Lista de obras - Rob N de Jong - Dominio Público Uruguay

A Novel Platform for the Potentiation of Therapeutic Antibodies Based on Antigen-Dependent Formation of IgG Hexamers at the Cell Surface

artículo científico publicado en 2016

A direct interaction between proliferating cell nuclear antigen (PCNA) and Cdk2 targets PCNA-interacting proteins for phosphorylation

artículo científico publicado en 2000

A simple, robust and highly efficient transient expression system for producing antibodies

artículo científico publicado en 2013

Adalimumab elicits a restricted anti-idiotypic antibody response in autoimmune patients resulting in functional neutralisation.

artículo científico publicado en 2012

Adenovirus DNA replication: protein priming, jumping back and the role of the DNA binding protein DBP.

artículo científico publicado en 2003

Annexin A5 reduces infarct size and improves cardiac function after myocardial ischemia-reperfusion injury by suppression of the cardiac inflammatory response.

artículo científico publicado en 2018

Biophysical Characterization and Stability of Modified IgG1 Antibodies with Different Hexamerization Propensities

CD20 and CD37 antibodies synergize to activate complement by Fc-mediated clustering.

artículo científico publicado en 2019

Complement is activated by IgG hexamers assembled at the cell surface

artículo científico publicado en 2014

Controlled Fab-arm exchange for the generation of stable bispecific IgG1.

artículo científico publicado en 2014

Cysteine-SILAC Mass Spectrometry Enabling the Identification and Quantitation of Scrambled Interchain Disulfide Bonds: Preservation of Native Heavy-Light Chain Pairing in Bispecific IgGs Generated by Controlled Fab-arm Exchange.

artículo científico publicado en 2017

DNA binding properties of the adenovirus DNA replication priming protein pTP.

artículo científico publicado en 2003

Dual epitope targeting and enhanced hexamerization by DR5 antibodies as a novel approach to induce potent anti-tumor activity through DR5 agonism

artículo científico publicado en 2020

E2-c-Cbl recognition is necessary but not sufficient for ubiquitination activity

artículo científico publicado en 2009

Enhancing Accuracy in Molecular Weight Determination of Highly Heterogeneously Glycosylated Proteins by Native Tandem Mass Spectrometry

artículo científico publicado en 2017

Enzyme free cloning for high throughput gene cloning and expression

artículo científico publicado en 2006

First steps towards effective methods in exploiting high-throughput technologies for the determination of human protein structures of high biomedical value.

artículo científico publicado en 2006

Fourteen residues of the U1 snRNP-specific U1A protein are required for homodimerization, cooperative RNA binding, and inhibition of polyadenylation.

artículo científico publicado en 2000

Functional analysis of the anti-adalimumab response using patient-derived monoclonal antibodies

artículo científico publicado en 2014

HER2 monoclonal antibodies that do not interfere with receptor heterodimerization-mediated signaling induce effective internalization and represent valuable components for rational antibody-drug conjugate design

artículo científico publicado en 2014

Human IgG is produced in a pro-form that requires clipping of C-terminal lysines for maximal complement activation

artículo científico publicado en 2015

IRF3 and IRF7 mediate neovascularization via inflammatory cytokines.

artículo científico publicado en 2019

Inhibition of 14q32 microRNA miR-495 reduces lesion formation, intimal hyperplasia and plasma cholesterol levels in experimental restenosis.

artículo científico publicado en 2017

Kinetic mechanism of controlled Fab-arm exchange for the formation of bispecific immunoglobulin G1 antibodies

artículo científico publicado en 2017

Mechanism of DNA replication in eukaryotic cells: cellular host factors stimulating adenovirus DNA replication.

artículo científico publicado en 1999

Molecular Basis of Assembly and Activation of Complement Component C1 in Complex with Immunoglobulin G1 and Antigen

artículo científico publicado en 2016

NMR characterization of foldedness for the production of E3 RING domains

artículo científico publicado en 2010

NMR in the SPINE Structural Proteomics project.

artículo científico publicado en 2006

P300/CBP Associated Factor (PCAF) Deficiency Enhances Diet-Induced Atherosclerosis in ApoE3<sup>*</sup>Leiden Mice via Systemic Inhibition of Regulatory T Cells

artículo científico publicado en 2020

Real-time analysis of the detailed sequence of cellular events in mAb-mediated complement-dependent cytotoxicity of B-cell lines and of chronic lymphocytic leukemia B-cells.

artículo científico publicado en 2015

Recruitment of the priming protein pTP and DNA binding occur by overlapping Oct-1 POU homeodomain surfaces

artículo científico publicado en 2002

Relaxed template specificity in fowl adenovirus 1 DNA replication initiation

artículo científico publicado en 2006

Solution structure of the human ubiquitin-specific protease 15 DUSP domain

artículo científico publicado en 2006

Structural characterization of Spo0E-like protein-aspartic acid phosphatases that regulate sporulation in bacilli

artículo científico publicado en 2006

Structure and DNA binding of the human Rtf1 Plus3 domain

artículo científico publicado en 2008

Structures of C1-IgG1 provide insights into how danger pattern recognition activates complement

artículo científico publicado en 2018

Symmetry and asymmetry of the RING-RING dimer of Rad18

artículo científico publicado en 2011

Tandem Native Mass-Spectrometry on Antibody-Drug Conjugates and Submillion Da Antibody-Antigen Protein Assemblies on an Orbitrap EMR Equipped with a High-Mass Quadrupole Mass Selector

artículo científico publicado en 2015

The Structure of Bypass of Forespore C, an Intercompartmental Signaling Factor during Sporulation inBacillus

artículo científico publicado en 2005

The epigenetic factor PCAF regulates vascular inflammation and is essential for intimal hyperplasia development

artículo científico publicado en 2017

Unraveling the Macromolecular Pathways of IgG Oligomerization and Complement Activation on Antigenic Surfaces

scientific article published on 11 June 2019

Lista de obras de Rob N de Jong

A Novel Platform for the Potentiation of Therapeutic Antibodies Based on Antigen-Dependent Formation of IgG Hexamers at the Cell Surface

A direct interaction between proliferating cell nuclear antigen (PCNA) and Cdk2 targets PCNA-interacting proteins for phosphorylation

A simple, robust and highly efficient transient expression system for producing antibodies

Adalimumab elicits a restricted anti-idiotypic antibody response in autoimmune patients resulting in functional neutralisation.

Adenovirus DNA replication: protein priming, jumping back and the role of the DNA binding protein DBP.

Annexin A5 reduces infarct size and improves cardiac function after myocardial ischemia-reperfusion injury by suppression of the cardiac inflammatory response.

Biophysical Characterization and Stability of Modified IgG1 Antibodies with Different Hexamerization Propensities

CD20 and CD37 antibodies synergize to activate complement by Fc-mediated clustering.

Complement is activated by IgG hexamers assembled at the cell surface

Controlled Fab-arm exchange for the generation of stable bispecific IgG1.

Cysteine-SILAC Mass Spectrometry Enabling the Identification and Quantitation of Scrambled Interchain Disulfide Bonds: Preservation of Native Heavy-Light Chain Pairing in Bispecific IgGs Generated by Controlled Fab-arm Exchange.

DNA binding properties of the adenovirus DNA replication priming protein pTP.

Dual epitope targeting and enhanced hexamerization by DR5 antibodies as a novel approach to induce potent anti-tumor activity through DR5 agonism

E2-c-Cbl recognition is necessary but not sufficient for ubiquitination activity

Enhancing Accuracy in Molecular Weight Determination of Highly Heterogeneously Glycosylated Proteins by Native Tandem Mass Spectrometry

Enzyme free cloning for high throughput gene cloning and expression

First steps towards effective methods in exploiting high-throughput technologies for the determination of human protein structures of high biomedical value.

Fourteen residues of the U1 snRNP-specific U1A protein are required for homodimerization, cooperative RNA binding, and inhibition of polyadenylation.

Functional analysis of the anti-adalimumab response using patient-derived monoclonal antibodies

HER2 monoclonal antibodies that do not interfere with receptor heterodimerization-mediated signaling induce effective internalization and represent valuable components for rational antibody-drug conjugate design

Human IgG is produced in a pro-form that requires clipping of C-terminal lysines for maximal complement activation

IRF3 and IRF7 mediate neovascularization via inflammatory cytokines.

Inhibition of 14q32 microRNA miR-495 reduces lesion formation, intimal hyperplasia and plasma cholesterol levels in experimental restenosis.

Kinetic mechanism of controlled Fab-arm exchange for the formation of bispecific immunoglobulin G1 antibodies

Mechanism of DNA replication in eukaryotic cells: cellular host factors stimulating adenovirus DNA replication.

Molecular Basis of Assembly and Activation of Complement Component C1 in Complex with Immunoglobulin G1 and Antigen

NMR characterization of foldedness for the production of E3 RING domains

NMR in the SPINE Structural Proteomics project.

P300/CBP Associated Factor (PCAF) Deficiency Enhances Diet-Induced Atherosclerosis in ApoE3<sup>*</sup>Leiden Mice via Systemic Inhibition of Regulatory T Cells

Real-time analysis of the detailed sequence of cellular events in mAb-mediated complement-dependent cytotoxicity of B-cell lines and of chronic lymphocytic leukemia B-cells.

Recruitment of the priming protein pTP and DNA binding occur by overlapping Oct-1 POU homeodomain surfaces

Relaxed template specificity in fowl adenovirus 1 DNA replication initiation

Solution structure of the human ubiquitin-specific protease 15 DUSP domain

Structural characterization of Spo0E-like protein-aspartic acid phosphatases that regulate sporulation in bacilli

Structure and DNA binding of the human Rtf1 Plus3 domain

Structures of C1-IgG1 provide insights into how danger pattern recognition activates complement

Symmetry and asymmetry of the RING-RING dimer of Rad18

Tandem Native Mass-Spectrometry on Antibody-Drug Conjugates and Submillion Da Antibody-Antigen Protein Assemblies on an Orbitrap EMR Equipped with a High-Mass Quadrupole Mass Selector

The Structure of Bypass of Forespore C, an Intercompartmental Signaling Factor during Sporulation inBacillus

The epigenetic factor PCAF regulates vascular inflammation and is essential for intimal hyperplasia development

Unraveling the Macromolecular Pathways of IgG Oligomerization and Complement Activation on Antigenic Surfaces