Lista de obras - Graham D. Pavitt - Dominio Público Uruguay

A Saccharomyces cerevisiae cell-based quantitative beta-galactosidase assay compatible with robotic handling and high-throughput screening

artículo científico publicado en 2008

A new function and complexity for protein translation initiation factor eIF2B

artículo científico publicado en 2014

A yeast purification system for human translation initiation factors eIF2 and eIF2Bε and their use in the diagnosis of CACH/VWM disease

artículo científico publicado en 2013

An eIF5/eIF2 complex antagonizes guanine nucleotide exchange by eIF2B during translation initiation

artículo científico publicado en 2006

Analysis and reconstitution of translation initiation in vitro

artículo científico publicado en 2002

Archetypal transcriptional blocks underpin yeast gene regulation in response to changes in growth conditions.

artículo científico publicado en 2018

Change in nutritional status modulates the abundance of critical pre-initiation intermediate complexes during translation initiation in vivo

artículo científico publicado en 2007

Characterization of the initiation factor eIF2B and its regulation in Drosophila melanogaster

artículo científico publicado en 2000

Characterization of the minimal catalytic domain within eIF2B: the guanine-nucleotide exchange factor for translation initiation

artículo científico publicado en 2002

Chromosomal domains of supercoiling in Salmonella typhimurium

artículo científico publicado en 1993

Clues to the mechanism of action of eIF2B, the guanine-nucleotide-exchange factor for translation initiation

artículo científico publicado en 2008

Conserved bipartite motifs in yeast eIF5 and eIF2Bepsilon, GTPase-activating and GDP-GTP exchange factors in translation initiation, mediate binding to their common substrate eIF2.

artículo científico publicado en 1999

Critical contacts between the eukaryotic initiation factor 2B (eIF2B) catalytic domain and both eIF2beta and -2gamma mediate guanine nucleotide exchange.

artículo científico publicado en 2007

Discovery of chemical modulators of a conserved translational control pathway by parallel screening in yeast

artículo científico publicado en 2009

Dynamic changes in eIF4F-mRNA interactions revealed by global analyses of environmental stress responses

artículo científico publicado en 2017

Enhanced translation initiation factor 4G levels correlate with production levels of monoclonal antibodies in recombinant CHO cell lines

artículo científico publicado en 2016

Expression and mutational analysis of the nucleoid-associated protein H-NS of Salmonella typhimurium

artículo científico publicado en 1992

Fail-safe control of translation initiation by dissociation of eIF2α phosphorylated ternary complexes

artículo científico publicado en 2017

Fusel alcohols regulate translation initiation by inhibiting eIF2B to reduce ternary complex in a mechanism that may involve altering the integrity and dynamics of the eIF2B body.

artículo científico publicado en 2010

Global gene expression profiling reveals widespread yet distinctive translational responses to different eukaryotic translation initiation factor 2B-targeting stress pathways

artículo científico publicado en 2005

Global mRNA selection mechanisms for translation initiation.

artículo científico publicado en 2015

Global translational responses to oxidative stress impact upon multiple levels of protein synthesis.

artículo científico publicado en 2006

Histone-like protein H1 (H-NS), DNA supercoiling, and gene expression in bacteria

artículo científico publicado en 1990

Homologous segments in three subunits of the guanine nucleotide exchange factor eIF2B mediate translational regulation by phosphorylation of eIF2.

artículo científico publicado en 1997

Identification of intersubunit domain interactions within eukaryotic initiation factor (eIF) 2B, the nucleotide exchange factor for translation initiation

artículo científico publicado en 2012

Identifying eIF4E-binding protein translationally-controlled transcripts reveals links to mRNAs bound by specific PUF proteins

artículo científico publicado en 2010

Impaired eIF5A function causes a Mendelian disorder that is partially rescued in model systems by spermidine

artículo científico publicado en 2021

Integrated multi-omics analyses reveal the pleiotropic nature of the control of gene expression by Puf3p

artículo científico publicado en 2015

Less translational control, more memory ⬇️

artículo científico publicado el 28 de mayo de 2013

Mechanism and Regulation of Protein Synthesis in Saccharomyces cerevisiae

artículo científico publicado en 2016

Mechanisms of translational regulation by a human eIF5-mimic protein

artículo científico publicado en 2011

Mutations causing childhood ataxia with central nervous system hypomyelination reduce eukaryotic initiation factor 2B complex formation and activity

artículo científico publicado en 2004

Mutations in SNORD118 cause the cerebral microangiopathy leukoencephalopathy with calcifications and cysts.

artículo científico publicado en 2016

New Insights into Translational Regulation in the Endoplasmic Reticulum Unfolded Protein Response ⬇️

artículo científico publicado el 1 de junio de 2012

Parallel High-Throughput Automated Assays to Measure Cell Growth and Beta-Galactosidase Reporter Gene Expression in the Yeast Saccharomyces cerevisiae

artículo científico publicado en 2011

Protein Synthesis Initiation in Eukaryotic Cells

artículo científico publicado en 2018

Protein synthesis and its control in neuronal cells with a focus on vanishing white matter disease

artículo científico publicado en 2009

Puf3p induces translational repression of genes linked to oxidative stress

artículo científico publicado en 2013

Purification and kinetic analysis of eIF2B from Saccharomyces cerevisiae

scientific article published on 01 August 2000

Purification of FLAG-tagged eukaryotic initiation factor 2B complexes, subcomplexes, and fragments from Saccharomyces cerevisiae

artículo científico publicado en 2007

Regulation of translation initiation factor eIF2B at the hub of the integrated stress response

scientific article published on 10 July 2018

Structure of the catalytic fragment of translation initiation factor 2B and identification of a critically important catalytic residue

artículo científico publicado en 2004

The 4E-BP Caf20p Mediates Both eIF4E-Dependent and Independent Repression of Translation

artículo científico publicado en 2015

The alpha subunit of eukaryotic initiation factor 2B (eIF2B) is required for eIF2-mediated translational suppression of vesicular stomatitis virus

artículo científico publicado en 2011

The chromatin-associated protein H-NS interacts with curved DNA to influence DNA topology and gene expression

artículo científico publicado en 1992

The structural basis of translational control by eIF2 phosphorylation

artículo científico publicado en 2019

The yeast La related protein Slf1p is a key activator of translation during the oxidative stress response.

artículo científico publicado en 2015

Translation controlled.

artículo científico publicado en 2008

Translation reprogramming is an evolutionarily conserved driver of phenotypic plasticity and therapeutic resistance in melanoma.

scientific article published on 17 January 2017

Translational regulation in response to stress in Saccharomyces cerevisiae

artículo científico publicado en 2018

Upstream sequence elements direct post-transcriptional regulation of gene expression under stress conditions in yeast.

artículo científico publicado en 2009

eIF2 independently binds two distinct eIF2B subcomplexes that catalyze and regulate guanine-nucleotide exchange.

artículo científico publicado en 1998

eIF2B is a decameric guanine nucleotide exchange factor with a γ2ε2 tetrameric core

artículo científico publicado en 2014

eIF2B promotes eIF5 dissociation from eIF2*GDP to facilitate guanine nucleotide exchange for translation initiation

artículo científico publicado en 2013

eIF2β is critical for eIF5-mediated GDP-dissociation inhibitor activity and translational control

artículo científico publicado en 2016

eIF5 has GDI activity necessary for translational control by eIF2 phosphorylation

artículo científico publicado en 2010

eIF5 is a dual function GAP and GDI for eukaryotic translational control

artículo científico publicado en 2010

Lista de obras de Graham D. Pavitt

A Saccharomyces cerevisiae cell-based quantitative beta-galactosidase assay compatible with robotic handling and high-throughput screening

A new function and complexity for protein translation initiation factor eIF2B

A yeast purification system for human translation initiation factors eIF2 and eIF2Bε and their use in the diagnosis of CACH/VWM disease

An eIF5/eIF2 complex antagonizes guanine nucleotide exchange by eIF2B during translation initiation

Analysis and reconstitution of translation initiation in vitro

Archetypal transcriptional blocks underpin yeast gene regulation in response to changes in growth conditions.

Change in nutritional status modulates the abundance of critical pre-initiation intermediate complexes during translation initiation in vivo

Characterization of the initiation factor eIF2B and its regulation in Drosophila melanogaster

Characterization of the minimal catalytic domain within eIF2B: the guanine-nucleotide exchange factor for translation initiation

Chromosomal domains of supercoiling in Salmonella typhimurium

Clues to the mechanism of action of eIF2B, the guanine-nucleotide-exchange factor for translation initiation

Conserved bipartite motifs in yeast eIF5 and eIF2Bepsilon, GTPase-activating and GDP-GTP exchange factors in translation initiation, mediate binding to their common substrate eIF2.

Critical contacts between the eukaryotic initiation factor 2B (eIF2B) catalytic domain and both eIF2beta and -2gamma mediate guanine nucleotide exchange.

Discovery of chemical modulators of a conserved translational control pathway by parallel screening in yeast

Dynamic changes in eIF4F-mRNA interactions revealed by global analyses of environmental stress responses

Enhanced translation initiation factor 4G levels correlate with production levels of monoclonal antibodies in recombinant CHO cell lines

Expression and mutational analysis of the nucleoid-associated protein H-NS of Salmonella typhimurium

Fail-safe control of translation initiation by dissociation of eIF2α phosphorylated ternary complexes

Fusel alcohols regulate translation initiation by inhibiting eIF2B to reduce ternary complex in a mechanism that may involve altering the integrity and dynamics of the eIF2B body.

Global gene expression profiling reveals widespread yet distinctive translational responses to different eukaryotic translation initiation factor 2B-targeting stress pathways

Global mRNA selection mechanisms for translation initiation.

Global translational responses to oxidative stress impact upon multiple levels of protein synthesis.

Histone-like protein H1 (H-NS), DNA supercoiling, and gene expression in bacteria

Homologous segments in three subunits of the guanine nucleotide exchange factor eIF2B mediate translational regulation by phosphorylation of eIF2.

Identification of intersubunit domain interactions within eukaryotic initiation factor (eIF) 2B, the nucleotide exchange factor for translation initiation

Identifying eIF4E-binding protein translationally-controlled transcripts reveals links to mRNAs bound by specific PUF proteins

Impaired eIF5A function causes a Mendelian disorder that is partially rescued in model systems by spermidine

Integrated multi-omics analyses reveal the pleiotropic nature of the control of gene expression by Puf3p

Less translational control, more memory ⬇️

Mechanism and Regulation of Protein Synthesis in Saccharomyces cerevisiae

Mechanisms of translational regulation by a human eIF5-mimic protein

Mutations causing childhood ataxia with central nervous system hypomyelination reduce eukaryotic initiation factor 2B complex formation and activity

Mutations in SNORD118 cause the cerebral microangiopathy leukoencephalopathy with calcifications and cysts.

New Insights into Translational Regulation in the Endoplasmic Reticulum Unfolded Protein Response ⬇️

Parallel High-Throughput Automated Assays to Measure Cell Growth and Beta-Galactosidase Reporter Gene Expression in the Yeast Saccharomyces cerevisiae

Protein Synthesis Initiation in Eukaryotic Cells

Protein synthesis and its control in neuronal cells with a focus on vanishing white matter disease

Puf3p induces translational repression of genes linked to oxidative stress

Purification and kinetic analysis of eIF2B from Saccharomyces cerevisiae

Purification of FLAG-tagged eukaryotic initiation factor 2B complexes, subcomplexes, and fragments from Saccharomyces cerevisiae

Regulation of translation initiation factor eIF2B at the hub of the integrated stress response

Structure of the catalytic fragment of translation initiation factor 2B and identification of a critically important catalytic residue

The 4E-BP Caf20p Mediates Both eIF4E-Dependent and Independent Repression of Translation

The alpha subunit of eukaryotic initiation factor 2B (eIF2B) is required for eIF2-mediated translational suppression of vesicular stomatitis virus

The chromatin-associated protein H-NS interacts with curved DNA to influence DNA topology and gene expression

The structural basis of translational control by eIF2 phosphorylation

The yeast La related protein Slf1p is a key activator of translation during the oxidative stress response.

Translation controlled.

Translation reprogramming is an evolutionarily conserved driver of phenotypic plasticity and therapeutic resistance in melanoma.

Translational regulation in response to stress in Saccharomyces cerevisiae

Upstream sequence elements direct post-transcriptional regulation of gene expression under stress conditions in yeast.

eIF2 independently binds two distinct eIF2B subcomplexes that catalyze and regulate guanine-nucleotide exchange.

eIF2B is a decameric guanine nucleotide exchange factor with a γ2ε2 tetrameric core

eIF2B promotes eIF5 dissociation from eIF2*GDP to facilitate guanine nucleotide exchange for translation initiation

eIF2β is critical for eIF5-mediated GDP-dissociation inhibitor activity and translational control

eIF5 has GDI activity necessary for translational control by eIF2 phosphorylation

eIF5 is a dual function GAP and GDI for eukaryotic translational control