Lista de obras - Oliver Sieber - Dominio Público Uruguay

A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21

article

A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk

article

A mutant BRAF V600E-specific immunohistochemical assay: correlation with molecular mutation status and clinical outcome in colorectal cancer

artículo científico publicado en 2014

A statistical approach for detecting genomic aberrations in heterogeneous tumor samples from single nucleotide polymorphism genotyping data

artículo científico publicado en 2010

APC and the three-hit hypothesis

artículo científico publicado en 2008

Activation of AKT and nuclear accumulation of wild type TP53 and MDM2 in anal squamous cell carcinoma

article

Analysis of Mammalian Cell Proliferation and Macromolecule Synthesis Using Deuterated Water and Gas Chromatography-Mass Spectrometry

artículo científico publicado en 2016

Analysis of colorectal cancers in British Bangladeshi identifies early onset, frequent mucinous histotype and a high prevalence of RBFOX1 deletion

artículo científico publicado en 2013

Analysis of copy number changes suggests chromosomal instability in a minority of large colorectal adenomas

artículo científico publicado en 2007

BRAF V600E Mutant Colorectal Cancer Subtypes Based on Gene Expression

artículo científico publicado en 2016

CDC4 mutations occur in a subset of colorectal cancers but are not predicted to cause loss of function and are not associated with chromosomal instability

artículo científico publicado en 2005

COGENT (COlorectal cancer GENeTics): an international consortium to study the role of polymorphic variation on the risk of colorectal cancer.

artículo científico publicado en 2009

Carcinogenesis in MYH-associated polyposis follows a distinct genetic pathway

artículo científico publicado en 2003

Cells with pathogenic biallelic mutations in the human MUTYH gene are defective in DNA damage binding and repair

artículo científico publicado en 2005

Colorectal Cancer Cell Line Proteomes are Representative of Primary Tumors and Predict Drug Sensitivity

artículo científico publicado en 2017

Colorectal cancer atlas: An integrative resource for genomic and proteomic annotations from colorectal cancer cell lines and tissues.

artículo científico publicado en 2015

Colorectal cancer cell lines are representative models of the main molecular subtypes of primary cancer

artículo científico publicado en 2014

Contribution of the CHEK2 1100delC variant to risk of multiple colorectal adenoma and carcinoma

artículo científico publicado en 2003

DNA copy-number alterations underlie gene expression differences between microsatellite stable and unstable colorectal cancers

artículo científico publicado en 2008

DUSP5 is methylated in CIMP-high colorectal cancer but is not a major regulator of intestinal cell proliferation and tumorigenesis.

artículo científico publicado en 2018

Defective Myb Function Ablates Cyclin E1 Expression and Perturbs Intestinal Carcinogenesis.

artículo científico publicado en 2015

Different APC genotypes in proximal and distal sporadic colorectal cancers suggest distinct WNT/β-catenin signalling thresholds for tumourigenesis.

artículo científico publicado en 2012

Differential RNA-seq analysis comparing APC-defective and APC-restored SW480 colorectal cancer cells

artículo científico publicado en 2016

Disease severity and genetic pathways in attenuated familial adenomatous polyposis vary greatly but depend on the site of the germline mutation.

artículo científico publicado en 2006

Dual Targeting of Bromodomain and Extraterminal Domain Proteins, and WNT or MAPK Signaling, Inhibits c-MYC Expression and Proliferation of Colorectal Cancer Cells.

artículo científico publicado en 2016

Ectopic expression of P-cadherin correlates with promoter hypomethylation early in colorectal carcinogenesis and enhanced intestinal crypt fission in vivo.

artículo científico publicado en 2008

Epigenetic inactivation of the candidate tumor suppressor USP44 is a frequent and early event in colorectal neoplasia

artículo científico publicado en 2014

Erratum: COGENT (COlorectal cancer GENeTics): an international consortium to study the role of polymorphic variation on the risk of colorectal cancer

article

Evaluation of PIK3CA mutation as a predictor of benefit from nonsteroidal anti-inflammatory drug therapy in colorectal cancer

artículo científico publicado en 2013

Evaluation of the transferability of survival calculators for stage II/III colon cancer across healthcare systems

scientific article published on 20 January 2019

FunRich: An open access standalone functional enrichment and interaction network analysis tool

artículo científico publicado en 2015

Functional screening identifies miRNAs influencing apoptosis and proliferation in colorectal cancer

artículo científico publicado en 2014

Genetic basis of variation in adenoma multiplicity in ApcMin/+ Mom1S mice

artículo científico publicado en 2005

Genetic determinants modulate susceptibility to pregnancy-associated tumourigenesis in a recombinant line of Min mice.

artículo científico publicado en 2006

Genomic instability--the engine of tumorigenesis?

artículo científico publicado en 2003

Germline mutations but not somatic changes at the MYH locus contribute to the pathogenesis of unselected colorectal cancers.

artículo científico publicado en 2003

Germline variants and advanced colorectal adenomas: adenoma prevention with celecoxib trial genome-wide association study

artículo científico publicado en 2013

Immunomodulation by MYB is associated with tumor relapse in patients with early stage colorectal cancer.

artículo científico publicado en 2016

Immunoscore-has it scored for colon cancer precision medicine?

scientific article published on 01 November 2018

Impact of BRAF mutation and microsatellite instability on the pattern of metastatic spread and prognosis in metastatic colorectal cancer

artículo científico publicado en 2011

Impact of regular aspirin use on overall and cancer-specific survival in patients with colorectal cancer harboring a PIK3CA mutation

artículo científico publicado en 2014

Inhibition of Hematopoietic Cell Kinase Activity Suppresses Myeloid Cell-Mediated Colon Cancer Progression

artículo científico publicado en 2017

Interleukin 33 signaling restrains sporadic colon cancer in an interferon-gamma-dependent manner.

artículo científico publicado en 2018

Interleukin-11 is the dominant IL-6 family cytokine during gastrointestinal tumorigenesis and can be targeted therapeutically

artículo científico publicado en 2013

Investigation of pathogenic mechanisms in multiple colorectal adenoma patients without germline APC or MYH/MUTYH mutations

artículo científico publicado en 2007

Investigation of the effects of DNA repair gene polymorphisms on the risk of colorectal cancer

artículo científico publicado en 2012

KRAS Mutation Is Associated with Lung Metastasis in Patients with Curatively Resected Colorectal Cancer

artículo científico publicado en 2011

Long noncoding RNA LINP1: scaffolding non-homologous end joining.

artículo científico publicado en 2016

Lymphocytic response to tumour and deficient DNA mismatch repair identify subtypes of stage II/III colorectal cancer associated with patient outcomes.

artículo científico publicado en 2018

MACROD2 Haploinsufficiency Impairs Catalytic Activity of PARP1 and Promotes Chromosome Instability and Growth of Intestinal Tumors

artículo científico publicado en 2018

Metastasis-Associated Gene Expression Changes Predict Poor Outcomes in Patients with Dukes Stage B and C Colorectal Cancer

artículo científico publicado en 2009

MiRNA-362-3p induces cell cycle arrest through targeting of E2F1, USF2 and PTPN1 and is associated with recurrence of colorectal cancer

artículo científico publicado en 2013

Multiple colorectal adenomas, classic adenomatous polyposis, and germ-line mutations in MYH

artículo científico publicado en 2003

Multiple common susceptibility variants near BMP pathway loci GREM1, BMP4, and BMP2 explain part of the missing heritability of colorectal cancer

artículo científico publicado en 2011

Mutation burden and other molecular markers of prognosis in colorectal cancer treated with curative intent: results from the QUASAR 2 clinical trial and an Australian community-based series

article

Mutational analysis of genes coding for cell surface proteins in colorectal cancer cell lines reveal novel altered pathways, druggable mutations and mutated epitopes for targeted therapy

artículo científico publicado en 2014

Myh deficiency enhances intestinal tumorigenesis in multiple intestinal neoplasia (ApcMin/+) mice.

artículo científico publicado en 2004

New reagents for improved in vitro and in vivo examination of TGF-β signalling

artículo científico publicado en 2011

Optimizing targeted therapeutic development: analysis of a colorectal cancer patient population with the BRAF(V600E) mutation

artículo científico publicado en 2011

Overexpression of TP53 protein is associated with the lack of adjuvant chemotherapy benefit in patients with stage III colorectal cancer

scientific article published on 30 August 2019

PHLDA1 expression marks the putative epithelial stem cells and contributes to intestinal tumorigenesis.

artículo científico publicado en 2011

PIK3CA and PTEN gene and exon mutation-specific clinicopathologic and molecular associations in colorectal cancer

artículo científico publicado en 2013

Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt-β-catenin-mediated intestinal tumor growth and regeneration.

artículo científico publicado en 2014

Ponatinib Inhibits Multiple Signaling Pathways Involved in STAT3 Signaling and Attenuates Colorectal Tumor Growth

Pregnancy does not influence colonic polyp multiplicity but may modulate upper gastrointestinal disease in patients with FAP.

artículo científico publicado en 2007

Promoter hypermethylation leads to decreased APC mRNA expression in familial polyposis and sporadic colorectal tumours, but does not substitute for truncating mutations

artículo científico publicado en 2008

Putative direct and indirect Wnt targets identified through consistent gene expression changes in APC-mutant intestinal adenomas from humans and mice

artículo científico publicado en 2008

Refinement of the associations between risk of colorectal cancer and polymorphisms on chromosomes 1q41 and 12q13.13

artículo científico publicado en 2011

Refining Molecular Analysis in the Pathways of Colorectal Carcinogenesis

article

Refining the relation between 'first hits' and 'second hits' at the APC locus: the 'loose fit' model and evidence for differences in somatic mutation spectra among patients

artículo científico publicado en 2003

Relative telomere lengths in tumor and normal mucosa are related to disease progression and chromosome instability profiles in colorectal cancer

scientific article published on 26 April 2016

SMAD2, SMAD3 and SMAD4 mutations in colorectal cancer

artículo científico publicado en 2013

Single nucleotide polymorphism array profiling identifies distinct chromosomal aberration patterns across colorectal adenomas and carcinomas

artículo científico publicado en 2015

Survival in stage II/III colorectal cancer is independently predicted by chromosomal and microsatellite instability, but not by specific driver mutations

artículo científico publicado en 2013

The TERT variant rs2736100 is associated with colorectal cancer risk

artículo científico publicado en 2012

The adenomatous polyposis coli (APC) tumour suppressor--genetics, function and disease.

artículo científico publicado en 2000

The intestinal epithelial cell differentiation marker intestinal alkaline phosphatase (ALPi) is selectively induced by histone deacetylase inhibitors (HDACi) in colon cancer cells in a Kruppel-like factor 5 (KLF5)-dependent manner

artículo científico publicado en 2014

The intestinal epithelial cell differentiation marker intestinal alkaline phosphatase (ALPi) is selectively induced by histone deacetylase inhibitors (HDACi) in colon cancer cells in a Kruppel-like factor 5 (KLF5)-dependent manner.

artículo científico publicado en 2015

Tissue, cell and stage specificity of (epi)mutations in cancers

scientific article published on 01 August 2005

Tolerance of whole-genome doubling propagates chromosomal instability and accelerates cancer genome evolution.

artículo científico publicado en 2014

Tumour infiltrating lymphocyte status is superior to histological grade, DNA mismatch repair and BRAF mutation for prognosis of colorectal adenocarcinomas with mucinous differentiation

scientific article published on 11 February 2020

Use of multivariate analysis to suggest a new molecular classification of colorectal cancer.

artículo científico publicado en 2013

Widespread FRA1-dependent control of mesenchymal transdifferentiation programs in colorectal cancer cells

artículo científico publicado en 2014

Wild-type APC predicts poor prognosis in microsatellite-stable proximal colon cancer

artículo científico publicado en 2015

deletions cause impaired PARP1 activity and chromosome instability in colorectal cancer

artículo científico publicado en 2018

Lista de obras de Oliver Sieber

A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21

A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk

A mutant BRAF V600E-specific immunohistochemical assay: correlation with molecular mutation status and clinical outcome in colorectal cancer

A statistical approach for detecting genomic aberrations in heterogeneous tumor samples from single nucleotide polymorphism genotyping data

APC and the three-hit hypothesis

Activation of AKT and nuclear accumulation of wild type TP53 and MDM2 in anal squamous cell carcinoma

Analysis of Mammalian Cell Proliferation and Macromolecule Synthesis Using Deuterated Water and Gas Chromatography-Mass Spectrometry

Analysis of colorectal cancers in British Bangladeshi identifies early onset, frequent mucinous histotype and a high prevalence of RBFOX1 deletion

Analysis of copy number changes suggests chromosomal instability in a minority of large colorectal adenomas

BRAF V600E Mutant Colorectal Cancer Subtypes Based on Gene Expression

CDC4 mutations occur in a subset of colorectal cancers but are not predicted to cause loss of function and are not associated with chromosomal instability

COGENT (COlorectal cancer GENeTics): an international consortium to study the role of polymorphic variation on the risk of colorectal cancer.

Carcinogenesis in MYH-associated polyposis follows a distinct genetic pathway

Cells with pathogenic biallelic mutations in the human MUTYH gene are defective in DNA damage binding and repair

Colorectal Cancer Cell Line Proteomes are Representative of Primary Tumors and Predict Drug Sensitivity

Colorectal cancer atlas: An integrative resource for genomic and proteomic annotations from colorectal cancer cell lines and tissues.

Colorectal cancer cell lines are representative models of the main molecular subtypes of primary cancer

Contribution of the CHEK2 1100delC variant to risk of multiple colorectal adenoma and carcinoma

DNA copy-number alterations underlie gene expression differences between microsatellite stable and unstable colorectal cancers

DUSP5 is methylated in CIMP-high colorectal cancer but is not a major regulator of intestinal cell proliferation and tumorigenesis.

Defective Myb Function Ablates Cyclin E1 Expression and Perturbs Intestinal Carcinogenesis.

Different APC genotypes in proximal and distal sporadic colorectal cancers suggest distinct WNT/β-catenin signalling thresholds for tumourigenesis.

Differential RNA-seq analysis comparing APC-defective and APC-restored SW480 colorectal cancer cells

Disease severity and genetic pathways in attenuated familial adenomatous polyposis vary greatly but depend on the site of the germline mutation.

Dual Targeting of Bromodomain and Extraterminal Domain Proteins, and WNT or MAPK Signaling, Inhibits c-MYC Expression and Proliferation of Colorectal Cancer Cells.

Ectopic expression of P-cadherin correlates with promoter hypomethylation early in colorectal carcinogenesis and enhanced intestinal crypt fission in vivo.

Epigenetic inactivation of the candidate tumor suppressor USP44 is a frequent and early event in colorectal neoplasia

Erratum: COGENT (COlorectal cancer GENeTics): an international consortium to study the role of polymorphic variation on the risk of colorectal cancer

Evaluation of PIK3CA mutation as a predictor of benefit from nonsteroidal anti-inflammatory drug therapy in colorectal cancer

Evaluation of the transferability of survival calculators for stage II/III colon cancer across healthcare systems

FunRich: An open access standalone functional enrichment and interaction network analysis tool

Functional screening identifies miRNAs influencing apoptosis and proliferation in colorectal cancer

Genetic basis of variation in adenoma multiplicity in ApcMin/+ Mom1S mice

Genetic determinants modulate susceptibility to pregnancy-associated tumourigenesis in a recombinant line of Min mice.

Genomic instability--the engine of tumorigenesis?

Germline mutations but not somatic changes at the MYH locus contribute to the pathogenesis of unselected colorectal cancers.

Germline variants and advanced colorectal adenomas: adenoma prevention with celecoxib trial genome-wide association study

Immunomodulation by MYB is associated with tumor relapse in patients with early stage colorectal cancer.

Immunoscore-has it scored for colon cancer precision medicine?

Impact of BRAF mutation and microsatellite instability on the pattern of metastatic spread and prognosis in metastatic colorectal cancer

Impact of regular aspirin use on overall and cancer-specific survival in patients with colorectal cancer harboring a PIK3CA mutation

Inhibition of Hematopoietic Cell Kinase Activity Suppresses Myeloid Cell-Mediated Colon Cancer Progression

Interleukin 33 signaling restrains sporadic colon cancer in an interferon-gamma-dependent manner.

Interleukin-11 is the dominant IL-6 family cytokine during gastrointestinal tumorigenesis and can be targeted therapeutically

Investigation of pathogenic mechanisms in multiple colorectal adenoma patients without germline APC or MYH/MUTYH mutations

Investigation of the effects of DNA repair gene polymorphisms on the risk of colorectal cancer

KRAS Mutation Is Associated with Lung Metastasis in Patients with Curatively Resected Colorectal Cancer

Long noncoding RNA LINP1: scaffolding non-homologous end joining.

Lymphocytic response to tumour and deficient DNA mismatch repair identify subtypes of stage II/III colorectal cancer associated with patient outcomes.

MACROD2 Haploinsufficiency Impairs Catalytic Activity of PARP1 and Promotes Chromosome Instability and Growth of Intestinal Tumors

Metastasis-Associated Gene Expression Changes Predict Poor Outcomes in Patients with Dukes Stage B and C Colorectal Cancer

MiRNA-362-3p induces cell cycle arrest through targeting of E2F1, USF2 and PTPN1 and is associated with recurrence of colorectal cancer

Multiple colorectal adenomas, classic adenomatous polyposis, and germ-line mutations in MYH

Multiple common susceptibility variants near BMP pathway loci GREM1, BMP4, and BMP2 explain part of the missing heritability of colorectal cancer

Mutation burden and other molecular markers of prognosis in colorectal cancer treated with curative intent: results from the QUASAR 2 clinical trial and an Australian community-based series

Mutational analysis of genes coding for cell surface proteins in colorectal cancer cell lines reveal novel altered pathways, druggable mutations and mutated epitopes for targeted therapy

Myh deficiency enhances intestinal tumorigenesis in multiple intestinal neoplasia (ApcMin/+) mice.

New reagents for improved in vitro and in vivo examination of TGF-β signalling

Optimizing targeted therapeutic development: analysis of a colorectal cancer patient population with the BRAF(V600E) mutation

Overexpression of TP53 protein is associated with the lack of adjuvant chemotherapy benefit in patients with stage III colorectal cancer

PHLDA1 expression marks the putative epithelial stem cells and contributes to intestinal tumorigenesis.

PIK3CA and PTEN gene and exon mutation-specific clinicopathologic and molecular associations in colorectal cancer

Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt-β-catenin-mediated intestinal tumor growth and regeneration.

Ponatinib Inhibits Multiple Signaling Pathways Involved in STAT3 Signaling and Attenuates Colorectal Tumor Growth

Pregnancy does not influence colonic polyp multiplicity but may modulate upper gastrointestinal disease in patients with FAP.

Promoter hypermethylation leads to decreased APC mRNA expression in familial polyposis and sporadic colorectal tumours, but does not substitute for truncating mutations

Putative direct and indirect Wnt targets identified through consistent gene expression changes in APC-mutant intestinal adenomas from humans and mice

Refinement of the associations between risk of colorectal cancer and polymorphisms on chromosomes 1q41 and 12q13.13

Refining Molecular Analysis in the Pathways of Colorectal Carcinogenesis

Refining the relation between 'first hits' and 'second hits' at the APC locus: the 'loose fit' model and evidence for differences in somatic mutation spectra among patients

Relative telomere lengths in tumor and normal mucosa are related to disease progression and chromosome instability profiles in colorectal cancer

SMAD2, SMAD3 and SMAD4 mutations in colorectal cancer

Single nucleotide polymorphism array profiling identifies distinct chromosomal aberration patterns across colorectal adenomas and carcinomas

Survival in stage II/III colorectal cancer is independently predicted by chromosomal and microsatellite instability, but not by specific driver mutations

The TERT variant rs2736100 is associated with colorectal cancer risk

The adenomatous polyposis coli (APC) tumour suppressor--genetics, function and disease.

The intestinal epithelial cell differentiation marker intestinal alkaline phosphatase (ALPi) is selectively induced by histone deacetylase inhibitors (HDACi) in colon cancer cells in a Kruppel-like factor 5 (KLF5)-dependent manner

The intestinal epithelial cell differentiation marker intestinal alkaline phosphatase (ALPi) is selectively induced by histone deacetylase inhibitors (HDACi) in colon cancer cells in a Kruppel-like factor 5 (KLF5)-dependent manner.

Tissue, cell and stage specificity of (epi)mutations in cancers