Lista de obras - John D. Hayes - Dominio Público Uruguay

1-Cyano-2,3-epithiopropane is a novel plant-derived chemopreventive agent which induces cytoprotective genes that afford resistance against the genotoxic alpha,beta-unsaturated aldehyde acrolein.

artículo científico publicado en 2009

A novel shogaol analog suppresses cancer cell invasion and inflammation, and displays cytoprotective effects through modulation of NF-κB and Nrf2-Keap1 signaling pathways

artículo científico publicado en 2013

A physiologically-based pharmacokinetic(PB-PK) model for ethylene dibromide: relevance of extrahepatic metabolism

artículo científico publicado en 2000

Activation of hepatic Nrf2 in vivo by acetaminophen in CD-1 mice

artículo científico publicado en 2004

Activation of the NRF2 signaling pathway by copper-mediated redox cycling of para- and ortho-hydroquinones

artículo científico publicado en 2010

Age-dependent change of metabolic capacity and genotoxic injury in rat intestine

artículo científico publicado en 1998

Aldo-keto reductases are biomarkers of NRF2 activity and are co-ordinately overexpressed in non-small cell lung cancer

artículo científico publicado en 2017

Alteration of glutathione S-transferase levels in Barrett's metaplasia compared to normal oesophageal epithelium

artículo científico publicado en 2003

Biochemical and genetic characterization of a murine class Kappa glutathione S-transferase

artículo científico publicado en 2003

Cancer chemoprevention mechanisms mediated through the Keap1-Nrf2 pathway

scientific article published on 14 August 2010

Characterization of the cancer chemopreventive NRF2-dependent gene battery in human keratinocytes: demonstration that the KEAP1-NRF2 pathway, and not the BACH1-NRF2 pathway, controls cytoprotection against electrophiles as well as redox-cycling comp

artículo científico publicado en 2009

Characterization of the rat aflatoxin B1 aldehyde reductase gene, AKR7A1. Structure and chromosomal localization of AKR7A1 as well as identification of antioxidant response elements in the gene promoter ⬇️

artículo científico publicado el 1 de abril de 2003

Conjugation of Highly Reactive Aflatoxin B1exo-8,9-Epoxide Catalyzed by Rat and Human Glutathione Transferases: Estimation of Kinetic Parameters†

scientific article published on 01 March 1997

Contribution of NAD(P)H:quinone oxidoreductase 1 to protection against carcinogenesis, and regulation of its gene by the Nrf2 basic-region leucine zipper and the arylhydrocarbon receptor basic helix-loop-helix transcription factors

artículo científico publicado en 2004

Contribution of the glutathione S-transferases to the mechanisms of resistance to aflatoxin B1.

artículo científico publicado en 1991

Cross-talk between transcription factors AhR and Nrf2: lessons for cancer chemoprevention from dioxin.

artículo científico publicado en 2009

Cut-price knockout?

scholarly article by John D. Hayes published November 1995 in Human & Experimental Toxicology

Cytotoxicity of xenobiotics and expression of glutathione-S-transferases in immortalised rat hepatocyte cell lines

artículo científico publicado en 1998

Decreased hepatic glutathione S-transferase A, AA and L concentration produced by prolonged thyroid hormone administration

artículo científico publicado en 1988

Deficiency of glutathione transferase zeta causes oxidative stress and activation of antioxidant response pathways

artículo científico publicado en 2006

Development of specific radioimmunoassays for the measurement of human hepatic basic and N/A2b glutathione S-transferases

article

Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a "tethering" mechanism: a two-site interaction model for the Nrf2-Keap1 complex

artículo científico publicado en 2006

Direct comparison of the nature of mouse and human GST T1-1 and the implications on dichloromethane carcinogenicity

artículo científico publicado en 2002

Dual regulation of transcription factor Nrf2 by Keap1 and by the combined actions of β-TrCP and GSK-3.

artículo científico

Elevation of AKR7A2 (succinic semialdehyde reductase) in neurodegenerative disease

artículo científico publicado en 2001

Enhanced expression of glutathione S-transferases in colorectal carcinoma compared to non-neoplastic mucosa

scientific article published on 01 January 1991

Erratum to “Expression of rat aldehyde reductase AKR7A1: influence of age and sex and tissue-specific inducibility”

scholarly article published in Biochemical Pharmacology

Evolutionary conserved N-terminal domain of Nrf2 is essential for the Keap1-mediated degradation of the protein by proteasome

artículo científico publicado en 2005

Expression and localization of rat aldo-keto reductases and induction of the 1B13 and 1D2 isoforms by phenolic antioxidants.

artículo científico publicado en 2009

Expression and polymorphism of glutathione S-transferase in human lungs: risk factors in smoking-related lung cancer

artículo científico publicado en 1995

Expression of glutathione S-transferases and cytochrome P450 in normal and tumor breast tissue

scientific article published on 01 December 1990

Expression of glyoxalase, glutathione peroxidase and glutathione S-transferase isoenzymes in different bovine tissues

scientific article published on 01 January 1989

Expression of rat aldehyde reductase AKR7A1: influence of age and sex and tissue-specific inducibility.

artículo científico publicado en 2001

Expression of the aflatoxin B1-8,9-epoxide-metabolizing murine glutathione S-transferase A3 subunit is regulated by the Nrf2 transcription factor through an antioxidant response element

artículo científico publicado en 2003

Expression of the murine glutathione S-transferase alpha3 (GSTA3) subunit is markedly induced during adipocyte differentiation: activation of the GSTA3 gene promoter by the pro-adipogenic eicosanoid 15-deoxy-Delta12,14-prostaglandin J2.

artículo científico publicado en 2003

Fish and mammalian liver cytosolic glutathione S-transferases: Substrate specificities and immunological comparison

article published in 1989

Generation of a stable antioxidant response element-driven reporter gene cell line and its use to show redox-dependent activation of nrf2 by cancer chemotherapeutic agents.

artículo científico publicado en 2006

Glutathione S-transferase and glutathione peroxidase expression in normal and tumour human tissues

artículo científico publicado en 1990

Glutathione S-transferase isoenzymes in human renal carcinoma demonstrated by immunohistochemistry

artículo científico publicado en 1989

Glutathione S-transferase isoenzymes in human tumours and tumour derived cell lines

artículo científico publicado en 1989

Glutathione S-transferase localization in aflatoxin B1-treated rat livers

artículo científico publicado en 1990

Glutathione S-transferase mu locus: use of genotyping and phenotyping assays to assess association with lung cancer susceptibility

artículo científico publicado en 1991

Glutathione and glutathione-dependent enzymes in ovarian adenocarcinoma cell lines derived from a patient before and after the onset of drug resistance: intrinsic differences and cell cycle effects

artículo científico publicado en 1988

Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress.

artículo científico publicado en 1999

Hepatic damage in the rat following administration of thyroxine or triiodothyronine, assessed by measurement of plasma glutathione S-transferase YaYa concentrations

artículo científico publicado en 1986

Human Mu-class glutathione S-transferases present in liver, skeletal muscle and testicular tissue

artículo científico publicado en 1993

Human embryonic stem cell derived astrocytes mediate non-cell-autonomous neuroprotection through endogenous and drug-induced mechanisms.

artículo científico publicado en 2011

Identification and characterisation of new inhibitors for the human hematopoietic prostaglandin D2 synthase

artículo científico publicado en 2010

Identification of a novel Nrf2-regulated antioxidant response element (ARE) in the mouse NAD(P)H:quinone oxidoreductase 1 gene: reassessment of the ARE consensus sequence

artículo científico publicado en 2003

Identification of retinoic acid as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha

artículo científico publicado en 2007

Identification of topological determinants in the N-terminal domain of transcription factor Nrf1 that control its orientation in the endoplasmic reticulum membrane

artículo científico publicado en 2010

Increased levels of alpha-class and pi-class glutathione S-transferases in cell lines resistant to 1-chloro-2,4-dinitrobenzene

artículo científico publicado en 1993

Induction of Phase I and Phase II Drug-Metabolizing Enzyme mRNA, Protein, and Activity by BHA, Ethoxyquin, and Oltipraz

artículo científico publicado en 1995

Induction of cancer chemopreventive enzymes by coffee is mediated by transcription factor Nrf2. Evidence that the coffee-specific diterpenes cafestol and kahweol confer protection against acrolein

artículo científico publicado en 2007

Induction of sulfiredoxin expression and reduction of peroxiredoxin hyperoxidation by the neuroprotective Nrf2 activator 3H-1,2-dithiole-3-thione.

artículo científico publicado en 2008

Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals

artículo científico publicado en 2010

Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression

artículo científico publicado en 2003

Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis.

artículo científico publicado en 2009

Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice.

artículo científico publicado en 2002

Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease

artículo científico publicado en 2015

Mechanisms of induction of cytosolic and microsomal glutathione transferase (GST) genes by xenobiotics and pro-inflammatory agents

artículo científico publicado en 2011

Metabolic competence and susceptibility of intestinal epithelium to genotoxic injury during regeneration

artículo científico publicado en 1997

Mild oxidative stress activates Nrf2 in astrocytes, which contributes to neuroprotective ischemic preconditioning.

artículo científico publicado en 2010

Modulation of glutathione S-transferases and glutathione peroxidase by the anticarcinogen butylated hydroxyanisole in murine extrahepatic organs

artículo científico publicado en 1992

Molecular basis for the contribution of the antioxidant responsive element to cancer chemoprevention ⬇️

artículo científico publicado el 28 de diciembre de 2001

Molecular cloning and heterologous expression of a cDNA encoding a mouse glutathione S-transferase Yc subunit possessing high catalytic activity for aflatoxin B1-8,9-epoxide ⬇️

artículo científico publicado el 1 de julio de 1992

NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer

artículo científico publicado en 2009

Negative regulation of the Nrf1 transcription factor by its N-terminal domain is independent of Keap1: Nrf1, but not Nrf2, is targeted to the endoplasmic reticulum

artículo científico publicado en 2006

Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2 ⬇️

artículo científico publicado en 2015

Nomenclature for mammalian soluble glutathione transferases

artículo científico publicado en 2005

Novel homodimeric and heterodimeric rat gamma-hydroxybutyrate synthases that associate with the Golgi apparatus define a distinct subclass of aldo-keto reductase 7 family proteins

artículo científico publicado en 2002

Nrf1 and Nrf2 play distinct roles in activation of antioxidant response element-dependent genes

artículo científico publicado en 2008

Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity.

artículo científico publicado en 2012

Nrf2 orchestrates fuel partitioning for cell proliferation

artículo científico publicado en 2012

Nrf2 target genes can be controlled by neuronal activity in the absence of Nrf2 and astrocytes.

artículo científico publicado en 2014

Nrf2, a guardian of healthspan and gatekeeper of species longevity

artículo científico publicado en 2010

Nrf2-Mediated Neuroprotection Against Recurrent Hypoglycemia Is Insufficient to Prevent Cognitive Impairment in a Rodent Model of Type 1 Diabetes

artículo científico publicado en 2016

Over-expression of P-glycoprotein and glutathione S-transferase pi in MCF-7 cells selected for vincristine resistance in vitro

artículo científico publicado en 1992

Peptide inhibitors of the Keap1-Nrf2 protein-protein interaction

artículo científico publicado en 2011

Peroxiredoxin Gene Expression Signatures in Liver Reflect Toxic Insult

article

Phosphoinositide 3-kinases upregulate system xc(-) via eukaryotic initiation factor 2α and activating transcription factor 4 - A pathway active in glioblastomas and epilepsy

artículo científico publicado en 2014

Plasma glutathione S-transferase measurements by radioimmunoassay: a sensitive index of hepatocellular damage in man.

artículo científico publicado en 1985

Positive and negative regulation of prostaglandin E2 biosynthesis in human colorectal carcinoma cells by cancer chemopreventive agents

artículo científico publicado en 2003

Potential contribution of the glutathione S-transferase supergene family to resistance to oxidative stress

artículo científico publicado en 1995

Prostaglandin D2 synthase enzymes and PPARgamma are co-expressed in mouse 3T3-L1 adipocytes and human tissues

artículo científico publicado en 2003

Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver.

artículo científico publicado en 2010

Purification from rat liver of a novel constitutively expressed member of the aldo-keto reductase 7 family that is widely distributed in extrahepatic tissues.

artículo científico publicado en 2000

Purification of acidic glutathione S-transferases from human lung, placenta and erythrocyte and the development of a specific radioimmunoassay for their measurement

article

RXRα inhibits the NRF2-ARE signaling pathway through a direct interaction with the Neh7 domain of NRF2.

artículo científico publicado en 2013

Redox-regulated turnover of Nrf2 is determined by at least two separate protein domains, the redox-sensitive Neh2 degron and the redox-insensitive Neh6 degron

artículo científico publicado en 2004

Reduction in antioxidant defenses may contribute to ochratoxin A toxicity and carcinogenicity

artículo científico publicado en 2006

Regulation of rat glutathione S-transferase A5 by cancer chemopreventive agents: mechanisms of inducible resistance to aflatoxin B1.

artículo científico publicado en 1998

SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner.

artículo científico publicado en 2011

Spatial monitoring of toxicity in HMOX-LacZ transgenic mice.

artículo científico publicado en 2010

Structural and functional characterization of Nrf2 degradation by the glycogen synthase kinase 3/β-TrCP axis

artículo científico publicado en 2012

Susceptibility of Nrf2-null mice to steatohepatitis and cirrhosis upon consumption of a high-fat diet is associated with oxidative stress, perturbation of the unfolded protein response, and disturbance in the expression of metabolic enzymes but not w ⬇️

scholarly article by Paul Meakin published in September 2014

Targeting the Ataxia Telangiectasia Mutated-null phenotype in chronic lymphocytic leukemia with pro-oxidants

artículo científico publicado en 2015

The Keap1/Nrf2 pathway in health and disease: from the bench to the clinic

artículo científico publicado en 2015

The NHB1 (N-terminal homology box 1) sequence in transcription factor Nrf1 is required to anchor it to the endoplasmic reticulum and also to enable its asparagine-glycosylation.

artículo científico publicado en 2007

The Nrf1 CNC/bZIP protein is a nuclear envelope-bound transcription factor that is activated by t-butyl hydroquinone but not by endoplasmic reticulum stressors

artículo científico publicado en 2009

The Nrf2 regulatory network provides an interface between redox and intermediary metabolism

artículo científico publicado en 2014

The Nrf3 transcription factor is a membrane-bound glycoprotein targeted to the endoplasmic reticulum through its N-terminal homology box 1 sequence

artículo científico publicado en 2008

The Primary and Secondary Metabolism of Aflatoxin B1 by Rat Hepatocytes Cultured on Matrigel

artículo científico publicado en 1994

The cancer chemopreventive actions of phytochemicals derived from glucosinolates

artículo científico publicado en 2008

The cap'n'collar transcription factor Nrf2 mediates both intrinsic resistance to environmental stressors and an adaptive response elicited by chemopreventive agents that determines susceptibility to electrophilic xenobiotics

artículo científico publicado en 2010

The double-edged sword of Nrf2: subversion of redox homeostasis during the evolution of cancer

artículo científico publicado en 2006

The gasotransmitter hydrogen sulfide induces nrf2-target genes by inactivating the keap1 ubiquitin ligase substrate adaptor through formation of a disulfide bond between cys-226 and cys-613.

artículo científico publicado en 2013

The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance

artículo científico publicado en 1995

The hepatotoxic metabolite of acetaminophen directly activates the Keap1-Nrf2 cell defense system

artículo científico publicado en 2008

The major glutathione S-transferase in salmonid fish livers is homologous to the mammalian pi-class GST

artículo científico publicado en 1991

The membrane-topogenic vectorial behaviour of Nrf1 controls its post-translational modification and transactivation activity ⬇️

artículo científico publicado el 1 de enero de 2013

The polymorphic expression of neutral glutathione S-transferase in human mononuclear leucocytes as measured by specific radioimmunoassay

artículo científico publicado en 1987

The selective post-translational processing of transcription factor Nrf1 yields distinct isoforms that dictate its ability to differentially regulate gene expression

artículo científico publicado en 2015

Transcription factor Nrf1 is topologically repartitioned across membranes to enable target gene transactivation through its acidic glucose-responsive domains

artículo científico publicado en 2014

Transcription factor Nrf1 negatively regulates the cystine/glutamate transporter and lipid-metabolizing enzymes

artículo científico publicado en 2014

Transcription factor Nrf2 mediates an adaptive response to sulforaphane that protects fibroblasts in vitro against the cytotoxic effects of electrophiles, peroxides and redox-cycling agents

artículo científico publicado en 2009

Utility of siRNA against Keap1 as a strategy to stimulate a cancer chemopreventive phenotype

artículo científico publicado en 2005

Variations in the glutathione S-transferase subunits expressed in human livers

artículo científico publicado en 1986

p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription

artículo científico publicado en 2010

Lista de obras de John D. Hayes

1-Cyano-2,3-epithiopropane is a novel plant-derived chemopreventive agent which induces cytoprotective genes that afford resistance against the genotoxic alpha,beta-unsaturated aldehyde acrolein.

A novel shogaol analog suppresses cancer cell invasion and inflammation, and displays cytoprotective effects through modulation of NF-κB and Nrf2-Keap1 signaling pathways

A physiologically-based pharmacokinetic(PB-PK) model for ethylene dibromide: relevance of extrahepatic metabolism

Activation of hepatic Nrf2 in vivo by acetaminophen in CD-1 mice

Activation of the NRF2 signaling pathway by copper-mediated redox cycling of para- and ortho-hydroquinones

Age-dependent change of metabolic capacity and genotoxic injury in rat intestine

Aldo-keto reductases are biomarkers of NRF2 activity and are co-ordinately overexpressed in non-small cell lung cancer

Alteration of glutathione S-transferase levels in Barrett's metaplasia compared to normal oesophageal epithelium

Biochemical and genetic characterization of a murine class Kappa glutathione S-transferase

Cancer chemoprevention mechanisms mediated through the Keap1-Nrf2 pathway

Characterization of the cancer chemopreventive NRF2-dependent gene battery in human keratinocytes: demonstration that the KEAP1-NRF2 pathway, and not the BACH1-NRF2 pathway, controls cytoprotection against electrophiles as well as redox-cycling comp

Characterization of the rat aflatoxin B1 aldehyde reductase gene, AKR7A1. Structure and chromosomal localization of AKR7A1 as well as identification of antioxidant response elements in the gene promoter ⬇️

Conjugation of Highly Reactive Aflatoxin B1exo-8,9-Epoxide Catalyzed by Rat and Human Glutathione Transferases: Estimation of Kinetic Parameters†

Contribution of NAD(P)H:quinone oxidoreductase 1 to protection against carcinogenesis, and regulation of its gene by the Nrf2 basic-region leucine zipper and the arylhydrocarbon receptor basic helix-loop-helix transcription factors

Contribution of the glutathione S-transferases to the mechanisms of resistance to aflatoxin B1.

Cross-talk between transcription factors AhR and Nrf2: lessons for cancer chemoprevention from dioxin.

Cut-price knockout?

Cytotoxicity of xenobiotics and expression of glutathione-S-transferases in immortalised rat hepatocyte cell lines

Decreased hepatic glutathione S-transferase A, AA and L concentration produced by prolonged thyroid hormone administration

Deficiency of glutathione transferase zeta causes oxidative stress and activation of antioxidant response pathways

Development of specific radioimmunoassays for the measurement of human hepatic basic and N/A2b glutathione S-transferases

Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a "tethering" mechanism: a two-site interaction model for the Nrf2-Keap1 complex

Direct comparison of the nature of mouse and human GST T1-1 and the implications on dichloromethane carcinogenicity

Dual regulation of transcription factor Nrf2 by Keap1 and by the combined actions of β-TrCP and GSK-3.

Elevation of AKR7A2 (succinic semialdehyde reductase) in neurodegenerative disease

Enhanced expression of glutathione S-transferases in colorectal carcinoma compared to non-neoplastic mucosa

Erratum to “Expression of rat aldehyde reductase AKR7A1: influence of age and sex and tissue-specific inducibility”

Evolutionary conserved N-terminal domain of Nrf2 is essential for the Keap1-mediated degradation of the protein by proteasome

Expression and localization of rat aldo-keto reductases and induction of the 1B13 and 1D2 isoforms by phenolic antioxidants.

Expression and polymorphism of glutathione S-transferase in human lungs: risk factors in smoking-related lung cancer

Expression of glutathione S-transferases and cytochrome P450 in normal and tumor breast tissue

Expression of glyoxalase, glutathione peroxidase and glutathione S-transferase isoenzymes in different bovine tissues

Expression of rat aldehyde reductase AKR7A1: influence of age and sex and tissue-specific inducibility.

Expression of the aflatoxin B1-8,9-epoxide-metabolizing murine glutathione S-transferase A3 subunit is regulated by the Nrf2 transcription factor through an antioxidant response element

Expression of the murine glutathione S-transferase alpha3 (GSTA3) subunit is markedly induced during adipocyte differentiation: activation of the GSTA3 gene promoter by the pro-adipogenic eicosanoid 15-deoxy-Delta12,14-prostaglandin J2.

Fish and mammalian liver cytosolic glutathione S-transferases: Substrate specificities and immunological comparison

Generation of a stable antioxidant response element-driven reporter gene cell line and its use to show redox-dependent activation of nrf2 by cancer chemotherapeutic agents.

Glutathione S-transferase and glutathione peroxidase expression in normal and tumour human tissues

Glutathione S-transferase isoenzymes in human renal carcinoma demonstrated by immunohistochemistry

Glutathione S-transferase isoenzymes in human tumours and tumour derived cell lines

Glutathione S-transferase localization in aflatoxin B1-treated rat livers

Glutathione S-transferase mu locus: use of genotyping and phenotyping assays to assess association with lung cancer susceptibility

Glutathione and glutathione-dependent enzymes in ovarian adenocarcinoma cell lines derived from a patient before and after the onset of drug resistance: intrinsic differences and cell cycle effects

Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress.

Hepatic damage in the rat following administration of thyroxine or triiodothyronine, assessed by measurement of plasma glutathione S-transferase YaYa concentrations

Human Mu-class glutathione S-transferases present in liver, skeletal muscle and testicular tissue

Human embryonic stem cell derived astrocytes mediate non-cell-autonomous neuroprotection through endogenous and drug-induced mechanisms.

Identification and characterisation of new inhibitors for the human hematopoietic prostaglandin D2 synthase

Identification of a novel Nrf2-regulated antioxidant response element (ARE) in the mouse NAD(P)H:quinone oxidoreductase 1 gene: reassessment of the ARE consensus sequence

Identification of retinoic acid as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha

Identification of topological determinants in the N-terminal domain of transcription factor Nrf1 that control its orientation in the endoplasmic reticulum membrane

Increased levels of alpha-class and pi-class glutathione S-transferases in cell lines resistant to 1-chloro-2,4-dinitrobenzene

Induction of Phase I and Phase II Drug-Metabolizing Enzyme mRNA, Protein, and Activity by BHA, Ethoxyquin, and Oltipraz

Induction of cancer chemopreventive enzymes by coffee is mediated by transcription factor Nrf2. Evidence that the coffee-specific diterpenes cafestol and kahweol confer protection against acrolein

Induction of sulfiredoxin expression and reduction of peroxiredoxin hyperoxidation by the neuroprotective Nrf2 activator 3H-1,2-dithiole-3-thione.

Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals

Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression

Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis.

Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice.

Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease

Mechanisms of induction of cytosolic and microsomal glutathione transferase (GST) genes by xenobiotics and pro-inflammatory agents

Metabolic competence and susceptibility of intestinal epithelium to genotoxic injury during regeneration

Mild oxidative stress activates Nrf2 in astrocytes, which contributes to neuroprotective ischemic preconditioning.

Modulation of glutathione S-transferases and glutathione peroxidase by the anticarcinogen butylated hydroxyanisole in murine extrahepatic organs

Molecular basis for the contribution of the antioxidant responsive element to cancer chemoprevention ⬇️

Molecular cloning and heterologous expression of a cDNA encoding a mouse glutathione S-transferase Yc subunit possessing high catalytic activity for aflatoxin B1-8,9-epoxide ⬇️

NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer

Negative regulation of the Nrf1 transcription factor by its N-terminal domain is independent of Keap1: Nrf1, but not Nrf2, is targeted to the endoplasmic reticulum

Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2 ⬇️

Nomenclature for mammalian soluble glutathione transferases

Novel homodimeric and heterodimeric rat gamma-hydroxybutyrate synthases that associate with the Golgi apparatus define a distinct subclass of aldo-keto reductase 7 family proteins

Nrf1 and Nrf2 play distinct roles in activation of antioxidant response element-dependent genes

Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity.

Nrf2 orchestrates fuel partitioning for cell proliferation

Nrf2 target genes can be controlled by neuronal activity in the absence of Nrf2 and astrocytes.

Nrf2, a guardian of healthspan and gatekeeper of species longevity

Nrf2-Mediated Neuroprotection Against Recurrent Hypoglycemia Is Insufficient to Prevent Cognitive Impairment in a Rodent Model of Type 1 Diabetes

Over-expression of P-glycoprotein and glutathione S-transferase pi in MCF-7 cells selected for vincristine resistance in vitro

Peptide inhibitors of the Keap1-Nrf2 protein-protein interaction