Lista de obras - Matthias Dobbelstein - Dominio Público Uruguay

5-Fluorouracil sensitizes colorectal tumor cells towards double stranded DNA breaks by interfering with homologous recombination repair

artículo científico publicado en 2015

A killer promoting survival: p53 as a selective means to avoid side effects of chemotherapy

artículo científico publicado en 2012

A polymorphic microsatellite that mediates induction of PIG3 by p53.

artículo científico publicado en 2002

A pro-apoptotic function of iASPP by stabilizing p300 and CBP through inhibition of BRMS1 E3 ubiquitin ligase activity

artículo científico publicado en 2015

A promoter that acquired p53 responsiveness during primate evolution

artículo científico publicado en 2003

Activating Ras mutations fail to ensure efficient replication of adenovirus mutants lacking VA-RNA.

artículo científico publicado en 2006

Adenovirus E1-transformed cells grow despite the continuous presence of transcriptionally active p53.

artículo científico publicado en 2002

Adenovirus type 5 E4orf3 protein relieves p53 inhibition by E1B-55-kilodalton protein.

artículo científico publicado en 1999

Adenovirus-induced extracellular signal-regulated kinase phosphorylation during the late phase of infection enhances viral protein levels and virus progeny

artículo científico publicado en 2006

Anthracyclines induce the accumulation of mutant p53 through E2F1-dependent and -independent mechanisms

scientific article published on 28 March 2011

BRCA1 and Tip60 determine the cellular response to ultraviolet irradiation through distinct pathways

artículo científico publicado en 2008

Bcl-xL mediates therapeutic resistance of a mesenchymal breast cancer cell subpopulation.

artículo científico publicado en 2014

Brdm2 - an aberrant hypomorphic p63 allele

artículo científico publicado en 2010

Cell cycle arrest or apoptosis by p53: are microRNAs-192/215 and -34 making the decision?

artículo científico publicado en 2009

Chromatin modifiers Mdm2 and RNF2 prevent RNA:DNA hybrids that impair DNA replication

artículo científico publicado en 2018

Comprehensive identification of genes driven by ERV9-LTRs reveals TNFRSF10B as a re-activatable mediator of testicular cancer cell death

artículo científico publicado en 2015

Damage-induced DNA replication stalling relies on MAPK-activated protein kinase 2 activity

scientific article published on 30 September 2013

DeltaNp73 can modulate the expression of various genes in a p53-independent fashion

artículo científico publicado en 2003

Differential regulation of p63 and p73 expression

scientific article published on 01 August 2003

Direct p53 transcriptional repression: in vivo analysis of CCAAT-containing G2/M promoters.

artículo científico publicado en 2005

Doxorubicin-induced activation of NF-κB in melanoma cells is abrogated by inhibition of IKKβ, but not by a novel IKKα inhibitor

artículo científico publicado en 2012

Dysfunctional p53 deletion mutants in cell lines derived from Hodgkin's lymphoma

artículo científico publicado en 2006

E1A genes of adenovirus type 2 and type 5 are expressed at different levels

artículo científico publicado en 2006

E1B 55-kilodalton oncoproteins of adenovirus types 5 and 12 inactivate and relocalize p53, but not p51 or p73, and cooperate with E4orf6 proteins to destabilize p53.

artículo científico publicado en 2000

E1B-55-kilodalton protein is not required to block p53-induced transcription during adenovirus infection

artículo científico publicado en 2004

E2F1-inducible microRNA 449a/b suppresses cell proliferation and promotes apoptosis

artículo científico publicado en 2009

Efficient replication of adenovirus despite the overexpression of active and nondegradable p53.

artículo científico publicado en 2001

Endogenous retrovirus drives hitherto unknown proapoptotic p63 isoforms in the male germ line of humans and great apes ⬇️

artículo científico publicado el 7 de febrero de 2011

Endothelial p53 deletion improves angiogenesis and prevents cardiac fibrosis and heart failure induced by pressure overload in mice

artículo científico publicado en 2015

Enhanced cytotoxicity without internuclear spread of adenovirus upon cell fusion by measles virus glycoproteins.

artículo científico publicado en 2005

Exploiting replicative stress to treat cancer

artículo científico

Export of hepatitis B virus RNA on a Rev-like pathway: inhibition by the regenerating liver inhibitory factor IkappaB alpha.

artículo científico publicado en 1997

Failure of viral oncoproteins to target the p53-homologue p51A

artículo científico publicado en 1999

G2E3 attenuating replicative stress

artículo científico publicado en 2015

HER2/ErbB2 activates HSF1 and thereby controls HSP90 clients including MIF in HER2-overexpressing breast cancer

artículo científico publicado en 2014

HSP90 inhibitor antagonizing MIF: The specifics of pleiotropic cancer drug candidates

artículo científico publicado en 2012

Identification of a microRNA expression signature for chemoradiosensitivity of colorectal cancer cells, involving miRNAs-320a, -224, -132 and let7g.

artículo científico publicado en 2013

Immunofluorescence-based screening identifies germ cell associated microRNA 302 as an antagonist to p63 expression

artículo científico publicado en 2009

Improving survival by exploiting tumour dependence on stabilized mutant p53 for treatment

artículo científico publicado en 2015

In vitro selection of RNA ligands for the ribosomal L22 protein associated with Epstein-Barr virus-expressed RNA by using randomized and cDNA-derived RNA libraries

artículo científico publicado en 1995

Inactivation of p53 but not p73 by adenovirus type 5 E1B 55-kilodalton and E4 34-kilodalton oncoproteins.

artículo científico publicado en 1998

Inactivation of the p53-homologue p73 by the mdm2-oncoprotein

artículo científico publicado en 1999

Infection with E1B-mutant adenovirus stabilizes p53 but blocks p53 acetylation and activity through E1A.

artículo científico publicado en 2010

Inhibiting the HSP90 chaperone destabilizes macrophage migration inhibitory factor and thereby inhibits breast tumor progression

artículo científico publicado en 2012

Inhibiting the HSP90 chaperone destabilizes macrophage migration inhibitory factor and thereby inhibits breast tumor progression

artículo científico publicado en 2012

Inhibition of MAPKAPK2/MK2 facilitates DNA replication upon cancer cell treatment with gemcitabine but not cisplatin

artículo científico publicado en 2018

Interaction of p53 with the adenovirus E1B-55 kDa protein

scientific article published on 01 January 2003

Interchanging heads: p53 re-composes the DREAM/MMB complex to repress transcription

artículo científico publicado en 2012

Intracistronic complementation reveals a new function of SV40 T antigen that co-operates with Rb and p53 binding to stimulate DNA synthesis in quiescent cells

artículo científico publicado en 1992

MDM2 Associates with Polycomb Repressor Complex 2 and Enhances Stemness-Promoting Chromatin Modifications Independent of p53

artículo científico publicado en 2016

Mdm2 - open questions

scientific article published on 26 April 2020

Mdm2 inhibition confers protection of p53-proficient cells from the cytotoxic effects of Wee1 inhibitors

artículo científico publicado en 2015

MicroRNA-101 Suppresses Tumor Cell Proliferation by Acting as an Endogenous Proteasome Inhibitor via Targeting the Proteasome Assembly Factor POMP.

artículo científico publicado en 2015

MicroRNA-449 in cell fate determination ⬇️

artículo científico publicado el 1 de septiembre de 2011

MicroRNA-449a levels increase by several orders of magnitude during mucociliary differentiation of airway epithelia

scientific article published on 15 November 2010

Mutual interference of adenovirus infection and myc expression

artículo científico publicado en 2003

NF-Y dependent epigenetic modifications discriminate between proliferating and postmitotic tissue

artículo científico publicado en 2008

Neutralization of SARS-CoV-2 by highly potent, hyperthermostable, and mutation-tolerant nanobodies

artículo científico publicado en 2021

Non-hominid TP63 lacks retroviral LTRs but contains a novel conserved upstream exon

artículo científico publicado en 2011

Nongenotoxic p53 activation protects cells against S-phase-specific chemotherapy

artículo científico publicado en 2006

Nuclear export of the E1B 55-kDa and E4 34-kDa adenoviral oncoproteins mediated by a rev-like signal sequence ⬇️

artículo científico publicado el 16 de julio de 1997

Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein.

artículo científico publicado en 1998

Overcoming EMT-driven therapeutic resistance by BH3 mimetics

artículo científico publicado en 2014

Protection against apoptosis by the vaccinia virus SPI-2 (B13R) gene product

artículo científico publicado en 1996

Reactivation of mutant p53 by a one-hybrid adaptor protein.

artículo científico publicado en 2003

Rev protein of human immunodeficiency virus type 1 and cellular exportin 1 protein relocalize each other to a subnucleolar structure

artículo científico publicado en 2000

Screening analysis of ubiquitin ligases reveals G2E3 as a potential target for chemosensitizing cancer cells

artículo científico publicado en 2015

Self-association of adenovirus type 5 E1B-55 kDa as well as p53 is essential for their mutual interaction

artículo científico publicado en 2009

TAp73 is essential for germ cell adhesion and maturation in testis.

artículo científico publicado en 2014

Targeting tumour-supportive cellular machineries in anticancer drug development

artículo científico publicado en 2014

Telethonin deficiency is associated with maladaptation to biomechanical stress in the mammalian heart

artículo científico publicado en 2011

The CDK4/6-EZH2 pathway is a potential therapeutic target for psoriasis

scientific article published on 23 July 2020

The MAPK-activated protein kinase 2 mediates gemcitabine sensitivity in pancreatic cancer cells

artículo científico publicado en 2014

The MDM2 oncoprotein binds specifically to RNA through its RING finger domain

artículo científico publicado en 1996

The alpha/beta carboxy-terminal domains of p63 are required for skin and limb development. New insights from the Brdm2 mouse which is not a complete p63 knockout but expresses p63 gamma-like proteins

artículo científico publicado en 2009

The large T antigen of simian virus 40 binds and inactivates p53 but not p73.

artículo científico publicado en 1998

The nuclear export signal within the E4orf6 protein of adenovirus type 5 supports virus replication and cytoplasmic accumulation of viral mRNA.

artículo científico publicado en 2000

Tumor-derived mutations within the DNA-binding domain of p53 that phenotypically resemble the deletion of the proline-rich domain

artículo científico publicado en 2000

UDP glucuronosyltransferase 1A expression levels determine the response of colorectal cancer cells to the heat shock protein 90 inhibitor ganetespib

artículo científico publicado en 2014

Usp22 deficiency impairs intestinal epithelial lineage specification in vivo

artículo científico publicado en 2015

Viral and cellular factors that target the promyelocytic leukemia oncogenic domains strongly activate a glucocorticoid-responsive promoter

artículo científico publicado en 2001

Wee1 and Chk1 - crosstalk between key players in replicative stress

artículo científico publicado en 2015

Wee1 is required to sustain ATR/Chk1 signaling upon replicative stress

artículo científico publicado en 2015

While p73 is essential, p63 is completely dispensable for the development of the central nervous system

artículo científico publicado en 2011

YB-1 relocates to the nucleus in adenovirus-infected cells and facilitates viral replication by inducing E2 gene expression through the E2 late promoter

artículo científico publicado en 2002

p21/CDKN1A mediates negative regulation of transcription by p53.

artículo científico publicado en 2003

p53 induces the expression of its antagonist p73 Delta N, establishing an autoregulatory feedback loop

artículo científico publicado en 2002

p53-Responsive micrornas 192 and 215 are capable of inducing cell cycle arrest

artículo científico publicado en 2008

p63 antagonizes Wnt-induced transcription

artículo científico publicado en 2010

p73 and p63: why do we still need them?

scientific journal article

p73 is an essential regulator of neural stem cell maintenance in embryonal and adult CNS neurogenesis

artículo científico publicado en 2010

Lista de obras de Matthias Dobbelstein

5-Fluorouracil sensitizes colorectal tumor cells towards double stranded DNA breaks by interfering with homologous recombination repair

A killer promoting survival: p53 as a selective means to avoid side effects of chemotherapy

A polymorphic microsatellite that mediates induction of PIG3 by p53.

A pro-apoptotic function of iASPP by stabilizing p300 and CBP through inhibition of BRMS1 E3 ubiquitin ligase activity

A promoter that acquired p53 responsiveness during primate evolution

Activating Ras mutations fail to ensure efficient replication of adenovirus mutants lacking VA-RNA.

Adenovirus E1-transformed cells grow despite the continuous presence of transcriptionally active p53.

Adenovirus type 5 E4orf3 protein relieves p53 inhibition by E1B-55-kilodalton protein.

Adenovirus-induced extracellular signal-regulated kinase phosphorylation during the late phase of infection enhances viral protein levels and virus progeny

Anthracyclines induce the accumulation of mutant p53 through E2F1-dependent and -independent mechanisms

BRCA1 and Tip60 determine the cellular response to ultraviolet irradiation through distinct pathways

Bcl-xL mediates therapeutic resistance of a mesenchymal breast cancer cell subpopulation.

Brdm2 - an aberrant hypomorphic p63 allele

Cell cycle arrest or apoptosis by p53: are microRNAs-192/215 and -34 making the decision?

Chromatin modifiers Mdm2 and RNF2 prevent RNA:DNA hybrids that impair DNA replication

Comprehensive identification of genes driven by ERV9-LTRs reveals TNFRSF10B as a re-activatable mediator of testicular cancer cell death

Damage-induced DNA replication stalling relies on MAPK-activated protein kinase 2 activity

DeltaNp73 can modulate the expression of various genes in a p53-independent fashion

Differential regulation of p63 and p73 expression

Direct p53 transcriptional repression: in vivo analysis of CCAAT-containing G2/M promoters.

Doxorubicin-induced activation of NF-κB in melanoma cells is abrogated by inhibition of IKKβ, but not by a novel IKKα inhibitor

Dysfunctional p53 deletion mutants in cell lines derived from Hodgkin's lymphoma

E1A genes of adenovirus type 2 and type 5 are expressed at different levels

E1B 55-kilodalton oncoproteins of adenovirus types 5 and 12 inactivate and relocalize p53, but not p51 or p73, and cooperate with E4orf6 proteins to destabilize p53.

E1B-55-kilodalton protein is not required to block p53-induced transcription during adenovirus infection

E2F1-inducible microRNA 449a/b suppresses cell proliferation and promotes apoptosis

Efficient replication of adenovirus despite the overexpression of active and nondegradable p53.

Endogenous retrovirus drives hitherto unknown proapoptotic p63 isoforms in the male germ line of humans and great apes ⬇️

Endothelial p53 deletion improves angiogenesis and prevents cardiac fibrosis and heart failure induced by pressure overload in mice

Enhanced cytotoxicity without internuclear spread of adenovirus upon cell fusion by measles virus glycoproteins.

Exploiting replicative stress to treat cancer

Export of hepatitis B virus RNA on a Rev-like pathway: inhibition by the regenerating liver inhibitory factor IkappaB alpha.

Failure of viral oncoproteins to target the p53-homologue p51A

G2E3 attenuating replicative stress

HER2/ErbB2 activates HSF1 and thereby controls HSP90 clients including MIF in HER2-overexpressing breast cancer

HSP90 inhibitor antagonizing MIF: The specifics of pleiotropic cancer drug candidates

Identification of a microRNA expression signature for chemoradiosensitivity of colorectal cancer cells, involving miRNAs-320a, -224, -132 and let7g.

Immunofluorescence-based screening identifies germ cell associated microRNA 302 as an antagonist to p63 expression

Improving survival by exploiting tumour dependence on stabilized mutant p53 for treatment

In vitro selection of RNA ligands for the ribosomal L22 protein associated with Epstein-Barr virus-expressed RNA by using randomized and cDNA-derived RNA libraries

Inactivation of p53 but not p73 by adenovirus type 5 E1B 55-kilodalton and E4 34-kilodalton oncoproteins.

Inactivation of the p53-homologue p73 by the mdm2-oncoprotein

Infection with E1B-mutant adenovirus stabilizes p53 but blocks p53 acetylation and activity through E1A.

Inhibiting the HSP90 chaperone destabilizes macrophage migration inhibitory factor and thereby inhibits breast tumor progression

Inhibiting the HSP90 chaperone destabilizes macrophage migration inhibitory factor and thereby inhibits breast tumor progression

Inhibition of MAPKAPK2/MK2 facilitates DNA replication upon cancer cell treatment with gemcitabine but not cisplatin

Interaction of p53 with the adenovirus E1B-55 kDa protein

Interchanging heads: p53 re-composes the DREAM/MMB complex to repress transcription

Intracistronic complementation reveals a new function of SV40 T antigen that co-operates with Rb and p53 binding to stimulate DNA synthesis in quiescent cells

MDM2 Associates with Polycomb Repressor Complex 2 and Enhances Stemness-Promoting Chromatin Modifications Independent of p53

Mdm2 - open questions

Mdm2 inhibition confers protection of p53-proficient cells from the cytotoxic effects of Wee1 inhibitors

MicroRNA-101 Suppresses Tumor Cell Proliferation by Acting as an Endogenous Proteasome Inhibitor via Targeting the Proteasome Assembly Factor POMP.

MicroRNA-449 in cell fate determination ⬇️

MicroRNA-449a levels increase by several orders of magnitude during mucociliary differentiation of airway epithelia

Mutual interference of adenovirus infection and myc expression

NF-Y dependent epigenetic modifications discriminate between proliferating and postmitotic tissue

Neutralization of SARS-CoV-2 by highly potent, hyperthermostable, and mutation-tolerant nanobodies

Non-hominid TP63 lacks retroviral LTRs but contains a novel conserved upstream exon

Nongenotoxic p53 activation protects cells against S-phase-specific chemotherapy

Nuclear export of the E1B 55-kDa and E4 34-kDa adenoviral oncoproteins mediated by a rev-like signal sequence ⬇️

Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein.

Overcoming EMT-driven therapeutic resistance by BH3 mimetics

Protection against apoptosis by the vaccinia virus SPI-2 (B13R) gene product

Reactivation of mutant p53 by a one-hybrid adaptor protein.

Rev protein of human immunodeficiency virus type 1 and cellular exportin 1 protein relocalize each other to a subnucleolar structure

Screening analysis of ubiquitin ligases reveals G2E3 as a potential target for chemosensitizing cancer cells

Self-association of adenovirus type 5 E1B-55 kDa as well as p53 is essential for their mutual interaction

TAp73 is essential for germ cell adhesion and maturation in testis.

Targeting tumour-supportive cellular machineries in anticancer drug development

Telethonin deficiency is associated with maladaptation to biomechanical stress in the mammalian heart

The CDK4/6-EZH2 pathway is a potential therapeutic target for psoriasis

The MAPK-activated protein kinase 2 mediates gemcitabine sensitivity in pancreatic cancer cells

The MDM2 oncoprotein binds specifically to RNA through its RING finger domain

The alpha/beta carboxy-terminal domains of p63 are required for skin and limb development. New insights from the Brdm2 mouse which is not a complete p63 knockout but expresses p63 gamma-like proteins

The large T antigen of simian virus 40 binds and inactivates p53 but not p73.

The nuclear export signal within the E4orf6 protein of adenovirus type 5 supports virus replication and cytoplasmic accumulation of viral mRNA.

Tumor-derived mutations within the DNA-binding domain of p53 that phenotypically resemble the deletion of the proline-rich domain

UDP glucuronosyltransferase 1A expression levels determine the response of colorectal cancer cells to the heat shock protein 90 inhibitor ganetespib