Lista de obras - Colin J Henderson - Dominio Público Uruguay

A general strategy for the expression of recombinant human cytochrome P450s in Escherichia coli using bacterial signal peptides: expression of CYP3A4, CYP2A6, and CYP2E1.

artículo científico publicado en 1997

A role for cytochrome b5 in the In vivo disposition of anticancer and cytochrome P450 probe drugs in mice

artículo científico publicado en 2013

A targeted in vivo SILAC approach for quantification of drug metabolism enzymes: regulation by the constitutive androstane receptor

artículo científico publicado en 2013

Adaptive responses to environmental chemicals

artículo científico publicado en 1999

Advances in the generation of mouse models to elucidate the pathways of drug metabolism in rodents and man

artículo científico publicado en 2009

Alterations in rat hepatic drug metabolism during pregnancy and lactation

scientific article published on 01 July 1993

Altered protein S-glutathionylation identifies a potential mechanism of resistance to acetaminophen-induced hepatotoxicity.

artículo científico publicado en 2015

An enhanced in vivo stable isotope labeling by amino acids in cell culture (SILAC) model for quantification of drug metabolism enzymes.

artículo científico publicado en 2015

Analysis of calmodulin acceptor proteins and the influence of calmodulin antagonists on human spermatozoa

artículo científico publicado en 1988

Analysis of the biological properties of antibodies raised against intact and deglycosylated porcine zonae pellucidae

articulo cientifico

Analysis of the surface labelling characteristics of human spermatozoa and the interaction with anti-sperm antibodies

artículo científico publicado en 1987

Application of Mice Humanized for CYP2D6 to the Study of Tamoxifen Metabolism and Drug-Drug Interaction with Antidepressants

scientific article published on 18 October 2016

Application of a novel regulatable Cre recombinase system to define the role of liver and gut metabolism in drug oral bioavailability.

artículo científico publicado en 2015

Attenuation of lung fibrosis in mice with a clinically relevant inhibitor of glutathione-S-transferase π.

artículo científico publicado en 2016

Bioactivation of 3-aminobenzanthrone, a human metabolite of the environmental pollutant 3-nitrobenzanthrone: evidence for DNA adduct formation mediated by cytochrome P450 enzymes and peroxidases

artículo científico publicado en 2006

Catalytic activities of human debrisoquine 4-hydroxylase cytochrome P450 (CYP2D6) expressed in yeast

artículo científico publicado en 1992

Cholesterol metabolism: the main pathway acting downstream of cytochrome P450 oxidoreductase in skeletal development of the limb

artículo científico publicado en 2009

Conditional deletion of cytochrome P450 oxidoreductase in the liver and gastrointestinal tract: a new model for studying the functions of the P450 system

artículo científico publicado en 2007

Contraceptive potential of antibodies to the zona pellucida

artículo científico publicado en 1988

Cytochrome P450s and chemoprevention

scientific article published on 01 February 2000

Cytochrome b5 and epoxide hydrolase contribute to benzo[a]pyrene-DNA adduct formation catalyzed by cytochrome P450 1A1 under low NADPH:P450 oxidoreductase conditions.

artículo científico publicado en 2014

Cytochrome b5 is a major determinant of human cytochrome P450 CYP2D6 and CYP3A4 activity in vivo.

artículo científico publicado en 2015

Cytochrome b5 null mouse: a new model for studying inherited skin disorders and the role of unsaturated fatty acids in normal homeostasis

artículo científico publicado en 2010

Deduced amino acid sequence of a murine cytochrome P-450 Cyp4a protein: developmental and hormonal regulation in liver and kidney

scientific journal article

Defining Human Pathways of Drug Metabolism In Vivo through the Development of a Multiple Humanized Mouse Model

artículo científico publicado en 2015

Defining the Contribution of CYP1A1 and CYP1A2 to Drug Metabolism Using Humanized CYP1A1/1A2 and Cyp1a1/Cyp1a2 Knockout Mice

artículo científico publicado en 2019

Defining the in Vivo Role for cytochrome b5 in cytochrome P450 function through the conditional hepatic deletion of microsomal cytochrome b5.

artículo científico publicado en 2008

Deletion of 30 murine cytochrome p450 genes results in viable mice with compromised drug metabolism

artículo científico publicado en 2014

Deletion of microsomal cytochrome b5 profoundly affects hepatic and extrahepatic drug metabolism

artículo científico publicado en 2010

Detection and quantitation of N-(deoxyguanosin-8-yl)-2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine adducts in DNA using online column-switching liquid chromatography tandem mass spectrometry.

artículo científico publicado en 2010

Development of a liquid chromatography-electrospray ionization tandem mass spectrometry method for detecting oxaliplatin-DNA intrastrand cross-links in biological samples

artículo científico publicado en 2007

Diminished toxicity of C-1748, 4-methyl-9-hydroxyethylamino-1-nitroacridine, compared with its demethyl analog, C-857, corresponds to its resistance to metabolism in HepG2 cells

scientific article published on 06 April 2012

Disruption of the glutathione transferase pi class genes.

artículo científico publicado en 2005

Drug-induced chromatin accessibility changes associate with sensitivity to liver tumor promotion

artículo científico publicado en 2019

Effect of hepatic cytochrome P450 (P450) oxidoreductase deficiency on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-DNA adduct formation in P450 reductase conditional null mice.

artículo científico publicado en 2011

Evidence that cytochrome b5 and cytochrome b5 reductase can act as sole electron donors to the hepatic cytochrome P450 system

artículo científico publicado en 2013

Evidence that the capacity of nongenotoxic carcinogens to induce oxidative stress is subject to marked variability.

artículo científico publicado en 2015

Exposure to benzo[a]pyrene of Hepatic Cytochrome P450 Reductase Null (HRN) and P450 Reductase Conditional Null (RCN) mice: Detection of benzo[a]pyrene diol epoxide-DNA adducts by immunohistochemistry and 32P-postlabelling.

artículo científico publicado en 2012

Expression of P450 isoenzymes during rat liver organogenesis

scientific article published on 01 November 1993

Functional expression and comparative characterization of nine murine cytochromes P450 by fluorescent inhibition screening

artículo científico publicado en 2008

Glutathione S-transferase pi mediates MPTP-induced c-Jun N-terminal kinase activation in the nigrostriatal pathway

artículo científico publicado en 2012

Glutathione transferase P1: an endogenous inhibitor of allergic responses in a mouse model of asthma.

artículo científico publicado en 2008

Glutathione transferase pi plays a critical role in the development of lung carcinogenesis following exposure to tobacco-related carcinogens and urethane.

artículo científico publicado en 2007

Glutathione transferases P1/P2 regulate the timing of signaling pathway activations and cell cycle progression during mouse liver regeneration

artículo científico publicado en 2015

HDAC inhibitors increase NRF2-signaling in tumour cells and blunt the efficacy of co-adminstered cytotoxic agents

artículo científico publicado en 2014

Hepatic cytochrome P-450 reductase-null mice show reduced transcriptional response to quercetin and reveal physiological homeostasis between jejunum and liver.

artículo científico publicado en 2006

High variability of nitrosamine metabolism among individuals: role of cytochromes P450 2A6 and 2E1 in the dealkylation of N-nitrosodimethylamine and N-nitrosodiethylamine in mice and humans

artículo científico publicado en 1993

Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo.

artículo científico publicado en 2010

Humanizing π-class glutathione S-transferase regulation in a mouse model alters liver toxicity in response to acetaminophen overdose

artículo científico publicado en 2011

Identification of retinoic acid as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha

artículo científico publicado en 2007

In vitro metabolism of aflatoxin B1 by normal and tumorous liver tissue from Thailand.

artículo científico publicado en 1993

In vivo regulation of human glutathione transferase GSTP by chemopreventive agents

artículo científico publicado en 2014

Inactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase.

artículo científico publicado en 2003

Increased skin papilloma formation in mice lacking glutathione transferase GSTP.

artículo científico publicado en 2011

Knockout and transgenic mice in glutathione transferase research ⬇️

artículo científico publicado el 22 de marzo de 2011

Knockout mice in xenobiotic metabolism

artículo científico publicado en 2003

Lactational transfer of 2,4,5,2',4',5'-hexachlorobiphenyl but not 3,4,3',4'-tetrachlorobiphenyl, induces neonatal CYP4A1

artículo científico publicado en 1993

Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice.

artículo científico publicado en 2002

Markedly enhanced colon tumorigenesis in Apc(Min) mice lacking glutathione S-transferase Pi.

artículo científico publicado en 2009

Metabolic activation of benzo[a]pyrene in vitro by hepatic cytochrome P450 contrasts with detoxification in vivo: experiments with hepatic cytochrome P450 reductase null mice.

artículo científico publicado en 2008

Metabolism of [3-14C] coumarin by human liver microsomes

artículo científico publicado en 1994

NADPH-cytochrome P450 oxidoreductase: roles in physiology, pharmacology, and toxicology.

artículo científico publicado en 2012

Nomenclature for alleles of the cytochrome P450 oxidoreductase gene

artículo científico publicado en 2009

Pharmacokinetics and pharmacodynamics of orally administered acetylenic tricyclic bis(cyanoenone), a highly potent Nrf2 activator with a reversible covalent mode of action.

artículo científico publicado en 2015

Phenobarbital induces cell cycle transcriptional responses in mouse liver humanized for constitutive androstane and pregnane x receptors

artículo científico publicado en 2014

Phenobarbital-mediated tumor promotion in transgenic mice with humanized CAR and PXR.

artículo científico publicado en 2014

Pi-class glutathione S-transferase: regulation and function.

artículo científico publicado en 1998

Polyclonal antibodies to a 32-kDa deglycosylated polypeptide from porcine zonae pellucidae will prevent human gamete interaction in vitro

artículo científico publicado en 1987

Precision-cut tissue slices from transgenic mice as an in vitro toxicology system.

artículo científico publicado en 2003

Preclinical toxicokinetic evaluation of phortress [2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole lysylamide dihydrochloride] in two rodent species

artículo científico publicado en 2008

Protein expression profiling of glutathione S-transferase pi null mice as a strategy to identify potential markers of resistance to paracetamol-induced toxicity in the liver

artículo científico publicado en 2003

Proteome-wide identification and quantification of S-glutathionylation targets in mouse liver.

artículo científico publicado en 2015

Purification of bile acid-binding proteins from rat hepatic cytosol. Use of a photoaffinity label to detect novel Y′ binders

Pyrethroid activity-based probes for profiling cytochrome P450 activities associated with insecticide interactions

artículo científico publicado en 2013

Relationship between hepatic phenotype and changes in gene expression in cytochrome P450 reductase (POR) null mice

artículo científico publicado en 2005

Role of cytochromes P450 1A1/2 in detoxication and activation of carcinogenic aristolochic acid I: studies with the hepatic NADPH:cytochrome P450 reductase null (HRN) mouse model.

artículo científico publicado en 2011

Role of hepatic cytochrome p450s in the pharmacokinetics and toxicity of cyclophosphamide: studies with the hepatic cytochrome p450 reductase null mouse

artículo científico publicado en 2005

Role of hepatic cytochromes P450 in bioactivation of the anticancer drug ellipticine: studies with the hepatic NADPH:cytochrome P450 reductase null mouse.

artículo científico publicado en 2007

Sexual differentiation and regulation of cytochrome P-450 CYP2C7

artículo científico publicado el 9 de enero de 1992

Suppression of multi-drug resistance gene expression in the mouse liver by 1,4-bis[2,(3,5-dichloropyridyloxy)]benzene.

artículo científico publicado en 1994

Synthesis and characterisation of an iodinated bile-salt derivative for photoaffinity labelling.

artículo científico publicado en 1984

Tauroursodeoxycholic acid prevents MPTP-induced dopaminergic cell death in a mouse model of Parkinson's disease.

artículo científico publicado en 2012

The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin

artículo científico publicado en 2000

The Role of Protein-Protein and Protein-Membrane Interactions on P450 Function

artículo científico publicado en 2016

The disruption of hepatic cytochrome p450 reductase alters mouse lipid metabolism

artículo científico publicado en 2007

The hepatic cytochrome P450 reductase null mouse as a tool to identify a successful candidate entity

artículo científico publicado en 2005

The imidazoacridinone antitumor drug, C-1311, is metabolized by flavin monooxygenases but not by cytochrome P450s

artículo científico publicado en 2011

The involvement of mitochondrial amidoxime reducing components 1 and 2 and mitochondrial cytochrome b5 in N-reductive metabolism in human cells

artículo científico publicado en 2013

The murine Cyp1a1 gene is expressed in a restricted spatial and temporal pattern during embryonic development.

artículo científico publicado en 2004

Transcription factor Nrf2 is essential for induction of NAD(P)H:quinone oxidoreductase 1, glutathione S-transferases, and glutamate cysteine ligase by broccoli seeds and isothiocyanates

artículo científico publicado en 2004

Transfer of PCBs via lactation simultaneously induces the expression of P450 isoenzymes and the protooncogenes c-Ha-ras and c-raf in neonates

scientific article published on 01 February 1996

Ubiquitin-proteasome system impairment and MPTP-induced oxidative stress in the brain of C57BL/6 wild-type and GSTP knockout mice

artículo científico publicado en 2012

Unsaturated fatty acid regulation of cytochrome P450 expression via a CAR-dependent pathway.

artículo científico publicado en 2009

Use of transgenic animals in understanding molecular mechanisms of toxicity.

artículo científico publicado en 1998

Lista de obras de Colin J Henderson

A general strategy for the expression of recombinant human cytochrome P450s in Escherichia coli using bacterial signal peptides: expression of CYP3A4, CYP2A6, and CYP2E1.

A role for cytochrome b5 in the In vivo disposition of anticancer and cytochrome P450 probe drugs in mice

A targeted in vivo SILAC approach for quantification of drug metabolism enzymes: regulation by the constitutive androstane receptor

Adaptive responses to environmental chemicals

Advances in the generation of mouse models to elucidate the pathways of drug metabolism in rodents and man

Alterations in rat hepatic drug metabolism during pregnancy and lactation

Altered protein S-glutathionylation identifies a potential mechanism of resistance to acetaminophen-induced hepatotoxicity.

An enhanced in vivo stable isotope labeling by amino acids in cell culture (SILAC) model for quantification of drug metabolism enzymes.

Analysis of calmodulin acceptor proteins and the influence of calmodulin antagonists on human spermatozoa

Analysis of the biological properties of antibodies raised against intact and deglycosylated porcine zonae pellucidae

Analysis of the surface labelling characteristics of human spermatozoa and the interaction with anti-sperm antibodies

Application of Mice Humanized for CYP2D6 to the Study of Tamoxifen Metabolism and Drug-Drug Interaction with Antidepressants

Application of a novel regulatable Cre recombinase system to define the role of liver and gut metabolism in drug oral bioavailability.

Attenuation of lung fibrosis in mice with a clinically relevant inhibitor of glutathione-S-transferase π.

Bioactivation of 3-aminobenzanthrone, a human metabolite of the environmental pollutant 3-nitrobenzanthrone: evidence for DNA adduct formation mediated by cytochrome P450 enzymes and peroxidases

Catalytic activities of human debrisoquine 4-hydroxylase cytochrome P450 (CYP2D6) expressed in yeast

Cholesterol metabolism: the main pathway acting downstream of cytochrome P450 oxidoreductase in skeletal development of the limb

Conditional deletion of cytochrome P450 oxidoreductase in the liver and gastrointestinal tract: a new model for studying the functions of the P450 system

Contraceptive potential of antibodies to the zona pellucida

Cytochrome P450s and chemoprevention

Cytochrome b5 and epoxide hydrolase contribute to benzo[a]pyrene-DNA adduct formation catalyzed by cytochrome P450 1A1 under low NADPH:P450 oxidoreductase conditions.

Cytochrome b5 is a major determinant of human cytochrome P450 CYP2D6 and CYP3A4 activity in vivo.

Cytochrome b5 null mouse: a new model for studying inherited skin disorders and the role of unsaturated fatty acids in normal homeostasis

Deduced amino acid sequence of a murine cytochrome P-450 Cyp4a protein: developmental and hormonal regulation in liver and kidney

Defining Human Pathways of Drug Metabolism In Vivo through the Development of a Multiple Humanized Mouse Model

Defining the Contribution of CYP1A1 and CYP1A2 to Drug Metabolism Using Humanized CYP1A1/1A2 and Cyp1a1/Cyp1a2 Knockout Mice

Defining the in Vivo Role for cytochrome b5 in cytochrome P450 function through the conditional hepatic deletion of microsomal cytochrome b5.

Deletion of 30 murine cytochrome p450 genes results in viable mice with compromised drug metabolism

Deletion of microsomal cytochrome b5 profoundly affects hepatic and extrahepatic drug metabolism

Detection and quantitation of N-(deoxyguanosin-8-yl)-2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine adducts in DNA using online column-switching liquid chromatography tandem mass spectrometry.

Development of a liquid chromatography-electrospray ionization tandem mass spectrometry method for detecting oxaliplatin-DNA intrastrand cross-links in biological samples

Diminished toxicity of C-1748, 4-methyl-9-hydroxyethylamino-1-nitroacridine, compared with its demethyl analog, C-857, corresponds to its resistance to metabolism in HepG2 cells

Disruption of the glutathione transferase pi class genes.

Drug-induced chromatin accessibility changes associate with sensitivity to liver tumor promotion

Effect of hepatic cytochrome P450 (P450) oxidoreductase deficiency on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-DNA adduct formation in P450 reductase conditional null mice.

Evidence that cytochrome b5 and cytochrome b5 reductase can act as sole electron donors to the hepatic cytochrome P450 system

Evidence that the capacity of nongenotoxic carcinogens to induce oxidative stress is subject to marked variability.

Exposure to benzo[a]pyrene of Hepatic Cytochrome P450 Reductase Null (HRN) and P450 Reductase Conditional Null (RCN) mice: Detection of benzo[a]pyrene diol epoxide-DNA adducts by immunohistochemistry and 32P-postlabelling.

Expression of P450 isoenzymes during rat liver organogenesis

Functional expression and comparative characterization of nine murine cytochromes P450 by fluorescent inhibition screening

Glutathione S-transferase pi mediates MPTP-induced c-Jun N-terminal kinase activation in the nigrostriatal pathway

Glutathione transferase P1: an endogenous inhibitor of allergic responses in a mouse model of asthma.

Glutathione transferase pi plays a critical role in the development of lung carcinogenesis following exposure to tobacco-related carcinogens and urethane.

Glutathione transferases P1/P2 regulate the timing of signaling pathway activations and cell cycle progression during mouse liver regeneration

HDAC inhibitors increase NRF2-signaling in tumour cells and blunt the efficacy of co-adminstered cytotoxic agents

Hepatic cytochrome P-450 reductase-null mice show reduced transcriptional response to quercetin and reveal physiological homeostasis between jejunum and liver.

High variability of nitrosamine metabolism among individuals: role of cytochromes P450 2A6 and 2E1 in the dealkylation of N-nitrosodimethylamine and N-nitrosodiethylamine in mice and humans

Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo.

Humanizing π-class glutathione S-transferase regulation in a mouse model alters liver toxicity in response to acetaminophen overdose

Identification of retinoic acid as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha

In vitro metabolism of aflatoxin B1 by normal and tumorous liver tissue from Thailand.

In vivo regulation of human glutathione transferase GSTP by chemopreventive agents

Inactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase.

Increased skin papilloma formation in mice lacking glutathione transferase GSTP.

Knockout and transgenic mice in glutathione transferase research ⬇️

Knockout mice in xenobiotic metabolism

Lactational transfer of 2,4,5,2',4',5'-hexachlorobiphenyl but not 3,4,3',4'-tetrachlorobiphenyl, induces neonatal CYP4A1

Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice.

Markedly enhanced colon tumorigenesis in Apc(Min) mice lacking glutathione S-transferase Pi.

Metabolic activation of benzo[a]pyrene in vitro by hepatic cytochrome P450 contrasts with detoxification in vivo: experiments with hepatic cytochrome P450 reductase null mice.

Metabolism of [3-14C] coumarin by human liver microsomes

NADPH-cytochrome P450 oxidoreductase: roles in physiology, pharmacology, and toxicology.

Nomenclature for alleles of the cytochrome P450 oxidoreductase gene

Pharmacokinetics and pharmacodynamics of orally administered acetylenic tricyclic bis(cyanoenone), a highly potent Nrf2 activator with a reversible covalent mode of action.

Phenobarbital induces cell cycle transcriptional responses in mouse liver humanized for constitutive androstane and pregnane x receptors

Phenobarbital-mediated tumor promotion in transgenic mice with humanized CAR and PXR.

Pi-class glutathione S-transferase: regulation and function.

Polyclonal antibodies to a 32-kDa deglycosylated polypeptide from porcine zonae pellucidae will prevent human gamete interaction in vitro

Precision-cut tissue slices from transgenic mice as an in vitro toxicology system.

Preclinical toxicokinetic evaluation of phortress [2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole lysylamide dihydrochloride] in two rodent species

Protein expression profiling of glutathione S-transferase pi null mice as a strategy to identify potential markers of resistance to paracetamol-induced toxicity in the liver

Proteome-wide identification and quantification of S-glutathionylation targets in mouse liver.

Purification of bile acid-binding proteins from rat hepatic cytosol. Use of a photoaffinity label to detect novel Y′ binders

Pyrethroid activity-based probes for profiling cytochrome P450 activities associated with insecticide interactions

Relationship between hepatic phenotype and changes in gene expression in cytochrome P450 reductase (POR) null mice

Role of cytochromes P450 1A1/2 in detoxication and activation of carcinogenic aristolochic acid I: studies with the hepatic NADPH:cytochrome P450 reductase null (HRN) mouse model.

Role of hepatic cytochrome p450s in the pharmacokinetics and toxicity of cyclophosphamide: studies with the hepatic cytochrome p450 reductase null mouse

Role of hepatic cytochromes P450 in bioactivation of the anticancer drug ellipticine: studies with the hepatic NADPH:cytochrome P450 reductase null mouse.

Sexual differentiation and regulation of cytochrome P-450 CYP2C7