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Lista de obras de Dylan R. Edwards

A novel stratification framework for predicting outcome in patients with prostate cancer

artículo científico publicado en 2020

A sequence-selective single-strand DNA-binding protein regulates basal transcription of the murine tissue inhibitor of metalloproteinases-1 (Timp-1) gene

artículo científico publicado en 1999

ADAM15 mediates upregulation of Claudin-1 expression in breast cancer cells

scientific article published on 29 August 2019

ADAMTS-1 and syndecan-4 intersect in the regulation of cell migration and angiogenesis

scientific article published on 08 April 2020

ADAMTS8 and ADAMTS15 expression predicts survival in human breast carcinoma

artículo científico publicado en 2006

ADAMs and protein disulfide isomerase: the key to regulated cell-surface protein ectodomain shedding?: Figure 1

artículo científico publicado en 2010

Activation of key profibrotic mechanisms in transgenic fibroblasts expressing kinase-deficient type II Transforming growth factor-{beta} receptor (T{beta}RII{delta}k).

artículo científico publicado en 2005

Activation of p38 and JNK MAPK pathways abrogates requirement for new protein synthesis for phorbol ester mediated induction of select MMP and TIMP genes.

artículo científico publicado en 2007

Acute depletion of endothelial β3-integrin transiently inhibits tumor growth and angiogenesis in mice

artículo científico publicado en 2013

Altered microenvironment promotes progression of preinvasive breast cancer: myoepithelial expression of αvβ6 integrin in DCIS identifies high-risk patients and predicts recurrence

artículo científico

An elevated matrix metalloproteinase (MMP) in an animal model of multiple sclerosis is protective by affecting Th1/Th2 polarization.

artículo científico publicado en 2005

Analyses of all matrix metalloproteinase members in leukocytes emphasize monocytes as major inflammatory mediators in multiple sclerosis.

artículo científico publicado en 2003

Avoiding spam in the proteolytic internet: future strategies for anti-metastatic MMP inhibition.

artículo científico publicado en 2009

Banking of fresh-frozen prostate tissue: methods, validation and use.

artículo científico publicado en 2003

Biology and genetics of implantation

artículo científico publicado en 1997

Brk protects breast cancer cells from autophagic cell death induced by loss of anchorage.

artículo científico publicado en 2009

Cancer. Proteases--invasion and more

artículo científico publicado en 1998

Cell signalling and the control of gene transcription.

artículo científico publicado en 1994

Collagenase-2 Deficiency or Inhibition Impairs Experimental Autoimmune Encephalomyelitis in Mice

artículo científico publicado en 2008

Combination of Tumor Necrosis Factor-α Ablation and Matrix Metalloproteinase Inhibition Prevents Heart Failure After Pressure Overload in Tissue Inhibitor of Metalloproteinase-3 Knock-Out Mice

article

Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer

artículo científico publicado en 2013

Cytokine stimulated vascular cell adhesion molecule-1 (VCAM-1) ectodomain release is regulated by TIMP-3.

artículo científico publicado en 2005

Development of a Novel Tumor-Targeted Vascular Disrupting Agent Activated by Membrane-Type Matrix Metalloproteinases

artículo científico publicado el 27 de julio de 2010

Differential Expression of Matrix Metalloproteinases During Impaired Wound Healing of the Diabetes Mouse

artículo científico publicado en 2002

Differential effects of histone deacetylase inhibitors on phorbol ester- and TGF-beta1 induced murine tissue inhibitor of metalloproteinases-1 gene expression

artículo científico publicado en 2005

Differential effects of transforming growth factor-β1 on the expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in young and old human fibroblasts

artículo científico publicado en 1996

Differential expression and localization of TIMP-1 and TIMP-4 in human gliomas

artículo científico publicado en 2001

Differential expression of the ccn3 (nov) proto-oncogene in human prostate cell lines and tissues.

artículo científico publicado en 2001

Differential regulation of TIMP-1 and TIMP-2 mRNA expression in normal and Ha-ras-transformed murine fibroblasts

artículo científico publicado en 1992

Distinct functionality of tumor cell-derived gelatinases during formation of liver metastases

artículo científico publicado en 2008

Distinct functions of natural ADAM-15 cytoplasmic domain variants in human mammary carcinoma.

artículo científico publicado en 2008

Diverse and potent activities of HGF/SF in skin wound repair

artículo científico publicado en 2004

Dysregulated expression of adamalysin-thrombospondin genes in human breast carcinoma

artículo científico publicado en 2004

Elevated plasma gelatinase A (MMP-2) activity is associated with quiescent Crohn's Disease

artículo científico publicado en 1999

Epithelial carcinogenesis: dynamic interplay between neoplastic cells and their microenvironment.

artículo científico publicado en 2002

Evaluation of effects caused by differentially spliced Ets-1 transcripts in fibroblasts

artículo científico publicado en 2011

Expression analysis of the entire MMP and TIMP gene families during mouse tissue development.

artículo científico publicado en 2004

Expression and Activity of Ovarian Tissue Inhibitors of Metalloproteinases during Pseudopregnancy in the Rat1

scientific article published on 01 September 1995

Expression of Sorsby's fundus dystrophy mutations in human retinal pigment epithelial cells reduces matrix metalloproteinase inhibition and may promote angiogenesis

artículo científico publicado en 2002

Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in the mouse uterus during the peri-implantation period

artículo científico publicado en 1997

Expression of metalloproteinases and inhibitors in the differentiation of P19CL6 cells into cardiac myocytes

artículo científico publicado en 2004

Expression profile of matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs in mature human odontoblasts and pulp tissue.

artículo científico publicado en 2003

Expression profiles and clinical correlations of degradome components in the tumor microenvironment of head and neck squamous cell carcinoma

artículo científico publicado en 2010

Expression profiling of metalloproteinases and their inhibitors in cartilage

artículo científico publicado en 2004

Expression profiling of metalloproteinases and tissue inhibitors of metalloproteinases in normal and degenerate human achilles tendon.

artículo científico publicado en 2006

Extracellular protease mRNAs are predominantly expressed in the stromal areas of microdissected mouse breast carcinomas.

artículo científico publicado en 2005

G-helix of maspin mediates effects on cell migration and adhesion

artículo científico publicado en 2010

Genome-Wide Responses of Female Fruit Flies Subjected to Divergent Mating Regimes.

artículo científico publicado en 2013

HDAC-mediated control of ERK- and PI3K-dependent TGF-β-induced extracellular matrix-regulating genes.

artículo científico publicado en 2010

HIF1α drives chemokine factor pro-tumoral signaling pathways in acute myeloid leukemia

artículo científico publicado en 2018

High levels of gelatinase-B and active gelatinase-A in metastatic glioblastoma

artículo científico publicado en 1998

Identification of degradome components associated with prostate cancer progression by expression analysis of human prostatic tissues

artículo científico publicado en 2005

Identification of novel peptide motifs in the serpin maspin that affect vascular smooth muscle cell function

artículo científico publicado en 2016

Identification, regulation and role of tissue inhibitor of metalloproteinases-4 (TIMP-4) in human platelets

artículo científico publicado en 2002

Increase of anti-metastatic efficacy by selectivity- but not affinity-optimization of synthetic serine protease inhibitors

artículo científico publicado en 2003

Increased gelatinase A (MMP-2) and gelatinase B (MMP-9) activities in human brain after focal ischemia

artículo científico publicado el 28 de noviembre de 1997

Insulin-like growth factor-II regulates PTEN expression in the mammary gland.

artículo científico publicado en 2003

Intradermal air pouch leukocytosis as an in vivo test for nanoparticles

artículo científico publicado en 2013

Involvement of AP1 and PEA3 binding sites in the regulation of murine tissue inhibitor of metalloproteinases-1 (TIMP-1) transcription

artículo científico publicado en 1992

Leukemic blasts program bone marrow adipocytes to generate a protumoral microenvironment.

artículo científico publicado en 2017

Loss of MMP-8 in ductal carcinoma in situ (DCIS)-associated myoepithelial cells contributes to tumour promotion through altered adhesive and proteolytic function

artículo científico publicado en 2017

MMP and TIMP expression in quiescent, dividing, and differentiating human lens cells

artículo científico publicado en 2007

MMP-1 drives immunopathology in human tuberculosis and transgenic mice.

artículo científico publicado en 2011

MMP2 activity is critical for TGFβ2-induced matrix contraction--implications for fibrosis

artículo científico publicado en 2012

Matrix Metalloproteinase 8 (Collagenase 2) Induces the Expression of Interleukins 6 and 8 in Breast Cancer Cells

artículo científico publicado el 30 de abril de 2013

Matrix metalloproteinase 13 is induced in fibroblasts in polyomavirus middle T antigen-driven mammary carcinoma without influencing tumor progression

artículo científico publicado en 2008

Matrix metalloproteinase-8 functions as a metastasis suppressor through modulation of tumor cell adhesion and invasion

artículo científico publicado en 2008

Matrix metalloproteinase-9 maps to the distal end of chromosome 2 in the mouse

artículo científico publicado el 1 de enero de 1997

Matrix metalloproteinases mediate the dismantling of mesenchymal structures in the tadpole tail during thyroid hormone-induced tail resorption

artículo científico publicado en 2002

Matrix metalloproteinases: protective roles in cancer.

artículo científico publicado en 2011

Membrane type matrix metalloproteinases (MMPs) show differential expression in non-small cell lung cancer (NSCLC) compared to normal lung: correlation of MMP-14 mRNA expression and proteolytic activity.

artículo científico publicado en 2007

Membrane-type 4 matrix metalloproteinase promotes breast cancer growth and metastases

artículo científico publicado en 2006

Metalloproteinase expression in PMA-stimulated THP-1 cells. Effects of peroxisome proliferator-activated receptor-gamma (PPAR gamma) agonists and 9-cis-retinoic acid.

artículo científico publicado en 2003

Metalloproteinase inhibitor TIMP-1 affects hepatocyte cell cycle via HGF activation in murine liver regeneration

article

Metalloproteinase inhibitors: biological actions and therapeutic opportunities.

artículo científico publicado en 2002

Metalloproteinase-dependent and -independent processes contribute to inhibition of breast cancer cell migration, angiogenesis and liver metastasis by a disintegrin and metalloproteinase with thrombospondin motifs-15

scientific article published on 18 August 2014

Metalloproteinases and their inhibitors in angiogenesis.

artículo científico publicado en 2003

Metalloproteinases and their inhibitors in tumor angiogenesis

artículo científico publicado en 2005

Metalloproteinases are enriched in microglia compared with leukocytes and they regulate cytokine levels in activated microglia

article

Metalloproteinases in biology and pathology of the nervous system.

artículo científico publicado en 2001

Murine tissue inhibitor of metalloproteinases-4 (Timp-4): cDNA isolation and expression in adult mouse tissues

artículo científico publicado en 1997

Mycobacterium tuberculosis upregulates microglial matrix metalloproteinase-1 and -3 expression and secretion via NF-kappaB- and Activator Protein-1-dependent monocyte networks

artículo científico publicado en 2010

Mycobacterium tuberculosis, but not vaccine BCG, specifically upregulates matrix metalloproteinase-1.

artículo científico publicado en 2005

NADPH oxidase-2 derived superoxide drives mitochondrial transfer from bone marrow stromal cells to leukemic blasts.

artículo científico publicado en 2017

New insights into the plasticity of the endothelial phenotype

artículo científico

Oncostatin M Stimulates c-Fos to Bind a Transcriptionally Responsive AP-1 Element within the Tissue Inhibitor of Metalloproteinase-1 Promoter

artículo científico publicado en 1998

PI3Kδ and PI3Kγ isoforms have distinct functions in regulating pro-tumoural signalling in the multiple myeloma microenvironment

artículo científico publicado en 2017

Perivascular cells regulate endothelial membrane type-1 matrix metalloproteinase activity

artículo científico publicado en 2001

Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases

artículo científico publicado en 2002

Pleiotropic functions of the tumor- and metastasis-suppressing matrix metalloproteinase-8 in mammary cancer in MMTV-PyMT transgenic mice.

artículo científico publicado en 2015

Prostate Single Nucleotide Polymorphism Provides a Crucial Clue to Cancer Aggression in Active Surveillance Patients

artículo científico publicado en 2015

Proteases in cancer drug delivery.

artículo científico publicado en 2016

Quantitative reverse transcription-polymerase chain reaction (RT-PCR): a comparison of primer-dropping, competitive, and real-time RT-PCRs

artículo científico publicado en 2002

Real-time PCR expression profiling of MMPs and TIMPs.

artículo científico publicado en 2010

Regulation of tissue inhibitor of metalloproteinases-1 gene expression by cytokines and dexamethasone in rat hepatocyte primary cultures

article

Reprogramming of TIMP-1 and TIMP-3 expression profiles in brain microvascular endothelial cells and astrocytes in response to proinflammatory cytokines

artículo científico publicado en 1999

Research tissue banking in otolaryngology: organization, methods and uses, with reference to practical, ethical and legal issues

artículo científico publicado en 2006

Reversible transdifferentiation of blood vascular endothelial cells to a lymphatic-like phenotype in vitro

artículo científico publicado en 2010

Sequence motifs of tissue inhibitor of metalloproteinases 2 (TIMP-2) determining progelatinase A (proMMP-2) binding and activation by membrane-type metalloproteinase 1 (MT1-MMP).

artículo científico publicado en 2003

Sorsby's fundus dystrophy tissue inhibitor of metalloproteinases-3 (TIMP-3) mutants have unimpaired matrix metalloproteinase inhibitory activities, but affect cell adhesion to the extracellular matrix

artículo científico publicado en 2002

Src stimulates fibroblast growth factor receptor-2 shedding by an ADAM15 splice variant linked to breast cancer

artículo científico publicado en 2009

Suppression of β3-integrin in mice triggers a neuropilin-1-dependent change in focal adhesion remodelling that can be targeted to block pathological angiogenesis

artículo científico publicado en 2015

Systemic Ablation of MMP-9 Triggers Invasive Growth and Metastasis of Pancreatic Cancer via Deregulation of IL6 Expression in the Bone Marrow.

artículo científico publicado en 2016

TGF-[beta]1 limits plaque growth, stabilizes plaque structure, and prevents aortic dilation in apolipoprotein E-null mice.

artículo científico publicado en 2009

TGF-β-elicited induction of tissue inhibitor of metalloproteinases (TIMP)-3 expression in fibroblasts involves complex interplay between Smad3, p38α, and ERK1/2.

artículo científico publicado en 2013

TIMP-1 enhancer sequence--real or bacterial?

artículo científico publicado en 2003

TIMP-3 and endocrine therapy of breast cancer: an apoptosis connection emerges

artículo científico publicado en 2004

TISSUE INHIBITOR OF METALLOPROTEINASE-3 IS UP-REGULATED BY TRANSFORMING GROWTH FACTOR-β1 IN VITRO AND EXPRESSED IN FIBROBLASTIC FOCI IN VIVO IN IDIOPATHIC PULMONARY FIBROSIS

article

Targeted photodynamic therapy of breast cancer cells using antibody-phthalocyanine-gold nanoparticle conjugates

artículo científico publicado en 2011

Tenascin-C stimulates glioma cell invasion through matrix metalloproteinase-12.

artículo científico publicado en 2006

The ADAM metalloproteinases

artículo científico publicado en 2008

The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) family

artículo científico publicado en 2015

The ADAMTS metalloproteinases

artículo científico publicado en 2005

The activity of a designer tissue inhibitor of metalloproteinases (TIMP)-1 against native membrane type 1 matrix metalloproteinase (MT1-MMP) in a cell-based environment

artículo científico publicado en 2009

The comparative role of activator protein 1 and Smad factors in the regulation of Timp-1 and MMP-1 gene expression by transforming growth factor-beta 1

scientific journal article

The modulation of matrix metalloproteinase and ADAM gene expression in human chondrocytes by interleukin-1 and oncostatin M: a time-course study using real-time quantitative reverse transcription-polymerase chain reaction

artículo científico publicado en 2002

The regulation of matrix metalloproteinases and their inhibitors.

artículo científico publicado en 2007

The roles of ADAMTS metalloproteinases in tumorigenesis and metastasis

artículo científico publicado en 2011

The β3-integrin endothelial adhesome regulates microtubule-dependent cell migration.

artículo científico publicado en 2018

Tissue inhibitor of metalloproteinases (TIMP, aka EPA): structure, control of expression and biological functions

artículo científico publicado en 1993

Tissue inhibitor of metalloproteinases-1 promotes liver metastasis by induction of hepatocyte growth factor signaling.

artículo científico publicado en 2007

Tissue inhibitor of metalloproteinases-3 is the major metalloproteinase inhibitor in the decidualizing murine uterus

artículo científico publicado en 1996

Tumour-associated tenascin-C isoforms promote breast cancer cell invasion and growth by matrix metalloproteinase-dependent and independent mechanisms

artículo científico publicado en 2009

Variation in dermcidin expression in a range of primary human tumours and in hypoxic/oxidatively stressed human cell lines

artículo científico publicado en 2008

mRNA profiling of the cancer degradome in oesophago-gastric adenocarcinoma.

artículo científico publicado en 2012