Lista de obras - Anastasios Lymperopoulos

A case report: Pharmacology and resistance patterns of three generations of ALK inhibitors in metastatic inflammatory myofibroblastic sarcoma

artículo científico publicado en 2018

Adrenal G protein-coupled receptor kinase-2 in regulation of sympathetic nervous system activity in heart failure

artículo científico publicado en 2015

Adrenal GRK2 lowering is an underlying mechanism for the beneficial sympathetic effects of exercise training in heart failure

artículo científico publicado en 2010

Adrenal GRK2 upregulation mediates sympathetic overdrive in heart failure

artículo científico publicado en 2007

Adrenal adrenoceptors in heart failure: fine-tuning cardiac stimulation

artículo científico publicado en 2007

Adrenal beta-arrestin 1 inhibition in vivo attenuates post-myocardial infarction progression to heart failure and adverse remodeling via reduction of circulating aldosterone levels

artículo científico publicado en 2011

Adrenal βarrestin1 targeting for tobacco-associated cardiac dysfunction treatment: Aldosterone production as the mechanistic link

scientific article published on 18 June 2019

Adrenergic nervous system in heart failure: pathophysiology and therapy

artículo científico publicado en 2013

Alpha 2-adrenergic receptors decrease DNA replication and cell proliferation and induce neurite outgrowth in transfected rat pheochromocytoma cells.

artículo científico publicado en 2006

Alpha2-adrenergic receptor subtype-specific activation of NF-kappaB in PC12 cells

artículo científico publicado en 2006

An adrenal beta-arrestin 1-mediated signaling pathway underlies angiotensin II-induced aldosterone production in vitro and in vivo

scientific journal article

Antagonistic Roles of GRK2 and GRK5 in Cardiac Aldosterone Signaling Reveal GRK5-Mediated Cardioprotection via Mineralocorticoid Receptor Inhibition

scientific article published on 20 April 2020

Arrestins in the Cardiovascular System: An Update

scientific article published on 09 August 2018

Arrestins in the cardiovascular system

artículo científico

Assays of adrenal GPCR signaling and regulation: Measuring adrenal β-arrestin activity in vivo through plasma membrane recruitment.

artículo científico publicado en 2017

Beta-arrestin biased agonism/antagonism at cardiovascular seven transmembrane-spanning receptors

artículo científico

Biased Agonism/Antagonism of Cardiovascular GPCRs for Heart Failure Therapy

artículo científico publicado en 2018

Cardiac βarrestin2 Improves Contractility and Adverse Remodeling in Heart Failure, But Is Underexpressed in Humans.

artículo científico publicado en 2017

Cardiomyocyte lipids impair β-adrenergic receptor function via PKC activation

artículo científico publicado en 2010

Caveolin-1 deficiency exacerbates cardiac dysfunction and reduces survival in mice with myocardial infarction

artículo científico publicado en 2011

Chemically synthesized Secoisolariciresinol diglucoside (LGM2605) improves mitochondrial function in cardiac myocytes and alleviates septic cardiomyopathy

scientific article published on 03 January 2019

Clinical pharmacogenomics of carvedilol: the stereo-selective metabolism angle

scientific article published on 08 August 2018

Co-IP assays for measuring GPCR-arrestin interactions

artículo científico publicado en 2018

Current and future G protein-coupled receptor signaling targets for heart failure therapy

artículo científico publicado en 2013

Deletion of Osteopontin Enhances β₂-Adrenergic Receptor-Dependent Anti-Fibrotic Signaling in Cardiomyocytes ⬇️

artículo científico publicado en 2019

Effect of sulfhydryl modification on rat kidney basolateral plasma membrane transport function

scientific article published on 02 August 2012

Exercise training and beta-blocker treatment ameliorate age-dependent impairment of beta-adrenergic receptor signaling and enhance cardiac responsiveness to adrenergic stimulation

artículo científico publicado en 2007

Future g protein-coupled receptor targets for treatment of heart failure.

artículo científico publicado en 2009

GPCRs of adrenal chromaffin cells & catecholamines: The plot thickens

artículo científico publicado en 2016

GRK2 Regulates α2-Adrenergic Receptor-Dependent Catecholamine Release in Human Adrenal Chromaffin Cells

artículo científico publicado en 2017

GRK2 Up-Regulation Creates a Positive Feedback Loop for Catecholamine Production in Chromaffin Cells

artículo científico publicado en 2016

GRK2 and Beta-Arrestins in Cardiovascular Disease: Established and Emerging Possibilities for Therapeutic Targeting.

artículo científico publicado en 2011

GRK2 and β-arrestins in cardiovascular disease: Something old, something new.

artículo científico publicado en 2011

GRK2 as a novel gene therapy target in heart failure.

artículo científico publicado en 2010

GRK2 inhibition in heart failure: something old, something new.

artículo científico

GRK2-Mediated Crosstalk Between β-Adrenergic and Angiotensin II Receptors Enhances Adrenocortical Aldosterone Production In Vitro and In Vivo

artículo científico publicado en 2020

Hypothesis: Paroxetine, a G Protein-Coupled Receptor Kinase 2 (GRK2) Inhibitor Reduces Morbidity and Mortality in Patients With Heart Failure.

artículo científico publicado en 2016

Impaired desensitization of a human polymorphic α2B-adrenergic receptor variant enhances its sympatho-inhibitory activity in chromaffin cells

artículo científico publicado en 2011

Ischemic emergency?: endothelial cells have their own "adrenaline shot" at hand

artículo científico publicado en 2012

Lack of association between alpha2B-adrenergic receptor polymorphism and risk of restenosis following coronary angioplasty and stent implantation--preliminary report.

artículo científico publicado en 2006

Modulation of adrenal catecholamine secretion by in vivo gene transfer and manipulation of G protein-coupled receptor kinase-2 activity

scientific journal article

Myocardial adeno-associated virus serotype 6-betaARKct gene therapy improves cardiac function and normalizes the neurohormonal axis in chronic heart failure

artículo científico publicado en 2009

Myocardial β(2) -adrenoceptor gene delivery promotes coordinated cardiac adaptive remodelling and angiogenesis in heart failure.

artículo científico publicado en 2012

Negative impact of β-arrestin-1 on post-myocardial infarction heart failure via cardiac and adrenal-dependent neurohormonal mechanisms

artículo científico publicado en 2013

Novel Insights into the Crosstalk between Mineralocorticoid Receptor and G Protein-Coupled Receptors in Heart Adverse Remodeling and Disease

artículo científico publicado en 2018

Pharmacogenetics of cardiac inotropy

artículo científico publicado en 2014

Pharmacogenomics of adrenoceptors.

artículo científico publicado en 2004

Pharmacogenomics of the heptahelical receptor regulators G-protein-coupled receptor kinases and arrestins: the known and the unknown

artículo científico

Physiology and pharmacology of the cardiovascular adrenergic system

artículo científico

Reduction of sympathetic activity via adrenal-targeted GRK2 gene deletion attenuates heart failure progression and improves cardiac function after myocardial infarction

artículo científico publicado en 2010

Role of βarrestin1 in AT R-mediated MAPK Activation in Wistar and SHR Brainstem Astrocytes

artículo científico publicado en 2018

Structure-activity relationship study of angiotensin II analogs in terms of β-arrestin-dependent signaling to aldosterone production

artículo científico publicado en 2016

Suppression of adrenal βarrestin1-dependent aldosterone production by ARBs: head-to-head comparison

artículo científico publicado en 2015

Sustained GRK2-dependent CREB activation is essential for α2-adrenergic receptor-induced PC12 neuronal differentiation

scientific article published on 31 October 2019

Sympatholytic Mechanisms for the Beneficial Cardiovascular Effects of SGLT2 Inhibitors: A Research Hypothesis for Dapagliflozin’s Effects in the Adrenal Gland

artículo científico publicado en 2021

Targeting the β-adrenergic receptor system through G-protein-coupled receptor kinase 2: a new paradigm for therapy and prognostic evaluation in heart failure: from bench to bedside

artículo científico

The place of ARBs in heart failure therapy: is aldosterone suppression the key?

scientific article published on 01 January 2019

Transcription factor Sp1 expression is upregulated in human glomerulonephritis: correlation with pSmad2/3 and p300 expression and renal injury

artículo científico publicado en 2010

alpha(2)-Adrenergic receptors activate MAPK and Akt through a pathway involving arachidonic acid metabolism by cytochrome P450-dependent epoxygenase, matrix metalloproteinase activation and subtype-specific transactivation of EGFR.

artículo científico publicado en 2005

β Adrenergic Receptor Kinase C-Terminal Peptide Gene-Therapy Improves β2-Adrenergic Receptor-Dependent Neoangiogenesis after Hindlimb Ischemia.

artículo científico publicado en 2015

β-Arrestin2 Improves Post-Myocardial Infarction Heart Failure via Sarco(endo)plasmic Reticulum Ca2+-ATPase-Dependent Positive Inotropy in Cardiomyocytes.

artículo científico publicado en 2017

β1-adrenoceptor Arg389Gly polymorphism confers differential β-arrestin-binding tropism in cardiac myocytes.

artículo científico publicado en 2016

βArrestins in cardiac G protein-coupled receptor signaling and function: partners in crime or "good cop, bad cop"?

scientific article published on 18 December 2013

Lista de obras de Anastasios Lymperopoulos

A case report: Pharmacology and resistance patterns of three generations of ALK inhibitors in metastatic inflammatory myofibroblastic sarcoma

Adrenal G protein-coupled receptor kinase-2 in regulation of sympathetic nervous system activity in heart failure

Adrenal GRK2 lowering is an underlying mechanism for the beneficial sympathetic effects of exercise training in heart failure

Adrenal GRK2 upregulation mediates sympathetic overdrive in heart failure

Adrenal adrenoceptors in heart failure: fine-tuning cardiac stimulation

Adrenal beta-arrestin 1 inhibition in vivo attenuates post-myocardial infarction progression to heart failure and adverse remodeling via reduction of circulating aldosterone levels

Adrenal βarrestin1 targeting for tobacco-associated cardiac dysfunction treatment: Aldosterone production as the mechanistic link

Adrenergic nervous system in heart failure: pathophysiology and therapy

Alpha 2-adrenergic receptors decrease DNA replication and cell proliferation and induce neurite outgrowth in transfected rat pheochromocytoma cells.

Alpha2-adrenergic receptor subtype-specific activation of NF-kappaB in PC12 cells

An adrenal beta-arrestin 1-mediated signaling pathway underlies angiotensin II-induced aldosterone production in vitro and in vivo

Antagonistic Roles of GRK2 and GRK5 in Cardiac Aldosterone Signaling Reveal GRK5-Mediated Cardioprotection via Mineralocorticoid Receptor Inhibition

Arrestins in the Cardiovascular System: An Update

Arrestins in the cardiovascular system

Assays of adrenal GPCR signaling and regulation: Measuring adrenal β-arrestin activity in vivo through plasma membrane recruitment.

Beta-arrestin biased agonism/antagonism at cardiovascular seven transmembrane-spanning receptors

Biased Agonism/Antagonism of Cardiovascular GPCRs for Heart Failure Therapy

Cardiac βarrestin2 Improves Contractility and Adverse Remodeling in Heart Failure, But Is Underexpressed in Humans.

Cardiomyocyte lipids impair β-adrenergic receptor function via PKC activation

Caveolin-1 deficiency exacerbates cardiac dysfunction and reduces survival in mice with myocardial infarction

Chemically synthesized Secoisolariciresinol diglucoside (LGM2605) improves mitochondrial function in cardiac myocytes and alleviates septic cardiomyopathy

Clinical pharmacogenomics of carvedilol: the stereo-selective metabolism angle

Co-IP assays for measuring GPCR-arrestin interactions

Current and future G protein-coupled receptor signaling targets for heart failure therapy

Deletion of Osteopontin Enhances β₂-Adrenergic Receptor-Dependent Anti-Fibrotic Signaling in Cardiomyocytes ⬇️

Effect of sulfhydryl modification on rat kidney basolateral plasma membrane transport function

Exercise training and beta-blocker treatment ameliorate age-dependent impairment of beta-adrenergic receptor signaling and enhance cardiac responsiveness to adrenergic stimulation

Future g protein-coupled receptor targets for treatment of heart failure.

GPCRs of adrenal chromaffin cells & catecholamines: The plot thickens

GRK2 Regulates α2-Adrenergic Receptor-Dependent Catecholamine Release in Human Adrenal Chromaffin Cells

GRK2 Up-Regulation Creates a Positive Feedback Loop for Catecholamine Production in Chromaffin Cells

GRK2 and Beta-Arrestins in Cardiovascular Disease: Established and Emerging Possibilities for Therapeutic Targeting.

GRK2 and β-arrestins in cardiovascular disease: Something old, something new.

GRK2 as a novel gene therapy target in heart failure.

GRK2 inhibition in heart failure: something old, something new.

GRK2-Mediated Crosstalk Between β-Adrenergic and Angiotensin II Receptors Enhances Adrenocortical Aldosterone Production In Vitro and In Vivo

Hypothesis: Paroxetine, a G Protein-Coupled Receptor Kinase 2 (GRK2) Inhibitor Reduces Morbidity and Mortality in Patients With Heart Failure.

Impaired desensitization of a human polymorphic α2B-adrenergic receptor variant enhances its sympatho-inhibitory activity in chromaffin cells

Ischemic emergency?: endothelial cells have their own "adrenaline shot" at hand

Lack of association between alpha2B-adrenergic receptor polymorphism and risk of restenosis following coronary angioplasty and stent implantation--preliminary report.

Modulation of adrenal catecholamine secretion by in vivo gene transfer and manipulation of G protein-coupled receptor kinase-2 activity

Myocardial adeno-associated virus serotype 6-betaARKct gene therapy improves cardiac function and normalizes the neurohormonal axis in chronic heart failure

Myocardial β(2) -adrenoceptor gene delivery promotes coordinated cardiac adaptive remodelling and angiogenesis in heart failure.

Negative impact of β-arrestin-1 on post-myocardial infarction heart failure via cardiac and adrenal-dependent neurohormonal mechanisms

Novel Insights into the Crosstalk between Mineralocorticoid Receptor and G Protein-Coupled Receptors in Heart Adverse Remodeling and Disease

Pharmacogenetics of cardiac inotropy

Pharmacogenomics of adrenoceptors.

Pharmacogenomics of the heptahelical receptor regulators G-protein-coupled receptor kinases and arrestins: the known and the unknown

Physiology and pharmacology of the cardiovascular adrenergic system

Reduction of sympathetic activity via adrenal-targeted GRK2 gene deletion attenuates heart failure progression and improves cardiac function after myocardial infarction

Role of βarrestin1 in AT R-mediated MAPK Activation in Wistar and SHR Brainstem Astrocytes

Structure-activity relationship study of angiotensin II analogs in terms of β-arrestin-dependent signaling to aldosterone production

Suppression of adrenal βarrestin1-dependent aldosterone production by ARBs: head-to-head comparison

Sustained GRK2-dependent CREB activation is essential for α2-adrenergic receptor-induced PC12 neuronal differentiation

Sympatholytic Mechanisms for the Beneficial Cardiovascular Effects of SGLT2 Inhibitors: A Research Hypothesis for Dapagliflozin’s Effects in the Adrenal Gland

Targeting the β-adrenergic receptor system through G-protein-coupled receptor kinase 2: a new paradigm for therapy and prognostic evaluation in heart failure: from bench to bedside

The place of ARBs in heart failure therapy: is aldosterone suppression the key?

Transcription factor Sp1 expression is upregulated in human glomerulonephritis: correlation with pSmad2/3 and p300 expression and renal injury

alpha(2)-Adrenergic receptors activate MAPK and Akt through a pathway involving arachidonic acid metabolism by cytochrome P450-dependent epoxygenase, matrix metalloproteinase activation and subtype-specific transactivation of EGFR.

β Adrenergic Receptor Kinase C-Terminal Peptide Gene-Therapy Improves β2-Adrenergic Receptor-Dependent Neoangiogenesis after Hindlimb Ischemia.

β-Arrestin2 Improves Post-Myocardial Infarction Heart Failure via Sarco(endo)plasmic Reticulum Ca2+-ATPase-Dependent Positive Inotropy in Cardiomyocytes.

β1-adrenoceptor Arg389Gly polymorphism confers differential β-arrestin-binding tropism in cardiac myocytes.

βArrestins in cardiac G protein-coupled receptor signaling and function: partners in crime or "good cop, bad cop"?