Lista de obras - Roberto Contestabile - Dominio Público Uruguay

A Bioinformatics Analysis Reveals a Group of MocR Bacterial Transcriptional Regulators Linked to a Family of Genes Coding for Membrane Proteins

artículo científico publicado en 2016

A Comprehensive Computational Analysis of Mycobacterium Genomes Pinpoints the Genes Co-occurring with YczE, a Membrane Protein Coding Gene Under the Putative Control of a MocR, and Predicts its Function.

artículo científico publicado en 2017

A pyrazolopyran derivative preferentially inhibits the activity of human cytosolic serine hydroxymethyltransferase and induces cell death in lung cancer cells.

artículo científico publicado en 2015

Alanine racemase from Tolypocladium inflatum: A key PLP-dependent enzyme in cyclosporin biosynthesis and a model of catalytic promiscuity

artículo científico publicado en 2012

Allosteric feedback inhibition of pyridoxine 5'-phosphate oxidase from Escherichia coli

scientific article published on 04 September 2019

An Engineered Escherichia coli Strain with Synthetic Metabolism for In-cell Production of Translationally Active Methionine Derivatives

artículo científico publicado en 2020

Arabidopsis thaliana serine hydroxymethyltransferases: functions, structures, and perspectives

artículo científico publicado en 2022

Asymmetry of the active site loop conformation between subunits of glutamate-1-semialdehyde aminomutase in solution

artículo científico publicado en 2013

Biochemical data from the characterization of a new pathogenic mutation of human pyridoxine-5'-phosphate oxidase (PNPO).

artículo científico publicado en 2017

Biomedical aspects of pyridoxal 5 -phosphate availability ⬇️

artículo científico publicado el 1 de enero de 2012

Catalytic and thermodynamic properties of tetrahydromethanopterin-dependent serine hydroxymethyltransferase from Methanococcus jannaschii

artículo científico publicado en 2003

Corrigendum to "Pyridoxine-5'-phosphate oxidase (Pnpo) deficiency: Clinical and biochemical alterations associated with the C.347g>A (P.·Arg116gln) mutation" [Mol. Genet. Metab. 122/1-2 (2017) 135-142]

artículo científico publicado en 2018

Coupling bioorthogonal chemistries with artificial metabolism: intracellular biosynthesis of azidohomoalanine and its incorporation into recombinant proteins.

artículo científico publicado en 2014

Crystal Structures of Human Pyridoxal Kinase in Complex with the Neurotoxins, Ginkgotoxin and Theophylline: Insights into Pyridoxal Kinase Inhibition

artículo científico publicado en 2012

Crystal structure of glutamate-1-semialdehyde aminomutase: an alpha2-dimeric vitamin B6-dependent enzyme with asymmetry in structure and active site reactivity

artículo científico publicado en 1997

Data from computational analysis of the peptide linkers in the MocR bacterial transcriptional regulators

artículo científico publicado en 2016

Differential 3-bromopyruvate inhibition of cytosolic and mitochondrial human serine hydroxymethyltransferase isoforms, key enzymes in cancer metabolic reprogramming.

artículo científico publicado en 2016

Differential inhibitory effect of a pyrazolopyran compound on human serine hydroxymethyltransferase-amino acid complexes

artículo científico publicado en 2018

Editorial: PLP-Dependent Enzymes: Extraordinary Versatile Catalysts and Ideal Biotechnological Tools for the Production of Unnatural Amino Acids and Related Compounds

artículo científico publicado en 2020

Enzymatic synthesis of ω-carboxy-β-hydroxy-(l)-α-amino acids

Functional Inactivation of Drosophila GCK Orthologs Causes Genomic Instability and Oxidative Stress in a Fly Model of MODY-2 ⬇️

artículo científico

Glycine consumption and mitochondrial serine hydroxymethyltransferase in cancer cells: the heme connection

artículo científico publicado en 2013

How pyridoxal 5'-phosphate differentially regulates human cytosolic and mitochondrial serine hydroxymethyltransferase oligomeric state

artículo científico publicado en 2015

Human Cytosolic and Mitochondrial Serine Hydroxymethyltransferase Isoforms in Comparison: Full Kinetic Characterization and Substrate Inhibition Properties

scientific article published on 07 December 2018

Identification and characterization of the pyridoxal 5’-phosphate allosteric site in Escherichia coli pyridoxine 5’-phosphate oxidase

artículo científico publicado en 2021

In silico and in vitro validation of serine hydroxymethyltransferase as a chemotherapeutic target of the antifolate drug pemetrexed

artículo científico publicado en 2011

Inhibition of human pyridoxal kinase by 2-acetyl-4-((1R,2S,3R)-1,2,3,4-tetrahydroxybutyl)imidazole (THI).

artículo científico publicado en 2014

Interaction of Bacillus subtilis GabR with the gabTD promoter: role of repeated sequences and effect of GABA in transcriptional activation

artículo científico publicado en 2020

Isolation of a Complex Formed Between HemA and HemL, Key Enzymes of Tetrapyrroles Biosynthesis

scientific article published on 26 February 2019

Molecular Basis of Reduced Pyridoxine 5′-Phosphate Oxidase Catalytic Activity in Neonatal Epileptic Encephalopathy Disorder

artículo científico publicado en 2009

Molecular basis of E. coli L-threonine aldolase catalytic inactivation at low pH.

artículo científico publicado en 2015

Molecular characterization of pyridoxine 5'-phosphate oxidase and its pathogenic forms associated with neonatal epileptic encephalopathy

artículo científico publicado en 2020

Molecular mechanism of PdxR – a transcriptional activator involved in the regulation of vitamin B6 biosynthesis in the probiotic bacterium Bacillus clausii

artículo científico publicado en 2015

Molecular mechanisms of the non-coenzyme action of thiamin in brain: biochemical, structural and pathway analysis.

artículo científico publicado en 2015

Mutation of tyrosine 332 to phenylalanine converts dopa decarboxylase into a decarboxylation-dependent oxidative deaminase

artículo científico publicado en 2002

On the catalytic mechanism and stereospecificity ofEscherichia colil-threonine aldolase

artículo científico publicado en 2014

On the mechanism of Escherichia coli pyridoxal kinase inhibition by pyridoxal and pyridoxal 5'-phosphate

artículo científico publicado en 2015

PLP-dependent enzymes

artículo científico publicado en 2014

Pyridoxal 5'-phosphate enzymes as targets for therapeutic agents

artículo científico publicado en 2007

Pyridoxal 5'-phosphate is a slow tight binding inhibitor of E. coli pyridoxal kinase.

artículo científico publicado en 2012

Pyridoxine-5'-phosphate oxidase (Pnpo) deficiency: Clinical and biochemical alterations associated with the C.347g>A (P.·Arg116gln) mutation.

artículo científico publicado en 2017

Role of a conserved active site cation-pi interaction in Escherichia coli serine hydroxymethyltransferase

artículo científico publicado en 2009

SHMT1 knockdown induces apoptosis in lung cancer cells by causing uracil misincorporation.

artículo científico publicado en 2014

Salmonella typhimurium PtsJ is a novel MocR-like transcriptional repressor involved in regulating the vitamin B6 salvage pathway

artículo científico publicado en 2016

Screening and in vitro testing of antifolate inhibitors of human cytosolic serine hydroxymethyltransferase.

artículo científico publicado en 2015

Serine hydroxymethyltransferase: a model enzyme for mechanistic, structural, and evolutionary studies

artículo científico publicado en 2010

Stereochemistry of the reactions of glutamate-1-semialdehyde aminomutase with 4,5-diaminovalerate

artículo científico publicado en 2003

Structural and kinetic properties of serine hydroxymethyltransferase from the halophytic cyanobacterium Aphanothece halophytica provide a rationale for salt tolerance

scientific article published on 14 May 2020

Structural basis of methotrexate and pemetrexed action on serine hydroxymethyltransferases revealed using plant models

scientific article published on 23 December 2019

Structural properties of the linkers connecting the N- and C- terminal domains in the MocR bacterial transcriptional regulators.

artículo científico publicado en 2016

Structural stability of the cofactor binding site in Escherichia coli serine hydroxymethyltransferase--the role of evolutionarily conserved hydrophobic contacts.

artículo científico publicado en 2009

Structure-based mechanism for early PLP-mediated steps of rabbit cytosolic serine hydroxymethyltransferase reaction

artículo científico publicado en 2013

Study of DNA binding and bending by Bacillus subtilis GabR, a PLP-dependent transcription factor

artículo científico publicado en 2016

The MocR-like transcription factors: pyridoxal 5'-phosphate-dependent regulators of bacterial metabolism

artículo científico publicado en 2018

The aspartate aminotransferase-like domain of Firmicutes MocR transcriptional regulators

The catalytic activity of serine hydroxymethyltransferase is essential for de novo nuclear dTMP synthesis in lung cancer cells

artículo científico publicado en 2018

The contribution of a conformationally mobile, active site loop to the reaction catalyzed by glutamate semialdehyde aminomutase

artículo científico publicado en 2000

The crystal structure of archaeal serine hydroxymethyltransferase reveals idiosyncratic features likely required to withstand high temperatures

artículo científico publicado en 2014

The expression of four pyridoxal kinase (PDXK) human variants in Drosophila impacts on genome integrity

scientific article published on 02 October 2019

The mechanism of addition of pyridoxal 5'-phosphate to Escherichia coli apo-serine hydroxymethyltransferase

artículo científico publicado en 2007

The moonlighting RNA-binding activity of cytosolic serine hydroxymethyltransferase contributes to control compartmentalization of serine metabolism

artículo científico publicado en 2019

The multifaceted role of vitamin B6 in cancer: Drosophila as a model system to investigate DNA damage

scientific article published on 25 March 2020

The role of evolutionarily conserved hydrophobic contacts in the quaternary structure stability of Escherichia coli serine hydroxymethyltransferase

artículo científico publicado en 2009

Threonine aldolase and alanine racemase: novel examples of convergent evolution in the superfamily of vitamin B6-dependent enzymes

artículo científico publicado en 2003

Vitamin B(6) salvage enzymes: mechanism, structure and regulation

artículo científico publicado en 2010

l-Threonine aldolase, serine hydroxymethyltransferase and fungal alanine racemase. A subgroup of strictly related enzymes specialized for different functions

artículo científico publicado en 2001

Lista de obras de Roberto Contestabile

A Bioinformatics Analysis Reveals a Group of MocR Bacterial Transcriptional Regulators Linked to a Family of Genes Coding for Membrane Proteins

A Comprehensive Computational Analysis of Mycobacterium Genomes Pinpoints the Genes Co-occurring with YczE, a Membrane Protein Coding Gene Under the Putative Control of a MocR, and Predicts its Function.

A pyrazolopyran derivative preferentially inhibits the activity of human cytosolic serine hydroxymethyltransferase and induces cell death in lung cancer cells.

Alanine racemase from Tolypocladium inflatum: A key PLP-dependent enzyme in cyclosporin biosynthesis and a model of catalytic promiscuity

Allosteric feedback inhibition of pyridoxine 5'-phosphate oxidase from Escherichia coli

An Engineered Escherichia coli Strain with Synthetic Metabolism for In-cell Production of Translationally Active Methionine Derivatives

Arabidopsis thaliana serine hydroxymethyltransferases: functions, structures, and perspectives

Asymmetry of the active site loop conformation between subunits of glutamate-1-semialdehyde aminomutase in solution

Biochemical data from the characterization of a new pathogenic mutation of human pyridoxine-5'-phosphate oxidase (PNPO).

Biomedical aspects of pyridoxal 5 -phosphate availability ⬇️

Catalytic and thermodynamic properties of tetrahydromethanopterin-dependent serine hydroxymethyltransferase from Methanococcus jannaschii

Corrigendum to "Pyridoxine-5'-phosphate oxidase (Pnpo) deficiency: Clinical and biochemical alterations associated with the C.347g>A (P.·Arg116gln) mutation" [Mol. Genet. Metab. 122/1-2 (2017) 135-142]

Coupling bioorthogonal chemistries with artificial metabolism: intracellular biosynthesis of azidohomoalanine and its incorporation into recombinant proteins.

Crystal Structures of Human Pyridoxal Kinase in Complex with the Neurotoxins, Ginkgotoxin and Theophylline: Insights into Pyridoxal Kinase Inhibition

Crystal structure of glutamate-1-semialdehyde aminomutase: an alpha2-dimeric vitamin B6-dependent enzyme with asymmetry in structure and active site reactivity

Data from computational analysis of the peptide linkers in the MocR bacterial transcriptional regulators

Differential 3-bromopyruvate inhibition of cytosolic and mitochondrial human serine hydroxymethyltransferase isoforms, key enzymes in cancer metabolic reprogramming.

Differential inhibitory effect of a pyrazolopyran compound on human serine hydroxymethyltransferase-amino acid complexes

Editorial: PLP-Dependent Enzymes: Extraordinary Versatile Catalysts and Ideal Biotechnological Tools for the Production of Unnatural Amino Acids and Related Compounds

Enzymatic synthesis of ω-carboxy-β-hydroxy-(l)-α-amino acids

Functional Inactivation of Drosophila GCK Orthologs Causes Genomic Instability and Oxidative Stress in a Fly Model of MODY-2 ⬇️

Glycine consumption and mitochondrial serine hydroxymethyltransferase in cancer cells: the heme connection

How pyridoxal 5'-phosphate differentially regulates human cytosolic and mitochondrial serine hydroxymethyltransferase oligomeric state

Human Cytosolic and Mitochondrial Serine Hydroxymethyltransferase Isoforms in Comparison: Full Kinetic Characterization and Substrate Inhibition Properties

Identification and characterization of the pyridoxal 5’-phosphate allosteric site in Escherichia coli pyridoxine 5’-phosphate oxidase

In silico and in vitro validation of serine hydroxymethyltransferase as a chemotherapeutic target of the antifolate drug pemetrexed

Inhibition of human pyridoxal kinase by 2-acetyl-4-((1R,2S,3R)-1,2,3,4-tetrahydroxybutyl)imidazole (THI).

Interaction of Bacillus subtilis GabR with the gabTD promoter: role of repeated sequences and effect of GABA in transcriptional activation

Isolation of a Complex Formed Between HemA and HemL, Key Enzymes of Tetrapyrroles Biosynthesis

Molecular Basis of Reduced Pyridoxine 5′-Phosphate Oxidase Catalytic Activity in Neonatal Epileptic Encephalopathy Disorder

Molecular basis of E. coli L-threonine aldolase catalytic inactivation at low pH.

Molecular characterization of pyridoxine 5'-phosphate oxidase and its pathogenic forms associated with neonatal epileptic encephalopathy

Molecular mechanism of PdxR – a transcriptional activator involved in the regulation of vitamin B6 biosynthesis in the probiotic bacterium Bacillus clausii

Molecular mechanisms of the non-coenzyme action of thiamin in brain: biochemical, structural and pathway analysis.

Mutation of tyrosine 332 to phenylalanine converts dopa decarboxylase into a decarboxylation-dependent oxidative deaminase

On the catalytic mechanism and stereospecificity ofEscherichia colil-threonine aldolase

On the mechanism of Escherichia coli pyridoxal kinase inhibition by pyridoxal and pyridoxal 5'-phosphate

PLP-dependent enzymes

Pyridoxal 5'-phosphate enzymes as targets for therapeutic agents

Pyridoxal 5'-phosphate is a slow tight binding inhibitor of E. coli pyridoxal kinase.

Pyridoxine-5'-phosphate oxidase (Pnpo) deficiency: Clinical and biochemical alterations associated with the C.347g>A (P.·Arg116gln) mutation.

Role of a conserved active site cation-pi interaction in Escherichia coli serine hydroxymethyltransferase

SHMT1 knockdown induces apoptosis in lung cancer cells by causing uracil misincorporation.

Salmonella typhimurium PtsJ is a novel MocR-like transcriptional repressor involved in regulating the vitamin B6 salvage pathway

Screening and in vitro testing of antifolate inhibitors of human cytosolic serine hydroxymethyltransferase.

Serine hydroxymethyltransferase: a model enzyme for mechanistic, structural, and evolutionary studies

Stereochemistry of the reactions of glutamate-1-semialdehyde aminomutase with 4,5-diaminovalerate

Structural and kinetic properties of serine hydroxymethyltransferase from the halophytic cyanobacterium Aphanothece halophytica provide a rationale for salt tolerance

Structural basis of methotrexate and pemetrexed action on serine hydroxymethyltransferases revealed using plant models

Structural properties of the linkers connecting the N- and C- terminal domains in the MocR bacterial transcriptional regulators.

Structural stability of the cofactor binding site in Escherichia coli serine hydroxymethyltransferase--the role of evolutionarily conserved hydrophobic contacts.

Structure-based mechanism for early PLP-mediated steps of rabbit cytosolic serine hydroxymethyltransferase reaction

Study of DNA binding and bending by Bacillus subtilis GabR, a PLP-dependent transcription factor

The MocR-like transcription factors: pyridoxal 5'-phosphate-dependent regulators of bacterial metabolism

The aspartate aminotransferase-like domain of Firmicutes MocR transcriptional regulators

The catalytic activity of serine hydroxymethyltransferase is essential for de novo nuclear dTMP synthesis in lung cancer cells

The contribution of a conformationally mobile, active site loop to the reaction catalyzed by glutamate semialdehyde aminomutase

The crystal structure of archaeal serine hydroxymethyltransferase reveals idiosyncratic features likely required to withstand high temperatures

The expression of four pyridoxal kinase (PDXK) human variants in Drosophila impacts on genome integrity

The mechanism of addition of pyridoxal 5'-phosphate to Escherichia coli apo-serine hydroxymethyltransferase

The moonlighting RNA-binding activity of cytosolic serine hydroxymethyltransferase contributes to control compartmentalization of serine metabolism

The multifaceted role of vitamin B6 in cancer: Drosophila as a model system to investigate DNA damage

The role of evolutionarily conserved hydrophobic contacts in the quaternary structure stability of Escherichia coli serine hydroxymethyltransferase

Threonine aldolase and alanine racemase: novel examples of convergent evolution in the superfamily of vitamin B6-dependent enzymes

Vitamin B(6) salvage enzymes: mechanism, structure and regulation

l-Threonine aldolase, serine hydroxymethyltransferase and fungal alanine racemase. A subgroup of strictly related enzymes specialized for different functions