Lista de obras - Karin Thevissen - Dominio Público Uruguay

2-(2-oxo-morpholin-3-yl)-acetamide derivatives as broad-spectrum antifungal agents.

artículo científico publicado en 2015

A Linear 19-Mer Plant Defensin-Derived Peptide Acts Synergistically with Caspofungin against Candida albicans Biofilms

artículo científico publicado en 2017

A fungicidal piperazine-1-carboxamidine induces mitochondrial fission-dependent apoptosis in yeast

artículo científico publicado en 2010

Affinity comparison of p3 and p8 peptide displaying bacteriophages using surface plasmon resonance

artículo científico publicado en 2013

Alternating Current Electrophoretic Deposition for the Immobilization of Antimicrobial Agents on Titanium Implant Surfaces.

artículo científico publicado en 2017

An antibiofilm coating of 5-aryl-2-aminoimidazole covalently attached to a titanium surface

artículo científico publicado en 2018

Angiotensin II type 1 receptor blockers increase tolerance of cells to copper and cisplatin.

artículo científico publicado en 2014

Antibacterial activity of a new broad-spectrum antibiotic covalently bound to titanium surfaces.

artículo científico publicado en 2016

Antibacterial and antifungal properties of alpha-helical, cationic peptides in the venom of scorpions from southern Africa.

artículo científico publicado en 2002

Antibiotic activities of host defense peptides: more to it than lipid bilayer perturbation.

artículo científico publicado en 2011

Antifungal activity in plants from Chinese traditional and folk medicine

artículo científico publicado en 2012

Antifungal activity of synthetic peptides derived from Impatiens balsamina antimicrobial peptides Ib-AMP1 and Ib-AMP4.

artículo científico publicado en 2005

Antifungal carbazoles.

scientific article published on January 2009

Antifungal plant defensins: increased insight in their mode of action as a basis for their use to combat fungal infections

artículo científico publicado en 2017

Antifungal plant defensins: mechanisms of action and production

artículo científico publicado en 2014

Antimicrobial Peptides as a Strategy to Combat Fungal Biofilms

artículo científico publicado en 2016

Apoptosis-inducing antifungal peptides and proteins.

artículo científico

Arabidopsis thaliana plants expressing human beta-defensin-2 are more resistant to fungal attack: functional homology between plant and human defensins

article

Artemisinins, new miconazole potentiators resulting in increased activity against Candida albicans biofilms.

artículo científico publicado en 2014

Azoles: Mode of Antifungal Action and Resistance Development. Effect of Miconazole on Endogenous Reactive Oxygen Species Production in Candida albicans

Ceramide involvement in apoptosis and apoptotic diseases.

artículo científico publicado en 2006

Combination Therapy to Treat Fungal Biofilm-Based Infections

scientific article published on 23 November 2020

Combination of miconazole and domiphen bromide is fungicidal against biofilms of resistant Candida spp

artículo científico publicado en 2020

Combinatorial drug approaches to tackle Candida albicans biofilms

artículo científico

Combining Biocontrol Agents with Chemical Fungicides for Integrated Plant Fungal Disease Control

artículo científico publicado en 2020

Controlled release of chlorhexidine antiseptic from microporous amorphous silica applied in open porosity of an implant surface

artículo científico publicado en 2011

Controlled release of chlorhexidine from a mesoporous silica-containing macroporous titanium dental implant prevents microbial biofilm formation.

artículo científico publicado en 2017

Correction to: International survey on influenza-associated pulmonary aspergillosis (IAPA) in intensive care units: responses suggest low awareness and potential underdiagnosis outside Europe

artículo científico publicado en 2020

Covalent immobilization of antimicrobial agents on titanium prevents Staphylococcus aureus and Candida albicans colonization and biofilm formation.

artículo científico publicado en 2015

Currently used antimycotics: spectrum, mode of action and resistance occurrence.

artículo científico publicado en 2005

Defensins from insects and plants interact with fungal glucosylceramides

artículo científico publicado en 2003

Derivatives of the mouse cathelicidin-related antimicrobial peptide (CRAMP) inhibit fungal and bacterial biofilm formation

artículo científico publicado en 2014

Design and synthesis of a series of piperazine-1-carboxamidine derivatives with antifungal activity resulting from accumulation of endogenous reactive oxygen species.

artículo científico publicado en 2009

Dietary intervention, but not losartan, completely reverses non-alcoholic steatohepatitis in obese and insulin resistant mice.

artículo científico publicado en 2017

Digital microfluidics for time-resolved cytotoxicity studies on single non-adherent yeast cells

artículo científico publicado en 2015

DmAMP1, an antifungal plant defensin from dahlia (Dahlia merckii), interacts with sphingolipids from Saccharomyces cerevisiae

artículo científico publicado en 2003

Editorial [Hot Topic: Fungal Infections and Antifungal Strategies (Guest Editor: Karin Thevissen)]

artículo científico publicado en 2005

Elucidation of the Mode of Action of a New Antibacterial Compound Active against Staphylococcus aureus and Pseudomonas aeruginosa ⬇️

artículo científico publicado en 2016

Establishing a Unified COVID-19 "Immunome": Integrating Coronavirus Pathogenesis and Host Immunopathology

artículo científico publicado en 2020

Evaluation of the toxicity of 5-aryl-2-aminoimidazole-based biofilm inhibitors against eukaryotic cell lines, bone cells and the nematode Caenorhabditis elegans.

artículo científico publicado en 2014

Expanding the pharmacological profile of κ-hefutoxin 1 and analogues: A focus on the inhibitory effect on the oncogenic channel Kv10.1.

artículo científico publicado en 2016

From Regulated Cell Death to Adaptive Stress Strategies: Convergence and Divergence in Eukaryotic Cells

Fungal Glucosylceramide-Specific Camelid Single Domain Antibodies Are Characterized by Broad Spectrum Antifungal Activity.

artículo científico publicado en 2017

Fungal Membrane Responses Induced by Plant Defensins and Thionins

artículo científico publicado en 1996

Fungal sphingolipids as targets for the development of selective antifungal therapeutics.

artículo científico publicado en 2005

Fungal β-1,3-glucan increases ofloxacin tolerance of Escherichia coli in a polymicrobial E. coli/Candida albicans biofilm.

artículo científico publicado en 2015

Fungicidal activity of truncated analogues of dihydrosphingosine

artículo científico publicado en 2008

Genome-wide expression analysis reveals TORC1-dependent and -independent functions of Sch9.

artículo científico publicado en 2008

Guidelines and recommendations on yeast cell death nomenclature.

artículo científico publicado en 2018

Guidelines for the use and interpretation of assays for monitoring autophagy

artículo científico publicado en 2012

How promising are combinatorial drug strategies in combating Candida albicans biofilms?

artículo científico publicado en 2016

IPT1-independent sphingolipid biosynthesis and yeast inhibition by syringomycin E and plant defensin DmAMP1.

artículo científico publicado en 2003

Identification and characterization of an anti-pseudomonal dichlorocarbazol derivative displaying anti-biofilm activity

scholarly article by Veerle Liebens et al published 1 December 2014 in Bioorganic & Medicinal Chemistry Letters

Identification of fungicidal 2,6-disubstituted quinolines with activity against Candida biofilms

artículo científico publicado en 2012

Identification of survival-promoting OSIP108 peptide variants and their internalization in human cells

artículo científico publicado en 2016

Implant functionalization with mesoporous silica: A promising antibac terial strategy, but does such an implant osseointegrate?

artículo científico publicado en 2020

In vitro activity of the antiasthmatic drug zafirlukast against the oral pathogens Porphyromonas gingivalis and Streptococcus mutans

artículo científico publicado en 2017

In vitro activity of the antifungal plant defensin RsAFP2 against Candida isolates and its in vivo efficacy in prophylactic murine models of candidiasis

artículo científico publicado en 2008

In vitro methods for the evaluation of antimicrobial surface designs

artículo científico publicado en 2018

Increasing the Fungicidal Action of Amphotericin B by Inhibiting the Nitric Oxide-Dependent Tolerance Pathway.

artículo científico publicado en 2017

Interactions of antifungal plant defensins with fungal membrane components.

artículo científico publicado en 2003

International survey on influenza-associated pulmonary aspergillosis (IAPA) in intensive care units: responses suggest low awareness and potential underdiagnosis outside Europe

artículo científico publicado en 2020

Isolation and characterisation of plant defensins from seeds of Asteraceae, Fabaceae, Hippocastanaceae and Saxifragaceae

article

Isolation and characterization of Neurospora crassa mutants resistant to antifungal plant defensins

artículo científico publicado en 2003

Joined in death: highlights of the Sixth International Meeting on Yeast Apoptosis in Leuven, Belgium, 30 April-4 May 2008.

artículo científico publicado en 2008

Level of M(IP)2C sphingolipid affects plant defensin sensitivity, oxidative stress resistance and chronological life-span in yeast

artículo científico publicado en 2006

Membrane rafts are involved in intracellular miconazole accumulation in yeast cells.

artículo científico publicado en 2009

Methodologies for in vitro and in vivo evaluation of efficacy of antifungal and antibiofilm agents and surface coatings against fungal biofilms.

artículo científico publicado en 2018

Miconazole Induces Changes in Actin Cytoskeleton prior to Reactive Oxygen Species Induction in Yeast

artículo científico publicado en 2007

Mining the genome of Arabidopsis thaliana as a basis for the identification of novel bioactive peptides involved in oxidative stress tolerance

artículo científico publicado en 2013

Mitochondrial dysfunction leads to reduced chronological lifespan and increased apoptosis in yeast

artículo científico publicado en 2008

Mode of action of plant defensins suggests therapeutic potential

artículo científico publicado en 2003

Modes of antifungal action and in planta functions of plant defensins and defensin-like peptides

article

Modulation of the Substitution Pattern of 5-Aryl-2-Aminoimidazoles Allows Fine-Tuning of Their Antibiofilm Activity Spectrum and Toxicity.

artículo científico publicado en 2016

Mutational Analysis of a Plant Defensin from Radish (Raphanus sativusL.) Reveals Two Adjacent Sites Important for Antifungal Activity

artículo científico publicado en 1997

Neutral glycolipids of the filamentous fungus Neurospora crassa: altered expression in plant defensin-resistant mutants

artículo científico publicado en 2005

Non-disulfide-bridged peptides from Tityus serrulatus venom: Evidence for proline-free ACE-inhibitors

artículo científico publicado en 2016

Novel anti-infective implant substrates: controlled release of antibiofilm compounds from mesoporous silica-containing macroporous titanium

artículo científico publicado en 2015

Novel fungicidal benzylsulfanyl-phenylguanidines

artículo científico publicado en 2011

Oral administration of the broad-spectrum antibiofilm compound toremifene inhibits Candida albicans and Staphylococcus aureus biofilm formation in vivo

artículo científico publicado en 2014

Phytosphingosine-1-phosphate is a signaling molecule involved in miconazole resistance in sessile Candida albicans cells

artículo científico publicado en 2012

Plant defensins.

artículo científico publicado en 2002

Plant-derived decapeptide OSIP108 interferes with Candida albicans biofilm formation without affecting cell viability

artículo científico publicado en 2014

Potentiation of antibiofilm activity of amphotericin B by superoxide dismutase inhibition

artículo científico publicado en 2013

Protocol for Determination of the Persister Subpopulation in Candida Albicans Biofilms

artículo científico publicado en 2016

Reactive oxygen species-inducing antifungal agents and their activity against fungal biofilms

artículo científico publicado en 2014

Regulated Cell Death as a Therapeutic Target for Novel Antifungal Peptides and Biologics.

artículo científico publicado en 2018

Repurposing AM404 for the treatment of oral infections by Porphyromonas gingivalis.

artículo científico publicado en 2017

Repurposing Toremifene for Treatment of Oral Bacterial Infections.

artículo científico publicado en 2016

Repurposing as a means to increase the activity of amphotericin B and caspofungin against Candida albicans biofilms.

artículo científico publicado en 2013

Repurposing the antidepressant sertraline as SHMT inhibitor to suppress serine/glycine synthesis addicted breast tumor growth

artículo científico publicado en 2020

Roux-en-y gastric bypass attenuates hepatic mitochondrial dysfunction in mice with non-alcoholic steatohepatitis.

artículo científico publicado en 2014

SKN1, a novel plant defensin-sensitivity gene in Saccharomyces cerevisiae, is implicated in sphingolipid biosynthesis

artículo científico publicado en 2005

Skn1 and Ipt1 negatively regulate autophagy in Saccharomyces cerevisiae

artículo científico publicado en 2009

Specific binding sites for an antifungal plant defensin from Dahlia (Dahlia merckii) on fungal cells are required for antifungal activity.

artículo científico publicado en 2000

Specific, High Affinity Binding Sites for an Antifungal Plant Defensin on Neurospora crassa Hyphae and Microsomal Membranes

artículo científico publicado en 1997

Sphingolipids and mitochondrial function in budding yeast

artículo científico publicado en 2014

Sphingolipids and mitochondrial function, lessons learned from yeast

scientific article published on 25 June 2014

Stimulation of superoxide production increases fungicidal action of miconazole against Candida albicans biofilms

artículo científico publicado en 2016

Structure-activity relationship study of the antimicrobial CRAMP-derived peptide CRAMP20-33

artículo científico publicado en 2018

Structure-activity relationship study of the plant-derived decapeptide OSIP108 inhibiting Candida albicans biofilm formation.

artículo científico publicado en 2014

Superoxide dismutases are involved in Candida albicans biofilm persistence against miconazole

artículo científico publicado en 2011

Synergistic Activity of the Plant Defensin HsAFP1 and Caspofungin against Candida albicans Biofilms and Planktonic Cultures

artículo científico publicado en 2015

Synergistic activity of the tyrocidines, antimicrobial cyclodecapeptides from Bacillus aneurinolyticus, with amphotericin B and caspofungin against Candida albicans biofilms

artículo científico publicado en 2014

Synthesis and fungicidal activity of 3,5-dichloropyrazin-2(1H)-one derivatives.

artículo científico publicado en 2009

Synthetic peptides derived from the beta2-beta3 loop of Raphanus sativus antifungal protein 2 that mimic the active site

artículo científico publicado en 2001

TEMPORARY REMOVAL: The antifungal plant defensin HsAFP1 induces autophagy, vacuolar dysfunction and cell cycle impairment in yeast

scientific article published on 05 March 2020

The Antifungal Activity of RsAFP2, a Plant Defensin from Raphanus sativus , Involves the Induction of Reactive Oxygen Species in Candida albicans

article

The Antifungal Plant Defensin HsAFP1 Is a Phosphatidic Acid-Interacting Peptide Inducing Membrane Permeabilization.

artículo científico publicado en 2017

The Antifungal Plant Defensin HsAFP1 from Heuchera sanguinea Induces Apoptosis in Candida albicans

artículo científico publicado en 2011

The Nonsteroidal Antiinflammatory Drug Diclofenac Potentiates the In Vivo Activity of Caspofungin Against Candida albicans Biofilms

artículo científico publicado en 2012

The antifungal plant defensin AtPDF2.3 from Arabidopsis thaliana blocks potassium channels.

artículo científico publicado en 2016

The antifungal plant defensin RsAFP2 from radish induces apoptosis in a metacaspase independent way in Candida albicans.

artículo científico publicado en 2009

The heat-induced molecular disaggregase Hsp104 of Candida albicans plays a role in biofilm formation and pathogenicity in a worm infection model

artículo científico publicado en 2012

The mode of antifungal action of plant, insect and human defensins

scientific article published on July 2008

The plant decapeptide OSIP108 can alleviate mitochondrial dysfunction induced by cisplatin in human cells.

artículo científico publicado en 2014

The plant decapeptide OSIP108 prevents copper-induced apoptosis in yeast and human cells

artículo científico publicado en 2014

The plant decapeptide OSIP108 prevents copper-induced toxicity in various models for Wilson disease

artículo científico publicado en 2014

The plant defensin RsAFP2 induces cell wall stress, septin mislocalization and accumulation of ceramides in Candida albicans.

artículo científico publicado en 2012

The protein kinase Sch9 is a key regulator of sphingolipid metabolism in Saccharomyces cerevisiae.

artículo científico publicado en 2014

The radish defensins RsAFP1 and RsAFP2 act synergistically with caspofungin against Candida albicans biofilms

artículo científico publicado en 2016

Therapeutic potential of antifungal plant and insect defensins

artículo científico publicado en 2007

Transcription factor Efg1 contributes to the tolerance of Candida albicans biofilms against antifungal agents in vitro and in vivo

artículo científico publicado en 2012

Tuning the Surface Interactions between Single Cells and an OSTE+ Microwell Array for Enhanced Single Cell Manipulation

artículo científico publicado en 2021

Ydc1p ceramidase triggers organelle fragmentation, apoptosis and accelerated ageing in yeast

artículo científico publicado en 2008

Yeast as a model for the identification of novel survival-promoting compounds applicable to treat degenerative diseases

artículo científico publicado en 2016

Lista de obras de Karin Thevissen

2-(2-oxo-morpholin-3-yl)-acetamide derivatives as broad-spectrum antifungal agents.

A Linear 19-Mer Plant Defensin-Derived Peptide Acts Synergistically with Caspofungin against Candida albicans Biofilms

A fungicidal piperazine-1-carboxamidine induces mitochondrial fission-dependent apoptosis in yeast

Affinity comparison of p3 and p8 peptide displaying bacteriophages using surface plasmon resonance

Alternating Current Electrophoretic Deposition for the Immobilization of Antimicrobial Agents on Titanium Implant Surfaces.

An antibiofilm coating of 5-aryl-2-aminoimidazole covalently attached to a titanium surface

Angiotensin II type 1 receptor blockers increase tolerance of cells to copper and cisplatin.

Antibacterial activity of a new broad-spectrum antibiotic covalently bound to titanium surfaces.

Antibacterial and antifungal properties of alpha-helical, cationic peptides in the venom of scorpions from southern Africa.

Antibiotic activities of host defense peptides: more to it than lipid bilayer perturbation.

Antifungal activity in plants from Chinese traditional and folk medicine

Antifungal activity of synthetic peptides derived from Impatiens balsamina antimicrobial peptides Ib-AMP1 and Ib-AMP4.

Antifungal carbazoles.

Antifungal plant defensins: increased insight in their mode of action as a basis for their use to combat fungal infections

Antifungal plant defensins: mechanisms of action and production

Antimicrobial Peptides as a Strategy to Combat Fungal Biofilms

Apoptosis-inducing antifungal peptides and proteins.

Arabidopsis thaliana plants expressing human beta-defensin-2 are more resistant to fungal attack: functional homology between plant and human defensins

Artemisinins, new miconazole potentiators resulting in increased activity against Candida albicans biofilms.

Azoles: Mode of Antifungal Action and Resistance Development. Effect of Miconazole on Endogenous Reactive Oxygen Species Production in Candida albicans

Ceramide involvement in apoptosis and apoptotic diseases.

Combination Therapy to Treat Fungal Biofilm-Based Infections

Combination of miconazole and domiphen bromide is fungicidal against biofilms of resistant Candida spp

Combinatorial drug approaches to tackle Candida albicans biofilms

Combining Biocontrol Agents with Chemical Fungicides for Integrated Plant Fungal Disease Control

Controlled release of chlorhexidine antiseptic from microporous amorphous silica applied in open porosity of an implant surface

Controlled release of chlorhexidine from a mesoporous silica-containing macroporous titanium dental implant prevents microbial biofilm formation.

Correction to: International survey on influenza-associated pulmonary aspergillosis (IAPA) in intensive care units: responses suggest low awareness and potential underdiagnosis outside Europe

Covalent immobilization of antimicrobial agents on titanium prevents Staphylococcus aureus and Candida albicans colonization and biofilm formation.

Currently used antimycotics: spectrum, mode of action and resistance occurrence.

Defensins from insects and plants interact with fungal glucosylceramides

Derivatives of the mouse cathelicidin-related antimicrobial peptide (CRAMP) inhibit fungal and bacterial biofilm formation

Design and synthesis of a series of piperazine-1-carboxamidine derivatives with antifungal activity resulting from accumulation of endogenous reactive oxygen species.

Dietary intervention, but not losartan, completely reverses non-alcoholic steatohepatitis in obese and insulin resistant mice.

Digital microfluidics for time-resolved cytotoxicity studies on single non-adherent yeast cells

DmAMP1, an antifungal plant defensin from dahlia (Dahlia merckii), interacts with sphingolipids from Saccharomyces cerevisiae

Editorial [Hot Topic: Fungal Infections and Antifungal Strategies (Guest Editor: Karin Thevissen)]

Elucidation of the Mode of Action of a New Antibacterial Compound Active against Staphylococcus aureus and Pseudomonas aeruginosa ⬇️

Establishing a Unified COVID-19 "Immunome": Integrating Coronavirus Pathogenesis and Host Immunopathology

Evaluation of the toxicity of 5-aryl-2-aminoimidazole-based biofilm inhibitors against eukaryotic cell lines, bone cells and the nematode Caenorhabditis elegans.

Expanding the pharmacological profile of κ-hefutoxin 1 and analogues: A focus on the inhibitory effect on the oncogenic channel Kv10.1.

From Regulated Cell Death to Adaptive Stress Strategies: Convergence and Divergence in Eukaryotic Cells

Fungal Glucosylceramide-Specific Camelid Single Domain Antibodies Are Characterized by Broad Spectrum Antifungal Activity.

Fungal Membrane Responses Induced by Plant Defensins and Thionins

Fungal sphingolipids as targets for the development of selective antifungal therapeutics.

Fungal β-1,3-glucan increases ofloxacin tolerance of Escherichia coli in a polymicrobial E. coli/Candida albicans biofilm.

Fungicidal activity of truncated analogues of dihydrosphingosine

Genome-wide expression analysis reveals TORC1-dependent and -independent functions of Sch9.

Guidelines and recommendations on yeast cell death nomenclature.

Guidelines for the use and interpretation of assays for monitoring autophagy

How promising are combinatorial drug strategies in combating Candida albicans biofilms?

IPT1-independent sphingolipid biosynthesis and yeast inhibition by syringomycin E and plant defensin DmAMP1.

Identification and characterization of an anti-pseudomonal dichlorocarbazol derivative displaying anti-biofilm activity

Identification of fungicidal 2,6-disubstituted quinolines with activity against Candida biofilms

Identification of survival-promoting OSIP108 peptide variants and their internalization in human cells

Implant functionalization with mesoporous silica: A promising antibac terial strategy, but does such an implant osseointegrate?

In vitro activity of the antiasthmatic drug zafirlukast against the oral pathogens Porphyromonas gingivalis and Streptococcus mutans

In vitro activity of the antifungal plant defensin RsAFP2 against Candida isolates and its in vivo efficacy in prophylactic murine models of candidiasis

In vitro methods for the evaluation of antimicrobial surface designs

Increasing the Fungicidal Action of Amphotericin B by Inhibiting the Nitric Oxide-Dependent Tolerance Pathway.

Interactions of antifungal plant defensins with fungal membrane components.

International survey on influenza-associated pulmonary aspergillosis (IAPA) in intensive care units: responses suggest low awareness and potential underdiagnosis outside Europe

Isolation and characterisation of plant defensins from seeds of Asteraceae, Fabaceae, Hippocastanaceae and Saxifragaceae

Isolation and characterization of Neurospora crassa mutants resistant to antifungal plant defensins

Joined in death: highlights of the Sixth International Meeting on Yeast Apoptosis in Leuven, Belgium, 30 April-4 May 2008.

Level of M(IP)2C sphingolipid affects plant defensin sensitivity, oxidative stress resistance and chronological life-span in yeast

Membrane rafts are involved in intracellular miconazole accumulation in yeast cells.

Methodologies for in vitro and in vivo evaluation of efficacy of antifungal and antibiofilm agents and surface coatings against fungal biofilms.

Miconazole Induces Changes in Actin Cytoskeleton prior to Reactive Oxygen Species Induction in Yeast

Mining the genome of Arabidopsis thaliana as a basis for the identification of novel bioactive peptides involved in oxidative stress tolerance

Mitochondrial dysfunction leads to reduced chronological lifespan and increased apoptosis in yeast

Mode of action of plant defensins suggests therapeutic potential

Modes of antifungal action and in planta functions of plant defensins and defensin-like peptides

Modulation of the Substitution Pattern of 5-Aryl-2-Aminoimidazoles Allows Fine-Tuning of Their Antibiofilm Activity Spectrum and Toxicity.

Mutational Analysis of a Plant Defensin from Radish (Raphanus sativusL.) Reveals Two Adjacent Sites Important for Antifungal Activity

Neutral glycolipids of the filamentous fungus Neurospora crassa: altered expression in plant defensin-resistant mutants

Non-disulfide-bridged peptides from Tityus serrulatus venom: Evidence for proline-free ACE-inhibitors

Novel anti-infective implant substrates: controlled release of antibiofilm compounds from mesoporous silica-containing macroporous titanium

Novel fungicidal benzylsulfanyl-phenylguanidines