Lista de obras - Monica Fedele - Dominio Público Uruguay

A mutated p53 gene alters thyroid cell differentiation.

artículo científico publicado en 1995

A novel member of the BTB/POZ family, PATZ, associates with the RNF4 RING finger protein and acts as a transcriptional repressor

artículo científico publicado en 2000

A polymorphism of HMGA1 protects against proliferative diabetic retinopathy by impairing HMGA1-induced VEGFA expression

artículo científico publicado en 2016

A truncated HMGA1 gene induces proliferation of the 3T3-L1 pre-adipocytic cells: a model of human lipomas

artículo científico publicado en 2003

Adenovirus-mediated suppression of HMGI(Y) protein synthesis as potential therapy of human malignant neoplasias

artículo científico publicado en 2000

Altered microRNA expression profile in human pituitary GH adenomas: down-regulation of miRNA targeting HMGA1, HMGA2, and E2F1.

artículo científico publicado en 2012

Animal Models of Human Pathology ⬇️

artículo científico publicado el 30 de junio de 2011

Animal Models of Human Pathology 2014.

artículo científico publicado en 2015

Animal Models of Human Pathology 2016.

artículo científico publicado en 2016

Animal models of human pathology 2012.

artículo científico publicado en 2012

Animal models of human pathology 2013

artículo científico publicado en 2014

Aptamer targeting EGFRvIII mutant hampers its constitutive autophosphorylation and affects migration, invasion and proliferation of glioblastoma cells

artículo científico publicado en 2015

Aptamer-mediated impairment of EGFR-integrin αvβ3 complex inhibits vasculogenic mimicry and growth of triple-negative breast cancers

artículo científico publicado en 2017

B-RAF mutations are a rare event in pituitary adenomas

artículo científico publicado en 2007

CBX7 gene expression plays a negative role in adipocyte cell growth and differentiation

artículo científico publicado en 2014

CBX7 is a tumor suppressor in mice and humans

artículo científico publicado en 2012

Chromobox protein homologue 7 protein, with decreased expression in human carcinomas, positively regulates E-cadherin expression by interacting with the histone deacetylase 2 protein

scientific journal article

Complementary actions of dopamine D2 receptor agonist and anti-vegf therapy on tumoral vessel normalization in a transgenic mouse model.

artículo científico publicado en 2017

Critical role of the HMGA2 gene in pituitary adenomas

artículo científico publicado en 2006

Detection of high-mobility group proteins A1 and A2 represents a valid diagnostic marker in post-pubertal testicular germ cell tumours

article

Downregulation of HMGA-targeting microRNAs has a critical role in human pituitary tumorigenesis

artículo científico publicado en 2011

Dual Oncogenic/Anti-Oncogenic Role of PATZ1 in FRTL5 Rat Thyroid Cells Transformed by the Oncogene

article

E2F1 activation is responsible for pituitary adenomas induced by HMGA2 gene overexpression

artículo científico publicado en 2006

Embryonic defects and growth alteration in mice with homozygous disruption of the Patz1 gene

artículo científico publicado en 2013

Establishment of a non-tumorigenic papillary thyroid cell line (FB-2) carrying the RET/PTC1 rearrangement

artículo científico publicado en 2002

Expression of the neoplastic phenotype by human thyroid carcinoma cell lines requires NFkappaB p65 protein expression.

artículo científico publicado en 1997

FRA-1 expression in hyperplastic and neoplastic thyroid diseases

artículo científico publicado en 2000

HAND1 gene expression is negatively regulated by the High Mobility Group A1 proteins and is drastically reduced in human thyroid carcinomas

article

HMGA and cancer

artículo científico publicado en 2010

HMGA proteins promote ATM expression and enhance cancer cell resistance to genotoxic agents

artículo científico publicado en 2011

HMGA1 and HMGA2 protein expression in mouse spermatogenesis

scientific journal article

HMGA1 protein expression sensitizes cells to cisplatin-induced cell death

artículo científico publicado en 2005

HMGA1 protein is a novel target of the ATM kinase

artículo científico publicado en 2008

HMGA1 protein overexpression in human breast carcinomas: correlation with ErbB2 expression

artículo científico publicado en 2004

HMGA2 cooperates with either p27(kip1) deficiency or Cdk4(R24C) mutation in pituitary tumorigenesis.

artículo científico publicado en 2017

HMGA2 induces pituitary tumorigenesis by enhancing E2F1 activity

artículo científico publicado en 2006

HMGA2: A pituitary tumour subtype-specific oncogene?

artículo científico publicado en 2010

Haploinsufficiency of the Hmga1 gene causes cardiac hypertrophy and myelo-lymphoproliferative disorders in mice.

artículo científico publicado en 2006

High level expression of the HMGI (Y) gene during embryonic development.

artículo científico publicado en 1996

High mobility group A-interacting proteins in cancer: focus on chromobox protein homolog 7, homeodomain interacting protein kinase 2 and PATZ

article

High mobility group HMGI(Y) protein expression in human colorectal hyperplastic and neoplastic diseases.

artículo científico publicado en 2001

High-mobility group A1 proteins are overexpressed in human leukaemias

artículo científico publicado en 2003

High-mobility-group A1 (HMGA1) proteins down-regulate the expression of the recombination activating gene 2 (RAG2).

artículo científico publicado en 2005

Hmga1 null mice are less susceptible to chemically induced skin carcinogenesis

artículo científico publicado en 2007

Hmga1/Hmga2 double knock-out mice display a "superpygmy" phenotype

artículo científico publicado en 2014

Hot Topics in Endocrine and Endocrine-Related Diseases

Human colorectal carcinomas express high levels of high mobility group HMGI(Y) proteins

artículo científico publicado en 1996

IFN-gamma gene expression is controlled by the architectural transcription factor HMGA1.

artículo científico publicado en 2005

Identification and Characterization of a Novel RING-Finger Gene (RNF4) Mapping at 4p16.3 ⬇️

artículo científico publicado el 15 de enero de 1998

Identification of the genes up- and down-regulated by the high mobility group A1 (HMGA1) proteins: tissue specificity of the HMGA1-dependent gene regulation

artículo científico publicado en 2004

Impairment of the p27kip1 function enhances thyroid carcinogenesis in TRK-T1 transgenic mice

artículo científico publicado en 2009

Increase in AP-1 activity is a general event in thyroid cell transformation in vitro and in vivo

artículo científico publicado en 1998

Involvement of the HMGIY gene in a microfollicular adenoma of the thyroid

artículo científico publicado en 1999

Lack of the architectural factor HMGA1 causes insulin resistance and diabetes in humans and mice

artículo científico publicado en 2005

Loss of Hmga1 gene function affects embryonic stem cell lympho-hematopoietic differentiation

artículo científico publicado en 2003

Loss of One or Two PATZ1 Alleles Has a Critical Role in the Progression of Thyroid Carcinomas Induced by the RET/PTC1 Oncogene.

artículo científico publicado en 2018

MicroRNAs in pituitary tumours

Negative Regulation of BRCA1 Gene Expression by HMGA1 Proteins Accounts for the Reduced BRCA1 Protein Levels in Sporadic Breast Carcinoma

artículo científico publicado en 2003

Neoplastic transformation of rat thyroid cells requires the junB and fra-1 gene induction which is dependent on the HMGI-C gene product

artículo científico publicado en 1997

Non-Histone Chromatin Proteins

Novel Aptamers Selected on Living Cells for Specific Recognition of Triple-Negative Breast Cancer

artículo científico publicado en 2020

Oligonucleotide aptamers against tyrosine kinase receptors: Prospect for anticancer applications.

artículo científico publicado en 2018

Onset of natural killer cell lymphomas in transgenic mice carrying a truncated HMGI-C gene by the chronic stimulation of the IL-2 and IL-15 pathway

artículo científico publicado en 2001

Overexpression of the HMGA2 gene in transgenic mice leads to the onset of pituitary adenomas

artículo científico publicado en 2002

PATZ attenuates the RNF4-mediated enhancement of androgen receptor-dependent transcription

artículo científico publicado en 2001

PATZ1 Is Overexpressed in Pediatric Glial Tumors and Correlates with Worse Event-Free Survival in High-grade Gliomas

artículo científico publicado en 2019

PATZ1 acts as a tumor suppressor in thyroid cancer via targeting p53-dependent genes involved in EMT and cell migration

artículo científico publicado en 2015

PATZ1 downregulation promotes proliferation and migration in Ras-driven thyroid transformation

PATZ1 expression correlates positively with BAX and negatively with BCL6 and survival in human diffuse large B cell lymphomas

artículo científico publicado en 2016

PATZ1 gene has a critical role in the spermatogenesis and testicular tumours

scientific journal article

PATZ1 interacts with p53 and regulates expression of p53-target genes enhancing apoptosis or cell survival based on the cellular context

artículo científico publicado en 2013

PATZ1 is a new prognostic marker of glioblastoma associated with the stem-like phenotype and enriched in the proneural subtype.

artículo científico publicado en 2017

PATZ1 is a target of miR-29b that is induced by Ha-Ras oncogene in rat thyroid cells

artículo científico publicado en 2016

PIT1 upregulation by HMGA proteins has a role in pituitary tumorigenesis

artículo científico publicado en 2012

Phosphorylation of high-mobility group protein A2 by Nek2 kinase during the first meiotic division in mouse spermatocytes

scientific journal article

Pituitary Adenoma: Role of HMGA Proteins

Proneural-Mesenchymal Transition: Phenotypic Plasticity to Acquire Multitherapy Resistance in Glioblastoma

scientific article published on 04 June 2019

RNF4 is a growth inhibitor expressed in germ cells but not in human testicular tumors

artículo científico publicado en 2001

Regulation of microRNA expression by HMGA1 proteins

artículo científico publicado en 2009

Regulation of thymosin beta10 expression by TSH and other mitogenic signals in the thyroid gland and in cultured thyrocytes

artículo científico publicado en 1999

Role of the high mobility group A proteins in the regulation of pituitary cell cycle

artículo científico publicado en 2010

Roles of HMGA proteins in cancer

artículo científico publicado en 2007

SOM230, A New Somatostatin Analogue, Is Highly Effective in the Therapy of Growth Hormone/Prolactin-Secreting Pituitary Adenomas

scientific article published on 01 May 2007

Selective Photo-Assisted Eradication of Triple-Negative Breast Cancer Cells through Aptamer Decoration of Doped Conjugated Polymer Nanoparticles

artículo científico publicado en 2022

Simian virus 40-like DNA sequences in human papillary thyroid carcinomas ⬇️

artículo científico publicado el 5 de febrero de 1998

Status and expression of thep16INK4 gene in human thyroid tumors and thyroid-tumor cell lines

article

Suppression of HMGA2 protein synthesis could be a tool for the therapy of well differentiated liposarcomas overexpressing HMGA2 ⬇️

artículo científico publicado el 1 de noviembre de 2003

TNBC Challenge: Oligonucleotide Aptamers for New Imaging and Therapy Modalities

scientific article published on 13 November 2018

Targeted imaging and inhibition of triple-negative breast cancer metastases by a PDGFRβ aptamer

artículo científico publicado en 2018

Targeting ofPATZ1by miR-29b is a downstream effect of oncogenic Ras signalling in thyroid cells

The Epithelial-to-Mesenchymal Transition in Breast Cancer: Focus on Basal-Like Carcinomas

artículo científico publicado en 2017

The Genetics of Pituitary Adenomas

article

The HMGA1-IGF-I/IGFBP system: a novel pathway for modulating glucose uptake

artículo científico publicado en 2012

The High Mobility Group A2 gene is amplified and overexpressed in human prolactinomas

article

The Mia/Cd-rap gene expression is downregulated by the high-mobility group A proteins in mouse pituitary adenomas.

artículo científico publicado en 2007

The POZ/BTB and AT-Hook Containing Zinc Finger 1 (PATZ1) Transcription Regulator: Physiological Functions and Disease Involvement

artículo científico publicado en 2017

The Transcription Regulator Patz1 Is Essential for Neural Stem Cell Maintenance and Proliferation

artículo científico publicado en 2021

The Tumor Suppressive Role of PATZ1 in Thyroid Cancer: A Matter of Epithelial-Mesenchymal Transition

article published in 2016

The dosage of Patz1 modulates reprogramming process.

artículo científico publicado en 2014

The expression of a truncated HMGI-C gene induces gigantism associated with lipomatosis.

artículo científico publicado en 1999

The homeodomain-interacting protein kinase 2 gene is expressed late in embryogenesis and preferentially in retina, muscle, and neural tissues

artículo científico publicado en 2002

Trabectedin modulates the senescence-associated secretory phenotype and promotes cell death in senescent tumor cells by targeting NF-κB.

artículo científico publicado en 2018

Transcriptional and post-transcriptional regulation of transmembrane protein 132A.

artículo científico publicado en 2015

Transgenic mice overexpressing the wild-type form of the HMGA1 gene develop mixed growth hormone/prolactin cell pituitary adenomas and natural killer cell lymphomas.

artículo científico publicado en 2005

Translational regulation of a novel testis-specific RNF4 transcript

artículo científico publicado en 2003

Truncated and chimeric HMGI-C genes induce neoplastic transformation of NIH3T3 murine fibroblasts

artículo científico publicado en 1998

Tumor suppressor activity of CBX7 in lung carcinogenesis

artículo científico publicado en 2012

Upregulation of vascular endothelial growth factor (VEGF) and downregulation of placenta growth factor (PlGF) associated with malignancy in human thyroid tumors and cell lines

artículo científico publicado en 1995

Lista de obras de Monica Fedele

A mutated p53 gene alters thyroid cell differentiation.

A novel member of the BTB/POZ family, PATZ, associates with the RNF4 RING finger protein and acts as a transcriptional repressor

A polymorphism of HMGA1 protects against proliferative diabetic retinopathy by impairing HMGA1-induced VEGFA expression

A truncated HMGA1 gene induces proliferation of the 3T3-L1 pre-adipocytic cells: a model of human lipomas

Adenovirus-mediated suppression of HMGI(Y) protein synthesis as potential therapy of human malignant neoplasias

Altered microRNA expression profile in human pituitary GH adenomas: down-regulation of miRNA targeting HMGA1, HMGA2, and E2F1.

Animal Models of Human Pathology ⬇️

Animal Models of Human Pathology 2014.

Animal Models of Human Pathology 2016.

Animal models of human pathology 2012.

Animal models of human pathology 2013

Aptamer targeting EGFRvIII mutant hampers its constitutive autophosphorylation and affects migration, invasion and proliferation of glioblastoma cells

Aptamer-mediated impairment of EGFR-integrin αvβ3 complex inhibits vasculogenic mimicry and growth of triple-negative breast cancers

B-RAF mutations are a rare event in pituitary adenomas

CBX7 gene expression plays a negative role in adipocyte cell growth and differentiation

CBX7 is a tumor suppressor in mice and humans

Chromobox protein homologue 7 protein, with decreased expression in human carcinomas, positively regulates E-cadherin expression by interacting with the histone deacetylase 2 protein

Complementary actions of dopamine D2 receptor agonist and anti-vegf therapy on tumoral vessel normalization in a transgenic mouse model.

Critical role of the HMGA2 gene in pituitary adenomas

Detection of high-mobility group proteins A1 and A2 represents a valid diagnostic marker in post-pubertal testicular germ cell tumours

Downregulation of HMGA-targeting microRNAs has a critical role in human pituitary tumorigenesis

Dual Oncogenic/Anti-Oncogenic Role of PATZ1 in FRTL5 Rat Thyroid Cells Transformed by the Oncogene

E2F1 activation is responsible for pituitary adenomas induced by HMGA2 gene overexpression

Embryonic defects and growth alteration in mice with homozygous disruption of the Patz1 gene

Establishment of a non-tumorigenic papillary thyroid cell line (FB-2) carrying the RET/PTC1 rearrangement

Expression of the neoplastic phenotype by human thyroid carcinoma cell lines requires NFkappaB p65 protein expression.

FRA-1 expression in hyperplastic and neoplastic thyroid diseases

HAND1 gene expression is negatively regulated by the High Mobility Group A1 proteins and is drastically reduced in human thyroid carcinomas

HMGA and cancer

HMGA proteins promote ATM expression and enhance cancer cell resistance to genotoxic agents

HMGA1 and HMGA2 protein expression in mouse spermatogenesis

HMGA1 protein expression sensitizes cells to cisplatin-induced cell death

HMGA1 protein is a novel target of the ATM kinase

HMGA1 protein overexpression in human breast carcinomas: correlation with ErbB2 expression

HMGA2 cooperates with either p27(kip1) deficiency or Cdk4(R24C) mutation in pituitary tumorigenesis.

HMGA2 induces pituitary tumorigenesis by enhancing E2F1 activity

HMGA2: A pituitary tumour subtype-specific oncogene?

Haploinsufficiency of the Hmga1 gene causes cardiac hypertrophy and myelo-lymphoproliferative disorders in mice.

High level expression of the HMGI (Y) gene during embryonic development.

High mobility group A-interacting proteins in cancer: focus on chromobox protein homolog 7, homeodomain interacting protein kinase 2 and PATZ

High mobility group HMGI(Y) protein expression in human colorectal hyperplastic and neoplastic diseases.

High-mobility group A1 proteins are overexpressed in human leukaemias

High-mobility-group A1 (HMGA1) proteins down-regulate the expression of the recombination activating gene 2 (RAG2).

Hmga1 null mice are less susceptible to chemically induced skin carcinogenesis

Hmga1/Hmga2 double knock-out mice display a "superpygmy" phenotype

Hot Topics in Endocrine and Endocrine-Related Diseases

Human colorectal carcinomas express high levels of high mobility group HMGI(Y) proteins

IFN-gamma gene expression is controlled by the architectural transcription factor HMGA1.

Identification and Characterization of a Novel RING-Finger Gene (RNF4) Mapping at 4p16.3 ⬇️

Identification of the genes up- and down-regulated by the high mobility group A1 (HMGA1) proteins: tissue specificity of the HMGA1-dependent gene regulation

Impairment of the p27kip1 function enhances thyroid carcinogenesis in TRK-T1 transgenic mice

Increase in AP-1 activity is a general event in thyroid cell transformation in vitro and in vivo

Involvement of the HMGIY gene in a microfollicular adenoma of the thyroid

Lack of the architectural factor HMGA1 causes insulin resistance and diabetes in humans and mice

Loss of Hmga1 gene function affects embryonic stem cell lympho-hematopoietic differentiation

Loss of One or Two PATZ1 Alleles Has a Critical Role in the Progression of Thyroid Carcinomas Induced by the RET/PTC1 Oncogene.

MicroRNAs in pituitary tumours

Negative Regulation of BRCA1 Gene Expression by HMGA1 Proteins Accounts for the Reduced BRCA1 Protein Levels in Sporadic Breast Carcinoma

Neoplastic transformation of rat thyroid cells requires the junB and fra-1 gene induction which is dependent on the HMGI-C gene product

Non-Histone Chromatin Proteins

Novel Aptamers Selected on Living Cells for Specific Recognition of Triple-Negative Breast Cancer

Oligonucleotide aptamers against tyrosine kinase receptors: Prospect for anticancer applications.

Onset of natural killer cell lymphomas in transgenic mice carrying a truncated HMGI-C gene by the chronic stimulation of the IL-2 and IL-15 pathway

Overexpression of the HMGA2 gene in transgenic mice leads to the onset of pituitary adenomas

PATZ attenuates the RNF4-mediated enhancement of androgen receptor-dependent transcription

PATZ1 Is Overexpressed in Pediatric Glial Tumors and Correlates with Worse Event-Free Survival in High-grade Gliomas

PATZ1 acts as a tumor suppressor in thyroid cancer via targeting p53-dependent genes involved in EMT and cell migration

PATZ1 downregulation promotes proliferation and migration in Ras-driven thyroid transformation

PATZ1 expression correlates positively with BAX and negatively with BCL6 and survival in human diffuse large B cell lymphomas

PATZ1 gene has a critical role in the spermatogenesis and testicular tumours

PATZ1 interacts with p53 and regulates expression of p53-target genes enhancing apoptosis or cell survival based on the cellular context

PATZ1 is a new prognostic marker of glioblastoma associated with the stem-like phenotype and enriched in the proneural subtype.

PATZ1 is a target of miR-29b that is induced by Ha-Ras oncogene in rat thyroid cells

PIT1 upregulation by HMGA proteins has a role in pituitary tumorigenesis

Phosphorylation of high-mobility group protein A2 by Nek2 kinase during the first meiotic division in mouse spermatocytes

Pituitary Adenoma: Role of HMGA Proteins

Proneural-Mesenchymal Transition: Phenotypic Plasticity to Acquire Multitherapy Resistance in Glioblastoma

RNF4 is a growth inhibitor expressed in germ cells but not in human testicular tumors

Regulation of microRNA expression by HMGA1 proteins