Lista de obras - Andrew G Bowie - Dominio Público Uruguay

A coding IRAK2 protein variant compromises Toll-like receptor (TLR) signaling and is associated with colorectal cancer survival

artículo científico publicado en 2014

A frequent hypofunctional IRAK2 variant is associated with reduced spontaneous hepatitis C virus clearance

artículo científico publicado en 2015

A novel anti-viral role for STAT3 in IFN-α signalling responses

artículo científico publicado en 2016

A46R and A52R from vaccinia virus are antagonists of host IL-1 and toll-like receptor signaling.

artículo científico publicado en 2000

Activation of host pattern recognition receptors by viruses.

scientific article published on 09 June 2010

Activation of innate defense against a paramyxovirus is mediated by RIG-I and TLR7 and TLR8 in a cell-type-specific manner

artículo científico publicado en 2005

Alum Activates the Bovine NLRP3 Inflammasome.

artículo científico publicado en 2017

An arms race: innate antiviral responses and counteracting viral strategies.

artículo científico publicado en 2007

Characterisation of viral proteins that inhibit Toll-like receptor signal transduction

artículo científico publicado en 2009

Cytosolic DNA sensors regulating type I interferon induction.

artículo científico publicado en 2011

DNA sensors are expressed in astrocytes and microglia in vitro and are upregulated during gliosis in neurodegenerative disease

artículo científico publicado en 2015

Evaluating the role of Toll-like receptors in diseases of the central nervous system

artículo científico publicado en 2011

Glycosylated low density lipoprotein is more sensitive to oxidation: implications for the diabetic patient?

scientific article published on 01 August 1993

Harnessing poxviral know-how for anti-cytokine therapies

artículo científico publicado en 2019

Human Interleukin-1 Receptor-associated Kinase-2 Is Essential for Toll-like Receptor-mediated Transcriptional and Post-transcriptional Regulation of Tumor Necrosis Factor α ⬇️

artículo científico publicado el 23 de mayo de 2011

IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes.

artículo científico publicado en 2017

IFI16 is an innate immune sensor for intracellular DNA

artículo científico publicado en 2010

Immune sensing of DNA

artículo científico publicado en 2013

Innate DNA sensing moves to the nucleus

artículo científico publicado en 2011

Innate antiviral signalling in the central nervous system

artículo científico

Innate immune activation of NFκB and its antagonism by poxviruses

artículo científico publicado en 2014

Innate immune detection of microbial nucleic acids.

artículo científico publicado en 2013

Innate immune recognition of DNA: A recent history

artículo científico publicado en 2015

Innate sensing of bacterial cyclic dinucleotides: more than just STING ⬇️

artículo científico publicado el 1 de diciembre de 2012

Insights from vaccinia virus into Toll-like receptor signalling proteins and their regulation by ubiquitin: role of IRAK-2.

scientific article published on June 2008

Lipid peroxidation is involved in the activation of NF-kappaB by tumor necrosis factor but not interleukin-1 in the human endothelial cell line ECV304. Lack of involvement of H2O2 in NF-kappaB activation by either cytokine in both primary and transf

artículo científico publicado en 1997

Low pH and Helicobacter pylori increase nuclear factor kappa B binding in gastric epithelial cells: a common pathway for epithelial cell injury?

artículo científico publicado en 2005

Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction

artículo científico publicado en 2001

Malaria parasite DNA-harbouring vesicles activate cytosolic immune sensors

artículo científico publicado en 2017

Malaria parasites both repress host CXCL10 and use it as a cue for growth acceleration

artículo científico publicado en 2021

Mechanism of NF kappa B activation by interleukin-1 and tumour necrosis factor in endothelial cells

artículo científico publicado en 1996

Molluscum Contagiosum Virus Protein MC005 Inhibits NF-κB Activation by Targeting NEMO-Regulated IκB Kinase Activation.

artículo científico publicado en 2017

Multi-omics characterization of the monkeypox virus infection

artículo científico publicado en 2024

Neuronal Toll-like receptor 4 signaling induces brain endothelial activation and neutrophil transmigration in vitro

artículo científico publicado en 2012

Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage

scholarly article by Gillian Dunphy published in September 2018

Novel strategies for targeting innate immune responses to influenza.

artículo científico publicado en 2016

Nucleotide-binding Oligomerization Domain-1 and Epidermal Growth Factor Receptor

artículo científico publicado en 2006

Oxidative stress and nuclear factor-kappaB activation: a reassessment of the evidence in the light of recent discoveries.

artículo científico publicado en 2000

PYHIN1 regulates pro-inflammatory cytokine induction rather than innate immune DNA sensing in airway epithelial cells

scientific article published on 26 February 2020

Polyinosinic Acid Is a Ligand for Toll-like Receptor 3

artículo científico publicado en 2007

Poxviral protein A52 stimulates p38 mitogen-activated protein kinase (MAPK) activation by causing tumor necrosis factor receptor-associated factor 6 (TRAF6) self-association leading to transforming growth factor β-activated kinase 1 (TAK1) recruitme

scientific article published on 10 October 2013

Poxviral protein E3-altered cytokine production reveals that DExD/H-box helicase 9 controls Toll-like receptor-stimulated immune responses

artículo científico publicado en 2018

Poxvirus K7 protein adopts a Bcl-2 fold: biochemical mapping of its interactions with human DEAD box RNA helicase DDX3

artículo científico publicado en 2009

Poxvirus Protein MC132 from Molluscum Contagiosum Virus Inhibits NF-B Activation by Targeting p65 for Degradation.

artículo científico publicado en 2015

Poxvirus protein N1L targets the I-kappaB kinase complex, inhibits signaling to NF-kappaB by the tumor necrosis factor superfamily of receptors, and inhibits NF-kappaB and IRF3 signaling by toll-like receptors

artículo científico publicado en 2004

Proteasomal degradation of herpes simplex virus capsids in macrophages releases DNA to the cytosol for recognition by DNA sensors

artículo científico publicado en 2013

RIG-I: tri-ing to discriminate between self and non-self RNA.

artículo científico publicado en 2007

Rad50 and CARD9, missing links in cytosolic DNA-stimulated inflammation

artículo científico publicado en 2014

Ras, protein kinase C zeta, and I kappa B kinases 1 and 2 are downstream effectors of CD44 during the activation of NF-kappa B by hyaluronic acid fragments in T-24 carcinoma cells

scientific article published on 01 February 2000

Recognition of herpesviruses by the innate immune system

artículo científico publicado en 2011

Removing the TREX1 safety net: oxidized DNA overcomes immune silencing by exonuclease TREX1.

artículo científico publicado en 2013

Role of non-degradative ubiquitination in interleukin-1 and toll-like receptor signaling.

artículo científico publicado en 2008

SARM regulates CCL5 production in macrophages by promoting the recruitment of transcription factors and RNA polymerase II to the Ccl5 promoter

artículo científico publicado en 2014

SARM: From immune regulator to cell executioner

artículo científico publicado en 2019

Schlafen-1 causes a cell cycle arrest by inhibiting induction of cyclin D1

scientific journal article

Schlafen-1 causes a cell cycle arrest by inhibiting induction of cyclin D1.

artículo científico publicado en 2016

Self-RNA sentinels signal viral invasion.

artículo científico publicado en 2018

Sensing and signaling in antiviral innate immunity

artículo científico publicado en 2010

Structures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor

artículo científico publicado en 2012

Studies into the mechanism of NF kappa B activation by IL1, TNF and H2O2 in primary and transformed endothelial cells

artículo científico publicado en 1997

TLR3 in antiviral immunity: key player or bystander?

artículo científico publicado en 2005

TRAF3: Uncovering the Real but Restricted Role in Human ⬇️

artículo científico publicado el 24 de septiembre de 2010

TRAM is required for TLR2 endosomal signaling to type I IFN induction

artículo científico publicado en 2014

TRIM-ing down Tolls

artículo científico publicado en 2008

The Powerstroke and Camshaft of the RIG-I Antiviral RNA Detection Machine ⬇️

artículo científico publicado el 14 de octubre de 2011

The STING in the Tail for Cytosolic DNA–Dependent Activation of IRF3 ⬇️

artículo científico publicado el 6 de marzo de 2012

The TLR signaling adaptor TRAM interacts with TRAF6 to mediate activation of the inflammatory response by TLR4.

artículo científico publicado en 2014

The Toll-IL-1 receptor adaptor family grows to five members.

artículo científico publicado en 2003

The Vaccine Adjuvant Chitosan Promotes Cellular Immunity via DNA Sensor cGAS-STING-Dependent Induction of Type I Interferons

artículo científico publicado en 2016

The effects of thiol modifiers on the activation of NF kappa B by interleukin-1.

artículo científico publicado en 1993

The emerging role of human PYHIN proteins in innate immunity: implications for health and disease

artículo científico

The endocannabinoid, anandamide, augments Notch-1 signaling in cultured cortical neurons exposed to amyloid-β and in the cortex of aged rats

artículo científico publicado en 2012

The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling

artículo científico publicado en 2007

The history of Toll-like receptors - redefining innate immunity.

artículo científico publicado en 2013

The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling

artículo científico publicado en 2006

The human endothelial cell line ECY304 as a model of endothelial cell activation by interleukin-1.

artículo científico publicado en 1995

The interleukin-1 receptor-associated kinases: critical regulators of innate immune signalling.

artículo científico publicado en 2010

The poxvirus protein A52R targets Toll-like receptor signaling complexes to suppress host defense

artículo científico publicado en 2003

The production of a reactive oxygen intermediate during the induction of apoptosis by cytotoxic insult.

artículo científico publicado en 1998

Toll-like receptor 2-dependent endosomal signaling by Staphylococcus aureus in monocytes induces type I interferon and promotes intracellular survival

artículo científico publicado en 2019

Toll-like receptor 3 L412F polymorphism promotes a persistent clinical phenotype in pulmonary sarcoidosis.

artículo científico publicado en 2017

Toll2011 at Lago di Garda: studying danger sensors by the guard towers at the lake

artículo científico publicado en 2011

Transactivation by the p65 subunit of NF-kappaB in response to interleukin-1 (IL-1) involves MyD88, IL-1 receptor-associated kinase 1, TRAF-6, and Rac1

artículo científico publicado en 2001

Uncovering novel gene function in Toll-like receptor signalling using siRNA.

artículo científico publicado en 2009

Unexpected roles for DEAD-box protein 3 in viral RNA sensing pathways.

artículo científico publicado en 2010

Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulence

artículo científico publicado en 2005

Vaccinia virus protein A52R activates p38 mitogen-activated protein kinase and potentiates lipopolysaccharide-induced interleukin-10

artículo científico publicado en 2005

Viral activation of macrophages through TLR-dependent and -independent pathways

artículo científico publicado en 2004

Viral evasion and subversion of pattern-recognition receptor signalling

artículo científico publicado en 2008

Viral immune modulators perturb the human molecular network by common and unique strategies

artículo científico publicado en 2012

Viral inhibition of IL-1- and neutrophil elastase-induced inflammatory responses in bronchial epithelial cells

artículo científico publicado en 2005

Viral inhibitory peptide of TLR4, a peptide derived from vaccinia protein A46, specifically inhibits TLR4 by directly targeting MyD88 adaptor-like and TRIF-related adaptor molecule

artículo científico publicado en 2010

Viral targeting of DEAD box protein 3 reveals its role in TBK1/IKKepsilon-mediated IRF activation

artículo científico publicado en 2008

Vitamin C inhibits NF kappa B activation in endothelial cells

artículo científico publicado en 1997

Vitamin C inhibits NF-kappa B activation by TNF via the activation of p38 mitogen-activated protein kinase.

artículo científico publicado en 2000

Lista de obras de Andrew G Bowie

A coding IRAK2 protein variant compromises Toll-like receptor (TLR) signaling and is associated with colorectal cancer survival

A frequent hypofunctional IRAK2 variant is associated with reduced spontaneous hepatitis C virus clearance

A novel anti-viral role for STAT3 in IFN-α signalling responses

A46R and A52R from vaccinia virus are antagonists of host IL-1 and toll-like receptor signaling.

Activation of host pattern recognition receptors by viruses.

Activation of innate defense against a paramyxovirus is mediated by RIG-I and TLR7 and TLR8 in a cell-type-specific manner

Alum Activates the Bovine NLRP3 Inflammasome.

An arms race: innate antiviral responses and counteracting viral strategies.

Characterisation of viral proteins that inhibit Toll-like receptor signal transduction

Cytosolic DNA sensors regulating type I interferon induction.

DNA sensors are expressed in astrocytes and microglia in vitro and are upregulated during gliosis in neurodegenerative disease

Evaluating the role of Toll-like receptors in diseases of the central nervous system

Glycosylated low density lipoprotein is more sensitive to oxidation: implications for the diabetic patient?

Harnessing poxviral know-how for anti-cytokine therapies

Human Interleukin-1 Receptor-associated Kinase-2 Is Essential for Toll-like Receptor-mediated Transcriptional and Post-transcriptional Regulation of Tumor Necrosis Factor α ⬇️

IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes.

IFI16 is an innate immune sensor for intracellular DNA

Immune sensing of DNA

Innate DNA sensing moves to the nucleus

Innate antiviral signalling in the central nervous system

Innate immune activation of NFκB and its antagonism by poxviruses

Innate immune detection of microbial nucleic acids.

Innate immune recognition of DNA: A recent history

Innate sensing of bacterial cyclic dinucleotides: more than just STING ⬇️

Insights from vaccinia virus into Toll-like receptor signalling proteins and their regulation by ubiquitin: role of IRAK-2.

Lipid peroxidation is involved in the activation of NF-kappaB by tumor necrosis factor but not interleukin-1 in the human endothelial cell line ECV304. Lack of involvement of H2O2 in NF-kappaB activation by either cytokine in both primary and transf

Low pH and Helicobacter pylori increase nuclear factor kappa B binding in gastric epithelial cells: a common pathway for epithelial cell injury?

Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction

Malaria parasite DNA-harbouring vesicles activate cytosolic immune sensors

Malaria parasites both repress host CXCL10 and use it as a cue for growth acceleration

Mechanism of NF kappa B activation by interleukin-1 and tumour necrosis factor in endothelial cells

Molluscum Contagiosum Virus Protein MC005 Inhibits NF-κB Activation by Targeting NEMO-Regulated IκB Kinase Activation.

Multi-omics characterization of the monkeypox virus infection

Neuronal Toll-like receptor 4 signaling induces brain endothelial activation and neutrophil transmigration in vitro

Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage

Novel strategies for targeting innate immune responses to influenza.

Nucleotide-binding Oligomerization Domain-1 and Epidermal Growth Factor Receptor

Oxidative stress and nuclear factor-kappaB activation: a reassessment of the evidence in the light of recent discoveries.

PYHIN1 regulates pro-inflammatory cytokine induction rather than innate immune DNA sensing in airway epithelial cells

Polyinosinic Acid Is a Ligand for Toll-like Receptor 3

Poxviral protein A52 stimulates p38 mitogen-activated protein kinase (MAPK) activation by causing tumor necrosis factor receptor-associated factor 6 (TRAF6) self-association leading to transforming growth factor β-activated kinase 1 (TAK1) recruitme

Poxviral protein E3-altered cytokine production reveals that DExD/H-box helicase 9 controls Toll-like receptor-stimulated immune responses

Poxvirus K7 protein adopts a Bcl-2 fold: biochemical mapping of its interactions with human DEAD box RNA helicase DDX3

Poxvirus Protein MC132 from Molluscum Contagiosum Virus Inhibits NF-B Activation by Targeting p65 for Degradation.

Poxvirus protein N1L targets the I-kappaB kinase complex, inhibits signaling to NF-kappaB by the tumor necrosis factor superfamily of receptors, and inhibits NF-kappaB and IRF3 signaling by toll-like receptors

Proteasomal degradation of herpes simplex virus capsids in macrophages releases DNA to the cytosol for recognition by DNA sensors

RIG-I: tri-ing to discriminate between self and non-self RNA.

Rad50 and CARD9, missing links in cytosolic DNA-stimulated inflammation

Ras, protein kinase C zeta, and I kappa B kinases 1 and 2 are downstream effectors of CD44 during the activation of NF-kappa B by hyaluronic acid fragments in T-24 carcinoma cells

Recognition of herpesviruses by the innate immune system

Removing the TREX1 safety net: oxidized DNA overcomes immune silencing by exonuclease TREX1.

Role of non-degradative ubiquitination in interleukin-1 and toll-like receptor signaling.

SARM regulates CCL5 production in macrophages by promoting the recruitment of transcription factors and RNA polymerase II to the Ccl5 promoter

SARM: From immune regulator to cell executioner

Schlafen-1 causes a cell cycle arrest by inhibiting induction of cyclin D1

Schlafen-1 causes a cell cycle arrest by inhibiting induction of cyclin D1.

Self-RNA sentinels signal viral invasion.

Sensing and signaling in antiviral innate immunity

Structures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor

Studies into the mechanism of NF kappa B activation by IL1, TNF and H2O2 in primary and transformed endothelial cells

TLR3 in antiviral immunity: key player or bystander?

TRAF3: Uncovering the Real but Restricted Role in Human ⬇️

TRAM is required for TLR2 endosomal signaling to type I IFN induction

TRIM-ing down Tolls

The Powerstroke and Camshaft of the RIG-I Antiviral RNA Detection Machine ⬇️

The STING in the Tail for Cytosolic DNA–Dependent Activation of IRF3 ⬇️

The TLR signaling adaptor TRAM interacts with TRAF6 to mediate activation of the inflammatory response by TLR4.

The Toll-IL-1 receptor adaptor family grows to five members.

The Vaccine Adjuvant Chitosan Promotes Cellular Immunity via DNA Sensor cGAS-STING-Dependent Induction of Type I Interferons

The effects of thiol modifiers on the activation of NF kappa B by interleukin-1.

The emerging role of human PYHIN proteins in innate immunity: implications for health and disease

The endocannabinoid, anandamide, augments Notch-1 signaling in cultured cortical neurons exposed to amyloid-β and in the cortex of aged rats

The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling

The history of Toll-like receptors - redefining innate immunity.

The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling

The human endothelial cell line ECY304 as a model of endothelial cell activation by interleukin-1.

The interleukin-1 receptor-associated kinases: critical regulators of innate immune signalling.

The poxvirus protein A52R targets Toll-like receptor signaling complexes to suppress host defense

The production of a reactive oxygen intermediate during the induction of apoptosis by cytotoxic insult.