Lista de obras - Opher Gileadi - Dominio Público Uruguay

A Ubiquitin-Binding Domain that Binds a Structural Fold Distinct from that of Ubiquitin

scientific article published on 13 June 2019

A prominent β-hairpin structure in the winged-helix domain of RECQ1 is required for DNA unwinding and oligomer formation.

artículo científico publicado en 2010

A small molecule inhibitor of the BLM helicase modulates chromosome stability in human cells

artículo científico publicado en 2013

An unusual eukaryotic protein phosphatase required for transcription by RNA polymerase II and CTD dephosphorylation in S. cerevisiae.

artículo científico publicado en 1999

Analysis of the Ac promoter: structure and regulation

artículo científico publicado en 1998

Autophosphorylation restrains the apoptotic activity of DRP-1 kinase by controlling dimerization and calmodulin binding

artículo científico publicado en 2001

Baculovirus expression vector system: an emerging host for high-throughput eukaryotic protein expression

artículo científico publicado en 2008

Binding and structural analyses of potent inhibitors of the human Ca2+/calmodulin dependent protein kinase kinase 2 (CAMKK2) identified from a collection of commercially-available kinase inhibitors

artículo científico publicado en 2019

CSB interacts with SNM1A and promotes DNA interstrand crosslink processing

artículo científico publicado en 2014

CTD kinase associated with yeast RNA polymerase II initiation factor b.

artículo científico publicado en 1991

Cak1 Is Required for Kin28 Phosphorylation and Activation In Vivo.

artículo científico publicado en 2000

Cephalosporins inhibit human metallo β-lactamase fold DNA repair nucleases SNM1A and SNM1B/apollo.

artículo científico publicado en 2016

Characterization of the human SNM1A and SNM1B/Apollo DNA repair exonucleases

artículo científico publicado en 2012

Codon optimization can improve expression of human genes in Escherichia coli: A multi-gene study.

artículo científico publicado en 2008

Crystal Structures of Malonyl-Coenzyme A Decarboxylase Provide Insights into Its Catalytic Mechanism and Disease-Causing Mutations

artículo científico publicado en 2013

Crystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changes

artículo científico publicado en 2015

Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity

artículo científico publicado en 2007

Crystal structures of the catalytic domain of human soluble guanylate cyclase

artículo científico publicado en 2013

Direct observation of RuvAB-catalyzed branch migration of single Holliday junctions.

scholarly article

Distinct regions of MAT1 regulate cdk7 kinase and TFIIH transcription activities

artículo científico publicado en 2000

EXD2 promotes homologous recombination by facilitating DNA end resection

scientific journal article

Electron microscopy of wet tissues: a case study in renal pathology

artículo científico publicado en 2004

Expressing the human proteome for affinity proteomics: optimising expression of soluble protein domains and in vivo biotinylation

artículo científico publicado en 2011

FOXN1 forms higher-order nuclear condensates displaced by mutations causing immunodeficiency

artículo científico publicado en 2021

Glucose starvation induces a drastic reduction in the rates of both transcription and degradation of mRNA in yeast

scientific article published on 01 April 2000

High-performance liquid chromatography separation and intact mass analysis of detergent-solubilized integral membrane proteins

artículo científico publicado en 2010

High-throughput production of human proteins for crystallization: the SGC experience.

artículo científico publicado en 2010

Homozygous mutations in a predicted endonuclease are a novel cause of congenital dyserythropoietic anemia type I

artículo científico publicado en 2013

Human RECQ1 helicase-driven DNA unwinding, annealing, and branch migration: insights from DNA complex structures

artículo científico publicado en 2015

Human SNM1A and XPF-ERCC1 collaborate to initiate DNA interstrand cross-link repair

artículo científico

Identification of LACTB2, a metallo-β-lactamase protein, as a human mitochondrial endoribonuclease

scientific journal article

Identification of human satellite DNA sequences associated with chemically resistant nonhistone polypeptide adducts

artículo científico publicado el 1 de octubre de 1992

Implementation of an antibody characterization procedure and application to the major ALS/FTD disease gene C9ORF72

artículo científico publicado en 2019

Insights into the RecQ helicase mechanism revealed by the structure of the helicase domain of human RECQL5.

artículo científico publicado en 2017

Involvement of yeast carboxy-terminal domain kinase I (CTDK-I) in transcription elongation in vivo

artículo científico publicado en 2001

Isolated short CTG/CAG DNA slip-outs are repaired efficiently by hMutSbeta, but clustered slip-outs are poorly repaired

artículo científico publicado en 2010

Location of RNase and RNase inhibitor on free cytoplasmic mRNA-protein particles from human placenta

artículo científico publicado en 1984

Mechanistic insight into the interaction of BLM helicase with intra-strand G-quadruplex structures

artículo científico publicado en 2014

Medium-throughput production of recombinant human proteins: ligation-independent cloning

artículo científico publicado en 2014

Medium-throughput production of recombinant human proteins: protein production in E. coli

artículo científico publicado en 2014

Medium-throughput production of recombinant human proteins: protein production in insect cells

artículo científico publicado en 2014

Metalloprotease SPRTN/DVC1 Orchestrates Replication-Coupled DNA-Protein Crosslink Repair

artículo científico publicado en 2016

Mutations in multidomain protein MEGF8 identify a Carpenter syndrome subtype associated with defective lateralization

artículo científico publicado en 2012

Mutations in the RING domain of TFB3, a subunit of yeast transcription factor IIH, reveal a role in cell cycle progression

artículo científico publicado en 2002

Protein production and purification

artículo científico publicado en 2008

Recent advances in the structural molecular biology of Ets transcription factors: interactions, interfaces and inhibition.

artículo científico

Scanning electron microscopy of cells and tissues under fully hydrated conditions

scholarly article

Squid sperm to clam eggs: imaging wet samples in a scanning electron microscope.

artículo científico publicado en 2003

Structural Analysis of Inhibitor Binding to CAMKK1 Identifies Features Necessary for Design of Specific Inhibitors

artículo científico publicado en 2018

Structural Basis for Cul3 Protein Assembly with the BTB-Kelch Family of E3 Ubiquitin Ligases

artículo científico publicado en 2013

Structural Basis of Metallo-β-Lactamase Inhibition by Captopril Stereoisomers

artículo científico publicado en 2015

Structural and functional insights into the DNA replication factor Cdc45 reveal an evolutionary relationship to the DHH family of phosphoesterases

artículo científico publicado en 2011

Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases

artículo científico publicado en 2013

Structural basis of fumarate hydratase deficiency

artículo científico publicado en 2011

Structural insights into the autoregulation and cooperativity of the human transcription factor Ets-2

artículo científico publicado en 2015

Structure of the Helicase Domain of DNA Polymerase Theta Reveals a Possible Role in the Microhomology-Mediated End-Joining Pathway.

artículo científico publicado en 2015

Structure of the helicase core of Werner helicase, a key target in microsatellite instability cancers

artículo científico publicado en 2020

Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states

artículo científico publicado en 2013

Structures of Two Melanoma-Associated Antigens Suggest Allosteric Regulation of Effector Binding

artículo científico publicado en 2016

Structures of soluble guanylate cyclase: implications for regulatory mechanisms and drug development

artículo científico

Structures of the Ets Protein DNA-binding Domains of Transcription Factors Etv1, Etv4, Etv5, and Fev: DETERMINANTS OF DNA BINDING AND REDOX REGULATION BY DISULFIDE BOND FORMATION.

artículo científico publicado en 2015

Synthesis and SAR studies of 5-(pyridin-4-yl)-1,3,4-thiadiazol-2-amine derivatives as potent inhibitors of Bloom helicase

artículo científico publicado en 2013

The PHD and chromo domains regulate the ATPase activity of the human chromatin remodeler CHD4

artículo científico publicado en 2012

The crystal structure of human forkhead box N1 in complex with DNA reveals the structural basis for forkhead box family specificity

scientific article published on 30 December 2019

The scientific impact of the Structural Genomics Consortium: a protein family and ligand-centered approach to medically-relevant human proteins

artículo científico publicado en 2007

The structures of the SNM1A and SNM1B/Apollo nuclease domains reveal a potential basis for their distinct DNA processing activities

artículo científico publicado en 2015

Transcription of the H19 gene in differentiating cytotrophoblasts from human placenta

artículo científico publicado el 1 de julio de 1992

Lista de obras de Opher Gileadi

A Ubiquitin-Binding Domain that Binds a Structural Fold Distinct from that of Ubiquitin

A prominent β-hairpin structure in the winged-helix domain of RECQ1 is required for DNA unwinding and oligomer formation.

A small molecule inhibitor of the BLM helicase modulates chromosome stability in human cells

An unusual eukaryotic protein phosphatase required for transcription by RNA polymerase II and CTD dephosphorylation in S. cerevisiae.

Analysis of the Ac promoter: structure and regulation

Autophosphorylation restrains the apoptotic activity of DRP-1 kinase by controlling dimerization and calmodulin binding

Baculovirus expression vector system: an emerging host for high-throughput eukaryotic protein expression

Binding and structural analyses of potent inhibitors of the human Ca2+/calmodulin dependent protein kinase kinase 2 (CAMKK2) identified from a collection of commercially-available kinase inhibitors

CSB interacts with SNM1A and promotes DNA interstrand crosslink processing

CTD kinase associated with yeast RNA polymerase II initiation factor b.

Cak1 Is Required for Kin28 Phosphorylation and Activation In Vivo.

Cephalosporins inhibit human metallo β-lactamase fold DNA repair nucleases SNM1A and SNM1B/apollo.

Characterization of the human SNM1A and SNM1B/Apollo DNA repair exonucleases

Codon optimization can improve expression of human genes in Escherichia coli: A multi-gene study.

Crystal Structures of Malonyl-Coenzyme A Decarboxylase Provide Insights into Its Catalytic Mechanism and Disease-Causing Mutations

Crystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changes

Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity

Crystal structures of the catalytic domain of human soluble guanylate cyclase

Direct observation of RuvAB-catalyzed branch migration of single Holliday junctions.

Distinct regions of MAT1 regulate cdk7 kinase and TFIIH transcription activities

EXD2 promotes homologous recombination by facilitating DNA end resection

Electron microscopy of wet tissues: a case study in renal pathology

Expressing the human proteome for affinity proteomics: optimising expression of soluble protein domains and in vivo biotinylation

FOXN1 forms higher-order nuclear condensates displaced by mutations causing immunodeficiency

Glucose starvation induces a drastic reduction in the rates of both transcription and degradation of mRNA in yeast

High-performance liquid chromatography separation and intact mass analysis of detergent-solubilized integral membrane proteins

High-throughput production of human proteins for crystallization: the SGC experience.

Homozygous mutations in a predicted endonuclease are a novel cause of congenital dyserythropoietic anemia type I

Human RECQ1 helicase-driven DNA unwinding, annealing, and branch migration: insights from DNA complex structures

Human SNM1A and XPF-ERCC1 collaborate to initiate DNA interstrand cross-link repair

Identification of LACTB2, a metallo-β-lactamase protein, as a human mitochondrial endoribonuclease

Identification of human satellite DNA sequences associated with chemically resistant nonhistone polypeptide adducts

Implementation of an antibody characterization procedure and application to the major ALS/FTD disease gene C9ORF72

Insights into the RecQ helicase mechanism revealed by the structure of the helicase domain of human RECQL5.

Involvement of yeast carboxy-terminal domain kinase I (CTDK-I) in transcription elongation in vivo

Isolated short CTG/CAG DNA slip-outs are repaired efficiently by hMutSbeta, but clustered slip-outs are poorly repaired

Location of RNase and RNase inhibitor on free cytoplasmic mRNA-protein particles from human placenta

Mechanistic insight into the interaction of BLM helicase with intra-strand G-quadruplex structures

Medium-throughput production of recombinant human proteins: ligation-independent cloning

Medium-throughput production of recombinant human proteins: protein production in E. coli

Medium-throughput production of recombinant human proteins: protein production in insect cells

Metalloprotease SPRTN/DVC1 Orchestrates Replication-Coupled DNA-Protein Crosslink Repair

Mutations in multidomain protein MEGF8 identify a Carpenter syndrome subtype associated with defective lateralization

Mutations in the RING domain of TFB3, a subunit of yeast transcription factor IIH, reveal a role in cell cycle progression

Protein production and purification

Recent advances in the structural molecular biology of Ets transcription factors: interactions, interfaces and inhibition.

Scanning electron microscopy of cells and tissues under fully hydrated conditions

Squid sperm to clam eggs: imaging wet samples in a scanning electron microscope.

Structural Analysis of Inhibitor Binding to CAMKK1 Identifies Features Necessary for Design of Specific Inhibitors

Structural Basis for Cul3 Protein Assembly with the BTB-Kelch Family of E3 Ubiquitin Ligases

Structural Basis of Metallo-β-Lactamase Inhibition by Captopril Stereoisomers

Structural and functional insights into the DNA replication factor Cdc45 reveal an evolutionary relationship to the DHH family of phosphoesterases

Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases

Structural basis of fumarate hydratase deficiency

Structural insights into the autoregulation and cooperativity of the human transcription factor Ets-2

Structure of the Helicase Domain of DNA Polymerase Theta Reveals a Possible Role in the Microhomology-Mediated End-Joining Pathway.

Structure of the helicase core of Werner helicase, a key target in microsatellite instability cancers

Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states

Structures of Two Melanoma-Associated Antigens Suggest Allosteric Regulation of Effector Binding

Structures of soluble guanylate cyclase: implications for regulatory mechanisms and drug development

Structures of the Ets Protein DNA-binding Domains of Transcription Factors Etv1, Etv4, Etv5, and Fev: DETERMINANTS OF DNA BINDING AND REDOX REGULATION BY DISULFIDE BOND FORMATION.

Synthesis and SAR studies of 5-(pyridin-4-yl)-1,3,4-thiadiazol-2-amine derivatives as potent inhibitors of Bloom helicase

The PHD and chromo domains regulate the ATPase activity of the human chromatin remodeler CHD4

The crystal structure of human forkhead box N1 in complex with DNA reveals the structural basis for forkhead box family specificity

The scientific impact of the Structural Genomics Consortium: a protein family and ligand-centered approach to medically-relevant human proteins

The structures of the SNM1A and SNM1B/Apollo nuclease domains reveal a potential basis for their distinct DNA processing activities

Transcription of the H19 gene in differentiating cytotrophoblasts from human placenta