Lista de obras - Geert Bultynck - Dominio Público Uruguay

A dual role for the anti-apoptotic Bcl-2 protein in cancer: mitochondria versus endoplasmic reticulum

artículo científico publicado en 2014

ABT-199 (Venetoclax), a BH3-mimetic Bcl-2 inhibitor, does not cause Ca2+ -signalling dysregulation or toxicity in pancreatic acinar cells

article

Adenine-nucleotide binding sites on the inositol 1,4,5-trisphosphate receptor bind caffeine, but not adenophostin A or cyclic ADP-ribose

artículo científico publicado en 1999

Alpha-helical destabilization of the Bcl-2-BH4-domain peptide abolishes its ability to inhibit the IP3 receptor

artículo científico publicado en 2013

Altered Ca(2+) signaling in cancer cells: proto-oncogenes and tumor suppressors targeting IP3 receptors.

artículo científico

Alzheimer's disease-associated peptide Aβ42 mobilizes ER Ca(2+) via InsP3R-dependent and -independent mechanisms.

artículo científico publicado en 2013

BDA-366, a putative Bcl-2 BH4 domain antagonist, induces apoptosis independently of Bcl-2 in a variety of cancer cell models

scientific article published on 17 September 2020

Bax Inhibitor-1-mediated Ca2+ leak is decreased by cytosolic acidosis

artículo científico publicado en 2013

Bax inhibitor-1 is a novel IP₃ receptor-interacting and -sensitizing protein

artículo científico publicado en 2012

Bcl-2 and IP3 compete for the ligand-binding domain of IP3Rs modulating Ca2+ signaling output

scientific article published on 16 April 2019

Bcl-2 binds to and inhibits ryanodine receptors

artículo científico publicado en 2014

Calcineurin and intracellular Ca2+-release channels: regulation or association?

artículo científico publicado en 2003

Calcium and connexin-based intercellular communication, a deadly catch?

scientific article published on 31 May 2011

Calmodulin increases the sensitivity of type 3 inositol-1,4, 5-trisphosphate receptors to Ca(2+) inhibition in human bronchial mucosal cells

artículo científico publicado en 2000

Caspase-3-induced truncation of type 1 inositol trisphosphate receptor accelerates apoptotic cell death and induces inositol trisphosphate-independent calcium release during apoptosis

artículo científico publicado en 2004

Caspase-3-truncated type 1 inositol 1,4,5-trisphosphate receptor enhances intracellular Ca2+ leak and disturbs Ca2+ signalling.

artículo científico publicado en 2008

Characterization and mapping of the 12 kDa FK506-binding protein (FKBP12)-binding site on different isoforms of the ryanodine receptor and of the inositol 1,4,5-trisphosphate receptor

artículo científico publicado en 2001

Connexin 43 hemichannels contribute to cytoplasmic Ca2+ oscillations by providing a bimodal Ca2+-dependent Ca2+ entry pathway

artículo científico publicado en 2012

Connexin channels provide a target to manipulate brain endothelial calcium dynamics and blood-brain barrier permeability

artículo científico publicado en 2011

Connexin targeting peptides as inhibitors of voltage- and intracellular Ca2+-triggered Cx43 hemichannel opening.

artículo científico

Connexins: sensors and regulators of cell cycling.

artículo científico publicado en 2010

Constitutive IP signaling underlies the sensitivity of B-cell cancers to the Bcl-2/IP receptor disruptor BIRD-2

scientific article published on 13 June 2018

Curcumin affects proprotein convertase activity: elucidation of the molecular and subcellular mechanism

artículo científico publicado en 2013

Cx43 channels and signaling via IP3/Ca2+, ATP, and ROS/NO propagate radiation-induced DNA damage to non-irradiated brain microvascular endothelial cells

scientific article published on 18 March 2020

Cx43 hemichannel microdomain signaling at the intercalated disc enhances cardiac excitability

DLBCL Cells with Acquired Resistance to Venetoclax Are Not Sensitized to BIRD-2 But Can Be Resensitized to Venetoclax through Bcl-XL Inhibition

scientific article published on 21 July 2020

Development of inositol-based antagonists for thed-myo-inositol 1,4,5-trisphosphate receptor

artículo científico publicado en 2011

Effects of the immunosuppressant FK506 on intracellular Ca2+ release and Ca2+ accumulation mechanisms.

artículo científico publicado en 2000

Emerging molecular mechanisms in chemotherapy: Ca2+ signaling at the mitochondria-associated endoplasmic reticulum membranes

artículo científico publicado en 2018

Endoplasmic Reticulum-Mitochondria Communication Through Ca2+ Signaling: The Importance of Mitochondria-Associated Membranes (MAMs).

artículo científico publicado en 2017

Endoplasmic-reticulum calcium depletion and disease

artículo científico publicado en 2011

Endothelial calcium dynamics, connexin channels and blood-brain barrier function.

artículo científico publicado en 2013

Extracellular and ER-stored Ca contribute to BIRD-2-induced cell death in diffuse large B-cell lymphoma cells

artículo científico publicado en 2018

Guidelines for the use and interpretation of assays for monitoring autophagy

artículo científico publicado en 2012

HA14-1, but not the BH3 mimetic ABT-737, causes Ca2+ dysregulation in platelets and human cell lines.

artículo científico publicado en 2013

IP3, a small molecule with a powerful message

artículo científico

IP3Receptors, Mitochondria, and Ca2+Signaling: Implications for Aging ⬇️

artículo científico publicado el 8 de marzo de 2011

Induction of Ca²+-driven apoptosis in chronic lymphocytic leukemia cells by peptide-mediated disruption of Bcl-2-IP3 receptor interaction

artículo científico publicado en 2010

Inositol 1,4,5-trisphosphate receptor-isoform diversity in cell death and survival

artículo científico publicado en 2014

Ins(1,4,5)P3 receptor-mediated Ca2+ signaling and autophagy induction are interrelated

artículo científico publicado en 2011

Intracellular Ca(2+) signaling: A novel player in the canonical mTOR-controlled autophagy pathway

artículo científico publicado en 2013

Intracellular Ca2+ storage in health and disease: a dynamic equilibrium.

artículo científico publicado en 2010

Intracellular calcium-releasing channels as cellular targets for immunophilins: a molecular, functional and structural analysis

artículo científico publicado en 2004

Intramolecular loop/tail interactions are essential for connexin 43-hemichannel activity

artículo científico publicado en 2010

Low extracellular Ca2+ conditions induce an increase in brain endothelial permeability that involves intercellular Ca2+ waves

artículo científico publicado en 2012

MICAL2 is essential for myogenic lineage commitment

scientific article published on 18 August 2020

Manipulating connexin communication channels: use of peptidomimetics and the translational outputs

artículo científico

Measurement of intracellular Ca2+ release in intact and permeabilized cells using 45Ca2+

artículo científico publicado en 2014

Measurement of intracellular Ca2+ release in intact cells using 45Ca2+.

artículo científico publicado en 2014

Measurement of intracellular Ca2+ release in permeabilized cells using 45Ca2+.

artículo científico publicado en 2014

Mechanical stimulation-induced calcium wave propagation in cell monolayers: the example of bovine corneal endothelial cells

artículo científico publicado en 2013

Necroptosis in Immuno-Oncology and Cancer Immunotherapy

artículo científico publicado en 2020

Negatively charged residues (Asp378 and Asp379) in the last ten amino acids of the C-terminal tail of Cx43 hemichannels are essential for loop/tail interactions

artículo científico publicado en 2013

Neuronal overexpression of IP₃ receptor 2 is detrimental in mutant SOD1 mice

artículo científico publicado en 2012

Non-channel functions of connexins in cell growth and cell death

artículo científico publicado en 2011

Organelle membrane derived patches: reshaping classical methods for new targets

artículo científico publicado en 2017

PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress

artículo científico publicado en 2012

Pannexin channels in ATP release and beyond: an unexpected rendezvous at the endoplasmic reticulum.

scientific article published on 03 August 2010

Pannexins, distant relatives of the connexin family with specific cellular functions?

artículo científico publicado en 2009

Paracrine signaling through plasma membrane hemichannels

artículo científico

Polycystin-1 and polycystin-2 are both required to amplify inositol-trisphosphate-induced Ca2+ release

artículo científico publicado en 2012

Polycystin-1 but not polycystin-2 deficiency causes upregulation of the mTOR pathway and can be synergistically targeted with rapamycin and metformin

artículo científico publicado en 2013

Polycystin-2 activation by inositol 1,4,5-trisphosphate-induced Ca2+ release requires its direct association with the inositol 1,4,5-trisphosphate receptor in a signaling microdomain.

artículo científico publicado en 2010

Profiling of the Bcl-2/Bcl-X(L)-binding sites on type 1 IP(3) receptor

scientific article published on 08 October 2012

Regioselective deprotection of orthobenzoates for the synthesis of inositol phosphates.

artículo científico publicado en 2009

Regulation of InsP3 receptor activity by neuronal Ca2+-binding proteins

artículo científico publicado en 2004

Regulation of connexin- and pannexin-based channels by post-translational modifications.

artículo científico publicado en 2013

Regulation of inositol 1,4,5-trisphosphate receptor type 1 function during oocyte maturation by MPM-2 phosphorylation.

artículo científico publicado en 2009

Regulation of inositol 1,4,5-trisphosphate-induced Ca2+ release by reversible phosphorylation and dephosphorylation.

artículo científico publicado en 2008

Release of gliotransmitters through astroglial connexin 43 hemichannels is necessary for fear memory consolidation in the basolateral amygdala

scientific journal article

RhoA GTPase switch controls Cx43-hemichannel activity through the contractile system

artículo científico publicado en 2012

Role of Mitochondria-Associated ER Membranes in Calcium Regulation in Cancer-Specific Settings.

artículo científico publicado en 2018

SOX9-induced Generation of Functional Astrocytes Supporting Neuronal Maturation in an All-human System

artículo científico publicado en 2021

STIM1 as a key regulator for Ca2+ homeostasis in skeletal-muscle development and function

artículo científico publicado en 2011

STIM1, but not STIM2, is required for proper agonist-induced Ca2+ signaling

artículo científico publicado en 2010

Selective inhibition of Cx43 hemichannels by Gap19 and its impact on myocardial ischemia/reperfusion injury.

artículo científico publicado en 2012

Selective regulation of IP3-receptor-mediated Ca2+ signaling and apoptosis by the BH4 domain of Bcl-2 versus Bcl-Xl.

artículo científico publicado en 2011

Slm1 and slm2 are novel substrates of the calcineurin phosphatase required for heat stress-induced endocytosis of the yeast uracil permease.

artículo científico publicado en 2006

Suramin and disulfonated stilbene derivatives stimulate the Ca2+-induced Ca2+ -release mechanism in A7r5 cells.

artículo científico publicado en 2005

Synthesis and biological action of novel 4-position-modified derivatives of D-myo-inositol 1,4,5-trisphosphate.

artículo científico publicado en 2007

TMBIM3/GRINA is a novel unfolded protein response (UPR) target gene that controls apoptosis through the modulation of ER calcium homeostasis

scientific journal article

Targeting Bcl-2-IP3 receptor interaction to reverse Bcl-2's inhibition of apoptotic calcium signals

artículo científico publicado en 2008

The 12 kDa FK506-binding protein, FKBP12, modulates the Ca(2+)-flux properties of the type-3 ryanodine receptor.

artículo científico publicado en 2004

The C terminus of Bax inhibitor-1 forms a Ca2+-permeable channel pore.

artículo científico publicado en 2011

The ER Stress Inducer l-Azetidine-2-Carboxylic Acid Elevates the Levels of Phospho-eIF2α and of LC3-II in a Ca-Dependent Manner

artículo científico publicado en 2018

The IP3 receptor–mitochondria connection in apoptosis and autophagy ⬇️

artículo científico publicado el 10 de diciembre de 2010

The N-terminal Ca2+-independent calmodulin-binding site on the inositol 1,4,5-trisphosphate receptor is responsible for calmodulin inhibition, even though this inhibition requires Ca2+.

artículo científico publicado en 2004

The SH3-binding domain of Cx43 participates in loop/tail interactions critical for Cx43-hemichannel activity.

artículo científico publicado en 2017

The contractile system as a negative regulator of the connexin 43 hemichannel.

artículo científico

The dual face of connexin-based astroglial Ca(2+) communication: a key player in brain physiology and a prime target in pathology.

artículo científico

The myosin II ATPase inhibitor blebbistatin prevents thrombin-induced inhibition of intercellular calcium wave propagation in corneal endothelial cells

artículo científico publicado en 2008

The protein phosphatase 2A phosphatase activator is a novel peptidyl-prolyl cis/trans-isomerase.

artículo científico publicado en 2006

The relative order of IP3 sensitivity of types 1 and 3 IP3 receptors is pH dependent.

artículo científico publicado en 1999

The role of calmodulin for inositol 1,4,5-trisphosphate receptor function

artículo científico publicado en 2002

The suppressor domain of inositol 1,4,5-trisphosphate receptor plays an essential role in the protection against apoptosis

artículo científico publicado en 2006

The trans-membrane domain of Bcl-2α, but not its hydrophobic cleft, is a critical determinant for efficient IP3 receptor inhibition

artículo científico publicado en 2016

The tumor suppressor eIF3e mediates calcium-dependent internalization of the L-type calcium channel CaV1.2.

artículo científico

Thimerosal stimulates Ca2+ flux through inositol 1,4,5-trisphosphate receptor type 1, but not type 3, via modulation of an isoform-specific Ca2+-dependent intramolecular interaction

artículo científico publicado en 2004

Transfer of IP₃ through gap junctions is critical, but not sufficient, for the spread of apoptosis

artículo científico publicado en 2011

Transmembrane BAX Inhibitor-1 Motif Containing Protein 5 (TMBIM5) Sustains Mitochondrial Structure, Shape, and Function by Impacting the Mitochondrial Protein Synthesis Machinery

scientific article published on 23 September 2020

Unraveling the role of polycystin-2/inositol 1,4,5-trisphosphate receptor interaction in Ca signaling

artículo científico publicado en 2010

Washing out of lipophilic compounds induces a transient increase in the passive Ca(2+) leak in permeabilized A7r5 cells

artículo científico publicado en 2002

Lista de obras de Geert Bultynck

A dual role for the anti-apoptotic Bcl-2 protein in cancer: mitochondria versus endoplasmic reticulum

ABT-199 (Venetoclax), a BH3-mimetic Bcl-2 inhibitor, does not cause Ca2+ -signalling dysregulation or toxicity in pancreatic acinar cells

Adenine-nucleotide binding sites on the inositol 1,4,5-trisphosphate receptor bind caffeine, but not adenophostin A or cyclic ADP-ribose

Alpha-helical destabilization of the Bcl-2-BH4-domain peptide abolishes its ability to inhibit the IP3 receptor

Altered Ca(2+) signaling in cancer cells: proto-oncogenes and tumor suppressors targeting IP3 receptors.

Alzheimer's disease-associated peptide Aβ42 mobilizes ER Ca(2+) via InsP3R-dependent and -independent mechanisms.

BDA-366, a putative Bcl-2 BH4 domain antagonist, induces apoptosis independently of Bcl-2 in a variety of cancer cell models

Bax Inhibitor-1-mediated Ca2+ leak is decreased by cytosolic acidosis

Bax inhibitor-1 is a novel IP₃ receptor-interacting and -sensitizing protein

Bcl-2 and IP3 compete for the ligand-binding domain of IP3Rs modulating Ca2+ signaling output

Bcl-2 binds to and inhibits ryanodine receptors

Calcineurin and intracellular Ca2+-release channels: regulation or association?

Calcium and connexin-based intercellular communication, a deadly catch?

Calmodulin increases the sensitivity of type 3 inositol-1,4, 5-trisphosphate receptors to Ca(2+) inhibition in human bronchial mucosal cells

Caspase-3-induced truncation of type 1 inositol trisphosphate receptor accelerates apoptotic cell death and induces inositol trisphosphate-independent calcium release during apoptosis

Caspase-3-truncated type 1 inositol 1,4,5-trisphosphate receptor enhances intracellular Ca2+ leak and disturbs Ca2+ signalling.

Characterization and mapping of the 12 kDa FK506-binding protein (FKBP12)-binding site on different isoforms of the ryanodine receptor and of the inositol 1,4,5-trisphosphate receptor

Connexin 43 hemichannels contribute to cytoplasmic Ca2+ oscillations by providing a bimodal Ca2+-dependent Ca2+ entry pathway

Connexin channels provide a target to manipulate brain endothelial calcium dynamics and blood-brain barrier permeability

Connexin targeting peptides as inhibitors of voltage- and intracellular Ca2+-triggered Cx43 hemichannel opening.

Connexins: sensors and regulators of cell cycling.

Constitutive IP signaling underlies the sensitivity of B-cell cancers to the Bcl-2/IP receptor disruptor BIRD-2

Curcumin affects proprotein convertase activity: elucidation of the molecular and subcellular mechanism

Cx43 channels and signaling via IP3/Ca2+, ATP, and ROS/NO propagate radiation-induced DNA damage to non-irradiated brain microvascular endothelial cells

Cx43 hemichannel microdomain signaling at the intercalated disc enhances cardiac excitability

DLBCL Cells with Acquired Resistance to Venetoclax Are Not Sensitized to BIRD-2 But Can Be Resensitized to Venetoclax through Bcl-XL Inhibition

Development of inositol-based antagonists for thed-myo-inositol 1,4,5-trisphosphate receptor

Effects of the immunosuppressant FK506 on intracellular Ca2+ release and Ca2+ accumulation mechanisms.

Emerging molecular mechanisms in chemotherapy: Ca2+ signaling at the mitochondria-associated endoplasmic reticulum membranes

Endoplasmic Reticulum-Mitochondria Communication Through Ca2+ Signaling: The Importance of Mitochondria-Associated Membranes (MAMs).

Endoplasmic-reticulum calcium depletion and disease

Endothelial calcium dynamics, connexin channels and blood-brain barrier function.

Extracellular and ER-stored Ca contribute to BIRD-2-induced cell death in diffuse large B-cell lymphoma cells

Guidelines for the use and interpretation of assays for monitoring autophagy

HA14-1, but not the BH3 mimetic ABT-737, causes Ca2+ dysregulation in platelets and human cell lines.

IP3, a small molecule with a powerful message

IP3Receptors, Mitochondria, and Ca2+Signaling: Implications for Aging ⬇️

Induction of Ca²+-driven apoptosis in chronic lymphocytic leukemia cells by peptide-mediated disruption of Bcl-2-IP3 receptor interaction

Inositol 1,4,5-trisphosphate receptor-isoform diversity in cell death and survival

Ins(1,4,5)P3 receptor-mediated Ca2+ signaling and autophagy induction are interrelated

Intracellular Ca(2+) signaling: A novel player in the canonical mTOR-controlled autophagy pathway

Intracellular Ca2+ storage in health and disease: a dynamic equilibrium.

Intracellular calcium-releasing channels as cellular targets for immunophilins: a molecular, functional and structural analysis

Intramolecular loop/tail interactions are essential for connexin 43-hemichannel activity

Low extracellular Ca2+ conditions induce an increase in brain endothelial permeability that involves intercellular Ca2+ waves

MICAL2 is essential for myogenic lineage commitment

Manipulating connexin communication channels: use of peptidomimetics and the translational outputs

Measurement of intracellular Ca2+ release in intact and permeabilized cells using 45Ca2+

Measurement of intracellular Ca2+ release in intact cells using 45Ca2+.

Measurement of intracellular Ca2+ release in permeabilized cells using 45Ca2+.

Mechanical stimulation-induced calcium wave propagation in cell monolayers: the example of bovine corneal endothelial cells

Necroptosis in Immuno-Oncology and Cancer Immunotherapy

Negatively charged residues (Asp378 and Asp379) in the last ten amino acids of the C-terminal tail of Cx43 hemichannels are essential for loop/tail interactions

Neuronal overexpression of IP₃ receptor 2 is detrimental in mutant SOD1 mice

Non-channel functions of connexins in cell growth and cell death

Organelle membrane derived patches: reshaping classical methods for new targets

PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress

Pannexin channels in ATP release and beyond: an unexpected rendezvous at the endoplasmic reticulum.

Pannexins, distant relatives of the connexin family with specific cellular functions?

Paracrine signaling through plasma membrane hemichannels

Polycystin-1 and polycystin-2 are both required to amplify inositol-trisphosphate-induced Ca2+ release

Polycystin-1 but not polycystin-2 deficiency causes upregulation of the mTOR pathway and can be synergistically targeted with rapamycin and metformin

Polycystin-2 activation by inositol 1,4,5-trisphosphate-induced Ca2+ release requires its direct association with the inositol 1,4,5-trisphosphate receptor in a signaling microdomain.

Profiling of the Bcl-2/Bcl-X(L)-binding sites on type 1 IP(3) receptor

Regioselective deprotection of orthobenzoates for the synthesis of inositol phosphates.

Regulation of InsP3 receptor activity by neuronal Ca2+-binding proteins

Regulation of connexin- and pannexin-based channels by post-translational modifications.

Regulation of inositol 1,4,5-trisphosphate receptor type 1 function during oocyte maturation by MPM-2 phosphorylation.

Regulation of inositol 1,4,5-trisphosphate-induced Ca2+ release by reversible phosphorylation and dephosphorylation.

Release of gliotransmitters through astroglial connexin 43 hemichannels is necessary for fear memory consolidation in the basolateral amygdala

RhoA GTPase switch controls Cx43-hemichannel activity through the contractile system

Role of Mitochondria-Associated ER Membranes in Calcium Regulation in Cancer-Specific Settings.

SOX9-induced Generation of Functional Astrocytes Supporting Neuronal Maturation in an All-human System

STIM1 as a key regulator for Ca2+ homeostasis in skeletal-muscle development and function

STIM1, but not STIM2, is required for proper agonist-induced Ca2+ signaling

Selective inhibition of Cx43 hemichannels by Gap19 and its impact on myocardial ischemia/reperfusion injury.

Selective regulation of IP3-receptor-mediated Ca2+ signaling and apoptosis by the BH4 domain of Bcl-2 versus Bcl-Xl.

Slm1 and slm2 are novel substrates of the calcineurin phosphatase required for heat stress-induced endocytosis of the yeast uracil permease.

Suramin and disulfonated stilbene derivatives stimulate the Ca2+-induced Ca2+ -release mechanism in A7r5 cells.