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Lista de obras de Daniel Metzger

180 PPARγ Is a Master Regulator of Lactase Production by Intestinal Epithelial Cells

62 Keratinocytic Thymic Stromal Lymphopoietin Plays an Important Role in Epicutaneous Sensitization and the Atopic March.

artículo científico publicado en 2012

A Brg1 null mutation in the mouse reveals functional differences among mammalian SWI/SNF complexes

scientific journal article

A chimeric Cre recombinase inducible by synthetic,but not by natural ligands of the glucocorticoid receptor

artículo científico publicado en 1998

A new murine model of sustainable and durable chronic critical limb ischemia fairly mimicking human pathology.

artículo científico publicado en 2015

A vitamin D receptor selectively activated by gemini analogs reveals ligand dependent and independent effects

artículo científico publicado en 2015

Abrogation of mitochondrial transcription in smooth muscle cells impairs smooth muscle contractility and vascular tone

artículo científico publicado en 2008

Acute effect of androgens on maximal force-generating capacity and electrically evoked calcium transient in mouse skeletal muscles

scholarly article by Bodvael Fraysse published in September 2014

Adipose tissue-specific inactivation of the retinoblastoma protein protects against diabesity because of increased energy expenditure

artículo científico publicado en 2007

Aggravated TSLP-induced atopic dermatitis in mice lacking Dicer in adult skin keratinocytes.

artículo científico publicado en 2011

Aging Exacerbates Ischemia-Reperfusion-Induced Mitochondrial Respiration Impairment in Skeletal Muscle

artículo científico publicado en 2019

Altered growth in male peroxisome proliferator-activated receptor gamma (PPARgamma) heterozygous mice: involvement of PPARgamma in a negative feedback regulation of growth hormone action

artículo científico publicado en 2004

An efficient system for conditional gene expression in embryonic stem cells and in their in vitro and in vivo differentiated derivatives

artículo científico publicado en 2001

Androgen signaling negatively controls group 2 innate lymphoid cells

artículo científico publicado en 2017

Apoptotic extinction of germ cells in testes of Cyp26b1 knockout mice.

artículo científico publicado en 2007

Autophagy is required to maintain muscle mass

artículo científico publicado en 2009

BRG1-SWI/SNF-dependent regulation of the Wt1 transcriptional landscape mediates epicardial activity during heart development and disease

artículo científico publicado en 2017

Brain masculinization requires androgen receptor function

artículo científico publicado en 2004

Brg1 is required for murine neural stem cell maintenance and gliogenesis

scientific journal article

Brg1 loss attenuates aberrant wnt-signalling and prevents wnt-dependent tumourigenesis in the murine small intestine

artículo científico publicado en 2014

Cell autonomous lipin 1 function is essential for development and maintenance of white and brown adipose tissue

artículo científico publicado en 2012

Characterization of the Amino-terminal Transcriptional Activation Function of the Human Estrogen Receptor in Animal and Yeast Cells

scientific article published in Journal of Biological Chemistry

Characterization of the fasting-induced adipose factor FIAF, a novel peroxisome proliferator-activated receptor target gene

artículo científico publicado en 2000

Chromatin remodeling enzyme Brg1 is required for mouse lens fiber cell terminal differentiation and its denucleation

scientific journal article

Chromatin remodelling complex dosage modulates transcription factor function in heart development

artículo científico publicado en 2011

Chromatin-remodeling factor Brg1 is required for Schwann cell differentiation and myelination

artículo científico publicado en 2012

Clearance of PML/RARA-bound promoters suffice to initiate APL differentiation

scientific article published on 25 September 2014

Compensatory regulation of dopamine after ablation of the tyrosine hydroxylase gene in the nigrostriatal projection

artículo científico publicado en 2011

Compromised intestinal lipid absorption in mice with a liver-specific deficiency of liver receptor homolog 1.

artículo científico publicado en 2007

Conditional expression of Ki-RasG12V in the mammary epithelium of transgenic mice induces estrogen receptor alpha (ERα)-positive adenocarcinoma

artículo científico publicado en 2017

Conditional site-specific recombination in mammalian cells using a ligand-dependent chimeric Cre recombinase

artículo científico publicado en 1995

Contribution of targeted conditional somatic mutagenesis to deciphering retinoid X receptor functions and to generating mouse models of human diseases.

artículo científico publicado en 2007

Corneodesmosin gene ablation induces lethal skin-barrier disruption and hair-follicle degeneration related to desmosome dysfunction.

artículo científico publicado en 2009

Ctip2/Bcl11b controls ameloblast formation during mammalian odontogenesis

artículo científico publicado en 2009

Cutaneous cancer stem cell maintenance is dependent on beta-catenin signalling

artículo científico publicado en 2008

Cytosolic sequestration of the vitamin D receptor as a therapeutic option for vitamin D-induced hypercalcemia

scientific article published on 07 December 2020

Developing with lethal RA levels: genetic ablation of Rarg can restore the viability of mice lacking Cyp26a1.

artículo científico publicado en 2003

Diabetes Worsens Skeletal Muscle Mitochondrial Function, Oxidative Stress, and Apoptosis After Lower-Limb Ischemia-Reperfusion: Implication of the RISK and SAFE Pathways?

artículo científico publicado en 2018

Direct regulation of blood pressure by smooth muscle cell mineralocorticoid receptors

artículo científico publicado en 2012

Distinct retinoid X receptor-retinoic acid receptor heterodimers are differentially involved in the control of expression of retinoid target genes in F9 embryonal carcinoma cells

artículo científico publicado en 1997

Disturbed epidermal structure in mice with temporally controlled fatp4 deficiency

scientific journal article

Dual role of COUP-TF-interacting protein 2 in epidermal homeostasis and permeability barrier formation

scientific journal article

Effect of antagonists on DNA binding properties of the human estrogen receptor in vitro and in vivo

article published in 1995

Effect of antagonists on DNA binding properties of the human estrogen receptor in vitro and in vivo

scientific article published on 01 May 1995

Efficient temporally controlled targeted somatic mutagenesis in hepatocytes of the mouse

artículo científico publicado en 2004

Efficient temporally-controlled targeted mutagenesis in smooth muscle cells of the adult mouse

artículo científico publicado en 2009

Epidermal γδ T cells sense precancerous cellular dysregulation and initiate immune responses

article

Epithelial Bmpr1a regulates differentiation and proliferation in postnatal hair follicles and is essential for tooth development

artículo científico publicado en 2004

Estrogen prevents bone loss via estrogen receptor alpha and induction of Fas ligand in osteoclasts

artículo científico publicado en 2007

Expression and function of the human estrogen receptor in yeast.

artículo científico publicado en 1988

F9 embryonal carcinoma cells engineered for tamoxifen-dependent Cre-mediated site-directed mutagenesis and doxycycline-inducible gene expression

artículo científico publicado en 2000

Friedreich ataxia mouse models with progressive cerebellar and sensory ataxia reveal autophagic neurodegeneration in dorsal root ganglia

scientific journal article

Functional role of RXRs and PPARgamma in mature adipocytes.

artículo científico publicado en 2005

Generation of Spatio-Temporally Controlled Targeted Somatic Mutations in the Mouse

artículo científico publicado en 2011

Genetic and pharmacological evidence that a retinoic acid cannot be the RXR-activating ligand in mouse epidermis keratinocytes

artículo científico publicado en 2006

Genetic dissection of retinoic acid function in epidermis physiology

artículo científico publicado en 2002

Genetically engineered mouse models of prostate cancer

artículo científico publicado en 2013

Germ cell expression of the transcriptional co-repressor TIF1beta is required for the maintenance of spermatogenesis in the mouse.

artículo científico publicado en 2002

Gonad-related factors promote muscle performance gain during postnatal development in male and female mice

artículo científico publicado en 2017

Hair follicle dermal stem cells regenerate the dermal sheath, repopulate the dermal papilla, and modulate hair type

artículo científico publicado en 2014

Hedgehog signaling regulates sebaceous gland development

artículo científico publicado en 2003

Hypoxia-inducible transcription factor 2α promotes steatohepatitis through augmenting lipid accumulation, inflammation, and fibrosis

artículo científico publicado en 2011

IFN-β-induced reactive oxygen species and mitochondrial damage contribute to muscle impairment and inflammation maintenance in dermatomyositis

artículo científico publicado en 2017

IL-13 induces expression of CD36 in human monocytes through PPARgamma activation.

artículo científico publicado en 2007

Impaired adipogenesis and lipolysis in the mouse upon selective ablation of the retinoid X receptor alpha mediated by a tamoxifen-inducible chimeric Cre recombinase (Cre-ERT2) in adipocytes

artículo científico publicado en 2001

Impaired skin wound healing in peroxisome proliferator-activated receptor (PPAR)alpha and PPARbeta mutant mice

artículo científico publicado en 2001

Improved Protocol for Chromatin Immunoprecipitation from Mouse Skeletal Muscle

artículo científico publicado en 2017

In vivo activation of PPAR target genes by RXR homodimers

artículo científico publicado en 2004

Inducible Cre/loxP recombination in the mouse proximal tubule

article

Inducible site-specific somatic mutagenesis in mouse hepatocytes

article

Induction of thymic stromal lymphopoietin expression in keratinocytes is necessary for generating an atopic dermatitis upon application of the active vitamin D3 analogue MC903 on mouse skin

artículo científico publicado en 2008

Inflammatory mediator TAK1 regulates hair follicle morphogenesis and anagen induction shown by using keratinocyte-specific TAK1-deficient mice

artículo científico publicado en 2010

Intestinal antiinflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator-activated receptor-gamma

artículo científico publicado en 2005

Knockdown of parathyroid hormone related protein in smooth muscle cells alters renal hemodynamics but not blood pressure.

artículo científico publicado en 2013

LPS-induced TNF-alpha factor (LITAF)-deficient mice express reduced LPS-induced cytokine: Evidence for LITAF-dependent LPS signaling pathways

scientific journal article

LRH-1-mediated glucocorticoid synthesis in enterocytes protects against inflammatory bowel disease

artículo científico publicado en 2007

LRP1 controls intracellular cholesterol storage and fatty acid synthesis through modulation of Wnt signaling

artículo científico publicado en 2008

LSD1 promotes oxidative metabolism of white adipose tissue

artículo científico publicado en 2014

Ligand-Independent Actions of Vitamin D Receptor

Ligand-activated site-specific recombination in mice

artículo científico publicado en 1996

Localized inflammatory skin disease following inducible ablation of I kappa B kinase 2 in murine epidermis

artículo científico publicado en 2006

Loss of Trim24 (Tif1alpha) gene function confers oncogenic activity to retinoic acid receptor alpha

scientific journal article

Lysine-specific demethylase 1 regulates differentiation onset and migration of trophoblast stem cells

artículo científico publicado en 2014

Malignant transformation of DMBA/TPA-induced papillomas and nevi in the skin of mice selectively lacking retinoid-X-receptor alpha in epidermal keratinocytes.

artículo científico publicado en 2007

Mammalian TAF(II)30 is required for cell cycle progression and specific cellular differentiation programmes

artículo científico publicado en 1999

Mammary stem cells have myoepithelial cell properties

artículo científico publicado en 2014

Mechanisms of antihormone action

artículo científico publicado en 1992

Moderate Exercise Allows for shorter Recovery Time in Critical Limb Ischemia

artículo científico

Modulation of transcriptional activation by ligand-dependent phosphorylation of the human oestrogen receptor A/B region.

artículo científico publicado en 1993

Mouse P450RAI (CYP26) expression and retinoic acid-inducible retinoic acid metabolism in F9 cells are regulated by retinoic acid receptor gamma and retinoid X receptor alpha

scientific journal article

Muscle expression of a malonyl-CoA-insensitive carnitine palmitoyltransferase-1 protects mice against high-fat/high-sucrose diet-induced insulin resistance.

artículo científico publicado en 2016

Myocytic androgen receptor controls the strength but not the mass of limb muscles

artículo científico publicado en 2010

Myod1 and GR coordinate myofiber-specific transcriptional enhancers

artículo científico publicado en 2021

Myofiber Androgen Receptor Promotes Maximal Mechanical Overload-Induced Muscle Hypertrophy and Fiber Type Transition in Male Mice

Noncanonical Wnt signaling mediates androgen-dependent tumor growth in a mouse model of prostate cancer

artículo científico publicado en 2011

Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation

artículo científico publicado en 2001

Nr4a receptors are essential for thymic regulatory T cell development and immune homeostasis.

artículo científico publicado en 2013

Nur77 deletion impairs muscle growth during developmental myogenesis and muscle regeneration in mice.

artículo científico publicado en 2017

Nurr1 expression is regulated by voltage-dependent calcium channels and calcineurin in cultured hippocampal neurons

artículo científico publicado en 2013

Nurr1 is required for maintenance of maturing and adult midbrain dopamine neurons

artículo científico publicado en 2009

Oncogenesis caused by loss of the SNF5 tumor suppressor is dependent on activity of BRG1, the ATPase of the SWI/SNF chromatin remodeling complex.

scientific article published on 29 September 2009

Orphan nuclear receptor NR4A1 regulates transforming growth factor-β signaling and fibrosis

artículo científico publicado en 2015

PGC-1β modulates statin-associated myotoxicity in mice

scientific article published on 03 December 2018

PGC1α expression is controlled in skeletal muscles by PPARβ, whose ablation results in fiber-type switching, obesity, and type 2 diabetes

article by Michael Schuler et al published November 2006 in Cell Metabolism

PPARβ/δ affects pancreatic β cell mass and insulin secretion in mice

artículo científico publicado en 2012

Patrolling monocytes control tumor metastasis to the lung.

artículo científico publicado en 2015

Peroxisome proliferator-activated receptor gamma is required in mature white and brown adipocytes for their survival in the mouse

scholarly article

Peroxisome-proliferator-activated receptor (PPAR)-gamma activation stimulates keratinocyte differentiation

artículo científico publicado en 2004

Physiological and retinoid-induced proliferations of epidermis basal keratinocytes are differently controlled

artículo científico publicado en 2002

Polyphenols prevent ageing-related impairment in skeletal muscle mitochondrial function through decreased reactive oxygen species production

artículo científico publicado en 2012

Postnatal tissue-specific disruption of transcription factor FoxN1 triggers acute thymic atrophy

artículo científico publicado en 2009

Premature aging in skeletal muscle lacking serum response factor

artículo científico publicado en 2008

Premature ovarian failure in androgen receptor-deficient mice

artículo científico publicado en 2005

Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7

artículo científico publicado en 2010

Production and Characterization of Monoclonal Antibodies Recognising Defined Regions of the Human Oestrogen Receptor

article

Prokineticin receptor 1 as a novel suppressor of preadipocyte proliferation and differentiation to control obesity

artículo científico publicado en 2013

Promoter specificity of the two transcriptional activation functions of the human oestrogen receptor in yeast

artículo científico publicado en 1992

Regenerated luminal epithelial cells are derived from preexisting luminal epithelial cells in adult mouse prostate

artículo científico publicado en 2011

Regeneration of fat cells from myofibroblasts during wound healing.

artículo científico publicado en 2017

Regulation of Cre recombinase activity by mutated estrogen receptor ligand-binding domains

artículo científico

Relevance of exocytotic glutamate release from retinal glia

artículo científico publicado en 2012

Retinal dystrophy resulting from ablation of RXR alpha in the mouse retinal pigment epithelium

artículo científico publicado en 2004

Retinoid X receptor ablation in adult mouse keratinocytes generates an atopic dermatitis triggered by thymic stromal lymphopoietin

artículo científico publicado en 2005

Retinoid X receptors orchestrate osteoclast differentiation and postnatal bone remodeling

artículo científico publicado en 2015

Retinoid signaling in progenitors controls specification and regeneration of the urothelium

artículo científico publicado en 2013

Role of the two activating domains of the oestrogen receptor in the cell-type and promoter-context dependent agonistic activity of the anti-oestrogen 4-hydroxytamoxifen

artículo científico publicado en 1990

SNF2β-BRG1 is Essential for the Viability of F9 Murine Embryonal Carcinoma Cells ⬇️

artículo científico publicado el 1 de octubre de 1997

SWI/SNF complexes containing Brahma or Brahma-related gene 1 play distinct roles in smooth muscle development

artículo científico publicado en 2011

SWI/SNF deficiency results in aberrant chromatin organization, mitotic failure, and diminished proliferative capacity

artículo científico publicado en 2009

Selective ablation of retinoid X receptor alpha in hepatocytes impairs their lifespan and regenerative capacity

artículo científico publicado en 2001

Senescence controls prostatic neoplasia driven by Pten loss

artículo científico publicado en 2018

Sequential roles of Brg, the ATPase subunit of BAF chromatin remodeling complexes, in thymocyte development

artículo científico publicado en 2003

Short-Term Fasting Reveals Amino Acid Metabolism as a Major Sex-Discriminating Factor in the Liver

scholarly article by Sara Della Torre published in August 2018

Site- and time-specific gene targeting in the mouse

artículo científico publicado en 2001

Site-specific somatic mutagenesis in the retinal pigment epithelium.

artículo científico publicado en 2002

Skeletal Muscle-Specific Activation of Gq Signaling Maintains Glucose Homeostasis

scientific article published on 01 April 2019

Skeletal muscle mitochondrial dysfunction precedes right ventricular impairment in experimental pulmonary hypertension.

artículo científico publicado en 2012

Skeletal myofiber VEGF is essential for the exercise training response in adult mice

artículo científico publicado en 2014

Skin abnormalities generated by temporally controlled RXRalpha mutations in mouse epidermis

artículo científico publicado en 2000

Skin epidermis lacking the c-Myc gene is resistant to Ras-driven tumorigenesis but can reacquire sensitivity upon additional loss of the p21Cip1 gene

artículo científico publicado en 2006

Skin lesion development in a mouse model of incontinentia pigmenti is triggered by NEMO deficiency in epidermal keratinocytes and requires TNF signaling.

artículo científico publicado en 2006

Smoothened is a master regulator of adult liver repair

artículo científico publicado en 2013

Spatio-temporally controlled site-specific somatic mutagenesis in the mouse.

artículo científico publicado en 1997

Specific and redundant functions of retinoid X Receptor/Retinoic acid receptor heterodimers in differentiation, proliferation, and apoptosis of F9 embryonal carcinoma cells

artículo científico publicado en 1997

Specific deletion of focal adhesion kinase suppresses tumor formation and blocks malignant progression.

artículo científico publicado en 2004

Strict control of transgene expression in a mouse model for sensitive biological applications based on RMCE compatible ES cells

artículo científico publicado en 2010

Suppressive function of androgen receptor in bone resorption

artículo científico publicado en 2003

TAF10 (TAF(II)30) is necessary for TFIID stability and early embryogenesis in mice.

artículo científico publicado en 2003

TAF10 is required for the establishment of skin barrier function in foetal, but not in adult mouse epidermis

artículo científico publicado en 2005

TGF-beta superfamily signaling is essential for tooth and hair morphogenesis and differentiation

artículo científico publicado en 2007

TRPC3 shapes the ER-mitochondria Ca<sup>2+</sup> transfer characterizing tumour-promoting senescence

artículo científico publicado en 2022

Tamoxifen-inducible glia-specific Cre mice for somatic mutagenesis in oligodendrocytes and Schwann cells

artículo científico publicado en 2003

Targeted conditional somatic mutagenesis in the mouse: temporally-controlled knock out of retinoid receptors in epidermal keratinocytes

artículo científico publicado en 2003

Targeted knockout of BRG1 potentiates lung cancer development

artículo científico publicado en 2008

Targeted somatic mutagenesis in mouse epidermis

artículo científico publicado en 2000

Targeted somatic mutagenesis in the mouse epidermis

artículo científico publicado en 2005

Temporal regulation of Cre recombinase activity in neural stem cells

artículo científico publicado en 2006

Temporally controlled ablation of PTEN in adult mouse prostate epithelium generates a model of invasive prostatic adenocarcinoma

artículo científico publicado en 2008

Temporally controlled site-specific mutagenesis in the germ cell lineage of the mouse testis

artículo científico publicado en 2003

Temporally controlled somatic mutagenesis in smooth muscle

article

Temporally controlled targeted somatic mutagenesis in embryonic surface ectoderm and fetal epidermal keratinocytes unveils two distinct developmental functions of BRG1 in limb morphogenesis and skin barrier formation

scientific journal article

Temporally controlled targeted somatic mutagenesis in mouse eye pigment epithelium

Temporally controlled targeted somatic mutagenesis in skeletal muscles of the mouse

artículo científico publicado en 2005

Temporally controlled targeted somatic mutagenesis in the mouse brain

artículo científico publicado en 2001

Temporally-controlled site-specific mutagenesis in the basal layer of the epidermis: comparison of the recombinase activity of the tamoxifen-inducible Cre-ER(T) and Cre-ER(T2) recombinases

artículo científico publicado en 1999

The BAF complex interacts with Pax6 in adult neural progenitors to establish a neurogenic cross-regulatory transcriptional network.

artículo científico

The Nuclear Receptor Nr4a1 Acts as a Microglia Rheostat and Serves as a Therapeutic Target in Autoimmune-Driven Central Nervous System Inflammation

artículo científico publicado en 2017

The TFIID subunit TAF4 regulates keratinocyte proliferation and has cell-autonomous and non-cell-autonomous tumour suppressor activity in mouse epidermis

artículo científico publicado en 2007

The histone code reader Spin1 controls skeletal muscle development.

artículo científico publicado en 2017

The human oestrogen receptor functions in yeast

scientific article published in Nature

The lack of transcriptional activation of the v-erbA oncogene is in part due to a mutation present in the DNA binding domain of the protein

artículo científico publicado en 1990

The nuclear hormone receptor PPARγ counteracts vascular calcification by inhibiting Wnt5a signalling in vascular smooth muscle cells

artículo científico publicado en 2012

The nuclear orphan receptor Nr4a2 induces Foxp3 and regulates differentiation of CD4+ T cells ⬇️

artículo científico publicado en 2011

The orphan nuclear receptor Nur77 is a determinant of myofiber size and muscle mass in mice

artículo científico publicado en 2015

The retinoic acid-metabolizing enzyme, CYP26A1, is essential for normal hindbrain patterning, vertebral identity, and development of posterior structures

artículo científico publicado en 2001

The transcriptional coregulator PGC-1β controls mitochondrial function and anti-oxidant defence in skeletal muscles

artículo científico publicado en 2015

The transcriptional coregulators TIF2 and SRC-1 regulate energy homeostasis by modulating mitochondrial respiration in skeletal muscles

artículo científico publicado en 2010

Thymic stromal lymphopoietin overproduced by keratinocytes in mouse skin aggravates experimental asthma

scholarly article

Tissue-specific and inducible Cre-mediated recombination in the gut epithelium

artículo científico publicado en 2004

Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis

artículo científico publicado en 2006

Transcription factor TBX4 regulates myofibroblast accumulation and lung fibrosis

artículo científico publicado en 2016

Transgenic mice for conditional gene manipulation in astroglial cells.

artículo científico publicado en 2007

VDR and gemini ligands

artículo científico publicado en 2015

Viral-mediated temporally controlled dopamine production in a rat model of Parkinson disease

artículo científico publicado en 2005

Vitamin D receptor in osteoblasts is a negative regulator of bone mass control

artículo científico publicado en 2013

Widespread negative response elements mediate direct repression by agonist-liganded glucocorticoid receptor

artículo científico publicado en 2011

[How to limit the progression of PTEN-deficient prostatic tumors?]

artículo científico publicado en 2018

deletion in luminal cells of mature prostate induces replication stress and senescence in vivo

scholarly article by Maxime Parisotto et al published 4 June 2018 in Journal of Experimental Medicine

p300 Mediates Functional Synergism between AF-1 and AF-2 of Estrogen Receptor α and β by Interacting Directly with the N-terminal A/B Domains

artículo científico publicado en 2000

γ-Secretase Inhibition Lowers Plasma Triglyceride-Rich Lipoproteins by Stabilizing the LDL Receptor

artículo científico publicado en 2018

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