Lista de obras - Mathieu Lupien - Dominio Público Uruguay

A Myc enhancer cluster regulates normal and leukaemic haematopoietic stem cell hierarchies

artículo científico publicado en 2018

A chemical toolbox for the study of bromodomains and epigenetic signaling

artículo científico publicado en 2019

A comprehensive view of nuclear receptor cancer cistromes

artículo científico publicado en 2011

A global assessment of cancer genomic alterations in epigenetic mechanisms

artículo científico

ABC: a tool to identify SNVs causing allele-specific transcription factor binding from ChIP-Seq experiments

artículo científico publicado en 2015

Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer

scientific article published on July 2009

Antibodies against the PER protein of Drosophila label neurons in the optic lobe, central brain, and thoracic ganglia of the crickets Teleogryllus commodus and Teleogryllus oceanicus

artículo científico publicado en 2003

BioID identifies novel c-MYC interacting partners in cultured cells and xenograft tumors

artículo científico publicado en 2015

Biological and therapeutic implications of a unique subtype of NPM1 mutated AML

artículo científico publicado en 2021

Blockade of AP-1 Potentiates Endocrine Therapy and Overcomes Resistance.

artículo científico publicado en 2016

Breast cancer risk-associated SNPs modulate the affinity of chromatin for FOXA1 and alter gene expression

artículo científico publicado en 2012

C3D: a tool to predict 3D genomic interactions between cis-regulatory elements

scientific article published on 01 March 2019

CARM1 regulates estrogen-stimulated breast cancer growth through up-regulation of E2F1.

artículo científico publicado en 2008

Cancer heterogeneity: origins and implications for genetic association studies

artículo científico publicado en 2012

Cell-type selective chromatin remodeling defines the active subset of FOXA1-bound enhancers

artículo científico publicado en 2009

Chromatin and epigenetic determinants of estrogen receptor alpha (ESR1) signaling.

artículo científico

Chromatin landscape and endocrine response in breast cancer.

artículo científico

Chromatin profiling reveals regulatory network shifts and a protective role for hepatocyte nuclear factor 4α during colitis.

artículo científico publicado en 2014

Cistromics of hormone-dependent cancer

artículo científico publicado en 2009

Coactivator function defines the active estrogen receptor alpha cistrome

artículo científico publicado en 2009

Combinatorial effects of multiple enhancer variants in linkage disequilibrium dictate levels of gene expression to confer susceptibility to common traits

artículo científico publicado en 2013

Combining chromatin immunoprecipitation and oligonucleotide tiling arrays (ChIP-Chip) for functional genomic studies

artículo científico publicado en 2009

Dual suppression of the cyclin-dependent kinase inhibitors CDKN2C and CDKN1A in human melanoma.

artículo científico publicado en 2012

Early-life antibiotic treatment enhances the pathogenicity of CD4+ T cells during intestinal inflammation.

artículo científico publicado en 2016

Elucidation of the ELK1 target gene network reveals a role in the coordinate regulation of core components of the gene regulation machinery

artículo científico publicado en 2009

Emergence of the Noncoding Cancer Genome: A Target of Genetic and Epigenetic Alterations

artículo científico publicado en 2016

Enhancer alterations in cancer: a source for a cell identity crisis

artículo científico publicado en 2014

Epigenetic switch involved in activation of pioneer factor FOXA1-dependent enhancers

artículo científico publicado en 2011

Epigenetic switch-induced viral mimicry evasion in chemotherapy resistant breast cancer

artículo científico publicado en 2020

Epigenomic alterations define lethal CIMP-positive ependymomas of infancy

artículo científico publicado en 2014

Epigenomic enhancer profiling defines a signature of colon cancer

artículo científico publicado en 2012

Estrogen controls the survival of BRCA1-deficient cells via a PI3K-NRF2-regulated pathway

scientific article published on 24 February 2014

Estrogen-dependent signaling in a molecularly distinct subclass of aggressive prostate cancer

artículo científico publicado en 2008

Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation

artículo científico publicado en 2014

Exploiting tumor epigenetics to improve oncolytic virotherapy

artículo científico publicado en 2013

Expression of constitutively active Notch1 in male genital tracts results in ectopic growth and blockage of efferent ducts, epididymal hyperplasia and sterility.

artículo científico publicado en 2006

FoxA1 translates epigenetic signatures into enhancer-driven lineage-specific transcription

artículo científico publicado en 2008

GLUT1 inhibition blocks growth of RB1-positive triple negative breast cancer

scientific article published on 21 August 2020

Genomic collaboration of estrogen receptor alpha and extracellular signal-regulated kinase 2 in regulating gene and proliferation programs

artículo científico publicado en 2010

Genomic hallmarks of localized, non-indolent prostate cancer.

artículo científico publicado en 2017

Growth factor stimulation induces a distinct ER(alpha) cistrome underlying breast cancer endocrine resistance

artículo científico publicado en 2010

Human somatic cell mutagenesis creates genetically tractable sarcomas

artículo científico publicado en 2014

Human-chromatin-related protein interactions identify a demethylase complex required for chromosome segregation

artículo científico publicado en 2014

Identification of PBX1 target genes in cancer cells by global mapping of PBX1 binding sites

artículo científico publicado en 2012

Identifying clusters of cis-regulatory elements underpinning TAD structures and lineage-specific regulatory networks

scientific article published on 18 September 2019

Inferring Human Phenotype Networks from Genome-Wide Genetic Associations

Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors

artículo científico publicado en 2016

Integrative functional genomics identifies an enhancer looping to the SOX9 gene disrupted by the 17q24.3 prostate cancer risk locus

artículo científico publicado en 2012

Intratumor DNA methylation heterogeneity reflects clonal evolution in aggressive prostate cancer.

artículo científico publicado en 2014

Layers of epistasis: genome-wide regulatory networks and network approaches to genome-wide association studies

artículo científico publicado en 2010

Laying a solid foundation for Manhattan--'setting the functional basis for the post-GWAS era'.

artículo científico publicado en 2014

MLL5 Orchestrates a Cancer Self-Renewal State by Repressing the Histone Variant H3.3 and Globally Reorganizing Chromatin

artículo científico publicado en 2015

Methyltransferase G9A regulates T cell differentiation during murine intestinal inflammation

artículo científico publicado en 2014

Modulation of long noncoding RNAs by risk SNPs underlying genetic predispositions to prostate cancer.

artículo científico publicado en 2016

Molecular Insights of Pathways Resulting from Two Common PIK3CA Mutations in Breast Cancer

artículo científico publicado en 2016

Multimodal regulation of E2F1 gene expression by progestins

artículo científico publicado en 2010

Mutant IDH1 Downregulates ATM and Alters DNA Repair and Sensitivity to DNA Damage Independent of TET2.

artículo científico publicado en 2016

Noncoding mutations target cis-regulatory elements of the FOXA1 plexus in prostate cancer

scientific article published on 23 January 2020

Noncoding somatic and inherited single-nucleotide variants converge to promote ESR1 expression in breast cancer.

scientific article published on 29 August 2016

Nucleosome dynamics define transcriptional enhancers

artículo científico publicado en 2010

PBX1 genomic pioneer function drives ERα signaling underlying progression in breast cancer.

artículo científico publicado en 2011

PRMT5 inhibition disrupts splicing and stemness in glioblastoma

artículo científico publicado en 2021

PRMT5 regulates ATF4 transcript splicing and oxidative stress response

artículo científico publicado en 2022

PRMT5 regulates ATF4 transcript splicing and oxidative stress response

preprint

Personalized diagnosis of medulloblastoma subtypes across patients and model systems

artículo científico publicado en 2015

PharmacoGx: an R package for analysis of large pharmacogenomic datasets.

artículo científico publicado en 2015

Pioneer factors: directing transcriptional regulators within the chromatin environment ⬇️

artículo científico publicado el 30 de agosto de 2011

Pioneer of prostate cancer: past, present and the future of FOXA1

scientific article published on 18 September 2020

Positive cross-regulatory loop ties GATA-3 to estrogen receptor alpha expression in breast cancer

artículo científico publicado en 2007

Pre-neoplastic epigenetic disruption of transcriptional enhancers in chronic inflammation.

artículo científico publicado en 2016

Raloxifene and ICI182,780 increase estrogen receptor-alpha association with a nuclear compartment via overlapping sets of hydrophobic amino acids in activation function 2 helix 12.

artículo científico publicado en 2007

SMuRF: a novel tool to identify regulatory elements enriched for somatic point mutations

scholarly article by Paul Guilhamon published in November 2018

Single-cell chromatin accessibility profiling of glioblastoma identifies an invasive cancer stem cell population associated with lower survival

scientific article published in 2021

TMPRSS2-ERG fusion co-opts master transcription factors and activates NOTCH signaling in primary prostate cancer.

artículo científico

Tamoxifen and raloxifene differ in their functional interactions with aspartate 351 of estrogen receptor alpha

artículo científico publicado en 2006

Targeting bivalency de-represses Indian Hedgehog and inhibits self-renewal of colorectal cancer-initiating cells

scientific article published on 29 March 2019

Telomere dysfunction cooperates with epigenetic alterations to impair murine embryonic stem cell fate commitment

scientific article published on 16 April 2020

The Transcriptional Repressor Polycomb Group Factor 6, PCGF6, Negatively Regulates Dendritic Cell Activation and Promotes Quiescence.

artículo científico publicado en 2016

The histone variant H2A.Z is an important regulator of enhancer activity

artículo científico publicado en 2015

Transcriptome-wide characterization of the endogenous miR-34A-p53 tumor suppressor network

artículo científico publicado en 2016

Unique ERalpha cistromes control cell type-specific gene regulation

artículo científico publicado en 2008

Variant Set Enrichment: an R package to identify disease-associated functional genomic regions.

artículo científico publicado en 2017

ZNF143 provides sequence specificity to secure chromatin interactions at gene promoters

artículo científico publicado en 2015

[Colorectal cancer is typified by enhancer specific epigenetic mutations]

artículo científico publicado en 2012

Lista de obras de Mathieu Lupien

A Myc enhancer cluster regulates normal and leukaemic haematopoietic stem cell hierarchies

A chemical toolbox for the study of bromodomains and epigenetic signaling

A comprehensive view of nuclear receptor cancer cistromes

A global assessment of cancer genomic alterations in epigenetic mechanisms

ABC: a tool to identify SNVs causing allele-specific transcription factor binding from ChIP-Seq experiments

Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer

Antibodies against the PER protein of Drosophila label neurons in the optic lobe, central brain, and thoracic ganglia of the crickets Teleogryllus commodus and Teleogryllus oceanicus

BioID identifies novel c-MYC interacting partners in cultured cells and xenograft tumors

Biological and therapeutic implications of a unique subtype of NPM1 mutated AML

Blockade of AP-1 Potentiates Endocrine Therapy and Overcomes Resistance.

Breast cancer risk-associated SNPs modulate the affinity of chromatin for FOXA1 and alter gene expression

C3D: a tool to predict 3D genomic interactions between cis-regulatory elements

CARM1 regulates estrogen-stimulated breast cancer growth through up-regulation of E2F1.

Cancer heterogeneity: origins and implications for genetic association studies

Cell-type selective chromatin remodeling defines the active subset of FOXA1-bound enhancers

Chromatin and epigenetic determinants of estrogen receptor alpha (ESR1) signaling.

Chromatin landscape and endocrine response in breast cancer.

Chromatin profiling reveals regulatory network shifts and a protective role for hepatocyte nuclear factor 4α during colitis.

Cistromics of hormone-dependent cancer

Coactivator function defines the active estrogen receptor alpha cistrome

Combinatorial effects of multiple enhancer variants in linkage disequilibrium dictate levels of gene expression to confer susceptibility to common traits

Combining chromatin immunoprecipitation and oligonucleotide tiling arrays (ChIP-Chip) for functional genomic studies

Dual suppression of the cyclin-dependent kinase inhibitors CDKN2C and CDKN1A in human melanoma.

Early-life antibiotic treatment enhances the pathogenicity of CD4+ T cells during intestinal inflammation.

Elucidation of the ELK1 target gene network reveals a role in the coordinate regulation of core components of the gene regulation machinery

Emergence of the Noncoding Cancer Genome: A Target of Genetic and Epigenetic Alterations

Enhancer alterations in cancer: a source for a cell identity crisis

Epigenetic switch involved in activation of pioneer factor FOXA1-dependent enhancers

Epigenetic switch-induced viral mimicry evasion in chemotherapy resistant breast cancer

Epigenomic alterations define lethal CIMP-positive ependymomas of infancy

Epigenomic enhancer profiling defines a signature of colon cancer

Estrogen controls the survival of BRCA1-deficient cells via a PI3K-NRF2-regulated pathway

Estrogen-dependent signaling in a molecularly distinct subclass of aggressive prostate cancer

Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation

Exploiting tumor epigenetics to improve oncolytic virotherapy

Expression of constitutively active Notch1 in male genital tracts results in ectopic growth and blockage of efferent ducts, epididymal hyperplasia and sterility.

FoxA1 translates epigenetic signatures into enhancer-driven lineage-specific transcription

GLUT1 inhibition blocks growth of RB1-positive triple negative breast cancer

Genomic collaboration of estrogen receptor alpha and extracellular signal-regulated kinase 2 in regulating gene and proliferation programs

Genomic hallmarks of localized, non-indolent prostate cancer.

Growth factor stimulation induces a distinct ER(alpha) cistrome underlying breast cancer endocrine resistance

Human somatic cell mutagenesis creates genetically tractable sarcomas

Human-chromatin-related protein interactions identify a demethylase complex required for chromosome segregation

Identification of PBX1 target genes in cancer cells by global mapping of PBX1 binding sites

Identifying clusters of cis-regulatory elements underpinning TAD structures and lineage-specific regulatory networks

Inferring Human Phenotype Networks from Genome-Wide Genetic Associations

Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors

Integrative functional genomics identifies an enhancer looping to the SOX9 gene disrupted by the 17q24.3 prostate cancer risk locus

Intratumor DNA methylation heterogeneity reflects clonal evolution in aggressive prostate cancer.

Layers of epistasis: genome-wide regulatory networks and network approaches to genome-wide association studies

Laying a solid foundation for Manhattan--'setting the functional basis for the post-GWAS era'.

MLL5 Orchestrates a Cancer Self-Renewal State by Repressing the Histone Variant H3.3 and Globally Reorganizing Chromatin

Methyltransferase G9A regulates T cell differentiation during murine intestinal inflammation

Modulation of long noncoding RNAs by risk SNPs underlying genetic predispositions to prostate cancer.

Molecular Insights of Pathways Resulting from Two Common PIK3CA Mutations in Breast Cancer

Multimodal regulation of E2F1 gene expression by progestins

Mutant IDH1 Downregulates ATM and Alters DNA Repair and Sensitivity to DNA Damage Independent of TET2.

Noncoding mutations target cis-regulatory elements of the FOXA1 plexus in prostate cancer

Noncoding somatic and inherited single-nucleotide variants converge to promote ESR1 expression in breast cancer.

Nucleosome dynamics define transcriptional enhancers

PBX1 genomic pioneer function drives ERα signaling underlying progression in breast cancer.

PRMT5 inhibition disrupts splicing and stemness in glioblastoma

PRMT5 regulates ATF4 transcript splicing and oxidative stress response

PRMT5 regulates ATF4 transcript splicing and oxidative stress response

Personalized diagnosis of medulloblastoma subtypes across patients and model systems

PharmacoGx: an R package for analysis of large pharmacogenomic datasets.

Pioneer factors: directing transcriptional regulators within the chromatin environment ⬇️

Pioneer of prostate cancer: past, present and the future of FOXA1

Positive cross-regulatory loop ties GATA-3 to estrogen receptor alpha expression in breast cancer

Pre-neoplastic epigenetic disruption of transcriptional enhancers in chronic inflammation.

Raloxifene and ICI182,780 increase estrogen receptor-alpha association with a nuclear compartment via overlapping sets of hydrophobic amino acids in activation function 2 helix 12.

SMuRF: a novel tool to identify regulatory elements enriched for somatic point mutations

Single-cell chromatin accessibility profiling of glioblastoma identifies an invasive cancer stem cell population associated with lower survival

TMPRSS2-ERG fusion co-opts master transcription factors and activates NOTCH signaling in primary prostate cancer.

Tamoxifen and raloxifene differ in their functional interactions with aspartate 351 of estrogen receptor alpha

Targeting bivalency de-represses Indian Hedgehog and inhibits self-renewal of colorectal cancer-initiating cells

Telomere dysfunction cooperates with epigenetic alterations to impair murine embryonic stem cell fate commitment

The Transcriptional Repressor Polycomb Group Factor 6, PCGF6, Negatively Regulates Dendritic Cell Activation and Promotes Quiescence.

The histone variant H2A.Z is an important regulator of enhancer activity