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Lista de obras de Jan Nedergaard

'Neuropeptide tyrosine' (NPY) is co-stored with noradrenaline in vascular but not in parenchymal sympathetic nerves of brown adipose tissue

artículo científico publicado en 1986

A classical brown adipose tissue mRNA signature partly overlaps with brite in the supraclavicular region of adult humans

artículo científico publicado en 2013

A dual component analysis explains the distinctive kinetics of cAMP accumulation in brown adipocytes

scientific article published on 01 December 1999

A human-specific role of cell death-inducing DFFA (DNA fragmentation factor-alpha)-like effector A (CIDEA) in adipocyte lipolysis and obesity

artículo científico publicado en 2005

A sequence predicted to form a stem-loop is proposed to be required for formation of an RNA-protein complex involving the 3'UTR of beta-subunit F0F1-ATPase mRNA

artículo científico publicado en 2008

A stringent validation of mouse adipose tissue identity markers.

artículo científico publicado en 2015

Adaptive facultative diet-induced thermogenesis in wild-type but not in UCP1-ablated mice.

artículo científico publicado en 2017

Adenosine 5'-monophosphate is a selective inhibitor of the brown adipocyte nonselective cation channel

artículo científico publicado en 2002

Adipose tissue pathways involved in weight loss of cancer cachexia

artículo científico publicado en 2010

Adrenergic receptor density in brown adipose tissue of active and hibernating hamsters and ground squirrels.

artículo científico publicado en 2006

Adrenergically stimulated blood flow in brown adipose tissue is not dependent on thermogenesis

artículo científico publicado en 2015

Alpha 1- and beta-adrenergic regulation of intracellular Ca2+ levels in brown adipocytes

artículo científico publicado en 1989

Alpha 1-adrenergic inositol trisphosphate production in brown adipocytes is Na+ dependent

artículo científico publicado en 1987

Alpha 1-adrenergic stimulation of Cl- efflux in isolated brown adipocytes

scientific article published on 01 March 1990

Alpha-adrenergic effects on 86Rb+ (K+) potentials and fluxes in brown fat cells

artículo científico publicado en 1984

Alpha1- and beta1-adrenoceptor signaling fully compensates for beta3-adrenoceptor deficiency in brown adipocyte norepinephrine-stimulated glucose uptake

artículo científico publicado en 2005

Alternatively activated macrophages do not synthesize catecholamines or contribute to adipose tissue adaptive thermogenesis

artículo científico publicado en 2017

An essential role for Tbx15 in the differentiation of brown and "brite" but not white adipocytes.

artículo científico publicado en 2012

An siRNA-based method for efficient silencing of gene expression in mature brown adipocytes

artículo científico publicado en 2015

Analysis of inhibition by H89 of UCP1 gene expression and thermogenesis indicates protein kinase A mediation of beta(3)-adrenergic signalling rather than beta(3)-adrenoceptor antagonism by H89.

artículo científico publicado en 2001

As the proliferation promoter noradrenaline induces expression of ICER (induced cAMP early repressor) in proliferative brown adipocytes, ICER may not be a universal tumour suppressor

artículo científico publicado en 2001

Beta 3- and alpha1-adrenergic Erk1/2 activation is Src- but not Gi-mediated in Brown adipocytes

artículo científico publicado en 2000

Beta-adrenergic stimulation of fatty acid release from brown fat cells differentiated in monolayer culture

scientific article published on 01 February 1986

Brown adipocytes differentiated in vitro can express the gene for the uncoupling protein thermogenin: effects of hypothyroidism and norepinephrine

artículo científico publicado en 1989

Brown adipose tissue as an anti-obesity tissue in humans

artículo científico

Brown adipose tissue: function and physiological significance

artículo científico publicado en 2004

Ca(2+) -independent effects of BAPTA and EGTA on single-channel Cl(-) currents in brown adipocytes

scientific article published on 17 July 2007

Carboxyatractyloside effects on brown-fat mitochondria imply that the adenine nucleotide translocator isoforms ANT1 and ANT2 may be responsible for basal and fatty-acid-induced uncoupling respectively.

artículo científico publicado en 2006

Carteolol is a weak partial agonist on beta 3-adrenergic receptors in brown adipocytes.

artículo científico publicado en 1998

Caveolin-1-ablated mice survive in cold by nonshivering thermogenesis despite desensitized adrenergic responsiveness.

artículo científico publicado en 2010

Chloride channels in brown adipocyte plasma membranes: candidates for mediation of alpha 1-adrenergic depolarization?

artículo científico publicado en 1995

Choline+ is a low-affinity ligand for alpha 1-adrenoceptors

scientific article published on 01 October 1994

Chronic peroxisome proliferator-activated receptor gamma (PPARgamma) activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent, UCP1-containing adipocytes molecularly distinct from classic [...]

artículo científico publicado en 2009

Cidea improves the metabolic profile through expansion of adipose tissue

artículo científico publicado en 2015

Cig30 and Pitx3 genes are arranged in a partially overlapping tail-to-tail array resulting in complementary transcripts

artículo científico publicado en 1999

Cig30, a mouse member of a novel membrane protein gene family, is involved in the recruitment of brown adipose tissue.

artículo científico publicado en 1997

Cold tolerance of UCP1-ablated mice: a skeletal muscle mitochondria switch toward lipid oxidation with marked UCP3 up-regulation not associated with increased basal, fatty acid- or ROS-induced uncoupling or enhanced GDP effects

artículo científico publicado en 2010

Cold-induced alterations of phospholipid fatty acyl composition in brown adipose tissue mitochondria are independent of uncoupling protein-1

article

Cold-induced expression of the VEGF gene in brown adipose tissue is independent of thermogenic oxygen consumption

artículo científico publicado en 2005

Comparison of the pharmacological profiles of adrenergic drugs (including BRL-agonists) at [3H]prazosin and [3H]CGP-12177 binding sites in brown adipose tissue

artículo científico publicado en 1989

Contrasting adrenergic effects on lipoprotein lipase gene expression in the brown adipose tissue of intact mice and in cultured brown adipocytes from mice

article

Contrasting effects of cold acclimation versus obesogenic diets on chemerin gene expression in brown and brite adipose tissues

artículo científico publicado en 2014

Corrigendum: Cidea improves the metabolic profile through expansion of adipose tissue

artículo científico publicado en 2016

DNA synthesis in mouse brown adipose tissue is under beta-adrenergic control

artículo científico publicado en 1989

Depressed thermogenesis but competent brown adipose tissue recruitment in mice devoid of all hormone-binding thyroid hormone receptors.

artículo científico publicado en 2003

Development of brown fat cells in monolayer culture. I. Morphological and biochemical distinction from white fat cells in culture

scientific article published on 01 November 1983

Developmental biology: Neither fat nor flesh.

artículo científico publicado en 2008

Differential adrenergic regulation of the gene expression of the beta-adrenoceptor subtypes beta1, beta2 and beta3 in brown adipocytes.

artículo científico publicado en 2000

Differential involvement of caveolin-1 in brown adipocyte signaling: impaired beta3-adrenergic, but unaffected LPA, PDGF and EGF receptor signaling.

artículo científico publicado en 2010

Differential role of Presenilin-1 and -2 on mitochondrial membrane potential and oxygen consumption in mouse embryonic fibroblasts

artículo científico publicado en 2006

Differential signalling pathways for EGF versus PDGF activation of Erk1/2 MAP kinase and cell proliferation in brown pre-adipocytes

artículo científico publicado en 2008

Distinct expression of muscle-specific microRNAs (myomirs) in brown adipocytes.

artículo científico publicado en 2009

Down-regulation of beta3 adrenoreceptor gene expression in brown fat cells is transient and recovery is dependent upon a short-lived protein factor

artículo científico publicado en 1996

ERRγ enhances UCP1 expression and fatty acid oxidation in brown adipocytes.

artículo científico publicado en 2013

Effect of transforming growth factor-beta on calcium homeostasis in prostate carcinoma cells.

artículo científico publicado en 2003

Effects of guanine nucleotides and cations on agonist affinity of alpha 1-adrenoceptors in brown adipose tissue

artículo científico publicado en 1985

Enzyme-linked immunosorbent assay (ELISA) studies of the interaction between mammalian and avian anti-thermogenin antibodies and brown-adipose-tissue mitochondria from different species

scientific article published on 01 January 1984

Essential role of UCP1 modulating the central effects of thyroid hormones on energy balance

artículo científico publicado en 2016

Euthyroid status is essential for the perinatal increase in thermogenin mRNA in brown adipose tissue of rat pups

scientific article published on 01 October 1987

Exclusive occurrence of thermogenin antigen in brown adipose tissue

scientific article published on 01 December 1982

Gene-chip studies of adipogenesis-regulated microRNAs in mouse primary adipocytes and human obesity

artículo científico publicado en 2011

Genetic and functional characterization of clonally derived adult human brown adipocytes

artículo científico publicado en 2015

Genome-wide profiling of peroxisome proliferator-activated receptor γ in primary epididymal, inguinal, and brown adipocytes reveals depot-selective binding correlated with gene expression

artículo científico publicado en 2012

Halothane selectively inhibits nonshivering thermogenesis. Possible implications for thermoregulation during anesthesia of infants.

artículo científico publicado en 1995

Hormone-induced mitochondrial fission is utilized by brown adipocytes as an amplification pathway for energy expenditure

scientific article published on 15 January 2014

How brown is brown fat? It depends where you look.

artículo científico publicado en 2013

Human mediastinal adipose tissue displays certain characteristics of brown fat.

artículo científico publicado en 2013

Hypoxia-Independent Angiogenesis in Adipose Tissues during Cold Acclimation

artículo científico publicado en 2009

Improved health-span and lifespan in mtDNA mutator mice treated with the mitochondrially targeted antioxidant SkQ1.

artículo científico publicado en 2017

In brown adipocytes, adrenergically induced β₁-/β₃-(Gs)-, α₂-(Gi)- and α₁-(Gq)-signalling to Erk1/2 activation is not mediated via EGF receptor transactivation

artículo científico publicado en 2013

Increased alpha 1-adrenergic receptor density in brown adipose tissue of cafeteria-fed rats

scientific article published on 01 October 1984

Increased alpha 1-adrenergic receptor density in brown adipose tissue of cold-acclimated rats and hamsters

artículo científico publicado en 1984

Increased fatigue resistance linked to Ca2+-stimulated mitochondrial biogenesis in muscle fibres of cold-acclimated mice

artículo científico publicado en 2010

Increased respiration in skeletal muscle mitochondria from cold-acclimated ducklings: uncoupling effects of free fatty acids.

artículo científico publicado en 1986

Induction of uncoupling protein in brown adipose tissue. Synergy between norepinephrine and pioglitazone, an insulin-sensitizing agent

artículo científico publicado en 1996

Inhibition of acetyl-carnitine oxidation in rat brown-adipose-tissue mitochondria by erucoyl-carnitine is due to sequestration of CoA.

artículo científico publicado en 1985

Inhibitory effects of halothane on the thermogenic pathway in brown adipocytes: localization to adenylyl cyclase and mitochondrial fatty acid oxidation.

artículo científico publicado en 2004

Kinetics of the inhibition of mitochondrial respiration by NO

artículo científico publicado en 1997

Leptin Raises Defended Body Temperature without Activating Thermogenesis

artículo científico publicado en 2016

Leptin-deficient mice are not hypothermic, they are anapyrexic

artículo científico publicado en 2016

Leptin: Is It Thermogenic?

scientific article published on 01 April 2020

Leydig cell steroidogenesis unexpectedly escapes mitochondrial dysfunction in prematurely aging mice.

artículo científico publicado en 2015

Life without UCP1: mitochondrial, cellular and organismal characteristics of the UCP1-ablated mice.

artículo científico publicado en 2001

Metabolic consequences of limited substrate anion permeability in brown fat mitochondria from a hibernator, the golden hamster

scientific article published on 01 August 1984

Metabolic consequences of the presence or absence of the thermogenic capacity of brown adipose tissue in mice (and probably in humans).

artículo científico publicado en 2010

Metabolically inert perfluorinated fatty acids directly activate uncoupling protein 1 in brown-fat mitochondria

artículo científico publicado en 2015

Mitochondrial ('mild') uncoupling and ROS production: physiologically relevant or not?

artículo científico

Mitochondrial ATP synthase levels in brown adipose tissue are governed by the c-Fo subunit P1 isoform

artículo científico publicado en 2007

Myogenic gene expression signature establishes that brown and white adipocytes originate from distinct cell lineages.

artículo científico publicado en 2007

Native UCP1 displays simple competitive kinetics between the regulators purine nucleotides and fatty acids.

artículo científico publicado en 2004

Neither brown nor white

artículo científico publicado en 2012

New powers of brown fat: fighting the metabolic syndrome

artículo científico publicado en 2011

No insulating effect of obesity.

artículo científico publicado en 2016

Non-transactivational, dual pathways for LPA-induced Erk1/2 activation in primary cultures of brown pre-adipocytes

artículo científico publicado en 2010

Nonshivering thermogenesis and its adequate measurement in metabolic studies

artículo científico publicado en 2011

Noradrenaline represses PPAR (peroxisome-proliferator-activated receptor) gamma2 gene expression in brown adipocytes: intracellular signalling and effects on PPARgamma2 and PPARgamma1 protein levels

artículo científico publicado en 2004

Norepinephrine but not hypoxia stimulates HIF-1alpha gene expression in brown adipocytes

artículo científico publicado en 2005

Norepinephrine specifically stimulates ribonucleotide reductase subunit R2 gene expression in proliferating brown adipocytes: mediation via a cAMP/PKA pathway involving Src and Erk1/2 kinases

artículo científico publicado en 2002

Norepinephrine-induced synthesis of the uncoupling protein thermogenin (UCP) and its mitochondrial targeting in brown adipocytes differentiated in culture

scientific article published on 01 July 1990

Optimal housing temperatures for mice to mimic the thermal environment of humans: An experimental study.

artículo científico publicado en 2017

Overview--preparation and properties of mitochondria from different sources

artículo científico publicado en 1979

PPARalpha does not suppress muscle-associated gene expression in brown adipocytes but does influence expression of factors that fingerprint the brown adipocyte

artículo científico publicado en 2010

PPARgamma in the control of brown adipocyte differentiation.

artículo científico publicado en 2005

Parallel increases in amount of (3H)GDP binding and thermogenin antigen in brown-adipose-tissue mitochondria of cafeteria-fed rats

scientific article published on 01 August 1984

Partial protection against erucoyl-carnitine inhibition in hamster brown-adipose-tissue mitochondria is due to high CoA levels: a comparison with rat brown-adipose-tissue mitochondria.

artículo científico publicado en 1986

Physiological activation of brown adipose tissue destabilizes thermogenin mRNA

artículo científico publicado en 1987

Presence of a Ca2+-dependent K+ channel in brown adipocytes. Possible role in maintenance of alpha 1-adrenergic stimulation

scientific article published on 01 January 1985

Promotion of lipid storage rather than of thermogenic competence by fetal versus newborn calf serum in primary cultures of brown adipocytes

artículo científico publicado en 2018

Protein kinase a-mediated cell proliferation in brown preadipocytes is independent of Erk1/2, PI3K and mTOR.

artículo científico publicado en 2014

Pyruvate kinase M2 represses thermogenic gene expression in brown adipocytes

scientific article published on 10 December 2019

Quantitative differentiation of alpha- and beta-adrenergic respiratory responses in isolated hamster brown fat cells: evidence for the presence of an alpha 1-adrenergic component

artículo científico publicado en 1983

ROS production in brown adipose tissue mitochondria: the question of UCP1-dependence.

artículo científico publicado en 2014

Random point mutations with major effects on protein-coding genes are the driving force behind premature aging in mtDNA mutator mice

artículo científico publicado en 2009

Recruited vs. nonrecruited molecular signatures of brown, "brite," and white adipose tissues

artículo científico publicado en 2011

Reply to letter to the editor: at thermoneutrality, neither the lean nor the obese freeze

artículo científico publicado en 2016

Requirement of gene transcription and protein synthesis for cold- and norepinephrine-induced stimulation of thyroxine deiodinase in rat brown adipose tissue

artículo científico publicado en 1986

Retinoblastoma protein functions as a molecular switch determining white versus brown adipocyte differentiation.

scholarly article

Reversible blockade of the calcium-activated nonselective cation channel in brown fat cells by the sulfhydryl reagents mercury and thimerosal

scientific article published on 01 December 1993

S10.25 Effect of targeted quinones on ROS production and lipid peroxidation in mitochondria: Mitochondrial DNA polymerase mutant mice exibit high sensitivity

S14.4 Random mtDNA mutations cause respiratory dysfunction through failure in complex assembly

S14.6 Impaired thermogenesis in PolgA mtDNA polymerase mutant mice

SOD2 overexpression: enhanced mitochondrial tolerance but absence of effect on UCP activity

artículo científico publicado en 2005

Single Case Method in Psychology: How to Improve as a Possible Methodology in Quantitative Research.

artículo científico

Studies of thermogenesis and mitochondrial function in adipose tissues

artículo científico publicado en 2008

Sulfonates are low-affinity ligands for the GDP-binding site of brown-fat mitochondria

scientific article published on 01 May 1994

The 'novel' 'uncoupling' proteins UCP2 and UCP3: what do they really do? Pros and cons for suggested functions.

artículo científico publicado en 2003

The Environmental Pollutants Perfluorooctane Sulfonate and Perfluorooctanoic Acid Upregulate Uncoupling Protein 1 (UCP1) in Brown-Fat Mitochondria Through a UCP1-Dependent Reduction in Food Intake.

artículo científico publicado en 2015

The bioenergetics of brown fat mitochondria from UCP1-ablated mice. Ucp1 is not involved in fatty acid-induced de-energization ("uncoupling")

artículo científico publicado en 1999

The browning of white adipose tissue: some burning issues

artículo científico publicado en 2014

The changed metabolic world with human brown adipose tissue: therapeutic visions.

scientific article published on April 2010

The effect of intermittent cold treatment on the adipose tissue of the cat. Apparent transformation from white to brown adipose tissue.

artículo científico publicado en 1986

The expression of subunit c correlates with and thus may limit the biosynthesis of the mitochondrial F0F1-ATPase in brown adipose tissue.

artículo científico publicado en 1995

The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue.

artículo científico publicado en 2009

The β3-adrenergic receptor is dispensable for browning of adipose tissues.

artículo científico publicado en 2017

Thermogenesis challenges the adipostat hypothesis for body-weight control.

artículo científico publicado en 2009

Thermogenesis inhibition in brown adipocytes is a specific property of volatile anesthetics.

artículo científico publicado en 2003

Thermogenic responses in brown fat cells are fully UCP1-dependent. UCP2 or UCP3 do not substitute for UCP1 in adrenergically or fatty scid-induced thermogenesis

artículo científico publicado en 2000

Thermogenically competent nonadrenergic recruitment in brown preadipocytes by a PPARgamma agonist.

artículo científico publicado en 2008

Three years with adult human brown adipose tissue

artículo científico publicado en 2010

Thyroid hormones: igniting brown fat via the brain

scientific article published on 01 September 2010

UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality

scientific journal article

UCP1 and defense against oxidative stress. 4-Hydroxy-2-nonenal effects on brown fat mitochondria are uncoupling protein 1-independent.

artículo científico publicado en 2006

UCP1 in adipose tissues: two steps to full browning.

artículo científico publicado en 2017

UCP1 in brite/beige adipose tissue mitochondria is functionally thermogenic.

artículo científico publicado en 2013

UCP1 induction during recruitment of brown adipocytes in white adipose tissue is dependent on cyclooxygenase activity

artículo científico publicado en 2010

UCP1 inhibition in Cidea-overexpressing mice is physiologically counteracted by brown adipose tissue hyperrecruitment.

artículo científico publicado en 2016

UCP1 is essential for adaptive adrenergic nonshivering thermogenesis

scientific article published on 04 April 2006

UCP1 mRNA does not produce heat.

artículo científico publicado en 2013

UCP1: the only protein able to mediate adaptive non-shivering thermogenesis and metabolic inefficiency.

artículo científico publicado en 2001

UCP1: the original uncoupling protein--and perhaps the only one? New perspectives on UCP1, UCP2, and UCP3 in the light of the bioenergetics of the UCP1-ablated mice.

artículo científico publicado en 1999

Ultraendurance exercise increases the production of reactive oxygen species in isolated mitochondria from human skeletal muscle.

artículo científico publicado en 2010

Uncoupled respiration, ROS production, acute lipotoxicity and oxidative damage in isolated skeletal muscle mitochondria from UCP3-ablated mice

artículo científico publicado en 2011

Uncoupling protein-1 is not leaky

artículo científico publicado en 2010

Uncoupling proteins: current status and therapeutic prospects

artículo científico publicado en 2005

Unexpected evidence for active brown adipose tissue in adult humans

artículo científico publicado en 2007

What Ignites UCP1?

artículo científico publicado en 2017

Within brown-fat cells, UCP1-mediated fatty acid-induced uncoupling is independent of fatty acid metabolism

artículo científico publicado en 2008

Yes, even human brown fat is on fire!

artículo científico publicado en 2012

alpha- and beta-adrenergic control of thermogenin mRNA expression in brown adipose tissue

artículo científico publicado en 1986

alpha1-Adrenergic stimulation potentiates the thermogenic action of beta3-adrenoreceptor-generated cAMP in brown fat cells

artículo científico publicado en 1997

β3-Adrenergically induced glucose uptake in brown adipose tissue is independent of UCP1 presence or activity: Mediation through the mTOR pathway

artículo científico publicado en 2017