Lista de obras - Gergely L Lukacs - Dominio Público Uruguay

(+)-Cyanidanol-3 prevents the functional deterioration of rat liver mitochondria induced by Fe2+ ions

scientific article published on 01 July 1986

A Christianson syndrome-linked deletion mutation (∆(287)ES(288)) in SLC9A6 disrupts recycling endosomal function and elicits neurodegeneration and cell death

artículo científico publicado en 2016

A human epithelium-specific vector optimized in rat pneumocytes for lung gene therapy

artículo científico publicado en 2000

Alcohol disrupts levels and function of the cystic fibrosis transmembrane conductance regulator to promote development of pancreatitis.

artículo científico publicado en 2014

Allosteric folding correction of F508del and rare CFTR mutants by elexacaftor-tezacaftor-ivacaftor (Trikafta) combination

artículo científico publicado en 2020

Amplification of thymosin beta 10 and AKAP13 genes in metastatic and aggressive papillary thyroid carcinomas.

artículo científico publicado en 2011

Analysis of differential lipofection efficiency in primary and established myoblasts

scientific article published on 01 February 2002

Analysis of endocytic trafficking by single-cell fluorescence ratio imaging

artículo científico publicado en 2008

Antibodies for CFTR studies.

artículo científico publicado en 2004

Antifungal activity of statins and their interaction with amphotericin B against clinically important Zygomycetes

artículo científico publicado en 2010

Ba2+ ions inhibit the release of Ca2+ ions from rat liver mitochondria

artículo científico publicado en 1985

Binding of inositol phosphates and induction of Ca2+ release from pituitary microsomal fractions

artículo científico publicado en 1987

Bioactive Thymosin Alpha-1 Does Not Influence F508del-CFTR Maturation and Activity

scientific article published on 16 July 2019

Biochemical methods to assess CFTR expression and membrane localization

article

C-terminal truncations destabilize the cystic fibrosis transmembrane conductance regulator without impairing its biogenesis. A novel class of mutation

artículo científico publicado en 1999

CFTR Folding Consortium: methods available for studies of CFTR folding and correction

artículo científico publicado en 2011

CFTR chloride channel drug discovery--inhibitors as antidiarrheals and activators for therapy of cystic fibrosis

artículo científico publicado en 2006

CFTR folding and maturation in cells

artículo científico publicado en 2002

CFTR: A New Horizon in the Pathomechanism and Treatment of Pancreatitis

artículo científico publicado en 2016

CFTR: folding, misfolding and correcting the ΔF508 conformational defect.

artículo científico publicado en 2011

Cell surface dynamics of CFTR: the ins and outs.

artículo científico publicado en 2007

Channel Gating Regulation by the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) First Cytosolic Loop

artículo científico publicado en 2015

Chaperone-Independent Peripheral Quality Control of CFTR by RFFL E3 Ligase.

artículo científico publicado en 2018

Chaperones rescue the energetic landscape of mutant CFTR at single molecule and in cell.

artículo científico publicado en 2017

Comparative processing and function of human and ferret cystic fibrosis transmembrane conductance regulator.

artículo científico publicado en 2012

Conformational and temperature-sensitive stability defects of the delta F508 cystic fibrosis transmembrane conductance regulator in post-endoplasmic reticulum compartments.

artículo científico publicado en 2000

Conformational maturation of CFTR but not its mutant counterpart (delta F508) occurs in the endoplasmic reticulum and requires ATP

artículo científico publicado en 1994

Constitutive internalization of cystic fibrosis transmembrane conductance regulator occurs via clathrin-dependent endocytosis and is regulated by protein phosphorylation

artículo científico publicado en 1997

Contrasting nuclear dynamics of the caspase-activated DNase (CAD) in dividing and apoptotic cells

artículo científico publicado en 2004

Cooperative assembly and misfolding of CFTR domains in vivo.

artículo científico publicado en 2009

Correction of both NBD1 energetics and domain interface is required to restore ΔF508 CFTR folding and function

artículo científico publicado en 2012

Correctors and Potentiators Rescue Function of the Truncated W1282X-Cystic Fibrosis Transmembrane Regulator (CFTR) Translation Product

artículo científico publicado en 2016

Curcumin, a major constituent of turmeric, corrects cystic fibrosis defects

artículo científico publicado en 2004

Cyanoquinolines with independent corrector and potentiator activities restore ΔPhe508-cystic fibrosis transmembrane conductance regulator chloride channel function in cystic fibrosis

artículo científico publicado en 2011

Cystic fibrosis mutations lead to carboxyl-terminal fragments that highlight an early biogenesis step of the cystic fibrosis transmembrane conductance regulator

artículo científico publicado en 2000

Degradation mechanism of a Golgi-retained distal renal tubular acidosis mutant of the kidney anion exchanger 1 in renal cells.

artículo científico publicado en 2014

Destabilization of the transmembrane domain induces misfolding in a phenotypic mutant of cystic fibrosis transmembrane conductance regulator

artículo científico publicado en 2004

Determinants of the phagosomal pH in macrophages. In situ assessment of vacuolar H(+)-ATPase activity, counterion conductance, and H+ "leak"

artículo científico publicado en 1991

Development and characterization of synthetic antibodies binding to the cystic fibrosis conductance regulator

artículo científico publicado en 2016

Development of an epithelium-specific expression cassette with human DNA regulatory elements for transgene expression in lung airways ⬇️

artículo científico publicado el 23 de diciembre de 1997

Device for filamentous fungi growth monitoring using the multimodal frequency response of cantilevers

artículo científico publicado en 2014

Differential Scanning Fluorimetry and Hydrogen Deuterium Exchange Mass Spectrometry to Monitor the Conformational Dynamics of NBD1 in Cystic Fibrosis

artículo científico publicado en 2019

Discovery of novel potent ΔF508-CFTR correctors that target the nucleotide binding domain

artículo científico publicado en 2013

Disruption of cytokeratin-8 interaction with F508del-CFTR corrects its functional defect

artículo científico publicado en 2012

Distinct structural domains confer cAMP sensitivity and ATP dependence to the Na+/H+ exchanger NHE3 isoform

artículo científico publicado en 1996

Dominant and recessive distal renal tubular acidosis mutations of kidney anion exchanger 1 induce distinct trafficking defects in MDCK cells

artículo científico publicado en 2006

Effect of inositol 1,4,5-trisphosphate and GTP on calcium release from pituitary microsomes

artículo científico publicado en 1987

Endocytic sorting of CFTR variants monitored by single-cell fluorescence ratiometric image analysis (FRIA) in living cells.

artículo científico publicado en 2011

Endosomal recycling of the Na+/H+ exchanger NHE3 isoform is regulated by the phosphatidylinositol 3-kinase pathway.

artículo científico publicado en 1998

Epithelial Anion Transport as Modulator of Chemokine Signaling

artículo científico publicado en 2016

Extracellular oxidation in Cystic Fibrosis airway epithelium causes enhanced EGFR/ADAM17 activity

artículo científico publicado en 2017

Fixing cystic fibrosis by correcting CFTR domain assembly

artículo científico publicado en 2012

From CFTR biology toward combinatorial pharmacotherapy: expanded classification of cystic fibrosis mutations

artículo científico publicado en 2016

Functional expression and apical localization of the cystic fibrosis transmembrane conductance regulator in MDCK I cells

artículo científico publicado en 1997

In vitro interactions between primycin and different statins in their effects against some clinically important fungi.

artículo científico publicado en 2009

Ins and outs of AlphaFold2 transmembrane protein structure predictions

artículo científico publicado en 2022

Insights into MLC pathogenesis: GlialCAM is an MLC1 chaperone required for proper activation of volume-regulated anion currents.

artículo científico publicado en 2013

Interplay of Endosomal pH and Ligand Occupancy in Integrin α5β1 Ubiquitination, Endocytic Sorting, and Cell Migration

artículo científico publicado en 2015

Intracellular barriers to non-viral gene transfer.

artículo científico publicado en 2002

Intracellular routing of plasmid DNA during non-viral gene transfer.

artículo científico publicado en 2005

Introduction to Section III: Biochemical Methods to Study CFTR Protein

article

Leukoencephalopathy-causing CLCN2 mutations are associated with impaired Cl- channel function and trafficking.

artículo científico publicado en 2017

Limited proteolysis as a probe for arrested conformational maturation of delta F508 CFTR

scientific article published on 01 March 1998

Measurement of the matrix free Ca2+ concentration in heart mitochondria by entrapped fura-2 and quin2.

artículo científico publicado en 1987

Mechanism-based corrector combination restores ΔF508-CFTR folding and function

artículo científico publicado en 2013

Metabolic instability of plasmid DNA in the cytosol: a potential barrier to gene transfer

artículo científico publicado en 1999

Misfolding diverts CFTR from recycling to degradation: quality control at early endosomes

artículo científico publicado en 2004

Molecular basis of oligoubiquitin-dependent internalization of membrane proteins in Mammalian cells

artículo científico publicado en 2006

Molecular proximity of cystic fibrosis transmembrane conductance regulator and epithelial sodium channel assessed by fluorescence resonance energy transfer

artículo científico publicado en 2007

Mutation-specific downregulation of CFTR2 variants by gating potentiators

artículo científico publicado en 2017

Mutation-specific dual potentiators maximize rescue of CFTR gating mutants

scientific article published on 30 October 2019

N-glycans are direct determinants of CFTR folding and stability in secretory and endocytic membrane traffic

artículo científico publicado en 2009

Nanomechanical sensors for single microbial cell growth monitoring

artículo científico publicado en 2014

Nanomolar affinity small molecule correctors of defective Delta F508-CFTR chloride channel gating.

artículo científico publicado en 2003

New insights into interactions between the nucleotide-binding domain of CFTR and keratin 8.

artículo científico publicado en 2016

Non-native Conformers of Cystic Fibrosis Transmembrane Conductance Regulator NBD1 Are Recognized by Hsp27 and Conjugated to SUMO-2 for Degradation

artículo científico publicado en 2015

Oligomerization state of the DNA fragmentation factor in normal and apoptotic cells

artículo científico publicado en 2005

PINK1 autophosphorylation is required for ubiquitin recognition

artículo científico publicado en 2018

Parallel measurement of oxoglutarate dehydrogenase activity and matrix free Ca2+ in fura-2-loaded heart mitochondria

artículo científico publicado en 1988

Peripheral protein quality control removes unfolded CFTR from the plasma membrane

artículo científico publicado en 2010

Phagosomal acidification is mediated by a vacuolar-type H(+)-ATPase in murine macrophages

scientific article published on 01 December 1990

Pharmacologic approaches to correcting the basic defect in cystic fibrosis

scientific article published on 01 October 2003

Pharmacological and biochemical properties of saxiphilin, a soluble saxitoxin-binding protein from the bullfrog (Rana catesbeiana) ⬇️

artículo científico publicado el 1 de enero de 1991

Phosphorylation-dependent modulation of CFTR macromolecular signalling complex activity by cigarette smoke condensate in airway epithelia

scientific article published on 03 September 2019

Polyubiquitination of prolactin receptor stimulates its internalization, postinternalization sorting, and degradation via the lysosomal pathway

artículo científico publicado en 2008

Potentiators of Defective ΔF508-CFTR Gating that Do Not Interfere with Corrector Action.

artículo científico publicado en 2015

Prevalence of postweaning multisystemic wasting syndrome in pigs sired by 13 Hungarian Landrace boars

artículo científico publicado en 2009

Proinflammatory cytokine secretion is suppressed by TMEM16A or CFTR channel activity in human cystic fibrosis bronchial epithelia

artículo científico publicado en 2012

Protein homeostasis at the plasma membrane

artículo científico publicado en 2014

Protein quality control at the plasma membrane

artículo científico publicado en 2011

Proteomics techniques for cystic fibrosis research.

artículo científico publicado en 2004

Proteostasis: Chaperoning for hearing loss

artículo científico publicado en 2016

Proton conductance of the plasma membrane: properties, regulation, and functional role

artículo científico publicado en 1993

Quality control for unfolded proteins at the plasma membrane

artículo científico publicado en 2010

Rattlesnake Phospholipase A2 Increases CFTR-Chloride Channel Current and Corrects ∆F508CFTR Dysfunction: Impact in Cystic Fibrosis

artículo científico publicado en 2016

Reduced PDZ interactions of rescued ΔF508CFTR increases its cell surface mobility.

artículo científico publicado en 2012

Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis

artículo científico publicado en 2010

Responsiveness of mutants of NHE1 isoform of Na+/H+ antiport to osmotic stress

artículo científico publicado en 1995

Revisiting the role of cystic fibrosis transmembrane conductance regulator and counterion permeability in the pH regulation of endocytic organelles

artículo científico publicado en 2009

Ribosomal Stalk Protein Silencing Partially Corrects the ΔF508-CFTR Functional Expression Defect

artículo científico publicado en 2016

Selective Binding of HSC70 and its Co-Chaperones to Structural Hotspots on CFTR

artículo científico publicado en 2020

Single Cell Fluorescence Ratio Image Analysis for Studying ESCRT Function in Receptor Trafficking

scientific article published on 01 January 2019

Single-particle electron microscopy structure of UDP-glucose:glycoprotein glucosyltransferase suggests a selectivity mechanism for misfolded proteins

artículo científico publicado en 2017

Small heat shock proteins target mutant cystic fibrosis transmembrane conductance regulator for degradation via a small ubiquitin-like modifier-dependent pathway

artículo científico publicado en 2012

Small-molecule correctors of defective DeltaF508-CFTR cellular processing identified by high-throughput screening.

artículo científico publicado en 2005

Some gating potentiators, including VX-770, diminish ΔF508-CFTR functional expression.

artículo científico publicado en 2014

Structure-guided combination therapy to potently improve the function of mutant CFTRs

article

Synergy-based small-molecule screen using a human lung epithelial cell line yields ΔF508-CFTR correctors that augment VX-809 maximal efficacy.

artículo científico publicado en 2014

The Ba2+ sensitivity of the Na+-induced Ca2+ efflux in heart mitochondria: the site of inhibitory action

artículo científico publicado en 1986

The DeltaF508 cystic fibrosis mutation impairs domain-domain interactions and arrests post-translational folding of CFTR.

artículo científico publicado en 2004

The ESCRT-III subunit hVps24 is required for degradation but not silencing of the epidermal growth factor receptor.

artículo científico publicado en 2006

The chloride channel blocker 5-nitro-2-(3-phenylpropyl-amino) benzoic acid (NPPB) uncouples mitochondria and increases the proton permeability of the plasma membrane in phagocytic cells

artículo científico publicado en 1991

The cystic fibrosis transmembrane regulator is present and functional in endosomes. Role as a determinant of endosomal pH

artículo científico publicado en 1992

The cystic fibrosis-causing mutation deltaF508 affects multiple steps in cystic fibrosis transmembrane conductance regulator biogenesis.

artículo científico publicado en 2010

The delta F508 mutation decreases the stability of cystic fibrosis transmembrane conductance regulator in the plasma membrane. Determination of functional half-lives on transfected cells

scientific article published on 01 October 1993

The effect of inositol 1,4,5-trisphosphate and GTP on calcium release from rat liver microsomes

artículo científico publicado en 1987

The epithelial sodium-hydrogen antiporter Na+/H+ exchanger 3 accumulates and is functional in recycling endosomes

artículo científico publicado en 1998

The first independent study on the complex trial protocol version of the P300-based concealed information test: Corroboration of previous findings and highlights on vulnerabilities

artículo científico publicado en 2016

The role of the C terminus and Na+/H+ exchanger regulatory factor in the functional expression of cystic fibrosis transmembrane conductance regulator in nonpolarized cells and epithelia

artículo científico publicado en 2003

Tracking of quantum dot-labeled CFTR shows near immobilization by C-terminal PDZ interactions

artículo científico publicado en 2006

Transcytosis maintains CFTR apical polarity in the face of constitutive and mutation-induced basolateral missorting

artículo científico publicado en 2019

Truncated SNAP-25 (1-197), like botulinum neurotoxin A, can inhibit insulin secretion from HIT-T15 insulinoma cells

artículo científico publicado en 1998

Ubiquitin-dependent sorting in endocytosis

artículo científico publicado en 2014

Ubiquitination-dependent quality control of hERG K+ channel with acquired and inherited conformational defect at the plasma membrane

artículo científico publicado en 2013

V-ATPases in phagocytic cells

artículo científico publicado el 1 de noviembre de 1992

[The role of preoperative investigation with 18-FDG-PET/CT in primary operable breast cancer].

artículo científico publicado en 2009

hERG quality control and the long QT syndrome

artículo científico

ΔF508-CFTR Modulator Screen Based on Cell Surface Targeting of a Chimeric Nucleotide Binding Domain 1 Reporter

artículo científico publicado en 2018

Lista de obras de Gergely L Lukacs

(+)-Cyanidanol-3 prevents the functional deterioration of rat liver mitochondria induced by Fe2+ ions

A Christianson syndrome-linked deletion mutation (∆(287)ES(288)) in SLC9A6 disrupts recycling endosomal function and elicits neurodegeneration and cell death

A human epithelium-specific vector optimized in rat pneumocytes for lung gene therapy

Alcohol disrupts levels and function of the cystic fibrosis transmembrane conductance regulator to promote development of pancreatitis.

Allosteric folding correction of F508del and rare CFTR mutants by elexacaftor-tezacaftor-ivacaftor (Trikafta) combination

Amplification of thymosin beta 10 and AKAP13 genes in metastatic and aggressive papillary thyroid carcinomas.

Analysis of differential lipofection efficiency in primary and established myoblasts

Analysis of endocytic trafficking by single-cell fluorescence ratio imaging

Antibodies for CFTR studies.

Antifungal activity of statins and their interaction with amphotericin B against clinically important Zygomycetes

Ba2+ ions inhibit the release of Ca2+ ions from rat liver mitochondria

Binding of inositol phosphates and induction of Ca2+ release from pituitary microsomal fractions

Bioactive Thymosin Alpha-1 Does Not Influence F508del-CFTR Maturation and Activity

Biochemical methods to assess CFTR expression and membrane localization

C-terminal truncations destabilize the cystic fibrosis transmembrane conductance regulator without impairing its biogenesis. A novel class of mutation

CFTR Folding Consortium: methods available for studies of CFTR folding and correction

CFTR chloride channel drug discovery--inhibitors as antidiarrheals and activators for therapy of cystic fibrosis

CFTR folding and maturation in cells

CFTR: A New Horizon in the Pathomechanism and Treatment of Pancreatitis

CFTR: folding, misfolding and correcting the ΔF508 conformational defect.

Cell surface dynamics of CFTR: the ins and outs.

Channel Gating Regulation by the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) First Cytosolic Loop

Chaperone-Independent Peripheral Quality Control of CFTR by RFFL E3 Ligase.

Chaperones rescue the energetic landscape of mutant CFTR at single molecule and in cell.

Comparative processing and function of human and ferret cystic fibrosis transmembrane conductance regulator.

Conformational and temperature-sensitive stability defects of the delta F508 cystic fibrosis transmembrane conductance regulator in post-endoplasmic reticulum compartments.

Conformational maturation of CFTR but not its mutant counterpart (delta F508) occurs in the endoplasmic reticulum and requires ATP

Constitutive internalization of cystic fibrosis transmembrane conductance regulator occurs via clathrin-dependent endocytosis and is regulated by protein phosphorylation

Contrasting nuclear dynamics of the caspase-activated DNase (CAD) in dividing and apoptotic cells

Cooperative assembly and misfolding of CFTR domains in vivo.

Correction of both NBD1 energetics and domain interface is required to restore ΔF508 CFTR folding and function

Correctors and Potentiators Rescue Function of the Truncated W1282X-Cystic Fibrosis Transmembrane Regulator (CFTR) Translation Product

Curcumin, a major constituent of turmeric, corrects cystic fibrosis defects

Cyanoquinolines with independent corrector and potentiator activities restore ΔPhe508-cystic fibrosis transmembrane conductance regulator chloride channel function in cystic fibrosis

Cystic fibrosis mutations lead to carboxyl-terminal fragments that highlight an early biogenesis step of the cystic fibrosis transmembrane conductance regulator

Degradation mechanism of a Golgi-retained distal renal tubular acidosis mutant of the kidney anion exchanger 1 in renal cells.

Destabilization of the transmembrane domain induces misfolding in a phenotypic mutant of cystic fibrosis transmembrane conductance regulator

Determinants of the phagosomal pH in macrophages. In situ assessment of vacuolar H(+)-ATPase activity, counterion conductance, and H+ "leak"

Development and characterization of synthetic antibodies binding to the cystic fibrosis conductance regulator

Development of an epithelium-specific expression cassette with human DNA regulatory elements for transgene expression in lung airways ⬇️

Device for filamentous fungi growth monitoring using the multimodal frequency response of cantilevers

Differential Scanning Fluorimetry and Hydrogen Deuterium Exchange Mass Spectrometry to Monitor the Conformational Dynamics of NBD1 in Cystic Fibrosis

Discovery of novel potent ΔF508-CFTR correctors that target the nucleotide binding domain

Disruption of cytokeratin-8 interaction with F508del-CFTR corrects its functional defect

Distinct structural domains confer cAMP sensitivity and ATP dependence to the Na+/H+ exchanger NHE3 isoform

Dominant and recessive distal renal tubular acidosis mutations of kidney anion exchanger 1 induce distinct trafficking defects in MDCK cells

Effect of inositol 1,4,5-trisphosphate and GTP on calcium release from pituitary microsomes

Endocytic sorting of CFTR variants monitored by single-cell fluorescence ratiometric image analysis (FRIA) in living cells.

Endosomal recycling of the Na+/H+ exchanger NHE3 isoform is regulated by the phosphatidylinositol 3-kinase pathway.

Epithelial Anion Transport as Modulator of Chemokine Signaling

Extracellular oxidation in Cystic Fibrosis airway epithelium causes enhanced EGFR/ADAM17 activity

Fixing cystic fibrosis by correcting CFTR domain assembly

From CFTR biology toward combinatorial pharmacotherapy: expanded classification of cystic fibrosis mutations

Functional expression and apical localization of the cystic fibrosis transmembrane conductance regulator in MDCK I cells

In vitro interactions between primycin and different statins in their effects against some clinically important fungi.

Ins and outs of AlphaFold2 transmembrane protein structure predictions

Insights into MLC pathogenesis: GlialCAM is an MLC1 chaperone required for proper activation of volume-regulated anion currents.

Interplay of Endosomal pH and Ligand Occupancy in Integrin α5β1 Ubiquitination, Endocytic Sorting, and Cell Migration

Intracellular barriers to non-viral gene transfer.

Intracellular routing of plasmid DNA during non-viral gene transfer.

Introduction to Section III: Biochemical Methods to Study CFTR Protein

Leukoencephalopathy-causing CLCN2 mutations are associated with impaired Cl- channel function and trafficking.

Limited proteolysis as a probe for arrested conformational maturation of delta F508 CFTR

Measurement of the matrix free Ca2+ concentration in heart mitochondria by entrapped fura-2 and quin2.

Mechanism-based corrector combination restores ΔF508-CFTR folding and function

Metabolic instability of plasmid DNA in the cytosol: a potential barrier to gene transfer

Misfolding diverts CFTR from recycling to degradation: quality control at early endosomes

Molecular basis of oligoubiquitin-dependent internalization of membrane proteins in Mammalian cells

Molecular proximity of cystic fibrosis transmembrane conductance regulator and epithelial sodium channel assessed by fluorescence resonance energy transfer

Mutation-specific downregulation of CFTR2 variants by gating potentiators

Mutation-specific dual potentiators maximize rescue of CFTR gating mutants

N-glycans are direct determinants of CFTR folding and stability in secretory and endocytic membrane traffic

Nanomechanical sensors for single microbial cell growth monitoring

Nanomolar affinity small molecule correctors of defective Delta F508-CFTR chloride channel gating.

New insights into interactions between the nucleotide-binding domain of CFTR and keratin 8.

Non-native Conformers of Cystic Fibrosis Transmembrane Conductance Regulator NBD1 Are Recognized by Hsp27 and Conjugated to SUMO-2 for Degradation

Oligomerization state of the DNA fragmentation factor in normal and apoptotic cells

PINK1 autophosphorylation is required for ubiquitin recognition

Parallel measurement of oxoglutarate dehydrogenase activity and matrix free Ca2+ in fura-2-loaded heart mitochondria