activation of calcium and mitogen-activated protein kinase pathways.

artículo científico publicado en 2009

Agonist-induced formation of unproductive receptor-G12 complexes

artículo científico publicado en 2020

Agonist-promoted internalization of a ternary complex between calcitonin receptor-like receptor, receptor activity-modifying protein 1 (RAMP1), and beta-arrestin

scientific article (publication date: 9 November 2001)

An aplysia dopamine1-like receptor: molecular and functional characterization

artículo científico publicado en 2005

An evolutionarily conserved autoinhibitory molecular switch in ELMO proteins regulates Rac signaling

artículo científico publicado en 2010

An interview with Michel Bouvier, Ph.D. Interview by Vicki Glaser

artículo científico publicado en 2006

Ang-(1-7) is an endogenous β-arrestin-biased agonist of the AT1 receptor with protective action in cardiac hypertrophy

artículo científico publicado en 2017

Apelin protects against abdominal aortic aneurysm and the therapeutic role of neutral endopeptidase resistant apelin analogs

artículo científico publicado en 2019

Appréhender la complexité du vivant à l’ère des « Omiques »

Assembly and signaling of CRLR and RAMP1 complexes assessed by BRET.

artículo científico publicado en 2007

Association of Treatment with Carvedilol, Bisoprolol and Metoprolol on the Risk of Mortality and Hospital Admission Among Older Adults with Heart Failure

Association of calnexin with wild type and mutant AVPR2 that causes nephrogenic diabetes insipidus.

artículo científico publicado en 2001

Author Correction: Exploring use of unsupervised clustering to associate signaling profiles of GPCR ligands to clinical response

scientific article published on 16 April 2020

BRET analysis of GPCR oligomerization: newer does not mean better

artículo científico publicado en 2007

Beta 1/beta 2-adrenergic receptor heterodimerization regulates beta 2-adrenergic receptor internalization and ERK signaling efficacy

artículo científico publicado en 2002

Beta(2)-adrenergic receptor down-regulation. Evidence for a pathway that does not require endocytosis.

artículo científico publicado en 1999

Beta-arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors

artículo científico publicado en 2003

Biased signaling favoring gi over β-arrestin promoted by an apelin fragment lacking the C-terminal phenylalanine

artículo científico publicado en 2014

Biochemical and biophysical demonstration of GPCR oligomerization in mammalian cells

artículo científico publicado en 2001

Biochemical characterization of beta2-adrenergic receptor dimers and oligomers

artículo científico publicado en 2003

Bioinactive ACTH causing glucocorticoid deficiency

artículo científico publicado en 2013

Bioluminescence resonance energy transfer assays reveal ligand-specific conformational changes within preformed signaling complexes containing delta-opioid receptors and heterotrimeric G proteins.

artículo científico publicado en 2008

Bioluminescence resonance energy transfer reveals ligand-induced conformational changes in CXCR4 homo- and heterodimers.

artículo científico publicado en 2005

Bioluminescence resonance energy transfer-based biosensors allow monitoring of ligand- and transducer-mediated GPCR conformational changes

scientific article published on 07 August 2018

Bioluminescence resonance energy transfer-based imaging of protein-protein interactions in living cells

scientific article published on 25 March 2019

Blockade of protease-activated receptor-4 (PAR4) provides robust antithrombotic activity with low bleeding

artículo científico publicado en 2017

Bradykinin decreases T-kininogen synthesis in a rat hepatoma cell line: evidence of bradykinin B2-type receptors

artículo científico publicado en 1996

Building a new conceptual framework for receptor heteromers

artículo científico publicado en 2009

CNIH4 interacts with newly synthesized GPCR and controls their export from the endoplasmic reticulum

artículo científico publicado en 2014

Ca(2+)-dependent sensitization of adenylyl cyclase activity

artículo científico publicado en 2001

Calcitonin gene-related peptide analogues with aza and indolizidinone amino acid residues reveal conformational requirements for antagonist activity at the human calcitonin gene-related peptide 1 receptor

artículo científico publicado en 2007

Cardiac adrenergic receptor effects of carvedilol

artículo científico publicado en 1996

Cardiomyocytes β-adrenergic receptors are resistants to short-term desensitization

Cellular and subcellular context determine outputs from signaling biosensors ⬇️

artículo científico publicado en 2016

Chapter 3 Receptor regulation

Characterization of oligomeric human ATP binding cassette transporter A1. Potential implications for determining the structure of nascent high density lipoprotein particles

artículo científico publicado en 2004

Characterization of the vasorelaxant activity of tyramine and other phenylethylamines in rat aorta

artículo científico publicado en 1995

Characterization, expression, and hormonal control of a thymic beta 2-adrenergic receptor

scientific journal article

Chemogenetics defines receptor-mediated functions of short chain free fatty acids

artículo científico publicado en 2019

Cholesterol-dependent separation of the beta2-adrenergic receptor from its partners determines signaling efficacy: insight into nanoscale organization of signal transduction

artículo científico publicado en 2008

Chronic β-blockade increases skeletal muscle β-adrenergicreceptor density and enhances contractile force

Combining resonance energy transfer methods reveals a complex between the alpha2A-adrenergic receptor, Galphai1beta1gamma2, and GRK2.

artículo científico publicado en 2010

Comparative analyses of downstream signal transduction targets modulated after activation of the AT1 receptor by two β-arrestin-biased agonists.

artículo científico publicado en 2015

Comparative binding study of rat natriuretic peptide receptor-A.

artículo científico publicado en 1999

Computational design of orthogonal membrane receptor-effector switches for rewiring signaling pathways

article published in the Proceedings of the National Academy of Sciences of the United States of America

Conformational dynamics of Kir3.1/Kir3.2 channel activation via δ-opioid receptors

artículo científico publicado en 2012

Conformational rearrangements and signaling cascades involved in ligand-biased mitogen-activated protein kinase signaling through the beta1-adrenergic receptor.

artículo científico publicado en 2008

Constitutive Agonist-independent CCR5 Oligomerization and Antibody-mediated Clustering Occurring at Physiological Levels of Receptors

artículo científico publicado en 2002

Contribution of Kv1.2 voltage-gated potassium channel to D2 autoreceptor regulation of axonal dopamine overflow

scientific journal article

Coordinated action of NSF and PKC regulates GABAB receptor signaling efficacy

artículo científico publicado en 2006

Cross-talk between cellular signalling pathways suggested by phorbol-ester-induced adenylate cyclase phosphorylation

artículo científico publicado en 1987

CrossTalk proposal: Weighing the evidence for Class A GPCR dimers, the evidence favours dimers

article

Cys-27 variant of human δ-opioid receptor modulates maturation and cell surface delivery of Phe-27 variant via heteromerization

artículo científico publicado en 2012

Desensitization, phosphorylation and palmitoylation of the human dopamine D1 receptor

artículo científico publicado en 1994

Detection of beta 2-adrenergic receptor dimerization in living cells using bioluminescence resonance energy transfer (BRET)

artículo científico publicado en 2000

Determination of protein-bound palmitate turnover rates using a three-compartment model that formally incorporates [3H]palmitate recycling

artículo científico publicado en 2004

Development and characterization of pepducins as Gs-biased allosteric agonists

artículo científico publicado en 2014

Differential β-arrestin-dependent conformational signaling and cellular responses revealed by angiotensin analogs

artículo científico publicado en 2012

Dimerization: an emerging concept for G protein-coupled receptor ontogeny and function

artículo científico publicado en 2002

Discovery of G Protein-Biased Dopaminergics with a Pyrazolo[1,5-a]pyridine Substructure

artículo científico publicado en 2017

Discovery of Potent Protease-Activated Receptor 4 Antagonists with in Vivo Antithrombotic Efficacy

scientific article published on 05 August 2019

Distinct conformations of GPCR-β-arrestin complexes mediate desensitization, signaling, and endocytosis

artículo científico publicado en 2017

Distinct motifs of neuropeptide Y receptors differentially regulate trafficking and desensitization

artículo científico publicado en 2007

Distinct receptor domains determine subtype-specific coupling and desensitization phenotypes for human beta1- and beta2-adrenergic receptors

article

Distinct signaling profiles of beta1 and beta2 adrenergic receptor ligands toward adenylyl cyclase and mitogen-activated protein kinase reveals the pluridimensionality of efficacy

artículo científico publicado en 2006

Distinct subcellular localization for constitutive and agonist-modulated palmitoylation of the human delta opioid receptor

artículo científico publicado en 2006

Diverse activation pathways in class A GPCRs converge near the G-protein-coupling region

artículo científico publicado en 2016

Dynamic palmitoylation of G-protein-coupled receptors in eukaryotic cells.

artículo científico

Dynamic regulation of G-protein coupled receptor palmitoylation: potential role in receptor function.

artículo científico publicado en 1995

Dysfunction of the beta- and alpha-adrenergic systems in a model of congestive heart failure. The pacing-overdrive dog.

artículo científico publicado en 1991

Effects of acute and chronic administration of sotalol on the blood pressure and the sympathoadrenal activity of anesthetized deoxycorticosterone acetate – salt hypertensive rats

article

Effects of trandolapril on the sympathetic tone and reactivity in systemic hypertension

article

Emerging Paradigm of Intracellular Targeting of G Protein-Coupled Receptors.

artículo científico publicado en 2018

Emerging role of homo- and heterodimerization in G-protein-coupled receptor biosynthesis and maturation

artículo científico publicado en 2005

Engagement of β-arrestin by transactivated insulin-like growth factor receptor is needed for V2 vasopressin receptor-stimulated ERK1/2 activation

artículo científico publicado en 2012

Enhanced sympathoadrenal reactivity to haemorrhagic stress in DOCA-salt hypertensive rats

Espoirs et défis en recherche biomédicale

Evolutionary action and structural basis of the allosteric switch controlling β2AR functional selectivity.

artículo científico publicado en 2017

Exploring use of unsupervised clustering to associate signaling profiles of GPCR ligands to clinical response

artículo científico publicado en 2019

Export from the endoplasmic reticulum represents the limiting step in the maturation and cell surface expression of the human delta opioid receptor

scientific journal article

Expression of G protein-coupled receptor kinase 4 is associated with breast cancer tumourigenesis

artículo científico publicado en 2008

Expression of a human cDNA encoding the beta 2-adrenergic receptor in Chinese hamster fibroblasts (CHW): functionality and regulation of the expressed receptors.

artículo científico publicado en 1988

Expression, regulation, and activity of ABCA1 in human cell lines

artículo científico publicado en 2003

FZD5 is a Gαq-coupled receptor that exhibits the functional hallmarks of prototypical GPCRs

scientific article published on 04 December 2018

Free and Conjugated Catecholamines in Plasma and Red Blood Cells of Normotensive and Hypertensive Patients

article by J de Champlain et al published January 1984 in Clinical and Experimental Hypertension

Functional New World monkey oxytocin forms elicit an altered signaling profile and promotes parental care in rats.

artículo científico

Functional calcitonin gene-related peptide receptors are formed by the asymmetric assembly of a calcitonin receptor-like receptor homo-oligomer and a monomer of receptor activity-modifying protein-1

artículo científico publicado en 2007

Functional characterization of a novel serotonin receptor (5-HTap2) expressed in the CNS of Aplysia californica

artículo científico publicado en 2002

Functional characterization of vasopressin type 2 receptor substitutions (R137H/C/L) leading to nephrogenic diabetes insipidus and nephrogenic syndrome of inappropriate antidiuresis: implications for treatments

artículo científico publicado en 2010

Functional effects of long-term activation on human beta 2- and beta 3-adrenoceptor signalling

artículo científico publicado en 1995

Functional rescue of a constitutively desensitized beta2AR through receptor dimerization.

artículo científico publicado en 1998

Functional rescue of beta-adrenoceptor dimerization and trafficking by pharmacological chaperones

artículo científico publicado en 2009

Functional rescue of the constitutively internalized V2 vasopressin receptor mutant R137H by the pharmacological chaperone action of SR49059.

artículo científico publicado en 2004

Functional selective oxytocin-derived agonists discriminate between individual G protein family subtypes

artículo científico publicado en 2011

Functional selectivity of natural and synthetic prostaglandin EP4 receptor ligands.

artículo científico publicado en 2009

Functional selectivity profiling of the angiotensin II type 1 receptor using pathway-wide BRET signaling sensors

artículo científico publicado en 2018

Functional significance of oligomerization of G-protein-coupled receptors.

artículo científico publicado en 2000

G protein-coupled receptor modulation with pepducins: moving closer to the clinic

artículo científico publicado en 2011

G protein-coupled receptors form stable complexes with inwardly rectifying potassium channels and adenylyl cyclase

artículo científico publicado en 2002

G-protein coupling specificity of the human oxytocin receptor

GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling

artículo científico publicado en 2016

GPCR-OKB: the G Protein Coupled Receptor Oligomer Knowledge Base.

artículo científico publicado en 2010

Glycoprotein hormone receptors: link between receptor homodimerization and negative cooperativity

artículo científico publicado en 2005

Hetero-oligomerization between beta2- and beta3-adrenergic receptors generates a beta-adrenergic signaling unit with distinct functional properties

artículo científico publicado en 2004

Heterodimerization of V1a and V2 vasopressin receptors determines the interaction with beta-arrestin and their trafficking patterns

artículo científico publicado en 2004

Heterodimerization of beta1- and beta2-adrenergic receptor subtypes optimizes beta-adrenergic modulation of cardiac contractility

artículo científico publicado en 2005

Heterotrimeric G proteins form stable complexes with adenylyl cyclase and Kir3.1 channels in living cells.

artículo científico publicado en 2006

High-throughput screening of G protein-coupled receptor antagonists using a bioluminescence resonance energy transfer 1-based beta-arrestin2 recruitment assay

artículo científico publicado en 2005

Homo- and hetero-oligomerization of beta-arrestins in living cells

artículo científico publicado en 2005

Homodimerization of adenosine A2A receptors: qualitative and quantitative assessment by fluorescence and bioluminescence energy transfer

artículo científico publicado en 2004

Homodimerization of the beta2-adrenergic receptor as a prerequisite for cell surface targeting

artículo científico publicado en 2004

Hybridization of β-Adrenergic Agonists and Antagonists Confers G Protein Bias

article

Identification and characterization of an activating F229V substitution in the V2 vasopressin receptor in an infant with NSIAD.

artículo científico publicado en 2012

Impedance responses reveal β₂-adrenergic receptor signaling pluridimensionality and allow classification of ligands with distinct signaling profiles

artículo científico publicado en 2012

Increased apparent norepinephrine release rate in anesthetized DOCA-salt hypertensive rats

artículo científico publicado en 1985

Increased basal and reactive plasma norepinephrine and epinephrine levels in awake DOCA-salt hypertensive rats

scientific article published on 01 February 1986

Increased pressure on G protein-coupled receptor kinases

artículo científico publicado en 1997

Increased production of active human beta(2)-adrenergic/G(alphas) fusion receptor in Sf-9 cells using nutrient limiting conditions

artículo científico publicado en 2001

Increased sympatho-adrenal tone and adrenal medulla reactivity in DOCA-salt hypertensive rats

artículo científico publicado en 1986

Influence of receptor density on the patterns of beta2-adrenocepter desensitization

artículo científico publicado en 1997

Inhibitors that stabilize a closed RAF kinase domain conformation induce dimerization

artículo científico publicado en 2013

Insights into signaling from the β2-adrenergic receptor structure

International Union of Basic and Clinical Pharmacology. LXVII. Recommendations for the recognition and nomenclature of G protein-coupled receptor heteromultimers.

artículo científico publicado en 2007

Inverse agonist activity of beta-adrenergic antagonists.

artículo científico publicado en 1994

KCTD Hetero-oligomers Confer Unique Kinetic Properties on Hippocampal GABAB Receptor-Induced K+ Currents

artículo científico publicado en 2016

La recherche académique

Les années 2000

Les années 2010

Ligand bias prevents class equality among beta-blockers.

artículo científico

Ligand functional selectivity and quantitative pharmacology at G protein-coupled receptors

artículo científico

Ligands act as pharmacological chaperones and increase the efficiency of delta opioid receptor maturation

artículo científico publicado en 2002

Manifold roles of β-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9

scientific article published on 25 September 2018

Mapping GPR88-Venus illuminates a novel role for GPR88 in sensory processing.

artículo científico publicado en 2017

Mapping physiological G protein-coupled receptor signaling pathways reveals a role for receptor phosphorylation in airway contraction

artículo científico publicado en 2016

Mapping the putative G protein-coupled receptor (GPCR) docking site on GPCR kinase 2: insights from intact cell phosphorylation and recruitment assays

artículo científico publicado en 2014

Mechanisms involved in adrenergic receptor desensitization.

artículo científico publicado en 1990

Metaphors, naming and new signaling paradigms by G-protein-coupled receptors

artículo científico publicado en 2012

Methods to monitor the quaternary structure of G protein-coupled receptors

artículo científico publicado en 2005

Molecular Biology of Adrenergic Receptors

artículo científico publicado en 1988

Molecular and cellular physiology of apolipoprotein A-I lipidation by the ATP-binding cassette transporter A1 (ABCA1).

artículo científico publicado en 2003

Molecular determinants of ligand efficacy and potency in GPCR signaling

artículo científico publicado en 2023

Monitoring G protein-coupled receptor and β-arrestin trafficking in live cells using enhanced bystander BRET

artículo científico publicado en 2016

Monitoring agonist-promoted conformational changes of beta-arrestin in living cells by intramolecular BRET.

artículo científico publicado en 2005

Monitoring ligand-dependent assembly of receptor ternary complexes in live cells by BRETFect

article published in the Proceedings of the National Academy of Sciences of the United States of America

Monitoring of ligand-independent dimerization and ligand-induced conformational changes of melatonin receptors in living cells by bioluminescence resonance energy transfer

artículo científico publicado en 2002

Monitoring protein-protein interactions in living cells by bioluminescence resonance energy transfer (BRET).

artículo científico publicado en 2006

Multimerization of Staufen1 in live cells

artículo científico publicado en 2010

Multiplexing of multicolor bioluminescence resonance energy transfer

artículo científico publicado en 2010

Mutant Frizzled 4 associated with vitreoretinopathy traps wild-type Frizzled in the endoplasmic reticulum by oligomerization

artículo científico publicado en 2004

Mutation of tyrosine-141 inhibits insulin-promoted tyrosine phosphorylation and increased responsiveness of the human beta 2-adrenergic receptor.

artículo científico publicado en 1995

Mutation of tyrosine-350 impairs the coupling of the beta 2-adrenergic receptor to the stimulatory guanine nucleotide binding protein without interfering with receptor down-regulation

artículo científico publicado en 1993

Médecine/Scienceset les passerelles du temps

N-Glycan-dependent and -independent quality control of human δ opioid receptor N-terminal variants

artículo científico publicado en 2014

Neutrophil elastase acts as a biased agonist for proteinase-activated receptor-2 (PAR2)

artículo científico publicado en 2011

New molecular and structural determinants involved in beta 2-adrenergic receptor desensitization and sequestration. Delineation using chimeric beta 3/beta 2-adrenergic receptors.

artículo científico publicado en 1996

Newly synthesized human delta opioid receptors retained in the endoplasmic reticulum are retrotranslocated to the cytosol, deglycosylated, ubiquitinated, and degraded by the proteasome.

artículo científico publicado en 2000

Nitric oxide modulates beta(2)-adrenergic receptor palmitoylation and signaling

artículo científico publicado en 1999

Nouveau dialogue entre récepteurs et protéines G trimériques : « une danse à corps enlacés »

artículo científico publicado en 2007

Novel Screening Paradigms for the Identification of Allosteric Modulators and/or Biased Ligands for Challenging G-Protein-Coupled Receptors

article

Older adults with heart failure treated with carvedilol, bisoprolol, or metoprolol tartrate: risk of mortality

artículo científico publicado en 2016

Oligomerization of G-protein-coupled transmitter receptors.

artículo científico publicado en 2001

Oligomerization of transcriptional intermediary factor 1 regulators and interaction with ZNF74 nuclear matrix protein revealed by bioluminescence resonance energy transfer in living cells

artículo científico publicado en 2003

Oxytocin and Vasopressin V1a and V2 Receptors Form Constitutive Homo- and Heterodimers during Biosynthesis

artículo científico publicado en 2002

PKA regulatory subunits mediate synergy among conserved G-protein-coupled receptor cascades.

artículo científico publicado en 2011

Palmitoylated cysteine 341 modulates phosphorylation of the beta2-adrenergic receptor by the cAMP-dependent protein kinase

artículo científico publicado en 1996

Palmitoylation of G-protein-coupled receptors: a dynamic modification with functional consequences.

artículo científico publicado en 1995

Palmitoylation of the V2 vasopressin receptor carboxyl tail enhances beta-arrestin recruitment leading to efficient receptor endocytosis and ERK1/2 activation

artículo científico publicado en 2003

Pepducin targeting the C-X-C chemokine receptor type 4 acts as a biased agonist favoring activation of the inhibitory G protein

scientific article published on 05 December 2013

Peptide G protein-coupled receptors meet at Erice

artículo científico publicado en 1998

Peripheral actions of GPCRs in energy homeostasis: view from the Chair

artículo científico publicado en 2014

Pharmacologic chaperones as a potential treatment for X-linked nephrogenic diabetes insipidus

artículo científico publicado en 2005

Pharmacological Chaperones Restore Function to MC4R Mutants Responsible for Severe Early-Onset Obesity

artículo científico publicado en 2010

Pharmacological Chaperones: Potential for the Treatment of Hereditary Diseases Caused by Mutations in G Protein-Coupled Receptors

scholarly article published 15 July 2010

Pharmacological Characterization of 5-Substituted 1-[(2,3-dihydro-1-benzofuran-2-yl)methyl]piperazines: Novel Antagonists for the Histamine H3 and H4 Receptors with Anti-inflammatory Potential.

artículo científico publicado en 2017

Pharmacological chaperone action on G-protein-coupled receptors.

artículo científico publicado en 2004

Pharmacological chaperones rescue cell-surface expression and function of misfolded V2 vasopressin receptor mutants

scientific journal article

Pharmacological chaperones: a new twist on receptor folding.

artículo científico publicado en 2000

Pharmacological chaperones: potential treatment for conformational diseases.

artículo científico publicado en 2004

Phorbol-ester-induced phosphorylation of the beta 2-adrenergic receptor decreases its coupling to Gs

artículo científico publicado en 1991

Phosphorylation sites on two domains of the beta 2-adrenergic receptor are involved in distinct pathways of receptor desensitization.

artículo científico publicado en 1989

Phosphorylation-independent desensitization of GABA(B) receptor by GRK4

artículo científico publicado en 2003

Post-endocytotic Deubiquitination and Degradation of the Metabotropic γ-Aminobutyric Acid Receptor by the Ubiquitin-specific Protease 14.

artículo científico publicado en 2016

Predicting phenotype from genotype: Improving accuracy through more robust experimental and computational modeling

artículo científico publicado en 2017

Primary sequence requirements for S-acylation of beta(2)-adrenergic receptor peptides

artículo científico publicado en 2001

Probing the Functional Selectivity of β-adrenergic Receptors Reveals New Signaling Modes and Potential Therapeutic Applications

Probing the activation-promoted structural rearrangements in preassembled receptor-G protein complexes.

artículo científico publicado en 2006

Propranolol Therapy for Ectopic β-Adrenergic Receptors in Adrenal Cushing's Syndrome

Protein-protein interactions monitored in cells from transgenic mice using bioluminescence resonance energy transfer

artículo científico publicado en 2010

Publisher Correction: Structural insights into binding specificity, efficacy and bias of a β2AR partial agonist

artículo científico publicado en 2019

Purinergic Receptor Transactivation by the β2-Adrenergic Receptor Increases Intracellular Ca2+ in Nonexcitable Cells

artículo científico publicado en 2017

Quantification of dynamic protein complexes using Renilla luciferase fragment complementation applied to protein kinase A activities in vivo

artículo científico publicado en 2007

Quantification of ligand bias for clinically relevant β2-adrenergic receptor ligands: implications for drug taxonomy.

artículo científico publicado en 2013

Quantitative assessment of beta 1- and beta 2-adrenergic receptor homo- and heterodimerization by bioluminescence resonance energy transfer

artículo científico publicado en 2002

Real-time monitoring of receptor and G-protein interactions in living cells.

artículo científico publicado en 2005

Real-time monitoring of ubiquitination in living cells by BRET.

artículo científico publicado en 2004

Rebuttal from Michel Bouvier and Terence E. Hébert

Receptor activity-independent recruitment of betaarrestin2 reveals specific signalling modes

artículo científico publicado en 2004

Receptor sequestration in response to β-arrestin-2 phosphorylation by ERK1/2 governs steady-state levels of GPCR cell-surface expression.

artículo científico publicado en 2015

Receptor-regulated interaction of activator of G-protein signaling-4 and Galphai

artículo científico publicado en 2010

Reciprocal regulation of agonist and inverse agonist signaling efficacy upon short-term treatment of the human delta-opioid receptor with an inverse agonist

artículo científico publicado en 2004

Recovery of homogeneous and functional beta 2-adrenergic receptors from extracellular baculovirus particles

artículo científico publicado en 1997

Red blood cell catecholamine levels in normotensive and DOCA-salt hypertensive rats.

artículo científico publicado en 1987

Regulation of adenylyl cyclase-coupled beta-adrenergic receptors

artículo científico publicado en 1988

Regulation of the AGS3·G{alpha}i signaling complex by a seven-transmembrane span receptor.

artículo científico publicado en 2010

Removal of phosphorylation sites from the β2-adrenergic receptor delays onset of agonist-promoted desensitization

scientific article published in Nature

Reply: beyond receptor dimerization

artículo científico publicado en 2000

Requirements and ontology for a G protein-coupled receptor oligomerization knowledge base

artículo científico publicado en 2007

Resonance energy transfer approaches in molecular pharmacology and beyond

artículo científico publicado en 2007

Restructuring G-protein- coupled receptor activation

artículo científico publicado en 2012

Role of SUMOylation in full antiestrogenicity

artículo científico publicado en 2012

Role of palmitoylation/depalmitoylation reactions in G-protein-coupled receptor function

artículo científico publicado en 2003

Roles of G-protein-coupled receptor dimerization

artículo científico publicado en 2004

Selective activation of the adrenal medulla during acute bilateral carotid occlusion and its modulation by alpha-adrenergic receptors in the rat.

artículo científico publicado en 1983

Sensory neuron-specific MAS-related gene-X1 receptors resist agonist-promoted endocytosis

artículo científico

Short-term inverse-agonist treatment induces reciprocal changes in delta-opioid agonist and inverse-agonist binding capacity.

artículo científico publicado en 2001

Simultaneous activation of the delta opioid receptor (deltaOR)/sensory neuron-specific receptor-4 (SNSR-4) hetero-oligomer by the mixed bivalent agonist bovine adrenal medulla peptide 22 activates SNSR-4 but inhibits deltaOR signaling

artículo científico publicado en 2006

Site-specific phosphorylation of CXCR4 is dynamically regulated by multiple kinases and results in differential modulation of CXCR4 signaling

artículo científico publicado en 2010

Spatiotemporal regulation of the GPCR activity of BAI3 by C1qL4 and Stabilin-2 controls myoblast fusion

artículo científico publicado en 2018

Src-dependent phosphorylation of beta2-adaptin dissociates the beta-arrestin-AP-2 complex.

artículo científico publicado en 2007

Structural and functional aspects of G protein-coupled receptor oligomerization

artículo científico publicado en 1998

Structural insights into binding specificity, efficacy and bias of a βAR partial agonist

artículo científico publicado en 2018

Structure-Activity Relationship and Bioactivity of Short Analogues of ELABELA as Agonists of the Apelin Receptor

artículo científico publicado en 2020

Subcellular distribution of GABA(B) receptor homo- and hetero-dimers.

artículo científico publicado en 2005

Subcellular imaging of dynamic protein interactions by bioluminescence resonance energy transfer

artículo científico publicado en 2007

Substitution of an extracellular cysteine in the beta 2-adrenergic receptor enhances agonist-promoted phosphorylation and receptor desensitization

artículo científico publicado en 1989

Subtype-Specific Regulation of the β-Adrenergic Receptors

Systematic protein-protein interaction mapping for clinically relevant human GPCRs

artículo científico publicado en 2017

TAK-875 is a Partial Agonist of the Free Fatty Acid Receptor GPR40

Targeting a Proteinase-Activated Receptor 4 (PAR4) Carboxyl Terminal Motif to Regulate Platelet Function.

artículo científico publicado en 2017

Technology combination to address GPCR allosteric modulator drug-discovery pitfalls.

artículo científico publicado en 2013

The BRET2/arrestin assay in stable recombinant cells: a platform to screen for compounds that interact with G protein-coupled receptors (GPCRS).

artículo científico publicado en 2002

The PAR2 inhibitor I-287 selectively targets Gαq and Gα12/13 signaling and has anti-inflammatory effects

artículo científico publicado en 2020

The V2 vasopressin receptor stimulates ERK1/2 activity independently of heterotrimeric G protein signalling

artículo científico publicado en 2006

The chemokine CXC4 and CC2 receptors form homo- and heterooligomers that can engage their signaling G-protein effectors and βarrestin.

artículo científico publicado en 2014

The evasive nature of drug efficacy: implications for drug discovery

artículo científico publicado en 2007

The experimental power of FR900359 to study Gq-regulated biological processes

artículo científico publicado en 2015

The gene product of the gp78/AMFR ubiquitin E3 ligase cDNA is selectively recognized by the 3F3A antibody within a subdomain of the endoplasmic reticulum

artículo científico publicado en 2004

The human beta 3-adrenergic receptor is resistant to short term agonist-promoted desensitization.

artículo científico publicado en 1993

The multiple membrane spanning topography of the beta 2-adrenergic receptor. Localization of the sites of binding, glycosylation, and regulatory phosphorylation by limited proteolysis

scientific article published in Journal of Biological Chemistry

The palmitoylation state of the beta(2)-adrenergic receptor regulates the synergistic action of cyclic AMP-dependent protein kinase and beta-adrenergic receptor kinase involved in its phosphorylation and desensitization

artículo científico publicado en 2001

Transcriptome analysis of G protein-coupled receptors in distinct genetic subgroups of acute myeloid leukemia: identification of potential disease-specific targets

artículo científico publicado en 2016

Translating biased signaling in the ghrelin receptor system into differential in vivo functions

article published in the Proceedings of the National Academy of Sciences of the United States of America

Type 2 diabetes–associated variants of the MT2melatonin receptor affect distinct modes of signaling

Unraveling G protein-coupled receptor endocytosis pathways using real-time monitoring of agonist-promoted interaction between beta-arrestins and AP-2.

artículo científico publicado en 2007

Unraveling the structural basis of GPCR activation and inactivation

artículo científico publicado en 2013

Upregulation ofα1A-andα1B-Adrenergic Receptor mRNAs in the Heart of Cardiomyopathic Hamsters

VRQ397 (CRAVKY): a novel noncompetitive V2 receptor antagonist

artículo científico publicado en 2009

Vasopressin Type 2 Receptor V88M Mutation: Molecular Basis of Partial and Complete Nephrogenic Diabetes Insipidus

artículo científico publicado en 2009

When an Inhibitor Promotes Activity

[19] Crosstalk between tyrosine kinase and G-protein-linked signal transduction systems

médecine/sciences2011

article published in 2011

β-Adrenergic receptor desensitization in the early stage of hereditary cardiomyopathy in hamsters

artículo científico publicado en 1994

β-Adrenoceptors and dexamethasone synergistically stimulate the expression of the angiotensinogen gene in opossum kidney cells

article

β-Arrestin Recruitment and Biased Agonism at Free Fatty Acid Receptor 1.

artículo científico publicado en 2015

β-Blockers have differential effects on the murine asthma phenotype

artículo científico publicado en 2015

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