Lista de obras - Hans Brandstetter - Dominio Público Uruguay

A Single Glycan at the 99-Loop of Human Kallikrein-related Peptidase 2 Regulates Activation and Enzymatic Activity

artículo científico publicado en 2015

A universal strategy for high-yield production of soluble and functional clostridial collagenases in E. coli

artículo científico publicado en 2009

Activation mechanisms of coagulation factor IX.

scientific article published on May 2009

Activation of legumain involves proteolytic and conformational events, resulting in a context- and substrate-dependent activity profile.

artículo científico publicado en 2011

Analytical Cascades of Enzymes for Sensitive Detection of Structural Variations in Protein Samples.

artículo científico publicado en 2018

Biochemical characterization of the catalytic domains of three different Clostridial collagenases.

artículo científico publicado en 2009

Bis-substituted malonic acid hydroxamate derivatives as inhibitors of human neutrophil collagenase (MMP8).

artículo científico publicado en 1998

Changing residue 338 in human factor IX from arginine to alanine causes an increase in catalytic activity

scientific article published on 01 May 1998

Cloning, Purification and Characterization of the Collagenase ColA Expressed by Bacillus cereus ATCC 14579

artículo científico publicado en 2016

Coagulation factor IXa: the relaxed conformation of Tyr99 blocks substrate binding

artículo científico publicado en 1999

Complex assemblies of factors IX and X regulate the initiation, maintenance, and shutdown of blood coagulation

artículo científico publicado en 2011

Converting blood coagulation factor IXa into factor Xa: dramatic increase in amidolytic activity identifies important active site determinants

artículo científico publicado en 1997

Crystal Structures of the Viral Protease Npro Imply Distinct Roles for the Catalytic Water in Catalysis

artículo científico publicado en 2013

Crystal structure of Pla l 1 reveals both structural similarity and allergenic divergence within the Ole e 1-like protein family

artículo científico publicado en 2016

Crystal structure of plant legumain reveals a unique two-chain state with pH-dependent activity regulation.

artículo científico publicado en 2018

Crystal structure of the NADP-dependent mannitol dehydrogenase from Cladosporium herbarum: Implications for oligomerisation and catalysis

artículo científico publicado en 2010

Crystal structure of the catalytic domain of human atypical protein kinase C-iota reveals interaction mode of phosphorylation site in turn motif

artículo científico publicado en 2005

Crystal structure of the tricorn protease reveals a protein disassembly line

artículo científico publicado en 2001

Crystal structures of the tricorn interacting factor F3 from Thermoplasma acidophilum, a zinc aminopeptidase in three different conformations

artículo científico publicado en 2005

Crystal structures of uninhibited factor VIIa link its cofactor and substrate-assisted activation to specific interactions

artículo científico publicado en 2002

Crystallization and preliminary X-ray characterization of the catalytic domain of collagenase G from Clostridium histolyticum

artículo científico

Crystallographic determination of thrombin complexes with small synthetic inhibitors as a starting point for the receptor-based design of antithrombotics

artículo científico publicado en 1993

Crystallographically Mapped Ligand Binding Differs in High and Low IgE Binding Isoforms of Birch Pollen Allergen Bet v 1

artículo científico publicado en 2012

Design and synthesis of malonic acid-based inhibitors of human neutrophil collagenase (MMP8)

scientific article published on 01 January 1998

Discovery of a Potent Inhibitor Class with High Selectivity toward Clostridial Collagenases.

artículo científico publicado en 2017

Distinct Roles of Catalytic Cysteine and Histidine in the Protease and Ligase Mechanisms of Human Legumain As Revealed by DFT-Based QM/MM Simulations

artículo científico publicado en 2017

Do-it-yourself histidine-tagged bovine enterokinase: a handy member of the protein engineer's toolbox.

artículo científico publicado en 2013

Enzyme flexibility, solvent and 'weak' interactions characterize thrombin-ligand interactions: implications for drug design

artículo científico publicado en 1996

ExteNDing Proteome Coverage with Legumain as a Highly Specific Digestion Protease

scientific article published on 31 January 2020

Fold stability during endolysosomal acidification is a key factor for allergenicity and immunogenicity of the major birch pollen allergen

artículo científico publicado en 2016

HAX1 deletion impairs BCR internalization and leads to delayed BCR-mediated apoptosis

artículo científico publicado en 2015

HAX1 deletion impairs BCR internalization and leads to delayed BCR-mediated apoptosis

Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease.

artículo científico publicado en 2017

Investigations on the maturation and regulation of archaebacterial proteasomes

artículo científico publicado en 2003

Ligand binding modulates the structural dynamics and compactness of the major birch pollen allergen.

artículo científico publicado en 2014

Mechanistic and structural studies on legumain explain its zymogenicity, distinct activation pathways, and regulation

artículo científico publicado en 2013

Molecular machines for protein degradation

artículo científico publicado en 2005

Molecular metamorphosis in polcalcin allergens by EF-hand rearrangements and domain swapping

artículo científico publicado en 2010

Multiple roles of Bet v 1 ligands in allergen stabilization and modulation of endosomal protease activity

scientific article published on 08 October 2019

Mutational and structural analyses of the regulatory protein B of soluble methane monooxygenase from Methylococcus capsulatus (Bath)

scientific article published on 01 July 1999

Natural and synthetic inhibitors of kallikrein-related peptidases (KLKs).

artículo científico publicado en 2010

Navigation inside a protease: substrate selection and product exit in the tricorn protease from Thermoplasma acidophilum

artículo científico publicado en 2002

Nitration of the birch pollen allergen Bet v 1.0101: efficiency and site-selectivity of liquid and gaseous nitrating agents.

artículo científico

OFF-State-Specific Inhibition of the Proprotein Convertase Furin

artículo científico publicado en 2021

Physiological fIXa activation involves a cooperative conformational rearrangement of the 99-loop

artículo científico publicado en 2002

Polycystic kidney disease-like domains of clostridial collagenases and their role in collagen recruitment ⬇️

artículo científico publicado el 28 de agosto de 2011

Protease recognition sites in Bet v 1a are cryptic, explaining its slow processing relevant to its allergenicity.

artículo científico publicado en 2015

Proteomic protease specificity profiling of clostridial collagenases reveals their intrinsic nature as dedicated degraders of collagen

artículo científico publicado en 2013

Real space refinement of crystal structures with canonical distributions of electrons

artículo científico publicado en 2011

Refined 2.3 A X-ray crystal structure of bovine thrombin complexes formed with the benzamidine and arginine-based thrombin inhibitors NAPAP, 4-TAPAP and MQPA. A starting point for improving antithrombotics

artículo científico publicado en 1992

Releasing the brakes in coagulation Factor IXa by co-operative maturation of the substrate-binding site

artículo científico publicado en 2016

Small Peptides Blocking Inhibition of Factor Xa and Tissue Factor-Factor VIIa by Tissue Factor Pathway Inhibitor (TFPI)

artículo científico publicado en 2014

Stabilization of the Dimeric Birch Pollen Allergen Bet v 1 Impacts Its Immunological Properties

artículo científico publicado en 2014

Structural Basis for Activity Regulation and Substrate Preference of Clostridial Collagenases G, H, and T

artículo científico publicado en 2013

Structural analyses of Arabidopsis thaliana legumain γ reveal the differential recognition and processing of proteolysis and ligation substrates.

artículo científico publicado en 2018

Structural and functional analysis of cystatin E reveals enzymologically relevant dimer and amyloid fibril states

artículo científico publicado en 2018

Structural and functional studies of Arabidopsis thaliana legumain beta reveal isoform specific mechanisms of activation and substrate recognition

artículo científico publicado en 2020

Structural basis for the Zn2+ inhibition of the zymogen-like kallikrein-related peptidase 10

artículo científico publicado en 2016

Structural basis for the processive protein degradation by tricorn protease

artículo científico publicado en 2002

Structural basis of the adaptive molecular recognition by MMP9

artículo científico publicado en 2002

Structural basis of the cofactor- and substrate-assisted activation of human coagulation factor IXa

artículo científico publicado en 2009

Structural determinants of specificity and regulation of activity in the allosteric loop network of human KLK8/neuropsin.

artículo científico publicado en 2018

Structural integrity of the antigen is a determinant for the induction of T-helper type-1 immunity in mice by gene gun vaccines against E. coli beta-galactosidase

artículo científico publicado en 2014

Structure and function of legumain in health and disease

artículo científico publicado en 2016

Structure and mechanism of an aspartimide-dependent peptide ligase in human legumain

artículo científico publicado en 2015

Structure of collagenase G reveals a chew-and-digest mechanism of bacterial collagenolysis

artículo científico publicado en 2011

Structure of the N-terminal domain of the adenylyl cyclase-associated protein (CAP) from Dictyostelium discoideum

artículo científico publicado en 2003

Structure-based design and synthesis of potent matrix metalloproteinase inhibitors derived from a 6H-1,3,4-thiadiazine scaffold

artículo científico publicado en 2001

Structure-function analyses of human kallikrein-related peptidase 2 establish the 99-loop as master regulator of activity.

artículo científico publicado en 2014

Structures of the NLRP14 pyrin domain reveal a conformational switch mechanism regulating its molecular interactions

artículo científico publicado en 2014

Structures of the tricorn-interacting aminopeptidase F1 with different ligands explain its catalytic mechanism

artículo científico publicado en 2002

Surface loops of trypsin-like serine proteases as determinants of function

artículo científico publicado en 2019

Sweetened kallikrein-related peptidases (KLKs): glycan trees as potential regulators of activation and activity.

artículo científico publicado en 2014

Synthesis and biological evaluation of potential inhibitors of the cysteine proteases cruzain and rhodesain designed by molecular simplification.

artículo científico publicado en 2017

The 1.8-A crystal structure of a matrix metalloproteinase 8-barbiturate inhibitor complex reveals a previously unobserved mechanism for collagenase substrate recognition

artículo científico publicado en 2001

The X-ray crystal structure of thrombin in complex with N alpha-2-naphthylsulfonyl-L-3-amidino-phenylalanyl-4-methylpiperidide: the beneficial effect of filling out an empty cavity

scientific article published on 01 January 1995

The crystal structure of dipeptidyl peptidase IV (CD26) reveals its functional regulation and enzymatic mechanism

artículo científico publicado en 2003

The impact of nitration on the structure and immunogenicity of the major birch pollen allergen Bet v 1.0101.

artículo científico publicado en 2014

The influence of residue 190 in the S1 site of trypsin-like serine proteases on substrate selectivity is universally conserved

artículo científico publicado en 2002

The nanotopography of SiO<sub>2</sub> particles impacts the selectivity and 3D fold of bound allergens

artículo científico publicado en 2021

The stability and activity of recombinant Helicobacter pylori HtrA under stress conditions

artículo científico publicado en 2012

The structure of a furin-antibody complex explains non-competitive inhibition by steric exclusion of substrate conformers.

artículo científico publicado en 2016

Two Distinct Conformations in Bet v 2 Determine Its Proteolytic Resistance to Cathepsin S.

artículo científico publicado en 2017

X-ray Structures of Human Furin in Complex with Competitive Inhibitors

artículo científico publicado en 2014

X-ray snapshots of peptide processing in mutants of tricorn-interacting factor F1 from Thermoplasma acidophilum

artículo científico publicado en 2005

X-ray structure of clotting factor IXa: active site and module structure related to Xase activity and hemophilia B

artículo científico publicado en 1995

Lista de obras de Hans Brandstetter

A Single Glycan at the 99-Loop of Human Kallikrein-related Peptidase 2 Regulates Activation and Enzymatic Activity

A universal strategy for high-yield production of soluble and functional clostridial collagenases in E. coli

Activation mechanisms of coagulation factor IX.

Activation of legumain involves proteolytic and conformational events, resulting in a context- and substrate-dependent activity profile.

Analytical Cascades of Enzymes for Sensitive Detection of Structural Variations in Protein Samples.

Biochemical characterization of the catalytic domains of three different Clostridial collagenases.

Bis-substituted malonic acid hydroxamate derivatives as inhibitors of human neutrophil collagenase (MMP8).

Changing residue 338 in human factor IX from arginine to alanine causes an increase in catalytic activity

Cloning, Purification and Characterization of the Collagenase ColA Expressed by Bacillus cereus ATCC 14579

Coagulation factor IXa: the relaxed conformation of Tyr99 blocks substrate binding

Complex assemblies of factors IX and X regulate the initiation, maintenance, and shutdown of blood coagulation

Converting blood coagulation factor IXa into factor Xa: dramatic increase in amidolytic activity identifies important active site determinants

Crystal Structures of the Viral Protease Npro Imply Distinct Roles for the Catalytic Water in Catalysis

Crystal structure of Pla l 1 reveals both structural similarity and allergenic divergence within the Ole e 1-like protein family

Crystal structure of plant legumain reveals a unique two-chain state with pH-dependent activity regulation.

Crystal structure of the NADP-dependent mannitol dehydrogenase from Cladosporium herbarum: Implications for oligomerisation and catalysis

Crystal structure of the catalytic domain of human atypical protein kinase C-iota reveals interaction mode of phosphorylation site in turn motif

Crystal structure of the tricorn protease reveals a protein disassembly line

Crystal structures of the tricorn interacting factor F3 from Thermoplasma acidophilum, a zinc aminopeptidase in three different conformations

Crystal structures of uninhibited factor VIIa link its cofactor and substrate-assisted activation to specific interactions

Crystallization and preliminary X-ray characterization of the catalytic domain of collagenase G from Clostridium histolyticum

Crystallographic determination of thrombin complexes with small synthetic inhibitors as a starting point for the receptor-based design of antithrombotics

Crystallographically Mapped Ligand Binding Differs in High and Low IgE Binding Isoforms of Birch Pollen Allergen Bet v 1

Design and synthesis of malonic acid-based inhibitors of human neutrophil collagenase (MMP8)

Discovery of a Potent Inhibitor Class with High Selectivity toward Clostridial Collagenases.

Distinct Roles of Catalytic Cysteine and Histidine in the Protease and Ligase Mechanisms of Human Legumain As Revealed by DFT-Based QM/MM Simulations

Do-it-yourself histidine-tagged bovine enterokinase: a handy member of the protein engineer's toolbox.

Enzyme flexibility, solvent and 'weak' interactions characterize thrombin-ligand interactions: implications for drug design

ExteNDing Proteome Coverage with Legumain as a Highly Specific Digestion Protease

Fold stability during endolysosomal acidification is a key factor for allergenicity and immunogenicity of the major birch pollen allergen

HAX1 deletion impairs BCR internalization and leads to delayed BCR-mediated apoptosis

HAX1 deletion impairs BCR internalization and leads to delayed BCR-mediated apoptosis

Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease.

Investigations on the maturation and regulation of archaebacterial proteasomes

Ligand binding modulates the structural dynamics and compactness of the major birch pollen allergen.

Mechanistic and structural studies on legumain explain its zymogenicity, distinct activation pathways, and regulation

Molecular machines for protein degradation

Molecular metamorphosis in polcalcin allergens by EF-hand rearrangements and domain swapping

Multiple roles of Bet v 1 ligands in allergen stabilization and modulation of endosomal protease activity

Mutational and structural analyses of the regulatory protein B of soluble methane monooxygenase from Methylococcus capsulatus (Bath)

Natural and synthetic inhibitors of kallikrein-related peptidases (KLKs).

Navigation inside a protease: substrate selection and product exit in the tricorn protease from Thermoplasma acidophilum

Nitration of the birch pollen allergen Bet v 1.0101: efficiency and site-selectivity of liquid and gaseous nitrating agents.

OFF-State-Specific Inhibition of the Proprotein Convertase Furin

Physiological fIXa activation involves a cooperative conformational rearrangement of the 99-loop

Polycystic kidney disease-like domains of clostridial collagenases and their role in collagen recruitment ⬇️

Protease recognition sites in Bet v 1a are cryptic, explaining its slow processing relevant to its allergenicity.

Proteomic protease specificity profiling of clostridial collagenases reveals their intrinsic nature as dedicated degraders of collagen

Real space refinement of crystal structures with canonical distributions of electrons

Refined 2.3 A X-ray crystal structure of bovine thrombin complexes formed with the benzamidine and arginine-based thrombin inhibitors NAPAP, 4-TAPAP and MQPA. A starting point for improving antithrombotics

Releasing the brakes in coagulation Factor IXa by co-operative maturation of the substrate-binding site

Small Peptides Blocking Inhibition of Factor Xa and Tissue Factor-Factor VIIa by Tissue Factor Pathway Inhibitor (TFPI)

Stabilization of the Dimeric Birch Pollen Allergen Bet v 1 Impacts Its Immunological Properties

Structural Basis for Activity Regulation and Substrate Preference of Clostridial Collagenases G, H, and T

Structural analyses of Arabidopsis thaliana legumain γ reveal the differential recognition and processing of proteolysis and ligation substrates.

Structural and functional analysis of cystatin E reveals enzymologically relevant dimer and amyloid fibril states

Structural and functional studies of Arabidopsis thaliana legumain beta reveal isoform specific mechanisms of activation and substrate recognition

Structural basis for the Zn2+ inhibition of the zymogen-like kallikrein-related peptidase 10

Structural basis for the processive protein degradation by tricorn protease

Structural basis of the adaptive molecular recognition by MMP9

Structural basis of the cofactor- and substrate-assisted activation of human coagulation factor IXa

Structural determinants of specificity and regulation of activity in the allosteric loop network of human KLK8/neuropsin.

Structural integrity of the antigen is a determinant for the induction of T-helper type-1 immunity in mice by gene gun vaccines against E. coli beta-galactosidase

Structure and function of legumain in health and disease

Structure and mechanism of an aspartimide-dependent peptide ligase in human legumain

Structure of collagenase G reveals a chew-and-digest mechanism of bacterial collagenolysis

Structure of the N-terminal domain of the adenylyl cyclase-associated protein (CAP) from Dictyostelium discoideum

Structure-based design and synthesis of potent matrix metalloproteinase inhibitors derived from a 6H-1,3,4-thiadiazine scaffold

Structure-function analyses of human kallikrein-related peptidase 2 establish the 99-loop as master regulator of activity.

Structures of the NLRP14 pyrin domain reveal a conformational switch mechanism regulating its molecular interactions

Structures of the tricorn-interacting aminopeptidase F1 with different ligands explain its catalytic mechanism

Surface loops of trypsin-like serine proteases as determinants of function

Sweetened kallikrein-related peptidases (KLKs): glycan trees as potential regulators of activation and activity.

Synthesis and biological evaluation of potential inhibitors of the cysteine proteases cruzain and rhodesain designed by molecular simplification.

The 1.8-A crystal structure of a matrix metalloproteinase 8-barbiturate inhibitor complex reveals a previously unobserved mechanism for collagenase substrate recognition

The X-ray crystal structure of thrombin in complex with N alpha-2-naphthylsulfonyl-L-3-amidino-phenylalanyl-4-methylpiperidide: the beneficial effect of filling out an empty cavity

The crystal structure of dipeptidyl peptidase IV (CD26) reveals its functional regulation and enzymatic mechanism

The impact of nitration on the structure and immunogenicity of the major birch pollen allergen Bet v 1.0101.

The influence of residue 190 in the S1 site of trypsin-like serine proteases on substrate selectivity is universally conserved