Filtros de búsqueda

Lista de obras de Max Crispin

A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield

artículo científico publicado en 2011

A cross-neutralizing antibody between HIV-1 and influenza virus

artículo científico publicado en 2021

A global approach to analysis and interpretation of metabolic data for plant natural product discovery.

artículo científico publicado en 2013

A human embryonic kidney 293T cell line mutated at the Golgi alpha-mannosidase II locus

scientific article published on 22 May 2009

A method for high-throughput, sensitive analysis of IgG Fc and Fab glycosylation by capillary electrophoresis

artículo científico publicado en 2014

A monoclonal antibody with anti-D-like activity in murine immune thrombocytopenia requires Fc domain function for immune thrombocytopenia ameliorative effects

artículo científico publicado en 2015

An Endoglycosidase with Alternative Glycan Specificity Allows Broadened Glycoprotein Remodelling

artículo científico publicado en 2012

An HIV-1 antibody from an elite neutralizer implicates the fusion peptide as a site of vulnerability

artículo científico publicado en 2016

Analysis of variable N-glycosylation site occupancy in glycoproteins by liquid chromatography electrospray ionization mass spectrometry

artículo científico publicado en 2006

Antibodies expose multiple weaknesses in the glycan shield of HIV.

artículo científico publicado en 2013

Antibody production using a ciliate generates unusual antibody glycoforms displaying enhanced cell-killing activity

artículo científico publicado en 2016

Breaking the allergic response by disrupting antibody glycosylation

artículo científico publicado en 2015

Building meaningful models of glycoproteins

article

Carbohydrate and domain architecture of an immature antibody glycoform exhibiting enhanced effector functions

artículo científico publicado en 2009

Cell- and Protein-Directed Glycosylation of Native Cleaved HIV-1 Envelope

artículo científico publicado en 2015

Chemical and Structural Analysis of an Antibody Folding Intermediate Trapped during Glycan Biosynthesis

artículo científico publicado en 2012

Cleavage-Independent HIV-1 Trimers From CHO Cell Lines Elicit Robust Autologous Tier 2 Neutralizing Antibodies

artículo científico publicado en 2018

Closing and opening holes in the glycan shield of HIV-1 envelope glycoprotein SOSIP trimers can redirect the neutralizing antibody response to the newly unmasked epitopes

article

Collision Cross Sections and Ion Mobility Separation of Fragment Ions from Complex N-Glycans

artículo científico publicado en 2018

Complement regulation at the molecular level: The structure of decay-accelerating factor

artículo científico publicado en 2004

Composition and Antigenic Effects of Individual Glycan Sites of a Trimeric HIV-1 Envelope Glycoprotein

artículo científico publicado en 2016

Contrasting IgG Structures Reveal Extreme Asymmetry and Flexibility

artículo científico publicado en 2002

Convergent immunological solutions to Argentine hemorrhagic fever virus neutralization

artículo científico publicado en 2017

Cryo-EM Structures of Eastern Equine Encephalitis Virus Reveal Mechanisms of Virus Disassembly and Antibody Neutralization

artículo científico publicado en 2018

Crystal Structure and Carbohydrate Analysis of Nipah Virus Attachment Glycoprotein: a Template for Antiviral and Vaccine Design

artículo científico publicado en 2008

Crystal structure of an intact human IgG: antibody asymmetry, flexibility, and a guide for HIV-1 vaccine design.

artículo científico publicado en 2003

Crystal structure of mouse CD1d bound to the self ligand phosphatidylcholine: a molecular basis for NKT cell activation

artículo científico publicado en 2005

Crystal structure of sialylated IgG Fc: Implications for the mechanism of intravenous immunoglobulin therapy

artículo científico publicado en 2013

Design and crystal structure of a native-like HIV-1 envelope trimer that engages multiple broadly neutralizing antibody precursors in vivo.

artículo científico publicado en 2017

Determination of N-linked Glycosylation in Viral Glycoproteins by Negative Ion Mass Spectrometry and Ion Mobility

artículo científico publicado en 2015

Differentiation between isomeric triantennary N-linked glycans by negative ion tandem mass spectrometry and confirmation of glycans containing galactose attached to the bisecting (beta1-4-GlcNAc) residue in N-glycans from IgG.

artículo científico publicado en 2008

Dimeric Architecture of the Hendra Virus Attachment Glycoprotein: Evidence for a Conserved Mode of Assembly

artículo científico publicado en 2010

Directing stem cell differentiation with antibodies.

artículo científico publicado en 2013

Disruption of alpha-mannosidase processing induces non-canonical hybrid-type glycosylation

artículo científico publicado en 2007

Dissecting the Molecular Mechanism of IVIg Therapy: The Interaction between Serum IgG and DC-SIGN is Independent of Antibody Glycoform or Fc Domain

artículo científico publicado en 2013

Elicitation of Neutralizing Antibodies Targeting the V2 Apex of the HIV Envelope Trimer in a Wild-Type Animal Model.

artículo científico publicado en 2018

Eliminating antibody polyreactivity through addition of N-linked glycosylation

artículo científico publicado en 2015

Emerging principles for the therapeutic exploitation of glycosylation.

artículo científico publicado en 2014

Engineering Hydrophobic Protein–Carbohydrate Interactions to Fine-Tune Monoclonal Antibodies

artículo científico publicado en 2013

Engineering and Characterization of a Fluorescent Native-Like HIV-1 Envelope Glycoprotein Trimer.

artículo científico publicado en 2015

Engineering well-expressed, V2-immunofocusing HIV-1 envelope glycoprotein membrane trimers for use in heterologous prime-boost vaccine regimens

artículo científico publicado en 2021

Enhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers with a two-component protein nanoparticle

scientific article published on 19 September 2019

Envelope glycans of immunodeficiency virions are almost entirely oligomannose antigens.

artículo científico publicado en 2010

Enzymatic Inactivation of Endogenous IgG by IdeS Enhances Therapeutic Antibody Efficacy

artículo científico publicado en 2017

Exploitation of glycosylation in enveloped virus pathobiology

scientific article published on 20 May 2019

Fragmentation of negative ions from N-linked carbohydrates: part 6. Glycans containing one N-acetylglucosamine in the core

artículo científico publicado en 2014

Fragments of bacterial endoglycosidase s and immunoglobulin g reveal subdomains of each that contribute to deglycosylation.

artículo científico publicado en 2014

Global N-Glycan Site Occupancy of HIV-1 gp120 by Metabolic Engineering and High-Resolution Intact Mass Spectrometry.

artículo científico publicado en 2016

Glycan Microheterogeneity at the PGT135 Antibody Recognition Site on HIV-1 gp120 Reveals a Molecular Mechanism for Neutralization Resistance

artículo científico publicado en 2015

Glycan Remodeling with Processing Inhibitors and Lectin-Resistant Eukaryotic Cells

artículo científico publicado en 2015

Glycan clustering stabilizes the mannose patch of HIV-1 and preserves vulnerability to broadly neutralizing antibodies

artículo científico publicado en 2015

Glycoprotein structural genomics: solving the glycosylation problem

artículo científico publicado en 2007

Glycosylation of Human IgA Directly Inhibits Influenza A and Other Sialic-Acid-Binding Viruses

artículo científico publicado en 2018

Glycosylation profiling to evaluate glycoprotein immunogens against HIV-1.

artículo científico publicado en 2017

HIV-1 Glycan Density Drives the Persistence of the Mannose Patch within an Infected Individual.

artículo científico publicado en 2016

HIV-1 vaccine design through minimizing envelope metastability

article

Harnessing post-translational modifications for next-generation HIV immunogens

article

Human complement factor I glycosylation: structural and functional characterisation of the N-linked oligosaccharides

artículo científico publicado en 2006

Identification of Lewis and Blood Group Carbohydrate Epitopes by Ion Mobility-Tandem-Mass Spectrometry Fingerprinting

artículo científico publicado en 2017

Identification of antibody glycosylation structures that predict monoclonal antibody Fc-effector function

artículo científico publicado en 2014

Identification of high-mannose and multiantennary complex-type N-linked glycans containing alpha-galactose epitopes from Nurse shark IgM heavy chain

artículo científico publicado en 2009

Immune recruitment or suppression by glycan engineering of endogenous and therapeutic antibodies

artículo científico publicado en 2016

Immunofocusing and enhancing autologous Tier-2 HIV-1 neutralization by displaying Env trimers on two-component protein nanoparticles

artículo científico publicado en 2021

Immunogenicity of Stabilized HIV-1 Envelope Trimers with Reduced Exposure of Non-neutralizing Epitopes

artículo científico publicado en 2015

Immunoglobulin G Fc glycans are not essential for antibody-mediated immune suppression to murine erythrocytes

artículo científico publicado en 2017

Improving Antibody-Based Cancer Therapeutics Through Glycan Engineering.

artículo científico publicado en 2017

Improving the Immunogenicity of Native-like HIV-1 Envelope Trimers by Hyperstabilization

artículo científico publicado en 2017

Influences on the Design and Purification of Soluble, Recombinant Native-Like HIV-1 Envelope Glycoprotein Trimers

artículo científico publicado en 2015

Inhibition of hybrid- and complex-type glycosylation reveals the presence of the GlcNAc transferase I-independent fucosylation pathway

artículo científico publicado en 2006

Inhibition of mammalian glycan biosynthesis produces non-self antigens for a broadly neutralising, HIV-1 specific antibody

artículo científico publicado en 2007

Innate immune recognition of glycans targets HIV nanoparticle immunogens to germinal centers

artículo científico publicado en 2018

Insertion of atypical glycans into the tumor antigen-binding site identifies DLBCLs with distinct origin and behavior

Integrity of Glycosylation Processing of a Glycan-Depleted Trimeric HIV-1 Immunogen Targeting Key B-Cell Lineages

artículo científico publicado en 2018

Ion Mobility Mass Spectrometry for Ion Recovery and Clean-Up of MS and MS/MS Spectra Obtained from Low Abundance Viral Samples

artículo científico publicado en 2015

Ion mobility mass spectrometry for extracting spectra of N-glycans directly from incubation mixtures following glycan release: application to glycans from engineered glycoforms of intact, folded HIV gp120.

artículo científico publicado en 2011

Isomer Information from Ion Mobility Separation of High-Mannose Glycan Fragments

artículo científico publicado en 2018

MALDI-MS/MS with traveling wave ion mobility for the structural analysis of N-linked glycans

artículo científico publicado en 2012

Manipulation of cytokine secretion in human dendritic cells using glycopolymers with picomolar affinity for DC-SIGN.

artículo científico publicado en 2017

Mechanisms of escape from the PGT128 family of anti-HIV broadly neutralizing antibodies

artículo científico publicado en 2016

Molecular Architecture of the Cleavage-Dependent Mannose Patch on a Soluble HIV-1 Envelope Glycoprotein Trimer

artículo científico publicado en 2016

Monoglucosylated glycans in the secreted human complement component C3: implications for protein biosynthesis and structure

artículo científico publicado en 2004

Mutations in SARS-CoV-2 spike protein impair epitope-specific CD4+ T cell recognition

artículo científico publicado en 2022

Native functionality and therapeutic targeting of arenaviral glycoproteins

artículo científico publicado en 2016

Natural variation in Fc glycosylation of HIV-specific antibodies impacts antiviral activity

artículo científico publicado en 2013

Networks of HIV-1 Envelope Glycans Maintain Antibody Epitopes in the Face of Glycan Additions and Deletions

scientific article published on 12 May 2020

Neutralizing antibody responses induced by HIV-1 envelope glycoprotein SOSIP trimers derived from elite neutralizers

artículo científico publicado en 2020

Nucleic acid delivery of immune-focused SARS-CoV-2 nanoparticles drives rapid and potent immunogenicity capable of single-dose protection

artículo científico publicado en 2022

Polysaccharide mimicry of the epitope of the broadly neutralizing anti-HIV antibody, 2G12, induces enhanced antibody responses to self oligomannose glycans

artículo científico publicado en 2010

Protein and Glycan Mimicry in HIV Vaccine Design.

artículo científico publicado en 2019

Quantitative mass imaging of single biological macromolecules.

artículo científico publicado en 2018

Rational Design of DNA-Expressed Stabilized Native-Like HIV-1 Envelope Trimers

article

Redirecting adenoviruses to tumour cells using therapeutic antibodies: Generation of a versatile human bispecific adaptor

artículo científico publicado en 2015

Reducing V3 Antigenicity and Immunogenicity on Soluble, Native-Like HIV-1 Env SOSIP Trimers

artículo científico publicado en 2017

Selective Deactivation of Serum IgG: A General Strategy for the Enhancement of Monoclonal Antibody Receptor Interactions

artículo científico publicado en 2012

Shared paramyxoviral glycoprotein architecture is adapted for diverse attachment strategies

artículo científico publicado el 1 de octubre de 2010

Signature of Antibody Domain Exchange by Native Mass Spectrometry and Collision-Induced Unfolding

scientific article published in 2018

Similarities and differences between native HIV-1 envelope glycoprotein trimers and stabilized soluble trimer mimetics

artículo científico publicado en 2019

Site-Specific Glycosylation of Virion-Derived HIV-1 Env Is Mimicked by a Soluble Trimeric Immunogen

article

Site-specific analysis of the SARS-CoV-2 glycan shield

artículo científico publicado en 2020

Site-specific glycan analysis of the SARS-CoV-2 spike

artículo científico publicado en 2020

Solution NMR analyses of the C-type carbohydrate recognition domain of DC-SIGNR protein reveal different binding modes for HIV-derived oligosaccharides and smaller glycan fragments

artículo científico

Structural Constraints Determine the Glycosylation of HIV-1 Envelope Trimers

artículo científico publicado en 2015

Structural analysis of glycoproteins: building N-linked glycans with Coot

artículo científico publicado en 2018

Structural and functional evaluation of de novo-designed, two-component nanoparticle carriers for HIV Env trimer immunogens

artículo científico publicado en 2020

Structural plasticity of the Semliki Forest virus glycome upon interspecies transmission.

artículo científico publicado en 2014

Structural principles controlling HIV envelope glycosylation

artículo científico publicado en 2017

Structure and immunogenicity of a stabilized HIV-1 envelope trimer based on a group-M consensus sequence

scientific article published on 29 May 2019

Structure of a cleavage-independent HIV Env recapitulates the glycoprotein architecture of the native cleaved trimer.

artículo científico publicado en 2018

Structure of a phleboviral envelope glycoprotein reveals a consolidated model of membrane fusion

artículo científico publicado en 2016

Structure of the Lassa virus glycan shield provides a model for immunological resistance

article published in the Proceedings of the National Academy of Sciences of the United States of America

Structure-Guided Redesign Improves NFL HIV Env Trimer Integrity and Identifies an Inter-Protomer Disulfide Permitting Post-Expression Cleavage

scientific article published on 17 July 2018

TNF receptor agonists induce distinct receptor clusters to mediate differential agonistic activity

artículo científico publicado en 2021

Targeting host-derived glycans on enveloped viruses for antibody-based vaccine design

artículo científico publicado en 2015

The Chimpanzee SIV Envelope Trimer: Structure and Deployment as an HIV Vaccine Template

article

The Tetrameric Plant Lectin BanLec Neutralizes HIV through Bidentate Binding to Specific Viral Glycans

artículo científico publicado en 2017

The glycan shield of HIV is predominantly oligomannose independently of production system or viral clade.

artículo científico publicado en 2011

The glycosylation of human serum IgD and IgE and the accessibility of identified oligomannose structures for interaction with mannan-binding lectin

artículo científico publicado en 2004

Therapeutic potential of deglycosylated antibodies.

artículo científico publicado en 2013

Through the barricades: overcoming the barriers to effective antibody-based cancer therapeutics

artículo científico publicado en 2018

Travelling wave ion mobility and negative ion fragmentation for the structural determination of N-linked glycans

artículo científico publicado en 2013

Travelling-wave ion mobility and negative ion fragmentation of high-mannose N-glycans.

artículo científico publicado en 2016

Travelling-wave ion mobility mass spectrometry and negative ion fragmentation of hybrid and complex N-glycans

artículo científico publicado en 2016

Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B, and G

artículo científico publicado en 2016

Two-component spike nanoparticle vaccine protects macaques from SARS-CoV-2 infection

artículo científico publicado en 2021

Unusual Molecular Architecture of the Machupo Virus Attachment Glycoprotein

artículo científico publicado en 2009

Use of the α-mannosidase I inhibitor kifunensine allows the crystallization of apo CTLA-4 homodimer produced in long-term cultures of Chinese hamster ovary cells.

artículo científico publicado en 2011

Uukuniemi Phlebovirus assembly and secretion leave a functional imprint on the virion glycome

artículo científico publicado en 2014

Vaccination with Glycan-Modified HIV NFL Envelope Trimer-Liposomes Elicits Broadly Neutralizing Antibodies to Multiple Sites of Vulnerability

scientific article published on 12 November 2019

Vaccine priming of rare HIV broadly neutralizing antibody precursors in nonhuman primates

artículo científico publicado en 2024

Vulnerabilities in coronavirus glycan shields despite extensive glycosylation

artículo científico publicado en 2020

Vulnerabilities in coronavirus glycan shields despite extensive glycosylation

artículo científico publicado en 2020

cGMP production and analysis of BG505 SOSIP.664, an extensively glycosylated, trimeric HIV-1 envelope glycoprotein vaccine candidate

artículo científico publicado en 2017